Ibyerekeye Imiti ya Antimyasthenic: Ibyo ikoreshwa, Uburyo bwo kuyifata, Ingaruka zayo, n'ibindi

Imiti ya Antimyasthenic ni imiti yihariye igamije gufasha abantu barwaye myasthenia gravis, indwara ituma imitsi icika intege kandi ikananirwa vuba. Iyi miti ikora neza mu kunoza imibanire hagati y'imitsi yawe n'imitsi, igafasha mu gusubiza imbaraga no kugabanya umunaniro. Bitekerezeho nk'abafasha bakomeza kandi bagasobanuza ibimenyetso by'imitsi yawe, bigatuma ushobora kwimuka neza mu buzima bwawe bwa buri munsi.

Icyo Antimyasthenic Aricyo?

Antimyasthenic yerekeza ku itsinda ry'imiti ivura by'umwihariko myasthenia gravis n'izindi ndwara zifitanye isano no gucika intege kw'imitsi. Umuti usanzwe ukoreshwa cyane wa antimyasthenic ni pyridostigmine (izina ry'ubucuruzi Mestinon), nubwo neostigmine nayo ikoreshwa mu bihe bimwe na bimwe.

Iyi miti yerekezwa mu cyiciro cyitwa cholinesterase inhibitors, ibyo bishobora kumvikana bigoye ariko bisobanura ko bafasha kubungabunga ubutumwa bw'imirasire y'imiti yitwa acetylcholine. Uyu muti ni ingenzi kugirango imitsi yawe ivugane neza n'imitsi yawe. Iyo urwaye myasthenia gravis, umubiri wawe ukora amakosa ugatera imitsi yakira ibi bimenyetso by'imitsi, bigatuma imitsi icika intege.

Imiti ya Antimyasthenic ntabwo ivura myasthenia gravis, ariko irashobora kunoza cyane ibimenyetso byawe n'imibereho yawe. Abantu benshi basanga bashobora gusubira mu bikorwa bisanzwe iyo bafashwe neza kandi bafata imiti neza.

Antimyasthenic Ikoreshwa Kuri Iki?

Imiti ya Antimyasthenic ikoreshwa cyane mu kuvura myasthenia gravis, ariko nanone ikoreshwa mu zindi ndwara zitandukanye zifitanye isano no gucika intege kw'imitsi. Muganga wawe ashobora kukwandikira iyi miti niba urimo guhura n'umunaniro w'imitsi utumvikana cyangwa gucika intege kw'imitsi bikiyongera iyo ukora ibikorwa runaka.

Ibyo imiti ifasha cyane birimo myasthenia gravis, aho umubiri wawe w'ubwirinzi wigabiza imitsi, na Lambert-Eaton myasthenic syndrome, indwara idakunze kubaho igira ingaruka ku mikoranire y'imitsi n'imitsi. Rimwe na rimwe abaganga bakoresha iyi miti kugira ngo bakureho ingaruka z'imiti imwe n'imwe ikoreshwa mu kubaga.

Mu bindi bihe, imiti ivura myasthenic ifasha mu zindi ndwara zifata imitsi n'imitsi nk'indwara ya myasthenic syndrome ivukana, izo zikaba ari indwara zireranwa zigira ingaruka ku mikorere y'imitsi. Umuganga wawe azagena niba iyi miti ikwiriye imiterere yawe yihariye hashingiwe ku bimenyetso byawe n'ibisubizo by'ibizamini.

Imiti ivura myasthenic ikora ite?

Imiti ivura myasthenic ikora ibuza enzyme yitwa acetylcholinesterase, isanzwe isenya acetylcholine. Mu kubuza uku gusenyuka, acetylcholine nyinshi iguma kuboneka kugira ngo itere imitsi yawe, ituma imbaraga zayo zigenda neza.

Iyi miti ifatwa nk'imiti ikomeye ku rugero ruciriritse ishobora gutanga ubufasha bukomeye ku bimenyetso ku bantu bafite myasthenia gravis. Imikorere myiza isanzwe ibaho mu minota 30-60 nyuma yo gufata umuti, kandi ingaruka zikunda kumara amasaha 3-6 bitewe n'umuti wihariye n'uburyo umubiri wawe ubyakira.

