Icyo Abiraterone ari cyo: Ibyo ikoreshwa, urugero rwo gufata, ingaruka ziterwa n'ibindi

Abiraterone ni umuti w'indwara ya kanseri ugamije gufasha kurwanya kanseri ya prostate yateye imbere binyuze mu kubuza umubiri gukora testosterone. Uyu muti ufata mu kanwa ukora ubu binyuze mu kubuza umubiri wawe gukora imisemburo itera ubwoko bumwe bwa selile za kanseri ya prostate, mu by'ukuri ukaniza kanseri ibyo ikeneye kugira ngo ikure.

Niba wowe cyangwa uwo ukunda yarandikiwe abiraterone, birashoboka ko urimo guhangana na kanseri ya prostate yateye imbere yateye ikwirakwira hanze y'urugingo rwa prostate. Ibi bishobora kumvikana nk'ibiremereye, ariko gusobanukirwa uko uyu muti ukora birashobora kugufasha kumva witeguye kandi ufite icyizere ku rugendo rwawe rwo kuvurwa.

Abiraterone ni iki?

Abiraterone ni umuti uvura imisemburo wagenewe kuvura kanseri ya prostate yateye imbere. Ijambo "micronized" risobanura ko umuti wategetswe mu duce duto cyane umubiri wawe ushobora kwinjiza byoroshye kandi neza.

Uyu muti ubarirwa mu cyiciro cy'imiti yitwa androgen biosynthesis inhibitors. Tekereza nk'igikoresho cyihariye cyane kigamije inzira zihariye selile za kanseri zikoresha kugira ngo ziteze imbere imikurire yazo. Bitandukanye na chimiothérapie igira ingaruka ku bwoko bwinshi bwa selile zitandukanye, abiraterone yibanda by'umwihariko ku nzira zikora imisemburo.

Umuti uza mu buryo bw'ibinini ufata mu kanwa, bigatuma biba byoroshye kurusha imiti isaba gusura ibitaro kugira ngo baterwe. Ibi bikugiraho kugumana byinshi mu bikorwa byawe bisanzwe mugihe wakira ubuvuzi bwiza bwa kanseri.

Abiraterone ikoreshwa mu iki?

Abiraterone ikoreshwa cyane cyane mu kuvura kanseri ya prostate itagira imisemburo (mCRPC). Ibi bisobanura kanseri ya prostate yateye ikwirakwira mu bindi bice by'umubiri wawe kandi igakomeza gukura nubwo urwego rwa testosterone ruri hasi cyane.

Muganga wawe ashobora kugutera umuti wa abiraterone niba kanseri ya prostate yawe yarateye imbere nubwo wakoresheje izindi nkingo z'imisemburo cyangwa gukuraho ibice bikora testosterone. Akenshi ikoreshwa iyo kanseri yateye mu magufa, imitsi ya lymph, cyangwa izindi ngingo, kandi imiti isanzwe ntigikora neza mu kugenzura indwara.

Mu bindi bihe, abaganga banatanga abiraterone ku kanseri ya prostate yateye ikoresha imisemburo hamwe n'izindi nkingo. Ubu buryo bufasha kwirinda ko kanseri irwanya imiti y'imisemburo kandi ishobora gutinda mbere y'uko indwara itera imbere.

Abiraterone ikora ite?

Abiraterone ikora ibuza enzyme yitwa CYP17A1, umubiri wawe ukoresha mu gukora testosterone n'izindi androgens. Icyurirwa cya kanseri ya prostate gikunda gukoresha iyi misemburo kugira ngo kibashe kubaho no kwiyongera, bityo guca urugomo rwabo bishobora gutinda cyangwa guhagarika gukura kwa kanseri.

Uyu muti ufatwa nk'uburyo bukomeye kandi bwiza bwo kuvura kanseri ya prostate yateye imbere. Ibuza ikorwa ry'imisemburo atari gusa mu ntanga zawe, ahubwo no mu ngingo zawe za adrenal no mu turanduriro twa kanseri ubwabo. Ubu buryo bwuzuye butuma bigora cyane ibice bya kanseri kubona imisemburo bakeneye.

Uyu muti akenshi utangira gukora mu byumweru bike, nubwo ushobora kutumva impinduka ako kanya. Muganga wawe azagenzura urwego rwawe rwa PSA (prostate-specific antigen) n'ibindi bimenyetso byo mu maraso kugira ngo akurikirane uko imiti ikora neza kuri wewe.

