Invasive Lobular Carcinoma ni iki? Ibimenyetso, Impamvu, n'Umuti

Invasive lobular carcinoma (ILC) ni ubwoko bwa kabiri bwa kanseri y'amabere, bugize hafi 10-15% bya kanseri yose y'amabere. Bitandukanye n'izindi kanseri z'amabere zikora ibintu by'umukene, ILC ikura mu buryo bwa file imwe mu mubiri w'amabere, ibyo bikaba bishobora gutuma bigorana kubibona mu bipimo by'umubiri no mu bipimo by'amashusho.

Ubu bwoko bwa kanseri butangira mu mitsi ikora amata (lobules) y'amabere hanyuma bugakwirakwira mu tundi tumwe two mu mubiri w'amabere. Nubwo ijambo "invasive" rishobora gutera ubwoba, risobanura gusa ko uturemangingo twa kanseri twavuye aho twatangiriye. Abantu benshi bafite ILC bagira umusaruro mwiza cyane mu kuvurwa, cyane cyane iyo byafashwe hakiri kare.

Ibimenyetso bya invasive lobular carcinoma ni ibihe?

ILC ikunze kudakora igituntu gikomeye abantu benshi bahuza na kanseri y'amabere. Ahubwo, ikura mu buryo bushobora gutuma yumvikana nk'ukubyimbagira cyangwa kwuzuza mu mubiri w'amabere.

Dore ibimenyetso ushobora kubona, wibuke ko ILC yo hakiri kare ishobora kutazigira ibimenyetso na kimwe:

• Ububyimbagira buke cyangwa gukomera mu gice kimwe cy'amabere aho kuba igituntu kigaragara
• Guhinduka mu buryo cyangwa mu buryo bwo kumva umubiri w'amabere
• Amabere kubyimbagira cyangwa kwiyongera ku ruhande rumwe
• Uruhu guhindagurika cyangwa gucika nk'uruhu rw'imikara
• Amata ava mu munwa utari amata y'amabere
• Munwa uhinduka imbere igihe utari uhindukiye mbere
• Guhinduka mu ishusho cyangwa mu bunini bw'amabere
• Kubabara cyangwa kubabara mu gice kimwe cy'amabere

Kubera ko ILC ishobora kuba idasobanutse, imibare myinshi iboneka mu bipimo bisanzwe bya mammogram mbere y'uko ibimenyetso ibyo ari byo byose bigaragara. Ibi ni amakuru meza kuko bisobanura ko kanseri ikunze gufatwa hakiri kare, mu cyiciro cyoroshye kuvura.

Uduce twa invasive lobular carcinoma ni utuhe?

Invasive lobular carcinomas nyinshi zigwa mu bwoko busanzwe, ariko hariho utundi duto dutandukanye muganga wawe ashobora kumenya. Gusobanukirwa ubwoko bwabyo bifasha kuyobora gahunda yawe yo kuvura.

Ubwoko busanzwe bugize hafi 80% by'ibibazo byose bya ILC. Utu turemangingo twa kanseri turera mu buryo bwa file imwe kandi akenshi tuba hormone receptor-positive, bisobanura ko bisubiza neza imiti yo kuvura hormone.

Ubundi bwoko buke harimo pleomorphic lobular carcinoma, busanzwe bukabije kandi bushobora kudakira imiti yo kuvura hormone. Hari kandi solid lobular carcinoma na alveolar lobular carcinoma, ariko ibyo ni bito cyane. Pathologiste wawe azamenya neza ubwoko ufite ahereye ku gusuzuma ibice by'umubiri munsi y'imikroskopu.

Icyateye invasive lobular carcinoma ni iki?

Kimwe n'izindi kanseri nyinshi z'amabere, ILC itera iyo uturemangingo tw'amabere bisanzwe bihinduka muri ADN yabyo bituma bikura kandi bigabanyamo uburyo budakozwe. Ariko, ntituzi neza impamvu ibyo bihinduka byihariye bibaho ku turemangingo twa lobular.

