Icyo Abiraterone ari cyo: Ibyo ikoreshwa, urugero rwo gufata, ingaruka zayo n'ibindi

Abiraterone ni umuti ukomeye wagenewe kuvura kanseri ya prostate yateye imbere mu bagabo. Uyu muti ufata mu kanwa ukora ubu ukoma mu nkokora umubiri wawe mu gukora testosterone, umusemburo utera ubwoko bumwe bwa kanseri ya prostate gukura.

Niba wowe cyangwa uwo ukunda warandikiwe abiraterone, birashoboka ko urimo guhangana no gusuzumwa bigoye. Kumva uko uyu muti ukora n'icyo witegura birashobora kugufasha kumva ufite icyizere cyinshi ku rugendo rwawe rw'ubuvuzi.

Abiraterone ni iki?

Abiraterone ni umuti uvura ukoresha imisemburo, ukaba mu cyiciro cy'imiti yitwa abahagarika imisemburo ya androgen. Iza mu buryo bw'ibinini ufata mu kanwa, akenshi rimwe ku munsi.

Uyu muti wibanda cyane ku rurenda rwitwa CYP17A1, umubiri wawe ukoresha mu gukora testosterone n'indi misemburo y'abagabo. Mu guhagarika uru rurenda, abiraterone igabanya cyane umubare wa testosterone uhari wo gutera selile za kanseri gukura.

Akenshi uzumva muganga wawe abyita izina ryayo ry'ubucuruzi, Zytiga. Uyu muti buri gihe wandikwa hamwe na steroid yitwa prednisone cyangwa prednisolone kugira ngo ifashe kwirinda ingaruka zimwe na zimwe.

Abiraterone ikoreshwa mu iki?

Abiraterone ikoreshwa cyane cyane mu kuvura kanseri ya prostate ya metastatic castration-resistant (mCRPC). Ibi bivuze ko kanseri yateye ikarenga urugingo rwa prostate kandi igakomeza gukura nubwo hari izindi mvura zikoresha imisemburo.

Muganga wawe ashobora kukwandikira abiraterone niba kanseri yawe ya prostate yaranze imiti y'ibanze ikoresha imisemburo nk'ubuganga bwo kubaga cyangwa imiti ihagarika gukorwa kwa testosterone. Akenshi ikoreshwa iyo kanseri yateye mu bindi bice by'umubiri wawe, nk'amagufa cyangwa imitsi y'amazi.

Mu bindi bihe, abaganga bashobora no kwandikira abarwayi abiraterone kubera kanseri ya prostate yateye ikaba ifite ibyago byinshi kandi ikaba igisubiza ku miti ikoresha imisemburo. Ibi biba iyo kanseri yateye ariko igisubiza ku miti ikoresha imisemburo, kandi muganga wawe ashaka gukoresha uburyo bwo kuvura bukaze kuva mu ntangiriro.

Abiraterone ikora ite?

Abiraterone ikora igabanya umubare wa testosterone, umusemburo wa ngombwa wa selile za kanseri ya prostate kugira ngo zibashe kubaho no kwiyongera. Tekereza kuri testosterone nk'igicanwa cya selile za kanseri.

Umubiri wawe ukora testosterone ahantu hatatu nyamukuru: mu ntanga, mu ngingo zikora imisemburo, ndetse no muri selile za kanseri ubwazo. Mu gihe izindi nzitizi zikoresha imisemburo zishobora guhagarika testosterone ituruka mu ntanga, abiraterone ikora cyane kurusha izindi kuko ihagarika ikorwa ryayo ahantu hose hatatu.

Uyu muti ubangamira enzyme yitwa CYP17A1, ikaba ari ingenzi mu ikorwa rya testosterone. Mu guhagarika iyi enzyme, abiraterone ishobora kugabanya urwego rwa testosterone mu maraso yawe ku buryo butagaragara. Ibi bituma habaho ahantu selile za kanseri ya prostate zigirira ingorane zo gukura no gukwirakwira.