Nkwiriye gufata abiraterone nte?

Fata abiraterone nk'uko muganga wawe abitegeka, akenshi rimwe ku munsi ku gifu cyambaye ubusa. Ibi bivuze ko ukwiriye kuyifata byibura isaha imwe mbere yo kurya cyangwa amasaha abiri nyuma yo kurya, kuko ibiryo bishobora kongera cyane urugero umubiri wawe wunguka umuti.

Mimina ibinini byose hamwe n'ikirahure cyuzuye cy'amazi. Ntukavunagure, uvunike, cyangwa urume ibinini, kuko ibi bishobora kugira ingaruka ku buryo umuti usohoka mu mubiri wawe. Kubifata ku gihe kimwe buri munsi bifasha kugumana urwego rumwe rw'umuti mu mubiri wawe.

Uzanakenera gufata prednisone cyangwa prednisolone hamwe na abiraterone. Uyu muti wa steroid ufasha kwirinda ingaruka ziterwa n'impinduka za hormone kandi ni igice cy'ingenzi cy'ubuvuzi bwawe. Muganga wawe azandika urugero rukwiye n'igihe cyo gufata imiti yombi.

Nzamara igihe kingana iki mfata Abiraterone?

Ubusanzwe uzakomeza gufata abiraterone igihe cyose irimo kugenzura kanseri yawe kandi ukaba uyihanganira neza. Ibi bishobora kumara amezi cyangwa imyaka, bitewe n'uko umubiri wawe witwara ku buvuzi.

Muganga wawe azakurikiza iterambere ryawe binyuze mu bizami by'amaraso bisanzwe, ibizamini byerekana ishusho, n'ibizamini by'umubiri. Niba urwego rwawe rwa PSA rutangiye kuzamuka buri gihe cyangwa ibizamini bigaragaza iterambere rya kanseri, muganga wawe ashobora guhindura gahunda yawe y'ubuvuzi cyangwa akajya ku miti itandukanye.

Abantu bamwe bafata abiraterone igihe kirekire bafite ibisubizo byiza, mu gihe abandi bashobora gukenera guhindura ubuvuzi vuba. Igisubizo cyawe bwite kizagenga igihe uzakomeza gufata uyu muti, kandi ikipe yawe y'ubuzima izakorana nawe kugirango ifate ibyemezo byiza kuri iyi mimerere yawe.

Ni izihe ngaruka ziterwa na Abiraterone?

Kimwe n'indi miti yose ya kanseri, abiraterone irashobora gutera ingaruka, nubwo atari buri wese uzibona. Ingaruka nyinshi zirashobora gucungwa, kandi ikipe yawe y'ubuzima izagukurikiranira hafi kugirango ikemure ibibazo byose bishobora kuvuka.

Ingaruka zisanzwe ushobora guhura nazo zirimo umunaniro, kuribwa mu ngingo, kubyimba amaguru cyangwa ibirenge, gushyuha cyane, na diarrea. Izi ngaruka akenshi zinoza uko umubiri wawe wimenyereza umuti, kandi hariho uburyo bwo kuzicunga neza.

Ingaruka zikomeye ariko zitabaho kenshi zirimo ibibazo by'umwijima, umuvuduko ukabije w'amaraso, urugero ruto rwa potasiyumu, n'imihindagurikire y'umuvuduko w'umutima. Muganga wawe azajya agenzura amaraso yawe buri gihe kugira ngo amenye ibi bibazo hakiri kare. Abagabo bamwe kandi bagira intege nke mu mikaya, kuribwa mu magufa, cyangwa impinduka mu rugero rw'isukari mu maraso.

Mu buryo butajegajega, abiraterone ishobora gutera ibibazo bikomeye by'umwijima, ibibazo by'umutima, cyangwa igabanuka ry'umuvuduko w'amaraso rishobora guteza akaga. Ibi nibyo bituma gukurikiranwa buri gihe ari ngombwa cyane. Niba ubonye uruhu rwawe cyangwa amaso yawe bihinduka umuhondo, umunaniro ukabije, kuribwa mu gituza, cyangwa guhumeka bigoranye, vugana n'umuganga wawe ako kanya.

Ninde utagomba gufata Abiraterone?

