Created at:1/16/2025
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Ububyimba bwa carcinoid ni ubwoko bw’uburwayi bwa kanseri bukura buhoro buhoro buturuka kuri selile za neuroendocrine, izo ni selile zidasanzwe zikora nk’iseli z’imyakura n’iseli zikora imisemburo. Aya bubyimba akunda kugaragara mu gice cy’igogorwa cyangwa mu bihaha, nubwo bishobora kuvuka ahantu hose mu mubiri.
Tekereza kuri selile za neuroendocrine nk’uburyo bwo kohereza ubutumwa bw’umubiri wawe. Zifasha kugenzura imikorere itandukanye binyuze mu kurekura imisemburo iyo bibaye ngombwa. Iyo izi selile zibaye kanseri, zishobora gukomeza gukora imisemburo, ariko mu bwinshi budasanzwe, ibyo bishobora gutera ibimenyetso bidasanzwe bitagaragara mu bindi binyabuzima bya kanseri.
Ububyimba bwinshi bwa carcinoid bukura buhoro cyane kandi bushobora kutazigera butera ibimenyetso mu myaka myinshi. Ibi bivuze ko abantu benshi babaho ubuzima busanzwe, bwiza nubwo bamaze kuvurwa neza no gukurikiranwa.
Ibimenyetso by’ububyimba bwa carcinoid bishobora kuba bigoye kuko abantu benshi nta bimenyetso na kimwe bagira, cyane cyane mu ntangiriro. Iyo ibimenyetso bigaragaye, bikunze kugaragara bitewe n’aho ububyibu bwoherejwe niba buri kurekura imisemburo myinshi mu maraso yawe.
Ibimenyetso bisanzwe ushobora kubona birimo impiswi idashira, kubabara mu nda, no gutukura mu maso no mu ijosi bihita bigenda. Bamwe bagira n’ikibazo cyo guhumeka cyangwa kugorana guhumeka, cyane cyane niba ububyibu buri mu bihaha byabo.
Dore ibimenyetso bishobora kuvuka iyo ububyibu bwa carcinoid burekure imisemburo myinshi:
Bamwe mu bantu bahura n’icyo abaganga bita “carcinoid crisis,” ikintu gicye ariko gikomeye. Ibi bibaho iyo igihumyo gitangira gutanga imisemburo myinshi mu buryo butunguranye, bigatera guhindagurika kw’uruhu, igitutu cy’amaraso gito cyane, no kugorana guhumeka. Niba ufite ibi bimenyetso bikomeye, shaka ubuvuzi bwihuse ako kanya.
Ni ngombwa kwibuka ko ibi bimenyetso bishobora guterwa n’ibindi bintu byinshi, kandi kuba ufite ntabwo bivuze ko ufite igihumyo cya carcinoid. Ariko rero, niba ubona ibimenyetso biramba bidakira n’ubuvuzi busanzwe, ni byiza kubiganiraho n’umuganga wawe.
Ibihumyo bya carcinoid bigabanywa hashingiwe aho bikura mu mubiri wawe, kandi aho biva akenshi bigena uko byitwara n’uburyo bw’ubuvuzi bukora neza. Gusobanukirwa ubwoko bufasha itsinda ry’abaganga bawe gutegura gahunda y’ubuvuzi ikwiranye n’umwanya wawe.
Ubwoko busanzwe ni ibihumyo bya carcinoid bya gastroenteropancreatic (GEP), bikura mu gice cy’igogora. Ibi birimo ibihumyo biri mu gifu, mu ruhago, mu muryango, mu mura, mu kibuno, no muri pancreas. Ibihumyo bya carcinoid biri mu ruhago ni byo biba byinshi kandi bishobora gukwirakwira mu bindi bice by’umubiri wawe.
Ibihumyo bya carcinoid byo mu mwijima, bizwi kandi nka bronchial carcinoids, bikura mu gice cy’ubuhumekero. Ibi bisanzwe bigabanywa mo ubwoko bubiri: carcinoids zisanzwe, zikura buhoro kandi zidakwirakwira, na carcinoids zidasanzwe, zikura vuba kandi zifite amahirwe menshi yo gukwirakwira.
