Ni iki Abrocitinib: Ibikoresho, Uburyo bwo Gukoresha, Ingaruka Ziterwa n'ibindi

Abrocitinib ni umuti wandikirwa na muganga ufasha mu kuvura indwara ya atopic dermatitis (eczema) ikaze cyangwa ikomeye mu bantu bakuru n'abana bafite imyaka 12 n'abarenga. Uyu muti unyobwa mu kanwa ukora ugamije inzira zihariye z'umubiri zirwanya indwara zitera umubiri kubyimba no kuribwa bifitanye isano na eczema, bitanga ubufasha igihe imiti ishyirwa ku ruhu itagize icyo itanga.

Niba urwaye eczema idahagarara ituma ubuzima bwawe bwa buri munsi butagenda neza, abrocitinib ishobora kuba ari uburyo umuganga w'uruhu ashobora gutekereza. Uyu muti ubarirwa mu cyiciro gishya cy'imiti yitwa JAK inhibitors, yagaragaje ibisubizo byiza mu gufasha abantu kongera kugenzura uruhu rwabo.

Abrocitinib ni iki?

Abrocitinib ni umuti unyobwa mu kanwa wa JAK1 inhibitor wagenewe kuvura atopic dermatitis ikaze cyangwa ikomeye. JAK isobanura Janus kinase, ari poroteyine zifasha kugenzura umubiri kubyimba.

Tekereza poroteyine za JAK nk'intumwa zibwira umubiri wawe kurwanya indwara ngo utere kubyimba. Iyo urwaye eczema, izi ntumwa zikora cyane, bigatuma uruhu rutukura, rugaragara, rugashyushye. Abrocitinib ikora ibi ikingira izi ntumwa zihariye, igafasha gutuza ibisubizo byo kurwanya indwara bitera ibimenyetso bya eczema yawe.

Uyu muti ni mushya ku isoko, umaze kubona uburenganzira bwo gukoreshwa na FDA mu mwaka wa 2022. Wagenewe abantu batabonye ubufasha buhagije ku miti ishyirwa ku ruhu cyangwa bakeneye ubuvuzi bw'umubiri bwose kugira ngo bavure indwara yabo neza.

Abrocitinib ikoreshwa mu kuvura iki?

Abrocitinib ikoreshwa cyane mu kuvura atopic dermatitis ikaze cyangwa ikomeye mu bantu bakuru n'urubyiruko rufite imyaka 12 n'abarenga bashobora gukoresha ubuvuzi bw'umubiri wose. Muganga wawe ashobora gutekereza uyu muti igihe imiti ishyirwa ku ruhu itatanze ubufasha buhagije.

Uyu muti ufasha kuvura ibimenyetso nyamukuru bya eczema bishobora kugira ingaruka zikomeye ku mibereho yawe. Ibi birimo gushishimuka kudahwema bibuza gusinzira, kubyimba uruhu hose, n'ahantu uruhu rwakomeretse cyangwa rwangiritse biturutse ku kwishimisha kenshi.

Umuhanga wawe mu by'uruhu ashobora kugusaba abrocitinib niba wagerageje imiti myinshi ikoreshwa ku ruhu ntigutange umusaruro, cyangwa niba eczema yawe ifata igice kinini cy'umubiri wawe. Bifasha cyane abantu bafite eczema ibuza ibikorwa bya buri munsi, akazi, cyangwa uburyo bwo gusinzira.

Abrocitinib ikora ite?

Abrocitinib ikora ibungabunga byihariye enzymes za JAK1, zifite uruhare runini mu mikoranire y'uburwayi butera ibimenyetso bya eczema. Ubu buryo bugamije gufasha kugabanya imikorere y'umubiri y'umubiri y'umubiri ituma uruhu rwawe rubyimba kandi rugashishimuka.

Iyo enzymes za JAK1 zibujijwe, urukurikirane rw'ibimenyetso by'uburwayi butera ibimenyetso bya eczema birahagarara. Ibi bivuze kubyimba guke, kugabanya gushishimuka, no kunoza imikorere y'uruhu uko igihe kigenda gihita. Uyu muti ufasha mu gusubiza imikorere y'umubiri wawe ku rwego rwo hasi.

Nka ubuvuzi bukoreshwa mu mubiri wose, abrocitinib ifatwa nk'umuti ufite imbaraga ziringaniye ukora mu mubiri wawe aho gukora ku ruhu gusa. Ubu buryo bwo mu mubiri bushobora gufasha cyane kuri eczema yagutse cyangwa iyo imiti ikoreshwa ku ruhu itagera ahantu hose hagaragaye uburwayi.

Nkwiriye gufata abrocitinib nte?