Uyu muti ufashwe nk'umuti ukomeye kandi ufite akamaro mu kuvura kanseri ya prostate yateye. Ubushakashatsi bwakozwe bwerekanye ko bishobora gutuma indwara itagenda vuba kandi ikongera igihe abarwayi bamara babaho.

Nkwiriye gufata abiraterone nte?

Fata abiraterone nk'uko muganga wawe abikwandikiye, akenshi rimwe ku munsi ku gifu cyambaye ubusa. Ukwiriye kuyifata nibura isaha imwe mbere yo kurya cyangwa amasaha abiri nyuma yo kurya.

Mimina ibinini byose hamwe n'amazi. Ntukabikore, ntukabihahane, cyangwa ngo ubimenagure, kuko ibi bishobora kugira ingaruka ku buryo umuti winjira mu mubiri. Gufata abiraterone hamwe n'ibiryo bishobora kongera umubare w'umuti umubiri wawe winjiza, ibi bikaba bishobora gutuma ugira ingaruka nyinshi.

Muganga wawe azanagutegeka gufata prednisone cyangwa prednisolone hamwe na abiraterone. Iyi steroid ifasha kwirinda indwara yitwa mineralocorticoid excess, ishobora gutera izamuka ry'umuvuduko w'amaraso kandi rigatuma urugero rwa potasiyumu rugabanuka.

Gerageza gufata imiti yawe ku gihe kimwe buri munsi kugira ngo urugero rwayo rugume mu mubiri wawe. Niba ugira ikibazo cyo kwibuka, tekereza gushyiraho alarme ya buri munsi cyangwa gukoresha umuteguro w'imiti.

Nzamara Igihe Kingana Iki Ndafata Abiraterone?

Ubusanzwe uzakomeza gufata abiraterone igihe cyose ifasha kugenzura kanseri yawe kandi ingaruka zayo zikaba zigikemuka. Ibi bishobora kumara amezi cyangwa imyaka, bitewe n'uko kanseri yawe yitwara.

Muganga wawe azagukurikiranira hafi akoresheje ibizamini by'amaraso n'ibizamini by'amashusho kugira ngo arebe uko umuti ukora neza. Bazashaka ibimenyetso byerekana ko kanseri yawe ikomeje, nk'izamuka ry'urugero rwa PSA cyangwa ahantu hashya kanseri yagereye.

Abarwayi bamwe bafata abiraterone imyaka myinshi bagatanga umusaruro mwiza, mu gihe abandi bashobora gukenera guhindura imiti vuba. Umwanzuro wo gukomeza cyangwa guhagarika imiti biterwa n'ibintu byinshi, harimo ubuzima bwawe muri rusange, ingaruka zayo, n'uko kanseri yawe yitwara.

Ntuzigere uhagarika gufata abiraterone utabanje kubiganiraho na muganga wawe. Guhagarika ako kanya bishobora gutuma kanseri yawe itangira gukura vuba.

Ni Iyihe Ngaruka Ziterwa na Abiraterone?

Kimwe n'indi miti yose ya kanseri, abiraterone ishobora gutera ingaruka zayo, nubwo atari buri wese uzazibona. Ingaruka nyinshi zishobora gucungwa neza hakoreshejwe uburyo bwo gukurikirana neza no gutanga ubufasha.