Ubwoko buke bushobora gukura mu zindi nzego zitandukanye:
Buri bwoko bufite imico n’imikorere yabwo bwite. Urugero, kanseri ya apendisi ikunze kuvumburwa mu gihe cyo kubaga apendisi kandi ntiyakwirakwira, mu gihe kanseri yo mu ruhago nto ifite ubushobozi bwo gukwirakwira cyane ariko ikura buhoro ugereranyije n’izindi kanseri.
Impamvu nyakuri y’indwara ya kanseri ntiyumvikana neza, ariko abashakashatsi bemeza ko iterwa n’uko uturemangingo twa neuroendocrine tugira impinduka za gene zituma twakura kandi tugakwirakwira mu buryo butagengwa. Izi mpinduka za gene zishobora kubaho gahoro gahoro mu gihe nta kintu cyihariye kibitera.
Bitandukanye n’izindi kanseri, indwara ya kanseri ntigaragara cyane ko ifitanye isano n’imikorere y’ubuzima nko kunywa itabi, indyo, cyangwa kunywa inzoga. Ibyinshi muri byo bigaragara ko bibaho ku bw’impanuka, nubwo uburwayi bumwe bwa gene bushobora kongera ibyago byawe.
Uburwayi bumwe bwa gene bw’umuryango bushobora gutuma indwara ya kanseri iba nyinshi:
Kugira amateka y’umuryango w’indwara ya kanseri cyangwa ibindi bibazo by’ubuzima bifitanye isano na neuroendocrine bishobora kongera gato ibyago byawe, ariko abantu benshi barwaye kanseri nta mateka y’umuryango w’iyo ndwara bafite. Ibintu byo mu kirere ntibyagaragaye neza ko ari byo bituma indwara ya kanseri itera.
Ni byiza kumenya ko kubera ko impamvu zayo zidafitanye isano n’imikorere y’ubuzima, kugira indwara ya kanseri ntibivuze ko wakoze ikintu kibisha cyangwa ko wari wakwirinda ukoresheje amahitamo atandukanye.
Wagombye kubona muganga wawe niba ufite ibimenyetso biramba bidakira n’uburyo busanzwe bwo kuvura, cyane cyane niba bigira ingaruka ku buzima bwawe bwa buri munsi. Kubera ko ibimenyetso bya kanseri ya carcinoid bishobora kuba bito kandi bikagenda bigaragara buhoro buhoro, biroroshye kubyirengagiza mu ntangiriro.
Tegura gahunda yo kubonana na muganga niba ubona ibimenyetso byisubiramo byo gutukura mu maso bifatanije n’uburwaye bw’ibihaza, cyane cyane niba ibyo bimenyetso bibaho rimwe na rimwe. Nubwo ibyo bimenyetso bishobora kuba bifite imvano nyinshi, guhuza kwabyo bikwiye gukorwaho ubushakashatsi, cyane cyane niba imiti yo mu iduka idafasha.
Shaka ubufasha bwa muganga vuba niba ufite:
Niba ufite amateka yo mu muryango wa kanseri ya neuroendocrine cyangwa ibibazo by’indwara bifitanye isano n’imiterere ya gene, ubwire muganga wawe nubwo udafite ibimenyetso. Bashobora kugutekerezaho gukora isuzuma buri gihe cyangwa kugira inama ku bijyanye na gene kugira ngo bafashe gusuzuma ibyago byawe.
Ibuka ko ubundi burwaye bwinshi bushobora gutera ibimenyetso nk’ibyo, rero gerageza kudahangayika ubusa. Muganga wawe ashobora kugufasha kumenya niba ibimenyetso byawe bikwiye gukorwaho ubushakashatsi bwimbitse kandi akayobora mu bipimo byose bikenewe mu buryo bw’ubufasha.
Kanseri ya carcinoid ishobora kwibasira umuntu uwo ari we wese, ariko hari ibintu bimwe na bimwe bishobora kongera amahirwe yo kuyirwara gato. Gusobanukirwa ibyo bintu byongera ibyago bishobora kugufasha wowe na muganga wawe kuba maso, nubwo ari ingenzi kwibuka ko kuba ufite ibyo bintu byongera ibyago bidakubera impamvu uzahita urwara kanseri ya carcinoid.