Fata abrocitinib nk'uko byategetswe na muganga wawe, akenshi rimwe ku munsi hamwe cyangwa nta funguro. Ibinini bigomba kumirwa byose n'amazi kandi ntibigomba gukubitwa, kuribwa, cyangwa gutandukanywa.

Urashobora gufata uyu muti hamwe n'ibiryo niba bitera isesemi, nubwo ibiryo bitakenewe kugirango bikore. Abantu benshi basanga kuwufata mu gihe kimwe buri munsi bifasha gukomeza urwego rumwe mu mubiri wabo kandi bikoroha kwibuka.

Muganga wawe azagutangirira urugero rwihariye rishingiye ku myaka yawe, uburemere bwawe, n'uburemere bw'ibimenyetso. Ntukagire urugero uhindura utabanje kubaza umuganga wawe, kuko urugero rugomba gukurikiranwa neza kugira ngo rukore neza kandi rutagira ingaruka.

Nzamara Igihe Kingana Iki Ndafashe Abrocitinib?

Igihe cyo kuvura na abrocitinib gitandukanye bitewe n'uburyo witwara ku muti n'imibereho yawe bwite. Abantu benshi batangira kubona impinduka mu byumweru 2-4, n'ibisubizo bifatika bikunda kugaragara nyuma y'ibyumweru 12-16 byo gukoresha buri gihe.

Muganga wawe azakurikiza iterambere ryawe binyuze mu nama zisanzwe kandi ashobora guhindura gahunda yawe yo kuvura bitewe n'uburyo witwara neza. Abantu bamwe bashobora gukenera kuvurwa igihe kirekire kugira ngo bagumane uruhu rwiza, mu gihe abandi bashobora kugabanya urugero rwabo cyangwa guhagarika gufata umuti.

Ni ngombwa gukomeza gufata abrocitinib nkuko byategetswe kabone niyo watangira kumva umeze neza. Guhagarara ako kanya utabanje kubisobanurira umuganga byatuma ibimenyetso byawe bya eczema bisubira, ndetse bikaba bibi cyane kurusha mbere.

Ni Iyihe Ngaruka Ziterwa na Abrocitinib?

Kimwe n'imiti yose, abrocitinib irashobora gutera ingaruka, nubwo atari buri wese uzibona. Kumva icyo ugomba kwitondera bifasha gukorana na muganga wawe kugira ngo ukemure ibibazo byose bivutse.

Ingaruka zisanzwe zikunda kuba zoroshye kandi zikagenda zikemuka uko umubiri wawe wimenyereza umuti:

• Isesemi no kutumva neza mu gifu
• Umutwe
• Ibimenyetso bya grip
• Urugero
• Umunaniro
• Ibimeme cyangwa ibibazo byo ku ruhu
• Kiyongera cyo kwandura indwara ntoya

Izi ngaruka zisanzwe mubisanzwe ntizisaba guhagarika umuti, ariko menyesha muganga wawe niba zikomeje cyangwa zikaba zirambye.

Ingaruka zikomeye ziterwa n'imiti ntizikunze kubaho ariko zisaba ubufasha bwihutirwa bw'abaganga. Izi zikubiyemo ibimenyetso by'indwara zikomeye zandura, kuva amaraso cyangwa gukomereka mu buryo budasanzwe, kuribwa cyane mu nda, cyangwa ibindi bimenyetso byose bikubabaza cyane.

Kubera ko abrocitinib igira ingaruka ku mikorere y'umubiri w'umuntu urwanya indwara, hariho ibyago byiyongera byo kurwara indwara zandura n'ubwoko runaka bwa kanseri, nubwo ibyo byago biba bike. Muganga wawe azajya agukurikiranira hafi akoresheje ibizamini by'amaraso n'ibindi bizamini kugira ngo amenye hakiri kare ikibazo icyo aricyo cyose gishobora kuvuka.

Ninde utagomba gufata Abrocitinib?

Abrocitinib ntabwo ikwiriye kuri buri wese, kandi ibibazo by'ubuzima runaka cyangwa ibihe runaka bituma bitagukwiriye. Muganga wawe azasuzuma neza amateka yawe y'ubuzima mbere yo kukwandikira uyu muti.

Ntabwo wagombye gufata abrocitinib niba urwaye indwara ikomeye yandura, harimo igituntu cyangwa izindi ndwara ziterwa na bagiteri, virusi, cyangwa fungi zitavurwa neza. Uyu muti ushobora gutuma umubiri wawe utabasha kurwanya indwara.

Abantu bafite ubwoko runaka bwa kanseri, cyane cyane kanseri z'amaraso, bagomba kwirinda abrocitinib. Niba waragize kanseri, muganga wawe azagomba gupima neza inyungu n'ibyago bishobora kuvuka.

