Atorvastatin ni iki: Ibikoreshwa, Urutonde rw'imiti, Ingaruka ziterwa n'iyo miti n'ibindi

Atorvastatin ni umuti wandikirwa na muganga ufasha kugabanya urugero rwa kolesteroli mu maraso yawe. Uyu muti ubarizwa mu itsinda ry'imiti yitwa statins, ikora ibikorwa byo guhagarika enzyme umwijima wawe ukoresha mu gukora kolesteroli. Ushobora kuwumenya neza ku izina ry'ubucuruzi rya Lipitor, kandi ni umwe mu miti ikoreshwa cyane mu gucunga kolesteroli nyinshi no kugabanya ibyago byo kurwara indwara z'umutima.

Atorvastatin ni iki?

Atorvastatin ni umuti wa statin muganga wawe akwandikira kugira ngo afashe gucunga urugero rwa kolesteroli. Ni umuti ukorwa mu buryo bwa sintetike ugamije cyane HMG-CoA reductase, enzyme umwijima wawe ukeneye kugira ngo ukore kolesteroli. Tekereza nk'ushyira feri yoroheje ku buryo umubiri wawe ukora kolesteroli.

Uyu muti uza mu buryo bw'ibinini bifatirwa mu kanwa, akenshi rimwe ku munsi. Uboneka mu ngufu zitandukanye kuva kuri 10mg kugeza kuri 80mg, bituma muganga wawe ashobora kubona urugero rukwiriye rw'imiti rukenewe. Uyu muti wigiweho cyane kandi ukoreshwa neza n'abantu babarirwa muri za miliyoni ku isi hose kuva watangira kwemezwa.

Atorvastatin ikoreshwa mu iki?

Atorvastatin ikoreshwa cyane mu kuvura urugero rwa kolesteroli nyinshi no gufasha kwirinda indwara z'umutima n'imitsi. Muganga wawe akenshi azakwandikira uyu muti iyo impinduka z'imibereho nk'imirire n'imyitozo ngororamubiri zitagabanyije kolesteroli yawe kugera ku rwego ruzima. Ifasha cyane mu kugabanya kolesteroli ya LDL, akenshi yitwa kolesteroli "mbi".

Usibye gucunga kolesteroli, atorvastatin ifite ibindi bikorwa by'ingenzi ku buzima bw'umutima wawe. Ishobora gufasha kwirinda guturika kw'umutima n'indwara z'ubwonko ku bantu bafite indwara z'umutima cyangwa diyabete. Uyu muti kandi ugabanya ibyago byo gukenera uburyo bwo kuvura nka angioplasty cyangwa kubaga.

Abaganga bamwe bandikira atoruvastatine abantu bafite indwara zimwe na zimwe ziterwa n'imiterere ya kamere ituma bagira urugero rwo hejuru cyane rwa kolesteroli. Ikoreshwa kandi hamwe n'indi miti iyo umuti umwe utagera ku rugero rwa kolesteroli rwifuzwa.

Atoruvastatine ikora ite?

Atoruvastatine ikora ibuza HMG-CoA reductase, urugingo rwingenzi umwijima wawe ukoresha mu gukora kolesteroli. Iyo urwo rugingo rubujijwe, umwijima wawe ukora kolesteroli nkeya karemano. Ibyo bituma umwijima wawe ukurura kolesteroli nyinshi mu maraso yawe kugira ngo uhaze ibyo ukeneye, ibyo bikagabanya urugero ruri mu maraso yawe.

Uyu muti ufashwe nk'umuti ukomeye wo hagati, ukomeye kurusha iyindi miti ya kera ariko ntabwo ari wo ukomeye cyane. Ubusanzwe ugabanya kolesteroli ya LDL ku kigero cya 30-50%, bitewe n'urugero ufata. Ingaruka zikunze kugaragara mu byumweru 2-4 nyuma yo gutangira kuvurwa.

Atoruvastatine ifite kandi ingaruka nziza zirenga kugabanya kolesteroli. Ifasha guhagarika imiterere ya plaque mu miyoboro yawe y'amaraso no kugabanya ububyimbirwe mu mikorere y'umutima wawe n'imitsi y'amaraso. Izi nyungu zongera uruhare mu ngaruka zayo zose zo kurinda umutima wawe n'imitsi y'amaraso.

Nkwiriye gufata atoruvastatine nte?