Ibintu byinshi bishobora gutera ILC, nubwo ufite ibyo bintu ntibisobanura ko uzagira kanseri:

• Imyaka - imibare myinshi iba mu bagore barengeje 50
• Amateka y'umuryango wa kanseri y'amabere cyangwa kanseri y'ovari
• Guhinduka kwa gene mu muryango nk'iya BRCA1 cyangwa BRCA2
• Amateka bwite ya kanseri y'amabere cyangwa ibibazo bimwe byiza by'amabere
• Gukoresha imiti yo kuvura hormone igihe kirekire
• Urubuga rw'amabere rukomeye
• Kuba warashyizweho imirasire mu gice cy'ibituza
• Imibereho nk'inyobwa y'inzoga no kutagira imyitozo ngororamubiri

Ni ngombwa kwibuka ko abantu benshi bafite ibyo bibazo by'ubuzima batagira kanseri y'amabere, mu gihe abandi badafite ibyo bibazo by'ubuzima babigira. Iterambere rya kanseri rigoye kandi akenshi ririmo ibintu byinshi bikorera hamwe igihe kirekire.

Igihe cyo kubonana na muganga kubera invasive lobular carcinoma ni iki?

Wagomba kuvugana na muganga wawe niba ubona impinduka zihoraho mu mabere yawe, nubwo zisa nkeya. Kubera ko ILC ishobora kuba idasobanutse, ni byiza ko ibibazo byose byakozwe aho gutegereza kureba niba bizagenda.

Tegura gahunda vuba niba ufite impinduka z'amabere zikomeza igihe kirekire kurusha icyiciro kimwe cy'ukwezi. Ibi birimo ibice bishya by'ububyimbagira, guhinduka mu bunini cyangwa ishusho y'amabere, guhinduka kw'uruhu, cyangwa amata ava mu munwa. Nubwo uherutse kugira mammogram isanzwe, ibimenyetso bishya bigomba gukorwaho.

Niba ufite amateka y'umuryango wa kanseri y'amabere cyangwa kanseri y'ovari, tekereza kuvugana n'umuganga w'umutungo. Bashobora kugufasha gusobanukirwa ibyago byawe no kumenya niba ibizamini bya gene bishobora kukubereye.

Ibyago bya invasive lobular carcinoma ni ibihe?

Gusobanukirwa ibyago byawe bishobora kugufasha wowe na muganga wawe gufata ibyemezo byiza bijyanye no gusuzuma no gukumira. Bimwe mu byago ushobora kubigenzura, ibindi ntushobora kubigenzura.

Ibintu udashobora guhindura birimo imyaka yawe, amateka y'umuryango, n'imiterere ya gene. ILC ikunze kugaragara mu bagore barengeje 50, kandi kugira abavandimwe ba hafi bafite kanseri y'amabere cyangwa kanseri y'ovari byongera ibyago byawe. Guhinduka kwa gene mu muryango, cyane cyane BRCA2, bishobora kongera gato ibyago bya ILC ugereranije n'izindi kanseri z'amabere.

Ibintu bishobora kuba biri mu bubasha bwawe birimo kugumana ibiro byiza, kugabanya kunywa inzoga, kuguma ukora imyitozo ngororamubiri, no kuvugana n'umuganga wawe ku byago n'inyungu zo kuvura hormone. Nubwo ibyo bihinduka mu mibereho bishobora kugabanya ibyago, ntibihamye kwirinda.

Ingaruka zishoboka za invasive lobular carcinoma ni izihe?

Iyo byafashwe hakiri kare kandi bikavurwa uko bikwiye, abantu benshi bafite ILC bagira umusaruro mwiza. Ariko, kimwe na kanseri iyo ari yo yose, hariho ingaruka zishoboka ugomba kumenya kugira ngo ukorane n'itsinda ryawe ry'ubuvuzi kugira ngo ubizunguruke kandi ubikemure.

Ikibazo nyamukuru cya kanseri yose y'amabere ni ubushobozi bwo gukwirakwira mu mitsi ya lymph cyangwa mu bindi bice by'umubiri. ILC ifite ubushobozi buke kurusha izindi kanseri z'amabere zo kuba mu mabere yombi, icyarimwe cyangwa nyuma y'imyaka myinshi. Niyo mpamvu muganga wawe ashobora kugutegeka gukurikirana amabere yombi kenshi.

Ingaruka ziterwa n'ubuvuzi zishobora kuba harimo ingaruka zo kubaga, nko guhinduka mu buryo bwo kumva amabere cyangwa kugenda kw'ukuboko nyuma yo gukuraho imiyoboro ya lymph. Chemotherapy na radiation therapy, niba ari ngombwa, bishobora gutera ingaruka z'igihe gito nko gucika intege, isesemi, cyangwa guhinduka kw'uruhu. Kuvura hormone igihe kirekire, nubwo ari ingirakamaro cyane, bishobora kongera ibyago by'amaraso cyangwa ibyago by'amagufwa mu bamwe.

