Icyo Abemaciclib ari cyo: Ibyo ikoreshwa, urugero rwo gufata, ingaruka zayo n'ibindi

Abemaciclib ni umuti uvura kanseri ugamije gufasha kugabanya umuvuduko wo gukura kwa kanseri zimwe na zimwe zo mu ibere. Uyu muti ubarirwa mu cyiciro cy'imiti yitwa CDK4/6 inhibitors, ikora ibi ikingira poroteyine zikenewe n'uturemangingo twa kanseri kugira ngo twororoke kandi twisanzure.

Uyu muti ugaragaza iterambere rikomeye mu kuvura kanseri y'ibere, uha icyizere abarwayi benshi iyo uvuzwe hamwe n'izindi nshuti. Reka dusuzume ibyo ukeneye kumenya kuri uyu muti w'ingenzi mu buryo bworoshye kumva.

Abemaciclib ni iki?

Abemaciclib ni umuti uvura kanseri ufata poroteyine zihariye mu turemangingo twa kanseri. Ugenewe guhagarika ubushobozi bw'uturemangingo twa kanseri bwo kwigabanya no gukura binyuze mu gukingira poroteyine ebyiri zizwi nka CDK4 na CDK6.

Tekereza kuri izi poroteyine nk'ibimenyetso byo "gutangira" bibwira uturemangingo twa kanseri kwororoka. Mu gukingira ibi bimenyetso, abemaciclib ifasha kugabanya cyangwa guhagarika kanseri gukura no kwisanzura mu bindi bice by'umubiri wawe.

Uyu muti ufashwe nk'ubuvuzi bugamije, bivuze ko wagaba ibitero ku turemangingo twa kanseri gusa aho kugira ingaruka ku turemangingo twose twihuta mu mubiri wawe nk'uko imiti gakondo ivura kanseri ibikora.

Abemaciclib ikoreshwa mu kuvura iki?

Abemaciclib ikoreshwa cyane cyane mu kuvura kanseri y'ibere ifite reseptori ya hormone-positive, HER2-negative. Ubu bwoko bwihariye bwa kanseri y'ibere bukura bitewe n'imisemburo nka estrogen na progesterone.

Muganga wawe ashobora kwandika uyu muti mu bihe bitandukanye. Akenshi ikoreshwa iyo kanseri y'ibere yisanzuye mu bindi bice by'umubiri wawe (kanseri y'ibere yimuka) cyangwa iyo hariho ibyago byinshi byo gusubira kwa kanseri nyuma yo kuvurwa bwa mbere.

Uyu muti ushobora gukoreshwa wenyine cyangwa uherekejwe n'ubundi buvuzi bwa kanseri, bitewe n'uko ubuzima bwawe bwifashe. Muganga wawe w'inzobere mu kuvura kanseri azagena uburyo bwiza bwo kuvura bushingiye ku miterere ya kanseri yawe n'ubuzima bwawe muri rusange.

Abemaciclib ikora ite?

Abemaciclib ikora yibanda ku ngingo y'inzego z'uturemangingo, ariyo inzira uturemangingo ducamo tukiyongera. Yihagarika by'umwihariko poroteyine za CDK4 na CDK6 zikora nk'ibikoresho byihutisha imikurire y'uturemangingo twa kanseri.

Iyo izo poroteyine zihagaze, uturemangingo twa kanseri turahagarara mu cyiciro cyitwa G1, aho tutabasha gukomeza mu ntambwe ikurikira yo kugabanyamo uturemangingo. Ibi bikaba bigabanya imikorere y'uturemangingo twa kanseri.

Nka terapiya yibanda ku ngingo, abemaciclib ifatwa nk'ikomeye ku rugero ruciriritse ariko muri rusange itera ingaruka zikomeye nke ugereranyije na shimioterapiya ya gakondo. Yagenewe gukora neza, yibanda ku turemangingo twa kanseri mu gihe ireka uturemangingo twiza.

Nkwiriye gufata Abemaciclib nte?

Abemaciclib iza mu buryo bw'ibinini ufata unywa mu kanwa, akenshi kabiri ku munsi mu gihe cy'amasaha 12. Urashobora kuyifata hamwe n'ibiryo cyangwa utabifite, ariko gerageza kuyifata mu buryo bumwe buri gihe kugira ngo bigende neza.

Mimina ibinini byose hamwe n'ikirahure cy'amazi. Ntugasenye, uteme cyangwa urume, kuko ibi bishobora kugira ingaruka ku buryo umuti winjira mu mubiri wawe.

Muganga wawe azagutangiza urugero runaka rishingiye ku buzima bwawe kandi ashobora kuruhindura uko igihe kigenda. Ni ngombwa gufata umuti nk'uko byategetswe, kabone n'iyo wumva umeze neza.

Niba warutse mu isaha imwe nyuma yo gufata urugero rwawe, ntufate urundi rugero. Tegereza kugeza igihe cy'urugero rwawe ruteganyijwe hanyuma ukomeze gahunda yawe isanzwe.

Nkwiriye gufata Abemaciclib igihe kingana iki?

