Icyo Alendronate ari cyo: Ibyo ikoreshwa, urugero rwa dose, ingaruka zayo n'ibindi

Alendronate ni umuti ukomeza amagufa ufasha kwirinda kuvunika ku bantu bafite osteoporosis cyangwa igabanuka ry'amagufa. Uyu muti ubarirwa mu itsinda ry'imiti yitwa bisphosphonates, ikora igabanya umuvuduko w'isenyuka ry'amagufa. Ibi bituma umubiri wawe ugira igihe cyo kubaka amagufa mashya, akomeye, bigafasha kugabanya ibyago byo kuvunika uko ushaje.

Alendronate ni iki?

Alendronate ni umuti wandikirwa n'abaganga ugamije kuvura no gukumira osteoporosis, indwara ituma amagufa acika intege akavunika. Wibuke ko ari nk'ingabo irinda amagufa yawe - ifasha kubungabunga ubwinshi bw'amagufa binyuze mu kubuza imikorere y'uturemangingo dusanzwe dusenya amagufa.

Uyu muti uza mu buryo bw'ibinini kandi ufashwe unyuzwa mu kanwa, akenshi rimwe mu cyumweru cyangwa rimwe ku munsi bitewe n'uko umuganga abitegeka. Uyu muti umaze imyaka myinshi ukoreshwa mu buryo bwizewe mu gufasha abantu babarirwa muri za miliyoni kubungabunga amagufa akomeye no kugabanya ibyago byo kuvunika.

Alendronate ifatwa nk'umuti wa mbere uvura osteoporosis, bivuze ko abaganga bakunda kuyitoranya nk'icyemezo cyabo cya mbere kubera imikorere yayo yemejwe n'ubushakashatsi ndetse n'uburyo bwizewe bwo kuyikoresha.

Alendronate ikoreshwa mu kuvura iki?

Alendronate ivura osteoporosis ku bagabo n'abagore, cyane cyane abafite ibyago byinshi byo kuvunika kw'amagufa. Ifasha cyane cyane abagore bageze mu gihe cyo gucura, kuko impinduka za hormone mu gihe cyo gucura zishobora kwihutisha igabanuka ry'amagufa.

Umuganga wawe ashobora kukwandikira alendronate niba ufite ibibazo byinshi byerekeye amagufa bikeneye kwitabwaho:

• Osteoporosis hamwe n'amateka yo kuvunika
• Ubwinshi bw'amagufa buke (osteopenia) buri kugana kuri osteoporosis
• Osteoporosis iterwa na steroid kubera gukoresha igihe kirekire corticosteroid
• Indwara ya Paget, aho amagufa akura mu buryo budasanzwe akaba manini kandi acika intege
• Gukumira igabanuka ry'amagufa ku bantu bafata imiti ituma amagufa acika intege

Uyu muti ufitiye akamaro kanini abantu bamaze kugira imvune imwe, kuko ugabanya cyane amahirwe yo kuzagira izindi mvune mu gihe kizaza. Uyu muti kandi ukoreshwa mu kwirinda ku bantu bafite ibintu byinshi bishobora gutera indwara ya osteoporosis.

Alendronate ikora ite?

Alendronate ikora ibuza uturemangingo twihariye twitwa osteoclasts dusanzwe dusenya uturemangingo tw'amagufa twashaje. Uyu ni umuti ukomeye mu rugero ruciriritse utuma habaho impinduka ikomeye mu buryo amagufa yawe asanzwe yisana.

Amagufa yawe ahora yongera kwiyubaka binyuze mu gukora ibintu byinshi no kubisana. Iyo iyi mikorere ihindutse ikarenga urugero rwo gusenya, amagufa aragabanuka kandi akagira imvune. Alendronate igabanya uruhande rwo gusenya.

Uyu muti winjira mu turemangingo tw'amagufa yawe ukahaguma amezi cyangwa imyaka, ugatanga uburinzi burambye. Ibi nibyo bituma ingaruka zigikomeza nubwo wareka kuwufata, nubwo uburinzi bugenda bugabanuka uko igihe kigenda.

Ubusanzwe uzatangira kubona impinduka mu gukomera kw'amagufa mu mezi 6 kugeza ku 12 umaze gutangira kuvurwa, n'inyungu nyinshi zikagaragara nyuma y'imyaka 2 kugeza kuri 3 ukoresha neza.