Fata atoruvastatine nk'uko umuganga wawe abitegeka, akenshi rimwe ku munsi ku gihe kimwe buri munsi. Urashobora kuyifata hamwe n'ibiryo cyangwa utabifite, kuko ibiryo ntibigira ingaruka zigaragara ku buryo umubiri wawe wunguka umuti. Abantu benshi basanga byoroshye kwibuka igihe bayifatiye ku gihe kimwe buri munsi, nko ku ifunguro rya nimugoroba cyangwa mbere yo kuryama.

Mimina urupapuro rwose hamwe n'ikirahure cyuzuye cy'amazi. Ntugasenya, ntugabanye, cyangwa ngo umene urupapuro, kuko ibyo bishobora kugira ingaruka ku buryo umuti ukora. Niba ugira ingorane zo kumira ibinini, ganira n'umuganga wawe ku bindi bisubizo cyangwa uburyo bushobora gufasha.

Ugomba kwitondera ibiryo n'ibinyobwa bimwe na bimwe mugihe ufata atorvastatin. Irinda imbuto za pome na juice yazo, kuko bishobora kongera umubare w'umuti mu maraso yawe kandi bikongera ibyago byo kugira ingaruka ziterwa n'umuti. Gabanura kunywa inzoga, kuko inzoga na atorvastatin byombi bishobora kugira ingaruka ku mwijima wawe.

Ugomba gutangira ufata urugero ruto rw'umuti kandi ushobora kuruhindura bitewe n'uko witwara n'urugero rwa cholesterol yawe. Ibizamini by'amaraso bisanzwe bizafasha gukurikirana iterambere ryawe no kureba niba umuti ukora neza utagize ibibazo.

Nzamara igihe kingana iki mfata Atorvastatin?

Abantu benshi bakeneye gufata atorvastatin igihe kirekire, akenshi imyaka myinshi cyangwa burundu. Cholesterol nyinshi akenshi ni indwara idakira isaba gukomeza kuyicunga aho gukoresha umuti w'igihe gito. Muganga wawe azagenzura buri gihe niba ugikeneye umuti bitewe n'urugero rwa cholesterol yawe n'ubuzima bwawe muri rusange.

Uzasura muganga wawe buri mezi 3-6 mugihe utangiye gufata atorvastatin. Uru ruzinduko rutuma muganga wawe akurikirana uko umuti ukora neza kandi agenzure niba hari ingaruka ziterwa n'umuti. Iyo urugero rwa cholesterol yawe rumaze guhagarara, ushobora kugira ibizamini bitavuba, ahari buri mezi 6-12.

Ntuzigere uhagarika gufata atorvastatin ako kanya utabanje kuvugana na muganga wawe. Iyo uhagaritse gufata statins, urugero rwa cholesterol yawe akenshi rusubira ku rugero rwayo rwo hejuru mbere yuko uhagarika mu byumweru bike. Niba ukeneye guhagarika umuti impamvu iyo ariyo yose, muganga wawe ashobora kugufasha kubikora neza kandi akaganira nawe ku zindi mvura zishobora gukoreshwa.

Ni izihe ngaruka ziterwa na Atorvastatin?

Abantu benshi bafata atorvastatin neza, ariko nk'imiti yose, ishobora gutera ingaruka ku bantu bamwe. Inkuru nziza ni uko ingaruka zikomeye zitaba kenshi, kandi abantu benshi ntibagira ingaruka na gato.

Ibi ni bimwe mu bimenyetso rusange bishobora kukubaho, wibuke ko ibi bikunze kugaragara ku bantu batarenze 1 kuri 10:

• Kubabara imitsi cyangwa kunanirwa, cyane cyane mu maboko no mu maguru
• Umutwe ushobora kumera nk'umutwe usanzwe
• Ibibazo byo mu gifu nk'isuka, impiswi, cyangwa kubura ubushake bwo kwituma
• Ibimenyetso bya grip, nk'amazuru yiruka cyangwa kubabara mu muhogo
• Kubabara mu ngingo bishobora kumera nk'indwara y'amagufi yoroheje

Ibi bimenyetso rusange bikunze gukira uko umubiri wawe umenyera umuti mu byumweru bike bya mbere by'ubuvuzi.