Imbaraga z'imiti ivura myasthenic bisaba kuyipima no kuyikurikirana neza. Muganga wawe azatangira n'urugero ruto hanyuma arushaho kuruhura hashingiwe ku buryo ubyakira n'ingaruka zose zikubaho. Kubona urugero rukwiriye bifata igihe, kandi icyo gikora neza gishobora gutandukana ku muntu ku giti cye.

Nkwiriye gufata imiti ivura myasthenic nte?

Imiti myinshi ivura myasthenic iza mu buryo bw'ibinini byo kunywa cyangwa amazi unywa mu kanwa, nubwo ibihe bimwe na bimwe bisaba inshinge. Muganga wawe azaguha amabwiriza yihariye yerekeye igihe n'urugero rwakozwe ku byo ukeneye n'imikorere yawe ya buri munsi.

Ku miti yo kunywa, ushobora gufata iyi miti urya cyangwa utarya, ariko kuyifata urya agafunguro gato bishobora kugufasha kugabanya kuribwa mu nda. Abantu bamwe basanga gufata umuti mbere yo kurya iminota nka 30 bibafasha guhekenya no kumira byoroshye. Niba wumva uruka, gerageza kuwufata hamwe n'imigati cyangwa toast.

Igihe ni ingenzi ku miti ivura myasthenia kuko ingaruka zayo ziba igihe gito. Muganga wawe ashobora kugusaba gufata imiti mbere y'ibikorwa bisaba imbaraga nyinshi z'imitsi, nko kurya, kugenda, cyangwa gukora. Guma ku gihe gihamye uko bishoboka kose, ariko ntugire impungenge niba ukeneye guhindura igihe rimwe na rimwe kubikorwa byingenzi.

Niba wandikiwe urukingo, ibi bikunda kubera ahantu havurirwa cyangwa uzahabwa imyitozo yuzuye kubijyanye n'uburyo bukwiye bwo guterwa urukingo. Ntukigere uhindura urugero rwawe utabanje kuvugana n'umuganga wawe, kuko byinshi bishobora gutera ingaruka zikomeye.

Nzagomba Kumara Igihe Kingana Gite Ndafa Antimyasthenic?

Abantu benshi bafite myasthenia gravis bakeneye gufata imiti ya antimyasthenic igihe kirekire kugirango bagumane imbaraga z'imitsi n'imikorere. Iyi si imiti y'igihe gito, ahubwo ni uburyo bukomeza bufasha gucunga uburwayi bwawe uko igihe kigenda.

Muganga wawe azagenzura imiti yawe buri gihe kugirango arebe ko umuti ugikora neza kandi ko ufata urugero rukwiye. Abantu bamwe bakeneye guhindurwa mugihe barwaye, bahuye n'umunabi, cyangwa bahinduye ubuzima bwabo muri rusange. Intego ni ukubona urugero ruto rukora neza rukagumana ibimenyetso byawe bigenzurwa neza.

Mu bihe bidasanzwe, abantu bamwe bashobora kugabanya cyangwa guhagarika imiti ya antimyasthenic niba izindi miti nka imiti igabanya ubudahangarwa itanga uburyo bwo kugenzura ibimenyetso bihagije. Ariko, iki cyemezo kigomba gufatwa witonze hamwe n'ikipe yawe y'ubuvuzi, kuko guhagarara vuba bishobora gutera ibimenyetso bikomeye byitwa myasthenic crisis.

Ni Iyihe Ngaruka Ziterwa na Antimyasthenic?

Nk'uko imiti yose imera, imiti ivura myasthenia gravis ishobora gutera ingaruka zidakunzwe, nubwo abantu benshi bayihanganira neza iyo bamaze kubona urugero rukwiye. Ingaruka zikunze kugaragara zifitanye isano no kongera imikorere ya acetylcholine mu mubiri wawe wose, atari mu misitsi yawe gusa.