Nkwiriye gufata Alendronate nte?

Alendronate isaba igihe cyihariye n'imyiteguro kugira ngo ikore neza kandi wirinde kuribwa mu gifu. Ugomba kuyifata mu gitondo kare utararya cyangwa kunywa ikintu icyo aricyo cyose, unywa amazi asanzwe yuzuye.

Ubu ni uburyo umuganga wawe ashobora kugusaba gukurikiza:

1. Fata ikinini ako kanya umaze gukanguka, utararya cyangwa kunywa ikintu icyo aricyo cyose
2. Kimire cyose hamwe n'amazi asanzwe ya ounces 6 kugeza kuri 8 (atari amazi ya minerale, ikawa, cyangwa umutobe)
3. Guma uhagaze (wicaye cyangwa uhagaze) byibuze iminota 30 umaze kuyifata
4. Tegereza byibuze iminota 30 mbere yo kurya, kunywa, cyangwa gufata indi miti
5. Ntukaryame, ntugoreke, cyangwa gukora imyitozo ikomeye muri iki gihe cyo gutegereza

Izi nyigisho si ibitekerezo gusa - ni ngombwa mu kwirinda ingaruka zikomeye kandi zikemeza ko umuti ukora neza. Kwicara neza bifasha kwirinda ko ikinini cyakwica mu muhogo wawe.

Niba ufata imiti yongera kalisiyumu cyangwa imiti igabanya aside, tegera byibuze amasaha 2 nyuma yo gufata alendronate, kuko ibi bishobora kubangamira imitsi.

Nzagomba Kumara Igihe Kingana Gite Ndafata Alendronate?

Abantu benshi bafata alendronate mu myaka 3 kugeza kuri 5 mbere na mbere, nubwo bamwe bashobora gukenera kuvurwa igihe kirekire bitewe n'uko bafite ibyago byo kuvunika. Muganga wawe azajya asuzuma buri gihe niba ukwiye gukomeza, guhagarika, cyangwa guhindura umuti.

Nyuma y'imyaka 5 yo kuvurwa, abantu benshi bashobora gufata icyo bita

Ibi bimenyetso bikunze kugaragara mu byumweru bya mbere byo kuvurwa kandi akenshi bikemuka byonyine. Gufata umuti uko byategetswe bigabanya cyane ibyago byo kugira ingaruka zifitanye isano n'igifu.

Hariho ingaruka zimwe na zimwe zitagaragara ariko zikomeye zisaba ubufasha bwihuse bw'abaganga, nubwo zifata abantu bake cyane, batarenze 1 kuri 1,000:

• Urubavu rukabije cyangwa kugorana gufungura umunwa wawe (osteonecrosis y'uruhanga)
• Urubavu rudasanzwe rwo mu itako cyangwa kubabara kutajya gushira
• Urubavu rukabije rwo mu gituza cyangwa kugorana kumira
• Urubavu rushya cyangwa rurushaho rwo mu gituza
• Imitsi ikabije, amagufwa, cyangwa kubabara kw'ingingo bitandukanye n'ububabare busanzwe

Gahoro cyane, abantu bamwe bashobora guhura no kuvunika bidasanzwe kw'igufwa ry'itako nyuma yo gukoresha igihe kirekire. Uku kuvunika bidasanzwe rimwe na rimwe bishobora kubaho hamwe n'imvune ntoya kandi bishobora kubanzirizwa n'ububabare bwo mu itako mu byumweru cyangwa amezi.

Ninde Utagomba Gufata Alendronate?

Alendronate ntabwo ikwiriye kuri buri wese, kandi ibibazo bimwe na bimwe by'ubuzima bituma bitaba byiza cyangwa bidatanga umusaruro. Muganga wawe azasuzuma neza amateka yawe y'ubuzima mbere yo gutanga uyu muti.