Izindi ndwara zishobora gutuma utafata abrocitinib zirimo ibibazo bikomeye by'umwijima, indwara zimwe na zimwe z'umutima, cyangwa niba utwite cyangwa wonka. Muganga wawe azaganira kuri ibi bintu nawe mu gihe cyo kugusuzuma.

Izina ry'ubwoko bwa Abrocitinib

Abrocitinib igurishwa ku izina ry'ubwoko rya Cibinqo muri Leta Zunze Ubumwe z'Amerika no mu bindi bihugu byinshi. Iri ni ryo zina ry'ubwoko ririho ubu kuri uyu muti.

Igihe uzaba wakiriye umuti wawe wandikiwe, uzabona ijambo

Imiti rusange ya abrocitinib ntiraboneka, kuko umuti ukiri mu buryo bwo kurengerwa na patenti. Ibi bivuze ko Cibinqo ariyo nzira yonyine yo kubona ubu buvuzi bwihariye.

Uburyo bwo gusimbuza Abrocitinib

Niba abrocitinib atagukwiriye, hari ubundi buryo bwo kuvura bwanduye bukomeye. Muganga wawe w'uruhu ashobora kugufasha gushakisha izi nzira zo gusimbuza zishingiye ku miterere yawe yihariye.

Izindi miti yo kunywa zirimo imiti isanzwe ikumira ubudahangarwa nk'umuti wa methotrexate, cyclosporine, cyangwa mycophenolate mofetil. Iyi miti imaze igihe ikoreshwa mu kuvura bwanduye ariko ishobora kugira ingaruka zitandukanye.

Imiti y'urushinge ya biologics nka dupilumab (Dupixent) itanga ubundi buryo bwo kuvura bwanduye. Iyi miti igamije ibice bitandukanye by'ubudahangarwa kandi bishobora gukwira abantu bamwe, cyane cyane abatafata imiti yo kunywa.

Imiti yo gusiga ku ruhu iracyakomeye nubwo hari ubuvuzi bwanduye. Imiti yo gusiga ku ruhu yandikwa na muganga, phototherapy, n'uburyo bwose bwo kwita ku ruhu akenshi bikorana n'imiti yo kunywa kugirango habeho ibisubizo byiza.

Ese Abrocitinib iruta Dupilumab?

Abrocitinib na dupilumab byombi ni imiti ikora neza mu kuvura bwanduye bukomeye, ariko bikora mu buryo butandukanye kandi bifite inyungu zitandukanye. Guhitamo “byiza” biterwa n'imimerere yawe bwite, ibyo ukunda, n'uko witwara ku buvuzi.

Abrocitinib ifatwa nk'ikibazo cya buri munsi, abantu bamwe bakabona ko byoroshye kurusha inshinge za dupilumab buri byumweru bibiri. Umuti wo kunywa ushobora no gukora vuba, abantu bamwe bakabona impinduka mu byumweru 2-4 ugereranije n'igihe cy'iminsi 8-16 ya dupilumab.

Ariko, dupilumab ifite amateka maremare y'umutekano n'ubushobozi, imaze kuboneka kuva mu 2017. Yemerewe kandi gukoreshwa mu bindi bibazo nk'umwuka mubi n'impyisi zo mu mazuru, bishobora kugira akamaro niba ufite ibibazo byinshi byo kwivumbura.

Muganga wawe azatekereza ibintu nk'amateka yawe y'ubuvuzi, izindi ndwara ufite, uko ubaho, n'ubwishingizi bwawe mu kugufasha guhitamo hagati y'ibi byemezo. Imiti yombi yagaragaje inyungu zigaragara mu igeragezwa ryo kwa muganga, bityo icyemezo gikunze gishingira ku bintu by'umuntu ku giti cye.

Ibikunze Kubazwa Kuri Abrocitinib

Ese Abrocitinib irakwiriye abantu barwaye indwara z'umutima?

Abrocitinib bisaba kwitonderwa cyane ku bantu barwaye indwara z'umutima, cyane cyane abafite amateka yo gufatwa n'umutima, sitiroki, cyangwa amaraso avuye mu maraso. Abahagarika JAK nk'icyiciro byagiye bifitanye isano n'ibibazo by'umutima byiyongera mu bushakashatsi bumwe.

Muganga wawe azasuzuma ibintu bikwerekeye ku mutima mbere yo kugutangira abrocitinib. Ibi birimo gusuzuma amateka yawe y'ibibazo by'umutima, kugenzura umuvuduko w'amaraso yawe, no gushobora gutumiza ibindi bizami nk'EKG cyangwa echocardiogram.