Ingaruka nke zishobora kuba harimo iterambere rya kanseri ya kabiri, itandukanye mu myaka iri imbere, nubwo ibyo byago ari bike. Itsinda ryawe ry'ubuvuzi rizavuga ku mimerere yawe kandi rikugufasha gusobanukirwa ingaruka zikubereyeho.

Invasive lobular carcinoma ishobora kwirindwa gute?

Nubwo nta buryo bwo kwirinda ILC buhamye, ushobora gufata ingamba kugira ngo ugabanye ibyago bya kanseri y'amabere muri rusange kandi ufate ibibazo hakiri kare igihe byoroshye kuvura.

Guhindura imibereho bishobora gufasha birimo kugumana ibiro byiza, gukora imyitozo ngororamubiri buri gihe, kugabanya kunywa inzoga, no kwirinda kuvura hormone bidakenewe. Niba utekereza kuvura hormone kubera ibimenyetso bya menopause, banza ubanze ubiganireho n'umuganga wawe.

Gusuzuma buri gihe ni intwaro yawe nziza yo kurwanya ILC. Kurikiza amabwiriza ya mammogram y'itsinda ry'imyaka yawe, kandi ntukareke gahunda. Niba ufite urubuga rw'amabere rukomeye cyangwa ibindi byago, muganga wawe ashobora kugutegeka ibindi bipimo by'amashusho nka MRI y'amabere cyangwa ultrasound.

Kubafite ibyago byinshi kubera amateka y'umuryango cyangwa ibintu bya gene, ingamba zo kwirinda zishobora kuba harimo gusuzuma kenshi, inama z'umutungo, cyangwa mu bihe bike, kubaga kwirinda. Ibyo byemezo ni ibya buri wese kandi bigomba gufatwa hagamijwe inama z'inzobere zisobanukiwe uko uhagaze.

Invasive lobular carcinoma imenyekanwa gute?

Kumenya ILC akenshi bisaba intambwe nyinshi kuko ubwo bwoko bwa kanseri bushobora kuba bigoye kubona mu bipimo bisanzwe by'amashusho. Muganga wawe azatangira asuzumye umubiri wawe kandi asuzume ibimenyetso byawe n'amateka yawe y'ubuzima.

Ibizamini by'amashusho bikunze kuba harimo mammogram, nubwo ILC ishobora kutagaragara neza kuri icyo kizami. Muganga wawe ashobora kandi gutegeka ultrasound y'amabere cyangwa MRI, bishobora kuba byiza mu kubona kanseri ya lobular. MRI ifasha cyane kuri ILC kuko ishobora kwerekana uko kanseri imeze neza no kureba niba hari kanseri mu kandi karenge.

Kumenya neza bisaba biopsy y'umubiri, aho igice gito cy'umubiri ukekwaho gukurwaho kandi kigasuzumwa munsi y'imikroskopu. Ibi bishobora gukorwa na core needle biopsy, ikorwa akenshi mu biro by'umuganga hakoreshejwe anesthésie y'aho. Pathologiste azamenya niba kanseri ihari gusa, ahubwo n'ibintu by'ingenzi nko kumenya hormone receptor na vitesse de croissance.

Ibindi bizamini bishobora kuba harimo gusuzuma amaraso kugira ngo urebe ubuzima bwawe muri rusange n'ibizamini by'amashusho kugira ngo urebe niba kanseri yarakwirakwiye mu bindi bice by'umubiri wawe. Itsinda ryawe ry'ubuvuzi rizagusobanurira buri kizami n'icyo ibisubizo bisobanura ku gahunda yawe yo kuvura.

Umuti wa invasive lobular carcinoma ni uwuhe?

Umuti wa ILC ugenwa bitewe n'ubunini n'aho kanseri yawe iri, niba yarakwirakwiye, n'imiterere yayo. Amakuru meza ni uko ILC ikunze gusubiza neza kuvura, cyane cyane iyo byafashwe hakiri kare.