Ntabwo ugomba gufata alendronate niba ufite kimwe muri ibi bibazo bituma umuti ushobora kuba mubi:

• Ibibazo by'umuhogo wawe, harimo kugabanuka cyangwa kugorana kumira
• Kutabasha kwicara cyangwa guhagarara neza byibura iminota 30
• Urwego rwo hasi cyane rwa kalisiyumu mu maraso (hypocalcemia)
• Indwara ikabije y'impyiko
• Allergies zizwi kuri alendronate cyangwa imiti isa nayo

Ibibazo bimwe na bimwe by'ubuzima bisaba kwitonda no gukurikiranwa cyane, nubwo bitakubuza gufata alendronate. Muganga wawe azagereranya inyungu n'ibishobora kuba byago niba ufite ibibazo by'igifu, ibibazo by'amenyo, cyangwa kubura vitamine D.

Abagore batwite kandi bonsa ntibagomba gufata alendronate, kuko bishobora gushyira mu kaga umwana ukura. Uyu muti ushobora kumara imyaka myinshi mu gice cy'amagufa, bityo abagore bateganya gutwita bakwiye kuganira n'abaganga babo ku gihe cyo kuwufata.

Amazina y'ubwoko bwa Alendronate

Alendronate iboneka mu mazina y'ubwoko butandukanye, Fosamax ikaba ari yo izwi cyane. Uyu muti wo mu bwoko bwa generic urimo ibintu bikora kimwe kandi ukora neza nk'ubwoko bw'amazina.

Amazina asanzwe arimo Fosamax, Fosamax Plus D (irimo vitamine D), na Binosto (ikibahuka gishonga mu mazi). Farumasi yawe ishobora kugira ubwoko butandukanye, ariko byose birimo umuti umwe.

Guhitamo hagati y'ubwoko bwa generic n'ubwoko bw'amazina akenshi biterwa n'ikiguzi n'ubwishingizi. Alendronate ya generic akenshi ihendutse cyane kandi ikora kimwe n'ubwoko bw'amazina.

Uburyo bwo gusimbuza Alendronate

Niba alendronate itagukundiye cyangwa ikaba itera ingaruka zitishimira, imiti itandukanye ishobora gufasha gukomeza amagufa yawe. Muganga wawe ashobora kugufasha kubona uburyo bwiza bushingiye ku byo ukeneye byihariye n'ubuzima bwawe.

Iindi miti ya bisphosphonate ikora kimwe na alendronate ariko irashobora koroha kuyihanganira:

• Risedronate (Actonel) - ifatwa buri cyumweru cyangwa buri kwezi
• Ibandronate (Boniva) - iboneka mu buryo bw'ibinini bifatwa buri kwezi cyangwa inshinge zifatwa buri gihembwe
• Asidi ya Zoledronic (Reclast) - itangwa nk'urushinge rwo mu rwungano rw'amaraso buri mwaka

Uburyo bwo gusimbuza butari bisphosphonate burimo denosumab (Prolia), itangwa nk'urushinge buri mezi 6, na teriparatide (Forteo), ikora rwose ituma amagufa mashya akorwa aho gukumira gusa gutakara kw'amagufa.

Ku bantu bamwe, uburyo bwo gusimbuza imisemburo, ibintu bihitamo bya estrogen receptor modulators, cyangwa calcitonin bishobora kuba bikwiye. Guhitamo neza biterwa n'imyaka yawe, igitsina, ibyago byo kuvunika, n'ibindi bintu by'ubuzima.

Mbese Alendronate iruta Risedronate?

Byombi alendronate na risedronate ni imiti ikora neza ya bisphosphonate ikora kimwe kugira ngo yirinde kuvunika no gukomeza amagufwa. Ubushakashatsi bwerekana ko bingana mu buryo bwo gukora, byombi bigabanya ibyago byo kuvunika kuri 30-50%.

Itandukaniro rikuru riri mu gihe cyo gufata imiti n'uko abantu boroherwa na buri muti. Alendronate ikunze gufatwa rimwe mu cyumweru, naho risedronate ishobora gufatwa buri cyumweru cyangwa buri kwezi. Abantu bamwe basanga imwe yoroshye kurusha iyindi mu bijyanye n'ingaruka zo mu nda.

Risedronate irashobora kuba yoroshye ku nda ku bantu bamwe, nubwo imiti yombi isaba uburyo bumwe bwo kuyifata ku gifu cyambaye ubusa hamwe n'amazi menshi. Guhitamo akenshi biterwa n'uburyo wowe ubwawe ubyakira n'ibyo ukunda.