Abiraterone ntibereye buri wese, kandi muganga wawe azagenzura neza niba bikwiriye kuri wowe. Abantu bafite indwara zikomeye z'umwijima mubisanzwe ntibashobora gufata uyu muti, kuko ushobora gutuma ibibazo by'umwijima birushaho kuba bibi.

Niba ufite amateka y'ibibazo by'umutima, umuvuduko ukabije w'amaraso utagenzurwa, cyangwa indwara zimwe na zimwe z'umuvuduko w'umutima, muganga wawe azagomba gupima neza inyungu n'akaga. Uyu muti ushobora kugira ingaruka ku mutima wawe n'umuvuduko w'amaraso, bityo ibi bibazo bisaba gukurikiranwa byihariye.

Abagore batwite cyangwa bashobora gutwita ntibagomba gukora ku binini bya abiraterone, kuko uyu muti ushobora kwangiza umwana ukiri mu nda. Abagabo bafata abiraterone bagomba gukoresha uburyo bwo kuboneza urubyaro neza niba uwo bashakanye ashobora gutwita, kuko uyu muti ushobora kuboneka mu ntanga.

Muganga wawe azatekereza kandi ku yindi miti urimo gufata, kuko abiraterone ishobora guhura n'imiti ituma amaraso ataguma, imiti imwe na rimwe y'umutima, n'indi miti igira ingaruka ku mikorere y'umwijima.

Amazina y'ubwoko bwa Abiraterone

Abiraterone iboneka mu mazina atandukanye y'ubwoko, Zytiga ikaba ari ryo zina rizwi cyane. Iyi ni yo yari verisiyo ya mbere yemejwe na FDA ya abiraterone acetate kandi ikorwa na Janssen Pharmaceuticals.

Imiti ya abiraterone isanzwe ubu iraboneka kuva mu nganda zitandukanye, ibyo bishobora koroshya kubona uwo muti ku giciro gito. Iyi miti isanzwe ikubiyemo ibintu bikora kimwe kandi ikora kimwe na ya miti izwi ku izina ryayo.

Farmasi yawe ishobora kubika ubwoko butandukanye cyangwa imiti isanzwe, ariko yose ni imiti imwe. Niba ufite ibibazo ku bwoko urimo guhabwa, umufarmasi wawe ashobora kukusobanurira itandukaniro kandi agafasha kureba ko urimo kubona uburyo buhendutse.

Izindi miti isimbura Abiraterone

Niba abiraterone atagukwiriye cyangwa igihe itagikora, hari ubundi buryo bwo kuvura kanseri ya prostate igeze kure. Enzalutamide (Xtandi) ni ubundi buryo bwo kuvura bukoresha imisemburo, bukora mu buryo butandukanye ariko bugamije inzira zisa.

Umuti wa chemotherapy wa Docetaxel akenshi ukoreshwa kuri kanseri ya prostate yimukiye, wenyine cyangwa uhujwe n'imiti ikoresha imisemburo. Ubuvuzi bushya nka radium-223 (Xofigo) bushobora gufasha niba kanseri yimukiye mu magufa, mugihe sipuleucel-T (Provenge) ari uburyo bwo kuvura bukoresha imbaraga z'umubiri.

Muganga wawe ashobora kandi gutekereza ku igeragezwa ry'imiti igeragezwa, cyane cyane niba ubuvuzi busanzwe butagikora neza. Uburyo bwo kuvura kanseri ya prostate burakomeza guhinduka, hamwe n'imiti mishya n'uburyo bujyanye bigenda bikorwa buri gihe.

Ese Abiraterone iruta Enzalutamide?

Byombi abiraterone na enzalutamide ni imiti ikora neza mu kuvura kanseri ya prostate igeze kure, ariko bikora mu buryo butandukanye gato. Abiraterone ibuza ikorwa ry'imisemburo, mugihe enzalutamide ibuza uburyo selile za kanseri zikoresha imisemburo isanzweho.

Ubushakashatsi bwerekana ko iyi miti yombi ishobora kongera imyaka yo kubaho no guteza imbere imibereho myiza y'abagabo bafite kanseri ya prostate yimukiye. Guhitamo hagati yayo akenshi biterwa n'uko ubuzima bwawe bumeze, izindi ndwara, n'uburyo witwara ku buvuzi.