Dore ingaruka zikunze kuvugwa ko ushobora guhura nazo:

• Urubu mu nda, isesemi, cyangwa impiswi
• Kongera umusonga cyangwa kuruka amazi
• Gucuruka cyangwa guhindagurika kw'imitsi
• Kongera ibyuya
• Izuru riva cyangwa kongera umusonga mu mazuru
• Umutwe cyangwa isereri

Izi ngaruka zisanzwe akenshi ziragenda zikemuka uko umubiri wawe wimenyereza umuti cyangwa mugihe muganga wawe akosoye urugero rw'umuti ukoresha.

Ingaruka zikomeye ariko zitagaragara cyane zisaba ubufasha bwihuse bw'abaganga. Izi zirimo kuribwa cyane mu nda, kugorwa no guhumeka, kuribwa mu gituza, cyangwa ibimenyetso bya cholinergic crisis (iyo ufite acetylcholine nyinshi ikora). Niba wumva intege nke zigaragara nk'izikabije, ibi bishobora kwerekana uko umuti utari mwinshi cyangwa ukabije, kandi ugomba guhita uvugana na muganga wawe.

Abantu bamwe bashobora kugira allergie, nubwo ibi bitaba kenshi. Reba ibimenyetso nk'uruhu rurya, kuribwa, kubyimba, cyangwa kugorwa no guhumeka, kandi ushake ubufasha bwihutirwa niba bibaye.

Ninde utagomba gufata imiti ivura myasthenia?

Uburwayi runaka n'ibihe bituma imiti ivura myasthenia idatekanye cyangwa bisaba ingamba zidasanzwe. Muganga wawe azasuzuma neza amateka yawe y'ubuzima mbere yo kugusaba iyi miti kugirango yemeze ko ikwiriye kuri wowe.

Abantu bafite ibibazo byo guhagarika mu mara cyangwa mu nkari ntibagomba gufata imiti ivura myasthenia kuko iyi miti ishobora gukomeza ibi bibazo. Niba ufite asima, ibibazo by'umutima, cyangwa ibisebe byo mu gifu, uzakenera gukurikiranwa neza kuko iyi miti ishobora kugira ingaruka kuri ibi bibazo.

Kugira inda no konsa bisaba kwitonderwa byihariye, nubwo imiti ivura myasthenia rimwe na rimwe ikoreshwa mugihe cyo gutwita iyo inyungu ziruta ibyago. Muganga wawe azakorana nawe kugirango amenye uburyo bwiza cyane niba utwite cyangwa uteganya gutwita.

Niba ufata indi miti imwe, cyane cyane iyo igira ingaruka kumikorere yimitsi cyangwa umutima, muganga wawe ashobora gukenera guhindura imiti cyangwa kugukurikiranira hafi. Buri gihe menyesha umuganga wawe imiti yose, ibyongerera imbaraga, nibimera ukoresha.

Amazina yimiti ivura myasthenia

Umuti uvura myasthenia ukoreshwa cyane ni pyridostigmine, uboneka munsi yizina rya Mestinon. Iyi niyo miterere yo kunywa abantu benshi bafite myasthenia gravis bafata kugirango bacunge ibimenyetso bya buri munsi.

Neostigmine ni undi muti uvura myasthenia ukoreshwa cyane mumavuriro cyangwa kubikorwa byihariye byubuvuzi. Iboneka nka Bloxiverz yo guterwa inshinge kandi rimwe na rimwe ikoreshwa mugukuraho imitsi iruhura nyuma yo kubagwa.

Ubwoko bumwe buza muburyo bwo kurekura igihe kirekire, bituma imiti ikoreshwa kenshi. Muganga wawe azahitamo ubwoko bwihariye n'uburyo bushingiye kubimenyetso byawe, imibereho yawe, n'uburyo witwara neza mugihe uvurwa.

Uburyo bwo kuvura myasthenia

Mugihe imiti ivura myasthenia akenshi ari uburyo bwa mbere bwo kuvura myasthenia gravis, hariho ubundi buryo bwinshi kubantu batitabira neza cyangwa badashobora kwihanganira iyi miti. Muganga wawe ashobora gutekereza kuri izi nzira niba imiti ivura myasthenia itatanga uburyo bwo kugenzura ibimenyetso bihagije.