Igihe cyo kuvurwa na abemaciclib gitandukana ku muntu ku muntu kandi biterwa n'uko umuti ukora neza n'uko uwihanganira. Abantu bamwe bashobora kuyifata mu gihe cy'amezi, mu gihe abandi bashobora kuyikeneye mu myaka.

Muganga wawe azakurikiza uko witwara ku muti binyuze mu gusuzuma buri gihe, ibizamini by'amaraso, n'ibizamini by'amashusho. Bazashaka ibimenyetso byerekana ko kanseri irimo gusubiza mu buryo bwiza ku kuvurwa kandi barebe ingaruka zose ziteye impungenge.

Ubuvuzi bukunze gukomeza igihe cyose umuti ugifasha kugenzura kanseri yawe kandi utagira ingaruka zikomeye zitagendeshwa. Itsinda ryawe ryo mu buvuzi rizakorana nawe kugirango ribone uburyo bwiza.

Ni Izihe Ngaruka Ziterwa na Abemaciclib?

Kimwe n'imiti yose, abemaciclib ishobora gutera ingaruka, nubwo atari buri wese uzigira. Kumva icyo witegura bishobora kugufasha kumva witeguye kandi ukamenya igihe wakwibutsa itsinda ryawe ry'ubuvuzi.

Ingaruka zisanzwe zikunda kugendeshwa n'ubufasha bukwiye no gukurikiranwa n'itsinda ryawe ry'abaganga:

• Impiswi (ingaruka isanzwe, igira ingaruka ku barwayi benshi)
• Umunaniro no kumva unaniwe
• Isesemi no kugabanya ubushake bwo kurya
• Umubare muto w'uturemangingo tw'amaraso twera (neutropenia)
• Umutwe
• Gucika cyangwa gutakaza umusatsi
• Kuruka
• Ibisebe mu kanwa

Muganga wawe azagukurikiranira hafi izi ngaruka kandi ashobora gutanga imiti cyangwa uburyo bwo gufasha kuzigendana. Ingaruka nyinshi ni iz'igihe gito kandi zikagenda zikorohera uko umubiri wawe wimenyereza umuti.

Ingaruka zimwe zitazwi cyane ariko zikomeye zisaba ubufasha bw'ubuvuzi bwihuse. Izi zirimo impiswi ikaze idakira n'ubuvuzi, ibimenyetso byo kwandura nko kuribwa cyangwa guhinda umushyitsi, kuva amaraso bidasanzwe cyangwa gukomeretsa, n'umunaniro ukabije utuma udakora imirimo yawe ya buri munsi.

Amabara y'amaraso, nubwo adakunze kubaho, ashobora kubaho hamwe na abemaciclib. Reba ibimenyetso nk'umwuka mubi utunguranye, kuribwa mu gituza, kubyimba ukuguru, cyangwa kuribwa mu gice cy'inyuma cy'ukuguru.

Ninde Utagomba Gufata Abemaciclib?

Abemaciclib ntabwo ikwiriye kuri buri wese, kandi muganga wawe azasuzuma neza niba ikwiriye kuri wewe. Indwara zimwe na zimwe n'ibihe bishobora gutuma uyu muti utaba umutekano cyangwa utagira akamaro.

Ntabwo ugomba gufata abemaciclib niba ufite allergie kuri wo cyangwa ibikoresho byawo byose. Abantu bafite ibibazo bikomeye by'umwijima ntibashobora gufata uyu muti mu buryo bwizewe, kuko ukoreshwa binyuze mu mwijima.

Kuba utwite no konka ni ibintu by'ingenzi byo kwitaho. Abemaciclib ishobora gukomeretsa umwana utaravuka, bityo uzakenera gukoresha uburyo bwo kuboneza urubyaro bukora neza mugihe uvurwa ndetse no mumwanya runaka nyuma yo guhagarika imiti.

Muganga wawe azanatekereza ku yindi miti urimo gufata, kuko imiti imwe n'imwe ishobora gukorana na abemaciclib kandi ikagira ingaruka ku buryo ikora neza cyangwa ikongera ibyago byo kugira ingaruka ziterwa n'iyo miti.

Amazina y'ubwoko bwa Abemaciclib

Abemaciclib iboneka munsi y'izina ry'ubwoko rya Verzenio. Iyi niyo miti ikoreshwa cyane kandi ikorwa na Eli Lilly and Company.

Igihe uzaba wakiriye umuti wawe, uzabona

Zose abemaciclib na palbociclib ni inhibitors ya CDK4/6 ikora neza, ariko zifite itandukaniro rishobora gutuma imwe ikwiriye kurusha iyindi. Nta n'imwe ifite "uburanga" rusange - guhitamo neza biterwa n'uko ubuzima bwawe bumeze.

Abemaciclib irashobora gufatwa buri gihe (buri munsi), mugihe palbociclib isanzwe ifatwa iminsi 21 ikurikirwa n'ikiruhuko cy'iminsi 7. Abantu bamwe bakunda gufata imiti buri gihe, mugihe abandi bashimishwa n'igihe cy'ikiruhuko.

