Allergic Granulomatosis

Churg-Strauss syndrome ni indwara irangwa no kwangirika kw'imijyana y'amaraso. Ukwangirika kw'imijyana y'amaraso bishobora kugabanya umuvuduko w'amaraso ugana mu ngingo n'imikaya, rimwe na rimwe bikabikomeretsa burundu. Iyi ndwara izwi kandi nka eosinophilic granulomatosis with polyangiitis (EGPA).

Iguka ry'ibitotsi mu bakuze ni ikimenyetso cy'ingenzi cya Churg-Strauss syndrome. Iyi ndwara ishobora kandi guteza ibindi bibazo, nko kugira allergie mu mazuru, ibibazo by'imikaya, ibibyimba ku ruhu, kuva amaraso mu gifu, no kubabara no kubabara mu ntoki no mu birenge.

Churg-Strauss syndrome ni indwara idahwitse kandi nta muti wayo. Ibimenyetso bishobora kumenyekana hakoreshejwe imiti ya steroide n'izindi miti ikomeye igabanya ubudahangarwa bw'umubiri.

Indwara ya Churg-Strauss itandukanye cyane ukurikije umuntu ku wundi. Bamwe bagira ibimenyetso bike gusa. Abandi bagira ingaruka zikomeye cyangwa zishobora kubica. Izwi kandi nka EGPA, iyi ndwara isanzwe igaragara mu byiciro bitatu kandi ikagenda irushaho kuba mbi. Haba hafi buri wese ufite iyi ndwara afite ibicurane, sinusite ikomeye n'umubare munini w'uturemangingo tw'amaraso yera twitwa eosinophils.

Ibindi bimenyetso bishobora kugaragara birimo:

• Kudashira amafunguro no kugabanuka k'uburemere
• Kubabara mu ngingo no mu mitsi
• Kubabara mu nda no kuva amaraso mu mara
• Kugenda nabi, umunaniro cyangwa kumva utameze neza muri rusange
• Imibembe cyangwa ibikomere ku ruhu
• Kubabara, kubabara, no kunanirwa gukora neza mu ntoki no mu birenge

Jya kwa muganga niba ufite ikibazo cyo guhumeka cyangwa ikinini mu mazuru kidakira, cyane cyane niba gifatanije n'ububabare bwa nyagasani budashira. Kandi jya kwa muganga niba ufite ibicurane cyangwa allergie zo mu mazuru byanze bikunze bikabije. Indwara ya Churg-Strauss ni inyoro, kandi birashoboka ko ibyo bimenyetso bifite indi mpamvu. Ariko ni ngombwa ko muganga akubigenzura. Kugirwaho isuzumwa hakiri kare no kuvurwa byongera amahirwe yo kugira umusaruro mwiza.

Intandaro ya Churg-Strauss syndrome ntiramenyekana neza. Birashoboka ko iterwa n'ihuriro ry'imiterere y'umuntu ndetse n'ibintu byo mu kirere, nka allergie cyangwa imiti imwe n'imwe, bigatera igikorwa cy'ubudahangarwa bukabije. Aho kurinda umubiri ku ndwara ziterwa na bagiteri na virusi, ubudahangarwa bugaba igitero ku mubiri muzima, bigatera kubyimba hose.

Nubwo umuntu uwo ari we wese ashobora kurwara Churg-Strauss syndrome, abantu baba bafite imyaka hafi 50 iyo basanzwe barwaye. Ibindi bintu bishobora guteza ubwo burwayi birimo ibicurane bya karande cyangwa ibibazo byo mu mazuru. Uburwayi bwa ba sekuruza na ba nyirakuru ndetse no kwandura ibintu byo mu kirere bishobora kugira uruhare.

Indwara ya Churg-Strauss ishobora kwibasira imyanya myinshi y'umubiri, irimo: ibigingo, imyanya y'amazuru, uruhu, urwungano rw'igogorwa, impyiko, imitsi, ingingo n'umutima. Iyo idakize, iyi ndwara ishobora kwica.

Ingaruka mbi, zishingiye ku myanya y'umubiri yibasiwe, zishobora kuba:

• Kubabara kw'imitsi yo ku nkengero. Indwara ya Churg-Strauss ishobora kwangiza imitsi yo mu ntoki no mu birenge, bigatuma umuntu atabasha kumva, akumva ubushyuhe cyangwa akabura imbaraga.
• Indwara z'umutima. Ingaruka mbi ku mutima ziterwa n'indwara ya Churg-Strauss, harimo: kubabara kw'urukuta rw'umutima, kubabara ku mitsi y'umutima, gufatwa n'indwara y'umutima no kunanirwa kw'umutima.
• Kwibasirwa kw'impyiko. Iyo indwara ya Churg-Strauss ibaye ku mpyiko, umuntu ashobora kurwara glomerulonephritis. Iyi ndwara ibangamira ubushobozi bw'impyiko bwo gukora isuku, bigatuma imyanda ikomeza kuba mu maraso.