Kumenya ibyo witegura bishobora kugufasha kumenya ingaruka hakiri kare no kubona ubufasha ukeneye. Hano hari ingaruka zisanzwe ushobora guhura nazo:

• Kugira umunaniro no kunanirwa: Iki ni kimwe mu bibazo bikunze kugaragara cyane, kikaba kigaragara ku barwayi bagera kuri 4 kuri 10. Uyu munaniro ushobora kuva ku kunanirwa guto ukagera ku kunanirwa gukabije kwangiza imirimo ya buri munsi.
• Urubavu rw'ingingo no kubyimba: Abagera kuri 3 kuri 10 barwara urubavu rw'ingingo, cyane cyane mu ntoki, ibirenge, cyangwa umugongo.
• Umubyimba mwinshi w'amaraso: Uyu muti ushobora gutuma umubyimba w'amaraso wawe wiyongera, ni yo mpamvu muganga wawe azajya awukurikiranira hafi.
• Kuguma kw'amazi: Ushobora kubona kubyimba mu maguru yawe, mu birenge, cyangwa mu birenge byawe kubera ko umubiri wawe uguma amazi menshi kuruta uko bisanzwe.
• Urugendo rw'ubushyuhe: Ibi byiyumvo by'ubushyuhe n'ibyuya bibaho bitewe no kugabanuka cyane kw'imisemburo ya testosterone.

Ibi bibazo bikunze kwihanganirwa, kandi ikipe yawe y'ubuzima ifite uburyo bwo kubifasha kubicunga neza.

Abandi barwayi bashobora guhura n'ibibazo bikomeye ariko bitagaragara cyane bisaba ubufasha bwihuse bw'abaganga:

• Kunanuka kw'imitsi bikabije: Ibi bishobora kwerekana urwego ruto rwa potasiyumu, rushobora kuba ruteje akaga niba rutavuwe vuba.
• Umutima utera nabi: Impinduka mu mutima zirashobora kubaho, cyane cyane niba urwego rwa potasiyumu rugabanutse cyane.
• Kugufi cyane umwuka: Ibi bishobora kwerekana amazi yiyongera hafi y'umutima cyangwa ibihaha.
• Urubavu mu gituza: Uru rubavu rushya cyangwa rurushaho gukomera rugomba gusuzumwa ako kanya.
• Ibimenyetso by'ibibazo by'umwijima: Harimo umuhondo w'uruhu cyangwa amaso, inkari z'umukara, cyangwa urubavu rukabije mu nda.

Nubwo ibi bibazo bikomeye bidasanzwe, bikaba bigera ku barwayi batarenze 1 kuri 20, ni ngombwa kumenya igihe cyo gushaka ubufasha bwihuse bw'abaganga.

Ninde utagomba gufata Abiraterone?

Abiraterone ntibereye buri wese, kandi muganga wawe azasuzuma neza niba ikwiriye kuri wowe. Uyu muti wemerewe gukoreshwa gusa n'abagabo barwaye kanseri ya prostate kandi ntugomba na rimwe guhabwa abagore cyangwa abana.

Ntugomba gufata abiraterone niba urwaye indwara ikomeye y'umwijima, kuko uyu muti ukoreshwa n'umwijima kandi ushobora gutuma imikorere yawo irushaho kuba mibi. Muganga wawe azagenzura imikorere y'umwijima wawe akoresheje ibizamini by'amaraso mbere yo gutangira kuvurwa.

Niba ufite amateka y'ibibazo by'umutima, muganga wawe azagereranya neza inyungu n'ingaruka. Uyu muti ushobora kugira ingaruka ku mikorere y'umutima n'umuvuduko w'amaraso, bityo kugenzura hafi ni ngombwa niba urwaye indwara z'imitsi y'amaraso.

Imiti imwe n'imwe ishobora gukorana na abiraterone, bityo bwire muganga wawe imiti yose wandikiwe, imiti igurishwa itagomba kwandikwa na muganga, n'ibyongerera imbaraga ufata. Ibi birimo imiti ituma amaraso atavura vuba, imiti ivura indwara z'imitsi, n'imiti imwe n'imwe y'umutima.

Amazina y'ubwoko bwa Abiraterone

Izina risanzwe rya abiraterone ni Zytiga, ikorwa na Janssen Pharmaceuticals. Iri ni ryo zina ry'ubwoko bwa mbere igihe uyu muti wemezwaga bwa mbere.