Kubaga ni bwo buryo bwa mbere kandi bushobora kuba harimo lumpectomy (gukuraho kanseri gusa n'utundi tumwe two hafi) cyangwa mastectomy (gukuraho amabere). Kubera ko ILC ishobora kuba nini kurusha uko bigaragara, umuganga wawe ashobora kugutegeka kubaga hakoreshejwe MRI kugira ngo akureho neza. Bamwe bashobora kandi gukenera gukuraho imiyoboro ya lymph kugira ngo barebe niba kanseri yarakwirakwiye.

Abantu benshi bafite ILC bazahabwa kuvura hormone kuko ubwo bwoko bwa kanseri akenshi buba hormone receptor-positive. Ibi bishobora kuba harimo imiti nka tamoxifen cyangwa aromatase inhibitors, ibyo bikaba bigabanya hormone zikurura ukurura kwa kanseri. Iyo miti ikunze gufatwa imyaka 5-10 kandi ifasha cyane mu kwirinda gusubira.

Bitewe n'imimerere yawe, oncologe wawe ashobora kandi kugutegeka chemotherapy, radiation therapy, cyangwa imiti yo kuvura ibintu byihariye. Icyemezo gishingiye ku bintu nko bunini bwa tumo, ibintu bya lymph node, n'ubuzima bwawe muri rusange. Itsinda ryawe ry'ubuvuzi rizakorana nawe kugira ngo mugire gahunda ikuha amahirwe meza yo gutsinda mu gihe ukomeza ubuzima bwawe.

Uburyo bwo gucunga invasive lobular carcinoma murugo ni ubuhe?

Guca ILC murugo birimo kwita ku buzima bwawe bw'umubiri n'ubw'amarangamutima mu gihe ukomeza gahunda yawe yo kuvura. Intambwe nto, zihoraho zishobora kugira uruhare mu buryo wumva mu gihe cyo kuvura no gukira.

Fata umwanya wo kurya ibiryo biringaniye bikuyeho imbaraga kandi bifasha umubiri wawe gukira. Ibi ntibisobanura gukurikiza indyo yihariye, ahubwo ni uguhitamo imbuto nyinshi, imboga, ibiryo byuzuye, n'ibinyampeke byuzuye igihe bishoboka. Komera amazi kandi ntukihute niba ubushake bwawe bwo kurya buhinduka mu gihe cyo kuvura - ibi ni ibisanzwe.

Imyitozo ngororamubiri yoroheje, nk'uko muganga wawe yabyemereye, ishobora kugabanya umunaniro no kunoza imitekerereze yawe. Ibi bishobora kuba byoroshye nko kugenda iminota mike cyangwa gukora imyitozo yoroheje. Ruhukira igihe ukeneye, kandi ntukihute kubera gufata umwanya wo gukira.

Guca ingaruka ni ingenzi kubw'umunezero wawe n'intsinzi y'ubuvuzi. Kora dosiye y'ibimenyetso byose kandi ubanze ube uvuga n'itsinda ryawe ry'ubuvuzi. Bashobora gutanga imiti cyangwa ingamba zo gufasha mu bibazo nko gucika intege, umunaniro, cyangwa kubabara. Ntugatinye kuvugana nabo hagati y'ibitaramo niba ufite impungenge.

Uko wakwitegura ku gahunda yawe yo kubonana na muganga ni iki?

Kwitegura ku gahunda yawe bishobora kugufasha gukoresha neza igihe cyawe n'itsinda ryawe ry'ubuvuzi kandi bikwizeze ko ubonye amakuru yose ukeneye. Tangira wandike ibibazo byawe mbere yo kugera aho.

Zana urutonde rw'imiti yose ufashe, harimo imiti yo kuvura no kuvura. Nanone, komora dosiye y'ubuvuzi, cyane cyane mammograms zabanje cyangwa ibizamini by'amashusho y'amabere. Niba bishoboka, zana inshuti cyangwa umuryango wawe kugira ngo bagufashe kwibuka amakuru yavuzwe mu gihe cy'urugendo.

Tekereza ku bimenyetso byawe n'igihe byatangiye. Tegura gusobanura impinduka zose wabonye mu mabere yawe, nubwo zisa nkeya. Muganga wawe azashaka kandi kumenya amateka y'umuryango wawe wa kanseri n'ibibazo byose by'amabere wari ufite mbere.