Uburwayi bwa kanseri yo mu mara bugaragara ko ari bwo bangaza cyane, aho abantu benshi bafite iyi kanseri babimenya bafite hagati y’imyaka 50 na 70. Ariko kandi, iyi kanseri ishobora kugaragara mu kigero icyo ari cyo cyose, harimo no mu bana n’abangavu, nubwo bitabaho kenshi.
Ibintu byinshi bishobora kugira ingaruka ku kaga ufite:
Indwara zimwe na zimwe z’umuzuko zidakunze kugaragara zongera cyane ibyago, ariko zigira ingaruka ku bantu bake cyane. Niba ufite indwara y’umuzuko izwi ifitanye isano na kanseri z’imisemburo, muganga wawe arashobora kugusaba gukurikiranwa buri gihe.
Bikwiye kuzirikana ko abantu benshi bafite kanseri yo mu mara badafite ibintu by’ibanze byongera ibyago. Iyi kanseri ikunda kuza utabizi, bisobanura ko utakwiriye kwibasira cyangwa guhangayika cyane ku gukumira niba udafite ibintu byongera ibyago ushobora kugenzura.
Nubwo kanseri nyinshi zo mu mara zikura buhoro kandi ziguma zigenzurwa imyaka myinshi, zimwe mu ngaruka zishobora kuza uko iminsi igenda. Gusobanukirwa ibyo bishoboka bishobora kugufasha gukorana n’itsinda ry’abaganga bawe kugira ngo bakurikirane impinduka kandi bakemure ibibazo hakiri kare iyo kuvura ari bwo kugira ingaruka.
Ikibazo gikomeye cyane ni indwara ya carcinoid, ibaho iyo imisemburo myinshi isohotse mu mubiri. Ibi bikunda kubaho iyo kanseri ikwirakwira mu mwijima cyangwa iyo kanseri yo mu mwijima isohora imisemburo mu mubiri.
Indwara ya carcinoid ishobora gutera ingaruka nyinshi zikomeye:
Kimwe n’utundi turere tw’indwara ya kanseri, uturere tw’indwara ya kanseri ya carcinoid rimwe na rimwe dushobora gukwirakwira (kwimuka) mu zindi ngingo, cyane cyane umwijima, ibinyabutabire, amagufwa, cyangwa ibihaha. Ariko kandi, nubwo byakwirakwira, utu turere two muri kanseri twiyongera buhoro buhoro, kandi abantu benshi bakomeza kubaho neza bafite ubuvuzi bukwiye.
Bamwe bashobora kugira ikibazo cyo gufunga mu mara niba uturere tw’indwara ya kanseri ya carcinoid mu mara dukuruye bihagije kugira ngo bibuze igogora risanzwe. Ibi birakunda kubaho mu turere tw’indwara ya kanseri ya carcinoid mu mara mato kandi bisaba ubutabazi bwa muganga.
Inkuru ishimishije ni uko byinshi muri ibi bibazo bishobora kwirindwa cyangwa bigacungwa neza hifashishijwe ubuvuzi bugezweho. Gukurikirana buri gihe bituma ibibazo bifatwa hakiri kare, kandi imiti ishobora kugenzura ibimenyetso bifitanye isano n’imisemburo mu bihe byinshi.
Ikibabaje ni uko nta buryo bwemewe bwo kwirinda uturere tw’indwara ya kanseri ya carcinoid kuko bisanzwe biterwa n’impinduka z’imiterere ya gene zidahwitse kuruta ibintu bijyanye n’imibereho. Ibi bishobora gutera agahinda, ariko binasobanura ko utakwiye kwibasira niba ubifashwe.
Kubera ko uturere twinshi tw’indwara ya kanseri ya carcinoid tudafitanye isano n’ibiryo, itabi, inzoga, cyangwa ibindi bintu bijyanye n’imibereho, ingamba zisanzwe zo kwirinda kanseri ntizikwiye hano. Ariko kandi, kugira ubuzima bwiza muri rusange binyuze mu myitozo ngororamubiri, indyo yuzuye, no kwitabwaho n’abaganga buri gihe bishyigikira ubushobozi rusange bw’umubiri wawe bwo gusanga no gukemura impinduka z’ubuzima.