Kuva patent yarangira, ubwoko butandukanye bwa abiraterone buraboneka ubu. Iyi miti ya generic ikubiyemo ibikoresho bikora kimwe kandi ikora kimwe n'ubwoko bw'izina ry'ubwoko.

Farmasi yawe ishobora gusimbuza ubwoko bwa generic keretse muganga wawe asabye by'umwihariko izina ry'ubwoko. Ubwoko bwombi burakora neza, nubwo abarwayi bamwe bakunda gukoresha ubwoko batangiranye.

Uburyo bwo kuvura busimbura Abiraterone

Niba abiraterone atagukwiriye cyangwa agahagarara gukora neza, hari ubundi buryo bwo kuvura buriho bwo kuvura kanseri ya prostate yateye imbere.

Enzalutamide (Xtandi) ni ubundi buvuzi bukoresha imisemburo bukora mu buryo butandukanye na abiraterone. Aho guhagarika umusaruro wa testosterone, ibuza testosterone kwifatanya n'uturemangingo twa kanseri. Abantu bamwe bahinduranya imiti iyo imwe itagikora.

Docetaxel ni umuti wa chemotherapy ukoreshwa kenshi kuri kanseri ya prostate igeze kure. Ikora igaba ibitero ku turemangingo twa kanseri aho guhagarika imisemburo. Muganga wawe ashobora kugusaba uyu muti niba imiti ikoresha imisemburo itagikora neza.

Ubuvuzi bushya burimo imiti nka apalutamide (Erleada) na darolutamide (Nubeqa), bikora kimwe na enzalutamide ariko bishobora kugira ingaruka zitandukanye.

Ese Abiraterone iruta Enzalutamide?

Byombi abiraterone na enzalutamide ni imiti ikora neza cyane kuri kanseri ya prostate igeze kure, kandi guhitamo hagati yayo biterwa n'uko ubuzima bwawe buhagaze. Nta muti n'umwe uruta undi.

Ubushakashatsi bwakozwe bwerekanye ko iyi miti yombi ishobora kongera cyane imyaka yo kubaho no gutinda ikwirakwira ry'indwara. Guhitamo akenshi biterwa n'ingaruka ziterwa n'iyo miti, izindi ndwara ushobora kuba ufite, n'uburyo kanseri yawe yitwaye ku buvuzi bwakoreshejwe mbere.

Abiraterone isaba ko uyifatanya na prednisone kandi ifite ibyo kurya byihariye, naho enzalutamide ntisaba steroid ariko ishobora gutera umunaniro mwinshi kandi ifite akaga gato ko gufatwa n'ibihungabanyo. Muganga wawe azatekereza kuri ibi bintu mu gihe atanga inama.

Abantu bamwe bashobora kuzahabwa iyi miti yombi mu bihe bitandukanye byo kuvurwa kwabo, kuko uturemangingo twa kanseri dushobora kwigiriza ubwirinzi kuri imwe mu gihe bagikora ku yindi.

Ibikunze Kubazwa Kuri Abiraterone

Ese Abiraterone irakwiriye ku ndwara z'umutima?

Abiraterone irashobora gukoreshwa ku barwayi bafite indwara z'umutima, ariko bisaba gukurikiranwa neza no guhindura urugero rw'umuti. Uyu muti ushobora kugira ingaruka ku mitsi y'amaraso no kuringaniza amazi mu mubiri, ibyo bishobora kugira ingaruka ku mikorere y'umutima.

Muganga wawe azajya akurikirana umuvuduko w'amaraso yawe buri gihe kandi ashobora kuguha imiti yo kuwugabanya niba bibaye ngombwa. Bazajya kandi bareba ibimenyetso byo kubika amazi mu mubiri, bishobora gushyira umutima mu kaga. Niba ufite uburwayi bukomeye bw'umutima, muganga wawe ashobora guhitamo uburyo butandukanye bwo kuvura.