Imiti igabanya ubudahangarwa nk'urugero prednisone, azathioprine, cyangwa mycophenolate irashobora gufasha kugabanya imikorere y'ubudahangarwa kumitsi. Iyi miti ikora muburyo butandukanye na imiti ivura myasthenia mugukemura ikibazo cyubudahangarwa aho gusa guteza imbere imikoranire yimitsi.

Mu bihe bikomeye cyangwa ibihe by'akaga, imiti nk'iyo gukuraho plasmapheresis (ivunjwa rya plasma) cyangwa immunoglobulin yo mu maraso (IVIG) ishobora gutanga impinduka zihuse. Abantu bamwe bungukirwa na thymectomy, uburyo bwo kubaga bwo gukuraho glande ya thymus, cyane cyane niba bafite thymoma cyangwa bakiri bato bafite myasthenia gravis rusange.

Imiti mishya nka eculizumab (Soliris) na efgartigimod (Vyvgart) itanga ubundi buryo ku bantu bafite myasthenia gravis idakira batitabiriye imiti gakondo.

Ese Antimyasthenic iruta Edrophonium?

Imiti ya Antimyasthenic nka pyridostigmine na edrophonium ikoreshwa mu ntego zitandukanye mu kuvura myasthenia gravis, bityo kubigereranya mu buryo butaziguye ntibyoroshye. Edrophonium ikoreshwa cyane nk'igikoresho cyo gupima aho gukoreshwa mu kuvura buri gihe.

Edrophonium ikora vuba cyane ariko imara iminota 10-15 gusa, bituma ikoreshwa mu gupima niba umuntu afite myasthenia gravis ariko ntibikoreshwa mu gucunga ibimenyetso bya buri munsi. Mu buryo butandukanye, imiti ya antimyasthenic nka pyridostigmine itanga ubufasha burambye bukwiye gukoreshwa buri munsi.

Mu kuvura igihe kirekire, pyridostigmine ikunze gukoreshwa kuko itanga uburyo bwo kugenzura ibimenyetso bya buri gihe mu masaha menshi icyarimwe. Igihe gito cya Edrophonium gisobanura ko cyagenewe cyane ibihe byo gupima byihariye munsi y'ubuyobozi bw'abaganga.

Muganga wawe azahitamo umuti ukwiye cyane bitewe niba ukeneye gupimwa cyangwa kuvurwa buri gihe kugira ngo ucunge ibimenyetso.

Ibikunze Kubazwa ku bijyanye na Antimyasthenic

Ese Antimyasthenic ni nziza ku ndwara z'umutima?

Imiti ya Antimyasthenic isaba kwitonderwa niba ufite indwara z'umutima, cyane cyane indwara zimwe na zimwe z'umuvuduko. Iyi miti ishobora kugira ingaruka ku muvuduko w'umutima wawe n'umuvuduko kubera ko yongera imikorere ya acetylcholine mu mubiri wawe wose, atari gusa mu misitsi yawe y'amagufwa.

Niba ufite bradycardia (umutima utera gahoro), heart block, cyangwa izindi ngorane zo gutwara amaraso, muganga wawe azagereranya neza ibyago n'inyungu. Ushobora gukenera gukurikiranwa kenshi cyangwa urugero ruto rwo gutangiriraho kugirango umutima wawe ugume utajegajega.

Abantu benshi bafite indwara zoroheje z'umutima barashobora gufata imiti ya antimyasthenic neza hamwe no gukurikiranwa neza. Umuganga w'umutima wawe n'umuganga w'imitsi bazakorana kugirango babone uburyo bwo kuvura bwizewe cyane kubera uko ubuzima bwawe bumeze.

Nkwiriye gukora iki niba nanyweye imiti ya antimyasthenic nyinshi bitunguranye?

Kunywa imiti ya antimyasthenic nyinshi bishobora gutera cholinergic crisis, indwara ikomeye ifite ibimenyetso nk'ibyuya byinshi, kuruka, guhinda umushyitsi kw'imitsi, no guhumeka nabi. Niba wanyoye imiti irenze urugero rwanditswe, hamagara muganga wawe ako kanya cyangwa ushake ubufasha bwihutirwa bw'ubuvuzi.