Niba ufite syndrome ya gene izwi izamura ibyago by’indwara ya kanseri ya carcinoid, inama y’abaganga ku bijyanye na gene ishobora kugufasha kumva uko ibintu byawe bihagaze. Muganga wawe ashobora kugutegeka:
Ku baturage muri rusange, uburyo bwiza ni ukumenya ibimenyetso bishoboka no kuguma usura abaganga buri gihe. Kumenya hakiri kare akenshi bigira ingaruka nziza, nubwo kudakira bitashoboka.
Ibanda ku byo ushobora kugenzura: kubaka umubano mwiza n’abaganga bawe, kuguma uzi imiterere isanzwe y’umubiri wawe, no gushaka ubuvuzi igihe ikintu cyumvikana kitari cyo igihe kirekire.
Kumenya uburwayi bwa carcinoid akenshi bisaba ibizamini bitandukanye kuko ibimenyetso bishobora kuba bito kandi bisa n’ibindi bibazo. Muganga wawe azatangira aganira nawe ku bimenyetso byawe n’amateka yawe y’ubuzima, akurikirwe no gusuzuma umubiri.
Uburyo bwo kuvura busanzwe butangira hakoreshejwe amaraso n’imisaraba kugira ngo harebwe urwego rwo hejuru rw’ibintu uburwayi bwa carcinoid bukunze gutera. Ibi birimo serotonin, chromogranin A, na 5-HIAA (umusaruro w’ubushe bukomeye bwa serotonin uboneka mu mirire).
Muganga wawe ashobora gutegeka ubwoko butandukanye bw’ibizamini kugira ngo abone ishusho yuzuye:
Kimwe mu bintu bidasanzwe mu isuzuma rya kanseri ya karusido ni ugusuzuma kwa octreotide, bizwi kandi nka somatostatin receptor scintigraphy. Iki kizamini cya nucléaire gifasha kubona kanseri ya karusido mu mubiri wose kuko izo kanseri zigira ibyakira (récepteurs) bifata ibyinjijwe bya radioactive.
Uburyo bwo kuvura bushobora gufata ibyumweru byinshi muganga akurikira amakuru aturuka mu bizamini bitandukanye. Iki gihe cyo gutegereza gishobora gutera impungenge, ariko ibuka ko kanseri ya karusido isanzwe ikura buhoro, bityo gufata umwanya wo kubona isuzuma nyaryo ni ingenzi kurusha kwihuta.
Rimwe na rimwe, kanseri ya karusido iboneka mu buryo butunguranye mu gihe cy’ubuganga cyangwa isuzuma ry’izindi ndwara, ibyo bishobora kuba byiza kuko kubimenya hakiri kare bikunze gusobanura ko hari uburyo bwiza bwo kuvura.
Kuvura kanseri ya karusido biterwa n’ibintu byinshi birimo aho kanseri iherereye, ubunini bwayo, niba yarakwirakwiye, niba itera ibimenyetso. Inkuru nziza ni uko hari uburyo bwinshi bwiza bwo kuvura, kandi abantu benshi barwaye kanseri ya karusido babaho ubuzima busanzwe, bukora neza, mugihe bavurwa neza.
Ubuganga ni bwo buryo bwo kuvura bukunze gukoreshwa iyo kanseri iherereye ahantu hamwe kandi ishobora gukurwaho burundu. Kuri kanseri nto zitakwirakwiye, gukuraho ubuganga rimwe na rimwe bishobora gukiza burundu. Nubwo kudakira bishoboka, ubuganga bushobora kugabanya cyane ibimenyetso no kugabanya iterambere ry’indwara.
Gahunda yawe yo kuvura ishobora kuba irimo uburyo butandukanye bukorera hamwe:
Imiterere ya somatostatine ikwiye kugarukwaho byihariye kuko ikunda kugira uruhare mu gukumira ubushyuhe bukabije, impiswi n’ibindi bimenyetso biterwa no kuba hari imisemburo myinshi. Aya miti igira uruhare mu kunoza ubuzima bwawe nubwo itazana impinduka ku kibyimba.
Ku bibyimba byamaze gukwirakwira mu mwijima, uburyo bwo kuvura buzwi nko gukuramo amaraso mu mwijima cyangwa gukoresha ubushyuhe bwo kwica utunyangingo tw’ibyimba bishobora kugera ku bibyimba biri mu mwijima bitabangamye imiterere y’umwijima muzima.