Niba urwaye indwara y'umutima, muganga wawe ashobora kugusaba gukurikiranwa kenshi cyangwa gutekereza ku zindi miti. Ariko, ku bantu benshi, inyungu zo kuvura eczema ikomeye zirashobora kurenga ibibazo bishoboka iyo bikurikiranwa neza.

Nigira iki niba mfashe abrocitinib nyinshi bitunguranye?

Niba ufata abrocitinib nyinshi kuruta uko byategetswe, vugana na muganga wawe cyangwa ikigo gishinzwe kugenzura uburozi ako kanya. Ntukegere kureba niba ibimenyetso bigaragara, kuko kubona inama z'ubuvuzi vuba ni bwo buryo bwiza buri gihe.

Mugihe gufata doze yinyongera rimwe na rimwe bishobora kutagira ingaruka zikomeye, gufata nyinshi cyane kuruta uko byategetswe byongera ibyago byo kugira ingaruka ziterwa n'imiti. Muganga wawe ashobora kwifuza kugukurikirana cyane cyangwa guhindura gahunda yawe y'imiti.

Kugirango wirinde gufata imiti nyinshi bitunguranye, tekereza gukoresha umuteguro w'ibinini cyangwa gushyiraho ibyibutso bya buri munsi kuri terefone yawe. Bika umuti mu gikoresho cyayo cy'umwimerere kandi ntuzigere ufata doze zinyongera kugirango "usubize" izatakaye.

Nigira iki niba nirengagije doze ya Abrocitinib?

Niba wibagiwe gufata urugero rwa abrocitinib, rufate uko wibukije, keretse igihe cyo gufata urugero rukurikira cyegereje. Mu gihe bimeze bityo, reka urugero wibagiwe ukomeze gahunda yawe isanzwe.

Ntugafate urugero rurenze rumwe icyarimwe kugira ngo usubize urugero wibagiwe, kuko ibyo bishobora kongera ibyago byo kugira ingaruka zidakunda. Ahubwo, komeza gahunda yawe isanzwe yo gufata imiti kandi ugerageze kujya uyifata ku gihe.

Niba ukunda kwibagirwa gufata imiti, ganira na muganga wawe kuri gahunda zagufasha kwibuka. Guhora ufata imiti buri munsi ni ingenzi kugira ngo urugero rw'umuti rugume mu mubiri wawe kandi ubashe kugira ibisubizo byiza.

Ni ryari nshobora kureka gufata Abrocitinib?

Ugomba kureka gufata abrocitinib gusa iyo ubisabwe na muganga wawe, kabone niyo ibimenyetso byawe bya eczema byaba byarushijeho gukira. Guhagarika gufata umuti ako kanya bishobora gutuma ibimenyetso byawe bisubira, bikaba bibi kurusha mbere.

Muganga wawe azakorana nawe kugira ngo amenye igihe cyiza cyo guhagarika ubuvuzi bitewe n'igihe umaze udafite ibimenyetso n'uburyo muri rusange wakiriye umuti. Abantu bamwe bashobora kureka gufata umuti nyuma yo kugera ku gukira birambye, mu gihe abandi bashobora gukenera ubuvuzi burambye.

Igihe kigeze cyo kureka gufata umuti, muganga wawe ashobora kugusaba kugabanya urugero rwawo buhoro buhoro aho kuwuhagarika ako kanya. Ibi bifasha kugabanya ibyago byo gusubira kw'ibimenyetso kandi bituma uruhu rwawe rukurikiranwa neza.

Nshobora guhabwa inkingo niba mfata Abrocitinib?

Inkingo nyinshi zisanzwe zifite umutekano niba ufata abrocitinib, ariko ugomba kwirinda inkingo zikoresha virusi zikiriho mu gihe uvurwa. Muganga wawe azareba amateka yawe y'inkingo kandi agushyireho inkingo zose zikenewe mbere yo gutangira gufata umuti.

Inkingo zikoresha virusi nzima nka urukingo rwo mu mazuru rwa gripe, MMR, cyangwa urukingo rwa chickenpox zigomba kwirindwa kuko abrocitinib ishobora guca intege ubushobozi bwa sisitemu yawe y'ubudahangarwa bwo guhangana na za virusi zikozweho intege. Ariko, inkingo zitagira ubuzima nka urukingo rwa gripe muri rusange zifite umutekano kandi zirashimwa.

Niba ukeneye inkingo iyo uri ku abrocitinib, ganira n'umuganga wawe ku gihe cyazo. Bashobora kugusaba guhabwa inkingo zimwe na zimwe mbere yo gutangira kuvurwa cyangwa guhindura igihe bitewe n'uko ubuzima bwawe bwifashe n'uko ubuzima bwawe buhagaze ubu.