Ntugategereze kureba niba ibimenyetso bigaragara, cyane cyane niba wanyoye imiti irenze urugero rwanditswe. Abaganga b'ubuvuzi bwihutirwa bashobora gutanga ubuvuzi bukwiye, bushobora kurimo imiti yo kurwanya imikorere y'acetilcholine nyinshi.

Bika urupapuro rw'imiti yawe hamwe nawe mugihe ushaka ubufasha bw'ubuvuzi kugirango abaganga babone neza icyo wanyoye n'igihe. Iri somo ribafasha gutanga ubuvuzi bukwiye cyane kubera uko ubuzima bwawe bumeze.

Nkwiriye gukora iki niba nirengagije kunywa imiti ya antimyasthenic?

Niba wirengagije kunywa imiti ya antimyasthenic, yinywe ako kanya wibuka, keretse igihe cyegereye kunywa urugero rwawe ruteganyijwe. Muricyo gihe, reka urugero wirengagije ukomeze gahunda yawe isanzwe.

Ntukarye urugero rurenzeho kugirango wuzuze urugero wirengagije, kuko ibi bishobora kongera ibyago byo kugira ingaruka ziterwa n'imiti. Niba ukunda kwibagirwa kunywa imiti, tekereza gushyiraho alarme cyangwa gukoresha umuteguro w'imiti kugirango ugufashe kuguma ku murongo.

Kutafata imiti rimwe na rimwe ntibitera ibibazo bikomeye, ariko ushobora kubona intege nke z'imitsi cyangwa umunaniro wiyongera. Niba utafashe imiti inshuro nyinshi cyangwa wumva urushijeho, vugana n'umuganga wawe kugira ngo akugire inama.

Ni ryari nshobora kureka gufata imiti ivura Myasthenia?

Ntugomba na rimwe kureka gufata imiti ivura Myasthenia utabanje kubaza umuganga wawe. Guhagarika imiti mu buryo butunguranye bishobora gutera icyorezo cya Myasthenia, kikaba ari ukwiyongera kw'intege nke z'imitsi bishobora gushyira ubuzima mu kaga, bikaba byagira ingaruka ku guhumeka no kumira.

Abantu bamwe bashobora kugabanya urugero rw'imiti ivura Myasthenia niba izindi nshuti nk'imiti ikumira ubudahangarwa bw'umubiri itanga uburyo bwo kugenzura ibimenyetso bihagije. Ariko, iki cyemezo gisaba kugenzurwa na muganga kandi urugero rugabanywa buhoro buhoro uko igihe kigenda.

Umuganga wawe azagenzura buri gihe niba ukeneye imiti ivura Myasthenia kandi ku rugero rungana iki. Impinduka zose ku buryo uvurwa zigomba gukorwa buhoro buhoro kandi ugenzura ibimenyetso byawe n'ubuzima bwawe muri rusange.

Nshobora gufata imiti ivura Myasthenia hamwe n'indi miti?

Imiti ivura Myasthenia ishobora gukorana n'indi miti myinshi, bityo ni ngombwa kubwira umuganga wawe imiti yose, ibiyobyabwenge, n'imiti y'ibyatsi ufata. Imikorere imwe n'imwe ishobora kuba ikomeye kandi ishobora gusaba guhindura urugero cyangwa uburyo bwo kuvura.

Antibiyotike zimwe na zimwe, imiti y'umutima, n'imiti iruhura imitsi bishobora kubangamira imiti ivura Myasthenia cyangwa bikongera ibimenyetso bya Myasthenia gravis. Umuganga wawe azasuzuma neza ibyemezo bishya byose kugira ngo yemeze ko bifatwa hamwe mu buryo bwizewe.

Gira urutonde rugezweho rw'imiti yawe yose uyizane mu gihe cyose ugiye kwa muganga. Ibi bifasha abaganga bawe bose gufata ibyemezo bifitiye akamaro ku buryo uvurwa kandi birinda imikorere ishobora guteza akaga.