Ikintu cy'ingenzi ni ukugirana ibiganiro byuzuye n'ikipe yawe y'abaganga ku bijyanye n'ibimenyetso byose by'umutima wumva, harimo kuribwa mu gituza, guhumeka nabi, cyangwa kubyimba amaguru.

Nigira iki niba mfashe abiraterone nyinshi ku buryo butunguranye?

Niba ufata abiraterone nyinshi ku buryo butunguranye kuruta uko byategetswe, vugana n'umuganga wawe cyangwa ikigo gishinzwe kurwanya ubumara ako kanya. Guha umuti mwinshi bishobora kongera ibyago byo kugira ingaruka zikomeye, cyane cyane izo zigira ingaruka ku mutima wawe n'imitsi y'amaraso.

Ntugerageze gusimbura urugero rurenzeho ukoresha urugero rukurikira. Ahubwo, kurikiza amabwiriza ya muganga wawe kugira ngo ugaruke ku gahunda yawe isanzwe. Bashobora kwifuza kugukurikirana neza mu minsi mike iri imbere.

Kugira ngo wirinde gufata imiti myinshi ku buryo butunguranye, bika umuti wawe mu gikoresho cy'umwimerere kandi ushobora gukoresha igikoresho cyo gutegura imiti kugira ngo ukurikirane urugero rwawe rwa buri munsi.

Nigira iki niba nirengagije gufata urugero rwa abiraterone?

Niba wibagiwe gufata urugero rwa abiraterone, fata ako kanya wibuka, igihe cyose kitari hafi y'igihe cyo gufata urugero rukurikira. Niba hafi y'urugero rwawe rukurikira rwatanzwe, reka urugero wibagiwe ukomeze gahunda yawe isanzwe.

Ntuzigere ufata urugero rurenzeho icyarimwe kugira ngo usimbure urugero wibagiwe. Ibi bishobora kongera ibyago byo kugira ingaruka zikomeye utagize inyungu zindi.

Niba ukunda kwibagirwa urugero, ganira n'umuganga wawe ku bijyanye n'uburyo bwo kugufasha kwibuka, nko gushyiraho alarme kuri terefone cyangwa gukoresha porogaramu yibutsa imiti.

Ryari nshobora kureka gufata Abiraterone?

Ugomba kureka gufata abiraterone gusa uyobowe na muganga wawe. Icyemezo cyo kureka akenshi kiza iyo umuti utagikora neza mu kugenzura kanseri yawe cyangwa iyo ingaruka zikabije ziba zigoye cyane gukemura.

Muganga wawe azagenzura urwego rwawe rwa PSA n'amasomo yo kugaragaza kugirango amenye niba umuti ugikora. Uruzamuka rwa PSA cyangwa gukura kwa kanseri bishya bishobora kugaragaza ko igihe kigeze cyo guhindura ku buryo bwo kuvura butandukanye.

Rimwe na rimwe abaganga basaba guhagarika imiti niba ufite ingaruka zikabije, ariko iki cyemezo gisaba gusuzuma neza inyungu n'ibibazo.

Nshobora kunywa inzoga niba mfata Abiraterone?

Mubisanzwe birashoboka kunywa inzoga mu rugero ruto niba ufata abiraterone, ariko ugomba kubiganiraho na muganga wawe mbere na mbere. Zose inzoga na abiraterone bikorwa n'umwijima, bityo kubivanga byombi bishobora kugira ingaruka ku mikorere y'umwijima.

Niba uhisemo kunywa, wikwirakwiza ku kinyobwa kimwe cyangwa bibiri kumunsi, kandi wirinde kunywa niba udafite ikintu cyo kurya kuko ufata abiraterone udafite ibiryo. Reba niba hariho kongera ingaruka zirimo umunaniro cyangwa isereri.

Muganga wawe ashobora gusaba kwirinda inzoga rwose niba ufite ibibazo by'umwijima cyangwa ufite ingaruka zikabije zituruka ku muti.