Uburyo bwo kugira ingaruka zisa ariko ntibisa. Abemaciclib irashobora gutera impiswi, mugihe palbociclib ishobora gutera kugabanuka kw'umubare w'uturemangingo tw'amaraso twera bishobora gusaba guhindura urugero rwa dose.

Umuvuzi wawe w'indwara z'umwijima azatekereza ibintu nk'imiterere yihariye ya kanseri yawe, ubuzima bwawe muri rusange, imiti yindi urimo gufata, n'imibereho yawe mugihe asaba umuti ushobora gukora neza kuri wowe.

Ibikunze Kubazwa Kuri Abemaciclib

Ese Abemaciclib irakwiriye abantu barwaye indwara z'umutima?

Abemaciclib muri rusange ifatwa nk'ikwiriye abantu barwaye indwara z'umutima, kuko ntisanzwe itera ingaruka zikomeye zijyanye n'umutima. Ariko, muganga wawe azashaka kugukurikiranira hafi niba ufite ibibazo by'umutima.

Abantu bamwe bafata abemaciclib bashobora kumva bananiwe, ibyo bishobora kuba bibangamiye niba ufite umutima udakora neza. Umuvuzi w'indwara z'umutima na oncologist bazakorana kugirango barebe ko indwara yawe y'umutima ifashwe neza mugihe cyo kuvurwa kanseri.

Ni ngombwa kubwira muganga wawe imiti yose y'umutima urimo gufata, kuko imwe ishobora guhura na abemaciclib cyangwa igasaba guhindura urugero rwa dose.

Nigomba gukora iki niba mfatye abemaciclib nyinshi ku buryo butunguranye?

Niba ku buryo butunguranye ufashe abemaciclib nyinshi kuruta uko byategetswe, hamagara muganga wawe cyangwa umufarumasiti ako kanya, n'iyo wumva umeze neza. Gufata nyinshi bishobora kongera ibyago byo kugira ingaruka zikomeye.

Ntugerageze gusimbura urugero rurenzeho wirinda urugero rukurikira rwateganyijwe. Ahubwo, kurikiza amabwiriza ya muganga wawe uko wakomeza neza.

Niba urimo guhura n'ibimenyetso bikomeye nk'umuriro udashira, impiswi ikabije, cyangwa ibimenyetso by'indwara, shakisha ubufasha bwihutirwa bw'ubuvuzi ako kanya.

Nkwiriye gukora iki niba nciwe urugero rwa Abemaciclib?

Niba waciwe urugero rwa abemaciclib, rwihutire kurufata uko wibuka, keretse igihe cyegereje urugero rwawe rukurikira rwateganyijwe. Muricyo gihe, irengagize urugero waciwe ukomeze gahunda yawe isanzwe.

Ntuzigere ufata urugero ebyiri icyarimwe kugirango usimbure urugero waciwe, kuko ibi bishobora kongera ibyago byo kugira ingaruka ziterwa n'imiti. Niba utazi neza igihe, vugana n'umuganga wawe kugirango akuyobore.

Tekereza gushyiraho ibyibutso kuri terefone cyangwa ukoreshe umuteguro w'imiti kugirango ugufashe kwibuka urugero rwawe. Guhora ukoresha imiti ni ngombwa kugirango imiti ikore neza.

Nshobora guhagarika ryari gufata Abemaciclib?

Ugomba guhagarika gufata abemaciclib gusa mugihe muganga wawe akubwiye ko ari byiza kubikora. N'ubwo wumva umeze neza, imiti irashobora kuba igikora kugirango igenzure kanseri yawe.

Muganga wawe azagenzura buri gihe uko imiti ikora neza binyuze mu bizami by'amaraso, amasomo yo gushushanya, n'ibizamini by'umubiri. Bazatekereza guhagarika imiti niba kanseri yawe ikomeje nubwo uvurwa cyangwa niba ugize ingaruka zikomeye.

Abantu bamwe bashobora gukenera guhagarika by'agateganyo imiti kugirango umubiri wabo ukire ingaruka ziterwa n'imiti, ariko ibi bigomba gukorwa buri gihe hakurikijwe ubugenzuzi bw'abaganga.

Nshobora kunywa inzoga niba ndimo gufata Abemaciclib?

Nubwo nta mikoranire itaziguye iri hagati ya abemaciclib na alukolo, muri rusange birasabwa kugabanya kunywa alukolo mugihe cyo kuvura kanseri. Alukolo irashobora gukomeza ingaruka zimwe nk'isuka n'umunaniro.

Abemaciclib na alukolo byombi bikoreshwa mu mwijima wawe, bityo kunywa alukolo bishobora kongera umunaniro kuri uru rukururano. Niba uhisemo kunywa, bikore mu rugero ruciriritse kandi ubiganireho n'ikipe yawe y'ubuvuzi.

Muganga wawe ashobora gutanga inama zihariye zishingiye ku buzima bwawe muri rusange, imiti yindi urimo gufata, n'uburyo wihanganira imiti ya abemaciclib.