Ibimenyetso bitagaragara cyane ariko biteye impungenge bisaba ubufasha bw'abaganga, nubwo bigaragara ku bantu batarenze 1 kuri 100:

• Kubabara cyane imitsi cyangwa kunanirwa kutagira icyo bigeraho uruhuka
• Umunaniro udasanzwe cyangwa kunanirwa bibuza gukora imirimo ya buri munsi
• Inkari zifite ibara ryijimye cyangwa umuhondo w'uruhu n'amaso
• Isuka ihoraho, kuruka, cyangwa kubabara mu nda
• Ibibazo byo kwibuka cyangwa urujijo

Niba ubonye kimwe muri ibi bimenyetso, vugana n'umuganga wawe vuba na bwangu kugira ngo agufashe.

Ibimenyetso bidasanzwe ariko bikomeye bibaho ku bantu batarenze 1 kuri 1,000 ariko bisaba ubufasha bw'abaganga bwihutirwa:

• Rhabdomyolysis - imitsi ikomeye yangiritse ishobora kwangiza impyiko
• Ibibazo by'umwijima bitera umunaniro uhoraho, kubura ubushake bwo kurya, no kubabara mu nda
• Urugero rukomeye rw'uburwayi bw'umubiri butuma ugira ingorane zo guhumeka cyangwa kubyimba
• Indwara ya diyabete nshya, cyane cyane ku bantu bafite ibyago byo kurwara

Nubwo ibi bimenyetso bikomeye biteye impungenge, wibuke ko umuganga wawe yaguhaye atorvastatine kuko inyungu ku buzima bw'umutima wawe ziruta ibi byago ku bantu benshi.

Ni bande batagomba gufata Atorvastatine?

Atorvastatine ntibishoboka kuri buri wese, kandi abantu bamwe bagomba kwirinda uyu muti rwose. Umuganga wawe azasuzuma neza amateka yawe y'ubuvuzi mbere yo kuguhereza kugira ngo yemeze ko bikwiriye kuri wowe.

Ntugomba gufata atorvastatin niba ufite indwara yawe y'umwijima cyangwa kuzamuka kudafite ibisobanuro kw'ibizamini by'imikorere y'umwijima. Uyu muti ushobora guteza ibibazo by'umwijima, bityo muganga wawe agomba kumenya neza ko umwijima wawe ufite ubuzima mbere yo gutangira kuvurwa.

Kutwita no konsa ni ibintu bitagomba gukorwa na atorvastatin. Uyu muti ushobora gukomeretsa umwana ukiri mu nda, bityo abagore batwite, bateganya gutwita, cyangwa konsa ntibagomba kuwufata. Niba utwite ukoresha atorvastatin, vugana n'umuganga wawe ako kanya uhagarike uyu muti.

Abantu bafite indwara zimwe na zimwe z'imitsi cyangwa amateka y'ibibazo by'imitsi hamwe n'indi miti ya statin bashobora gukenera kwirinda atorvastatin. Muganga wawe azasuzuma neza ibyago byawe, cyane cyane niba waragize ububabare bw'imitsi cyangwa intege nke hamwe n'iyo miti isa n'iyo mu gihe gishize.

Indwara zimwe na zimwe zisaba kwitonda cyane, kandi muganga wawe ashobora guhitamo undi muti cyangwa akagukurikiranira hafi:

• Indwara y'impyiko, kuko ishobora kugira ingaruka ku buryo umubiri wawe ukoresha uwo muti
• Indwara z'imitsi, zishobora kongera ibyago by'ibibazo by'imitsi
• Gukoresha inzoga nyinshi, bishobora kongera ibyago bifitanye isano n'umwijima
• Uko byahoze byitwara mu buryo bwo kwanga imiti ya statin

Muganga wawe azagereranya ibi bintu n'inyungu zo kugabanya cholesterol kugira ngo afate icyemezo cyiza ku miterere yawe bwite.

Amazina y'ubwoko bwa Atorvastatin

Atorvastatin izwi cyane ku izina ry'ubwoko bwa Lipitor, ryari verisiyo y'umwimerere yakozwe na Pfizer. Lipitor yabaye imwe mu miti yagurishijwe cyane ku isi kandi iracyamenyekana cyane kuri iri zina, nubwo ubu hariho verisiyo rusange.