Uburyo bushya bwo kuvura bukoresha imiti iboneye nka everolimus na sunitinib byagaragaje akamaro mu kuvura ibibyimba bya carcinoid byateye imbere binyuze mu kubangamira ibimenyetso bifasha ibibyimba gukura no gukwirakwira.
Kwita ku bibyimba bya carcinoid iwawe bigamije gukumira ibimenyetso, kubungabunga ubuzima bwawe, no gushyigikira ubuzima bwawe muri rusange ufashwa n’abaganga. Abantu benshi basanga impinduka nto mu mibereho yabo zishobora kugira uruhare mu buryo bumva buri munsi.
Niba ufite ibimenyetso bya carcinoid syndrome, hari ibintu bimwe na bimwe bishobora kongera ubushyuhe bukabije n’ibindi bimenyetso. Ibintu bisanzwe bibitera birimo ibiryo birimo amakariso menshi, inzoga, foromaje zishaje, n’ibibazo by’umutima. Kwandukura ibimenyetso byawe bishobora kugufasha kumenya ibintu bikubangamira.
Dore ingamba abantu benshi basanga zibafasha guhangana n’ibimenyetso:
Ubufasha mu mirire burakomeye cyane iyo ufite impiswi kenshi, kuko bishobora gutera kubura vitamine n’imyunyu ngugu. Muganga wawe ashobora kugutegurira imiti yongerera, cyane cyane vitamine B, vitamine D, n’imyunyu ngugu nka magnésium na potasiyumu.
Guhangana n’umunaniro ni ikindi kintu gikomeye mu kwitaho mu rugo. Gukora imyitozo ngororamubiri buri gihe, nko kugenda, bishobora kugufasha kubungabunga ingufu zawe n’imibereho myiza muri rusange, ariko utega amatwi umubiri wawe kandi uruhuke igihe bikenewe.
Komerezaho guhuza n’incuti n’umuryango, kuko inkunga yo mu mutima igira uruhare rukomeye mu guhangana n’uburwayi buhoraho ubwo aribwo bwose. Tekereza kujya mu matsinda y’abantu barwaye ibibyimba bya neuroendocrine niba bihari mu karere kawe.
Gutegura inama yawe na muganga bishobora kugufasha kugira icyo ubona cyinshi mu ruzinduko rwawe no guha itsinda ryawe ry’ubuvuzi amakuru bakeneye kugufasha neza. Gutegura neza bishobora kandi kugabanya impungenge ku bijyanye n’inama.
Tangira wandike ibimenyetso byawe byose, harimo igihe byatangiye, ukuntu biba kenshi, n’icyo bisa n’ikibitera. Jya ugaragaza neza igihe n’uburemere, kuko ayo makuru afasha muganga wawe kumva neza uburwayi bwawe.
Komerezaho amakuru akomeye ugomba kuzana:
Andika ibibazo byawe mbere y’igihe kugira ngo utabyibagirwa mu gihe cy’inama. Ibibazo by’ingenzi bishobora kuba birimo kubaza ku bwoko bwawe bw’ibibyimba bya carcinoid, uburyo bwo kuvura, ingaruka mbi zishoboka, n’icyo ugomba kwitega mu gihe kizaza.
Tegereza kuzana inshuti cyangwa umuntu wo mu muryango w’umunyamuryango wizewe mu buvuzi. Bashobora kugufasha kwibuka amakuru yavuzwe no kugutera inkunga mu buryo bw’amarangamutima, cyane cyane niba ubonye ibisubizo by’ibizamini cyangwa uganira ku buryo bwo kuvura.
Niba uhangayikishijwe n’ubu buvuzi, ni ibintu bisanzwe. Iyitegure mu mutwe wibuke ko udukoko twa carcinoid muri rusange twakura buhoro buhoro kandi tukavurwa, kandi ko itsinda ry’abaganga bawe rihari kugufasha muri uwo muhigo.
Ikintu gikomeye cyane cyo gusobanukirwa ku birebana n’indwara ya carcinoid ni uko nubwo kubona iyi ndwara bishobora kuguhagarara, aya madudu muri rusange akura buhoro buhoro kandi afite uburyo bwo kuyakurikirana neza. Abantu benshi bafite indwara ya carcinoid bakomeza kubaho ubuzima buzuye, bukora imyaka myinshi nyuma yo kubona iyi ndwara.