Abantu bamwe babona ko umuti umwe ubafasha kurusha undi, kandi muganga wawe azatekereza ku bintu nk'ubuzima bwawe bw'ubu, imiti indi urimo gufata, n'ingaruka zishobora kubaho igihe agutera imiti. Byombi bifatwa nk'imiti ikoreshwa bwa mbere mu kuvura kanseri ya prostate igeze kure.

Ibibazo Bikunze Kubazwa Kuri Abiraterone

Q1. Ese Abiraterone irakwiriye ku bantu barwaye indwara z'umutima?

Abiraterone irashobora gukoreshwa ku bantu barwaye indwara z'umutima, ariko bisaba gukurikiranwa no gucungwa neza. Uyu muti ushobora kugira ingaruka ku muvuduko w'amaraso n'umuvuduko w'umutima, bityo umuganga w'umutima n'umuganga uvura kanseri bazakenera gukorana kugira ngo bamenye umutekano wawe.

Muganga wawe ashobora gukurikiranira hafi umutima wawe, agenzure umuvuduko w'amaraso yawe buri gihe, kandi ashobora guhindura imiti yindi y'umutima urimo gufata. Abantu benshi bafite indwara z'umutima baracyashobora kungukira ku kuvurwa na abiraterone iyo bikozwe neza.

Q2. Nakora iki niba mfashe abiraterone nyinshi ku buryo butunganye?

Niba ufata abiraterone nyinshi ku buryo butunganye, vugana na muganga wawe cyangwa ikigo gishinzwe ubumara ako kanya. Gufata nyinshi bishobora kongera ibyago byo kugira ingaruka zikomeye, cyane cyane ibibazo by'umwijima n'imihindagurikire y'umuvuduko w'umutima.

Ntugategereze ngo urebe niba wumva umeze neza. N'iyo utabona ibimenyetso ako kanya, kunywa nyinshi bishobora gutera ingaruka zitinze zikeneye ubufasha bwa muganga. Itsinda ryawe ry'ubuzima rishobora kukugira inama y'icyo ugomba kwitondera niba ukeneye ubuvuzi bwihutirwa.

Q3. Nakora iki niba nirengagije doze ya abiraterone?

Niba wibagiwe gufata doze ya abiraterone, yifate uko wibuka, ariko niba hashize amasaha atarenze 12 uhereye igihe wari uteganyirijwe gufata. Niba hashize amasaha arenga 12, reka doze wibagiwe hanyuma ufate doze yawe ikurikira ku gihe gisanzwe.

Ntugasubire gufata doze ebyiri icyarimwe kugira ngo usimbure doze wasibye, kuko ibyo bishobora kongera ibyago byo kugira ingaruka zidakurikira. Niba ukunda kwibagirwa gufata imiti, tekereza gushyiraho ibyibutso kuri terefone yawe cyangwa ukoreshe agasanduku kabugenewe kugufasha gukurikiza gahunda.

Q4. Ni ryari nshobora guhagarika gufata Abiraterone?

Ugomba guhagarika gufata abiraterone gusa igihe muganga wawe abikugiriye inama. Ibi bikunda kuba iyo kanseri ikomeje kwiyongera nubwo uvurwa, niba ugize ingaruka zikomeye zidakurikira, cyangwa niba muganga wawe agushishikariza guhindura uburyo bwo kuvura.

Ntuzigere uhagarika gufata abiraterone ako kanya utabihuguriwe na muganga, kuko ibyo bishobora gutuma kanseri yawe ikomeza kwiyongera vuba. Muganga wawe azagenzura uko umeze buri gihe kandi aganire nawe ku mpinduka zose ziri mu buryo bwo kuvura.

Q5. Nshobora kunywa inzoga nkanwa abiraterone?

Ni byiza kugabanya kunywa inzoga mugihe ufata abiraterone, kuko zombi, inzoga n'umuti, bishobora kugira ingaruka ku mwijima wawe. Kunywa inzoga rimwe na rimwe, mu rugero ruto, mubisanzwe birabyemewe, ariko ugomba kubiganiraho na muganga wawe bitewe n'uko ubuzima bwawe bwifashe.

Niba ufite ibibazo by'umwijima cyangwa ufata indi miti igira ingaruka ku mwijima, muganga wawe ashobora kugusaba kwirinda inzoga burundu. Itsinda ryawe ry'ubuvuzi rishobora gutanga ubujyanama bwihariye bushingiye ku buzima bwawe muri rusange no ku buryo bwo kuvura.