Mu gusobanura indwara ya Churg-Strauss,abaganga bakunze gusaba ubu buryo bwo gupima, harimo:

• Ibizamini by'amaraso. Ibizamini by'amaraso bishobora kugaragaza antikorose zimwe na zimwe mu maraso yawe zishobora kugaragaza, ariko ntibyemeze, uburwayi bwa Churg-Strauss. Bishobora kandi kupima urugero rw' eosinophils, nubwo izindi ndwara, harimo n' umusonga, zishobora kongera umubare w'izo cellules.
• Ibizamini byo kubona ishusho. X-rays na CT scans zishobora kugaragaza ibitagenda neza mu mpyiko zawe no mu myanya y'amazuru. Niba ugize ibimenyetso by' ikibazo cy'umutima, muganga wawe ashobora kugutekerezaho gukora echocardiograms buri gihe.
• Biopsy y'umubiri ubangamiwe. Niba ibindi bipimo bigaragaza indwara ya Churg-Strauss, ushobora gukuraho igice gito cy'umubiri kugira ngo gisuzuzwe kuri microscope. Uwo mubiri ushobora kuva mu mpyiko zawe cyangwa mu zindi ngingo, nko ku ruhu cyangwa mu mitsi, kugira ngo hamenyekane niba hari vasculitis cyangwa ntayo ihari.

Nta muti uwo ari wo wose uravura indwara ya Churg-Strauss, izwi kandi nka eosinophilic granulomatosis with polyangiitis (EGPA). Ariko imiti ishobora gufasha gucunga ibimenyetso byayo.

Prednisone, igabanya kubyimba, ni yo miti ikoreshwa cyane mu kuvura indwara ya Churg-Strauss. Muganga wawe ashobora kwandika umuti wa corticosteroids ukoreshwa cyane cyangwa kongera umwanya wa corticosteroids umaze gufata kugira ngo ibimenyetso byawe bigabanuke vuba.

Ukoresha corticosteroids nyinshi bishobora gutera ingaruka mbi zikomeye, bityo muganga wawe azagabanya umwanya buhoro buhoro kugeza ubwo ukoresha make cyane azagumisha indwara yawe mugenzura. Nubwo ukoresha make igihe kirekire bishobora gutera ingaruka mbi.

Ingaruka mbi za corticosteroids zirimo gutakaza amagufwa, isukari y'amaraso iri hejuru, kwiyongera k'uburemere, cataracte n'indwara zoroheje kuvura.

Ku bantu bafite ibimenyetso bike, corticosteroid yonyine ishobora guhagije. Abandi bashobora gukenera kongeramo undi muti ufasha kugabanya ubudahangarwa bw'umubiri.

Mepolizumab (Nucala) kuri ubu ni yo miti yonyine yemewe na U.S. Food and Drug Administration mu kuvura indwara ya Churg-Strauss. Ariko, bitewe n'uburemere bw'indwara n'imigabane y'umubiri ikozweho, imiti indi ishobora kuba ikenewe. Urugero harimo:

Kuko iyi miti igabanya ubushobozi bw'umubiri bwo kurwanya indwara kandi ishobora gutera izindi ngaruka mbi zikomeye, ubuzima bwawe buzakurikiranwa hafi mugihe uyifata.

• Azathioprine (Azasan, Imuran)
• Benralizumab (Fasenra)
• Cyclophosphamide
• Methotrexate (Trexall)
• Rituximab (Rituxan)

Kuvura igihe kirekire hakoreshejwe imiti ya corticoïdes bishobora gutera ingaruka mbi nyinshi. Urashobora kugabanya ibyo bibazo ukora ibi bikurikira:

• Kurengera amagufa yawe. Baza muganga wawe umubare wa vitamine D na calcium ukeneye mu mirire yawe, kandi muganire ku kwifashisha imiti y'inyongera.
• Gukora imyitozo ngororamubiri. Gukora imyitozo ngororamubiri bishobora kugufasha kugumana ibiro byiza, ibyo bikaba ari ingenzi iyo ufashe imiti ya corticoïdes ishobora gutera ubwuzu. Imikino yo gushimangira imitsi n'imyitozo ikora ku magufa nko kugenda no kwiruka bigira uruhare mu kunoza ubuzima bw'amagufa.
• Kurya indyo yuzuye. Steroide zishobora gutera umwanya mwinshi w'isukari mu maraso, kandi amaherezo, diabete yo mu bwoko bwa 2. Funga ibiryo bifasha kugumana isukari mu maraso ku rugero rwiza, nka imbuto, imboga n'ibinyampeke bitaracunguwe.