Muganga wawe azatekereza ku buzima bwawe bwihariye, indi miti urimo gufata, n'uburambe bwose waba ufite na bisphosphonates mugihe cyo guhitamo hagati y'izi mpuzamiti.

Ibikunze Kubazwa Kuri Alendronate

Mbese Alendronate irakwiriye abantu barwaye indwara y'impyiko?

Alendronate irashobora gukoreshwa witonze ku bantu bafite ibibazo byoroheje by'impyiko, ariko ntibisabwa kubafite indwara zikomeye z'impyiko. Muganga wawe azagenzura imikorere y'impyiko zawe akoresheje ibizamini by'amaraso mbere yo kwandika alendronate kandi ashobora kubikurikirana buri gihe mugihe cy'imiti.

Niba urwaye indwara y'impyiko, muganga wawe ashobora guhitamo undi muti w'amagufwa cyangwa agahindura gahunda yawe yo kuvurwa. Abantu barwaye indwara zikomeye z'impyiko ntibagomba gufata alendronate kuko ishobora kwiyongera mu mubiri kandi ikaba yateza ibibazo.

Ninkora iki niba mfashe alendronate nyinshi bitunguranye?

Niba ufata nyinshi kuruta urugero rwanditsweho, ntugahungabane, ariko vugana na muganga wawe cyangwa abashinzwe ubumara ako kanya. Ntugagerageze kuruka, kuko ibi bishobora gutuma umuti urakaza umuhogo wawe n'umwanya w'ibiryo mu nzira yo gusubira hejuru.

Nywa amata menshi cyangwa amazi kugira ngo bifashe mu gukwiza umuti mu gifu cyawe. Guma uhagaze kandi wirinde kuryama. Abantu benshi bafata doze zinyongera ku buryo butunguranye ntibagira ibibazo bikomeye, ariko ubujyanama bwa muganga ni ingenzi kugira ngo umutekano wawe wizerwe.

Nkwiriye gukora iki niba nciwe doze ya Alendronate?

Niba wacikanwe na doze yawe ya buri cyumweru ukibuka mu munsi umwe cyangwa ibiri, uyifate uko wibuka vuba, ukurikiza amabwiriza yose asanzwe. Hanyuma garuka ku gahunda yawe isanzwe mu cyumweru gikurikira.

Niba hashize iminsi myinshi utarafata doze yawe wacikanwe nayo, uyirengagize rwose maze ufate doze yawe ikurikira ku munsi wawe usanzwe uteganyijwe. Ntukafate doze ebyiri mu cyumweru kimwe kugira ngo usimbure doze wacikanwe nayo, kuko ibi byongera ibyago byo kugira ingaruka ziterwa n'umuti.

Nshobora guhagarika ryari gufata Alendronate?

Ntuzigere uhagarika gufata alendronate mu buryo butunguranye utabanje kubiganiraho na muganga wawe. Abantu benshi bashobora gufata akaruhuko kateguwe kavuye ku muti nyuma yimyaka 3 kugeza kuri 5 bavurwa, ariko iki cyemezo kigomba gufatwa buri gihe hamwe nubujyanama bwa muganga.

Muganga wawe azasuzuma ubucucike bw'amagufa yawe, ibyago byo kuvunika, n'ubuzima bwawe muri rusange mbere yo kugusaba gukomeza kuvurwa, gufata akaruhuko, cyangwa guhindurira ku wundi muti. Abantu bamwe bashobora gukenera gukomeza kuvurwa igihe kirekire hashingiwe ku mpamvu zabo z'ibyago.

Nshobora gufata Alendronate hamwe n'indi miti?

Alendronate irashobora gukururana n'indi miti myinshi, bityo ni ngombwa kubwira muganga wawe ibyo urimo gufata byose. Imisemburo ya kalisiyumu, antacids, n'imisemburo ya feri irashobora kubangamira imikorere ya alendronate niba ifashwe hafi cyane.

Ukwiye gutegereza byibuze amasaha 2 nyuma yo gufata alendronate mbere yo gufata kalisiyumu, antacids, cyangwa indi miti. Imiti imwe nka antibiyotike zimwe na zimwe cyangwa imiti igabanya umubyimbirwe irashobora kongera ibyago byo kuribwa mu gifu iyo ihujwe na alendronate.