Andika ibibazo byawe by'ingenzi mbere, mu gihe igihe cyabuze. Ntugatinye gusaba ibisobanuro niba utumva ikintu - itsinda ryawe ry'ubuvuzi rishaka ko uhawe amakuru yuzuye ku mimerere yawe n'uburyo bwo kuvura.

Icyingenzi cyo kuzirikana kuri invasive lobular carcinoma ni iki?

Ikintu cy'ingenzi cyo gusobanukirwa kuri ILC ni uko ari ubwoko bwo kuvura kanseri y'amabere, cyane cyane iyo byafashwe hakiri kare. Nubwo bishobora kuba bigoye kubibona kurusha izindi kanseri z'amabere, iterambere mu buryo bwo kubona no kuvura byongereye cyane umusaruro kubantu bafite iyi ndwara.

Kumenya hakiri kare binyuze mu gusuzuma buri gihe no kwita ku guhinduka kw'amabere bikomeza kuba intwaro yawe nziza yo kugira umusaruro mwiza. Ntukareke imiterere idasobanutse y'ibimenyetso bya ILC gutuma utinda gushaka ubufasha bw'abaganga niba ubona impinduka mu mabere yawe.

Wibuke ko kugira ILC ntibikumenya, kandi ukoresheje kuvura neza no gufashwa, abantu benshi bakomeza kubaho ubuzima buzuye, bwiza. Itsinda ryawe ry'ubuvuzi riri aho kugufasha mu ntambwe zose, kandi hariho ibikoresho byinshi biboneka kugufasha wowe n'abakunzi bawe kugenda muri uru rugendo.

Ibibazo byakajwe cyane kuri invasive lobular carcinoma

Q1: Invasive lobular carcinoma ikabije kurusha izindi kanseri z'amabere?

ILC muri rusange ntikabije kurusha ubwoko busanzwe bwa kanseri y'amabere (invasive ductal carcinoma). Mu by'ukuri, ILC ikunze gukura buhoro kandi ikunze kuba hormone receptor-positive, bisobanura ko isubiza neza kuvura hormone. Ariko, bishobora kuba bigoye kubibona kandi bishobora kugira amahirwe make yo kuba mu mabere yombi igihe kirekire.

Q2: Kuki mammogram yanjye itarerekanye invasive lobular carcinoma?

ILC ikura mu buryo bwa file imwe mu mubiri w'amabere aho kuba igituntu kigaragara, ibyo bikaba bigoye kubibona kuri mammograms. Niyo mpamvu muganga wawe ashobora kugutegeka ibindi bipimo by'amashusho nka ultrasound cyangwa MRI, cyane cyane niba ufite ibimenyetso cyangwa ibyago. MRI ifasha cyane mu kubona ILC no kumenya uko imeze neza.

Q3: Nzakenera mastectomy niba mfite invasive lobular carcinoma?

Oya. Abantu benshi bafite ILC bashobora kubagwa amabere (lumpectomy) bakurikirwa na radiation therapy. Guhitamo hagati ya lumpectomy na mastectomy biterwa n'ibintu nko bunini n'aho kanseri yawe iri, niba iri mu bice byinshi, n'ibyo ukunda. Umuganga wawe azakuganira ku buryo bwiza bukubereye.

Q4: Kugira invasive lobular carcinoma byongera ibyago bya kanseri mu kandi karenge?

Yego, ILC ifite ibyago byinshi byo kugira kanseri mu kandi karenge ugereranije n'izindi kanseri z'amabere. Niyo mpamvu muganga wawe azakugira inama yo gukurikirana amabere yombi buri gihe hakoreshejwe ibizamini by'amashusho. Bamwe bahitamo kubagwa mu karenge katagira kanseri, ariko icyo ni icyemezo cya buri wese gikwiye gufatwa hagamijwe inama z'inzobere.

Q5: Igihe kingana iki nzakenera kuvurwa hormone kubera invasive lobular carcinoma?

Abantu benshi bafite ILC ya hormone receptor-positive bafata imiti yo kuvura hormone imyaka 5-10 nyuma yo kuvurwa bwa mbere. Igihe nyacyo giterwa n'ibyago byawe n'uko wihanganira imiti. Oncologe wawe azakorana nawe kugira ngo umenye igihe cyiza cyo kuvura, ugereranije inyungu zo kuvura bikomeza n'ingaruka zishobora kukugeraho.