Kumenya hakiri kare no kuvurwa neza bigira uruhare runini mu musaruro. Nubwo indwara ya carcinoid yamaze gukwirakwira, hari uburyo bwo kuvura buriho kugira ngo bugabanye ibimenyetso kandi bugabanye iterambere, bituma abantu benshi bakomeza ubuzima bwabo bwiza.
Icyingenzi ni ukubaka ubufatanye bukomeye n’itsinda ry’abaganga bawe, kuguma uzi ibyerekeye uburwayi bwawe, no kugira uruhare mu gucunga ibimenyetso. Uburyo bwo kuvura indwara ya carcinoid muri iki gihe bukorwa neza kurusha uko byari bimeze mu myaka icumi ishize, kandi ubushakashatsi bukomeza kuzana amahitamo mashya.
Wibuke ko kugira indwara ya carcinoid ntabwo bikugaragaza cyangwa bikagabanya ibyo ushobora kugeraho. Hamwe no kuvurwa neza no kwita ku buzima bwawe, abantu benshi basanga bashobora gukomeza gukora, gukora ingendo, no kwishimira imibanire yabo n’ibikorwa byabo nk’uko byari bimeze mbere yo kubona iyi ndwara.
Komereza ku cyizere kandi wibande ku byo ushobora kugenzura: gukurikiza gahunda yawe yo kuvura, kugumana itumanaho ryiza n’itsinda ry’abaganga bawe, no kwita ku buzima bwawe rusange.
Yego, udukoko twa carcinoid ni kanseri mu buryo bw’ubuhanga, ariko zitwara mu buryo butandukanye cyane n’izindi kanseri. Akenshi zikura buhoro cyane kandi akenshi ziguma zimeze kimwe imyaka myinshi zitatera ibibazo bikomeye. Udukoko twinshi twa carcinoid turera buhoro cyane ku buryo dushobora kutazigera duteza ibibazo bikomeye by’ubuzima, cyane cyane iyo twafashwe hakiri kare kandi tugakurikiranwa neza.
Iyo udukoko twa carcinoid duto kandi tudakwirakwira uretse aho twaturutse, kubivura hakoreshejwe ubuvuzi burashobora kubikiza burundu. Ariko kandi, nubwo gukira bitashoboka, abantu benshi babaho imyaka yabo isanzwe bafite ubuvuzi bukwiye. Kuba izi tumo zikura buhoro bivuze ko kubigenzura neza bikunda guha abantu ubushobozi bwo kubungabunga ubuzima bwabo bwiza imyaka myinshi.
Ushobora kuba ugomba kwirinda ibiryo bimwe na bimwe biterwa n’indwara ya carcinoid, ariko abantu benshi bafite udukoko twa carcinoid ntibakenera guhindura imirire yabo cyane. Ibintu bisanzwe biterwa harimo inzoga, ibiryo birimo amakariso, na foromaje zishaje, ariko ibitera bitandukanye ukurikije umuntu. Ikipe yawe y’ubuvuzi irashobora kugufasha kumenya ibiryo byose bigutera ibibazo no kugutegurira ibindi.
Igihe cyo gukurikirana gitandukanye bitewe n’imimerere yawe, ariko abantu benshi bakenera gukora ibizami buri mezi 3-6 mu ntangiro, kandi umubare ushobora kugabanuka uko igihe gihita niba udukoko tuguma duhagaze. Uzasabwa gukora ibizami by’amaraso buri gihe kugira ngo hagenzurwe ibimenyetso by’indwara n’ibizamini byo kureba amafoto kugira ngo harebwe impinduka. Muganga wawe azakora gahunda yo gukurikirana ikubereyeho ukurikije imiterere y’udukoko twawe n’uburyo ugendera mu buvuzi.
Umuhumeka wa kanseri nyinshi ubaho ku buryo butunguranye kandi ntabwo urazwa, ariko zimwe mu ndwara z’impyiko zidasanzwe zishobora kongera ibyago byo kurwara izi tumo. Niba ufite amateka y’umuryango w’indwara z’umuhumeka wa kanseri cyangwa izindi ndwara zifitanye isano nka MEN1, inama y’abaganga b’abahanga mu by’indwara zishobora kugufasha. Ariko rero, abantu benshi bafite indwara z’umuhumeka wa kanseri nta mateka y’umuryango bafite kuri iyo ndwara.