Fibrose Y'Umubiri Iterwa Na Nephrogène

Fibrose y'umubiri iterwa n'ubukungu bw'impyiko ni indwara y'akataraboneka iba ahanini mu bantu barwaye indwara zikomeye z'impyiko, baba bafite dialyse cyangwa batayifite. Fibrose y'umubiri iterwa n'ubukungu bw'impyiko ishobora kumera nk'indwara z'uruhu, nka scleroderma na scleromyxedema, aho kwangirika no kwijimiriza bikaba ku bice binini by'uruhu.

Fibrose y'umubiri iterwa n'ubukungu bw'impyiko ishobora kandi kwibasira imyanya y'imbere y'umubiri, nka mutima na mapa, kandi ishobora gutera gupfapfa kw'imitsi n'udutambitse mu biungo (gufata kw'ibiungo).

Kuri bamwe mu bantu barwaye indwara zikomeye z'impyiko, kwibasirwa n'ibintu bya kera byifashishwa mu gupima binyuze mu buryo bwa magnéti (itsinda rya 1) mu gupima binyuze mu buryo bwa magnéti (MRI) n'ibindi bipimo byo kubona ishusho byagaragaye ko ari cyo gitera iyi ndwara. Kumenya iyi mibanire byagabanije cyane ubwandu bwa fibrose y'umubiri iterwa n'ubukungu bw'impyiko. Ibintu bishya byifashishwa mu gupima binyuze mu buryo bwa magnéti (itsinda rya 2) ntabwo bifitanye isano n'ingaruka nyinshi za fibrose y'umubiri iterwa n'ubukungu bw'impyiko.

Nephrogenic systemic fibrosis ishobora gutangira nyuma y'iminsi, amezi, ndetse n'imyaka nyuma yo kwandura umuti wa gadolinium-based contrast agent (itsinda rya mbere). Bimwe mu bimenyetso bya nephrogenic systemic fibrosis birimo:

• Kubyimba no gukomera kw'uruhu
• Ibice by'uruhu byatukura cyangwa byijimye
• Umutobe n'ugukomera kw'uruhu, cyane cyane ku maboko n'amaguru, rimwe na rimwe ku mubiri, ariko hafi ya nta na rimwe ku maso cyangwa ku mutwe
• Uruhu rushobora kumva nk'igiti kandi rugira isura nk'iy'igikoma cya orange
• Gutwika, gukorora cyangwa kubabara cyane mu bice byafashwe
• Umutobe w'uruhu ubuza imitwaro, bigatuma ubushobozi bw'ingingo bugabanuka
• Gake, ibisebe cyangwa ibinyoro

Mu bamwe, kwibasira imikaya n'ingingo z'umubiri bishobora gutera:

• Intege nke z'imikaya
• Kugabanuka kw'imitwaro y'ingingo bitewe no gukomera kw'imikaya (contractures) mu maboko, mu ntoki, mu maguru no mu birenge
• Kubabara kw'amagufa, cyane cyane mu magufwa y'ikibero cyangwa amabati
• Kugabanuka kw'imikorere y'ingingo zo imbere, harimo umutima, ibihumeka, diafragme, urwungano rw'igogorwa cyangwa umwijima
• Ibibara by'umuhondo ku ruhu rw'amaso (sclera)

Iyi ndwara muri rusange iba igihe kirekire (chronic), ariko bamwe bashobora kumera neza. Mu bamwe, ishobora gutera ubumuga bukomeye, ndetse n'urupfu.

Intandukira nyakuri ya nephrogenic systemic fibrosis ntiirasobanuwe neza.Uruhu rukora imyenda ihuza, bigatera uburwayi bw'umubiri wose, cyane cyane uruhu n'imiterere yo munsi y'uruhu.

Kuba warakoresheje imiti ya gadolinium-based contrast agents (itsinda rya mbere) mu bipimo bya magnetic resonance imaging (MRI) byagaragaye nk'intandaro yo gutera iyi ndwara ku bantu barwaye indwara z'impyiko.Iyi kamere yo kwiyongera kw'ibyago byatekerejweho ko bifitanye isano n'ubushobozi buke bw'impyiko bwo gukuramo imiti mu maraso.

Ikigo cy'Amerika gishinzwe ibiryo n'imiti (FDA) kirabuza gukoresha imiti ya gadolinium-based contrast agents (itsinda rya mbere) ku bantu barwaye indwara z'impyiko zikaze cyangwa izidakira.

Izindi ndwara zishobora kongera ibyago bya nephrogenic systemic fibrosis iyo zifatanije n'indwara z'impyiko n'imiti ya gadolinium-based contrast agents (itsinda rya mbere), ariko umubano nturasobanuka.Izo ndwara zirimo:

• Gukoresha imiti myinshi ya erythropoietin (EPO), imiti ikora amaraso y'umutuku, ikunze gukoreshwa mu kuvura ubumuga bw'amaraso
• Kubagwa mu mitsi vuba aha
• Ibibazo byo gukomera kw'amaraso
• Indwara ikomeye

Ibyago byinshi byo kugira nephrogenic systemic fibrosis nyuma yo kwandura imiti ikoreshwa mu gupima ibintu byo mu mubiri ikoresha gadolinium (itsinda rya mbere) bibaho ku bantu bagira:

• Indwara zikomeye cyangwa zikaze z'impumyi
• Abakorewe ikuzimya ry'impumyi ariko bafite ubumuga bw'imikorere y'impumyi
• Abahabwa hemodialysis cyangwa peritoneal dialysis
• Abafite ikibazo cy'impumyi gikomeye

Kwirinda imiti ya gadolinium yo hambere (itsinda rya 1) ni ingenzi mu gukumira nephrogenic systemic fibrosis, kuko imiti mishya ya gadolinium (itsinda rya 2) itekanye kandi idahuje n'ingaruka mbi.

Ubwoko bwa nephrogenic systemic fibrosis bumenyekana hakoreshejwe:

• Isuzuma ry'umubiri kugira ngo harebwe ibimenyetso n'ibibonwa by'indwara, no gusuzuma amateka ashoboka ya MRI ikoresha umuti wa gadolinium-based contrast agent iyo indwara ikomeye y'impyiko ibayeho
• Icyitegererezo cy'umubiri (biopsy) gifashwe kuva ku ruhu no ku mitsi
• Ibindi bipimo nkuko bikenewe bishobora kugaragaza ibikorwa by'imitsi n'imigongo y'imbere