Atoruvastatine rusanzwe iboneka kuva mu nganda nyinshi kandi akenshi ihendutse cyane kurusha verisiyo y'izina ry'ubucuruzi. Izi verisiyo rusange zikubiyemo ibikoresho bikora kimwe kandi bikora neza kimwe na Lipitor. Farumasi yawe ishobora kugira ubwoko butandukanye bwa rusange, ariko byose bingana mu bijyanye n'imikorere n'umutekano.

Andi mazina y'ubucuruzi ya atoruvastatine harimo Atorlip, Atorva, na Lipvas, nubwo ibi bidakunze gukoreshwa muri Leta Zunze Ubumwe z'Amerika. Muganga wawe cyangwa umufarumasiti ashobora kugufasha gusobanukirwa verisiyo ya atoruvastatine urimo gufata niba guhindura hagati y'amoko bikwiriye kuri wewe.

Uburyo bwo gusimbuza Atoruvastatine

Imiti itandukanye ishobora gufasha kugenzura kolesteroli yo hejuru niba atoruvastatine itagukwiriye. Ibindi byongerera imiti bikora kimwe na atoruvastatine ariko bishobora kugira ingaruka zitandukanye cyangwa gahunda yo gufata imiti ikwiriye neza ibyo ukeneye.

Uburyo busanzwe bwo gusimbuza imiti yongerera harimo simvastatine, akenshi ikora gake kandi ishobora gutera ibibazo bike by'imitsi. Rosuvastatine (Crestor) irakomeye kurusha atoruvastatine kandi ishobora guhitwamo niba ukeneye kugabanya kolesteroli cyane. Pravastatine ni ubundi buryo bushobora kwihanganirwa neza nabantu bagira ibibazo by'imitsi hamwe n'ibindi byongerera.

Imiti itari iyongerera kolesteroli itanga uburyo butandukanye bwo kugenzura urwego rwa kolesteroli. Ibi birimo ezetimibe (Zetia), ikoma mu nzira imitsi ya kolesteroli mu mara yawe, n'imiti mishya nka PCSK9 inhibitors itangwa nk'inkingo. Ibikoresho bya aside ya bile na fibrates ni andi mahitamo kubibazo byihariye.

Muganga wawe azatekereza urwego rwa kolesteroli yawe, izindi ndwara z'ubuzima, n'uburyo wabyitwayemo kubuvuzi bwa mbere mugihe uhitamo uburyo bwiza kuri wewe.

Ese Atoruvastatine iruta Simvastatine?

Atorvastatin na simvastatin zombi ni imiti ikora neza ya statin, ariko zifite itandukaniro rikomeye rishobora gutuma imwe ikwira kurusha iyindi. Atorvastatin akenshi irakomeye cyane, bivuze ko ishobora kugabanya urugero rwa kolesteroli cyane kurusha izindi doze zisa.

Atorvastatin ifite igihe kirekire cyo kubaho, bivuze ko imara igihe kirekire mu mubiri wawe kandi ishobora gufatwa igihe icyo aricyo cyose cy'umunsi. Simvastatin, ku rundi ruhande, ikora neza iyo ifashwe nimugoroba kuko umubiri wawe ukora kolesteroli nyinshi nijoro. Iyi ngengabihe yoroshye irashobora gutuma atorvastatin ibera abantu bamwe byoroshye.

Mu bijyanye n'ingaruka ziterwa n'imiti, imiti yombi ifite imiterere isa, ariko abantu bamwe boroherwa n'imwe kurusha iyindi. Simvastatin ishobora guhuzwa n'ibibazo by'imitsi byinshi gato kuri doze nyinshi, mugihe atorvastatin ishobora gutera ibibazo byinshi byo mu gifu ku bantu bamwe.

Gu hitamo hagati yiyi miti akenshi biterwa n'intego zawe bwite za kolesteroli, indi miti urimo gufata, n'uburyo witwara ku miti. Muganga wawe ashobora kugufasha kumenya uburyo bukwiye cyane kubibazo byawe byihariye.

Ibikunze Kubazwa Kuri Atorvastatin

Ese Atorvastatin irakwiriye abantu barwaye diyabete?

Yego, atorvastatin akenshi irakwiriye kandi ikunze gushyirwaho abantu barwaye diyabete. Abantu barwaye diyabete bafite ibyago byinshi byo kurwara indwara z'umutima, kandi atorvastatin irashobora gufasha kugabanya ibi byago mugabanya urugero rwa kolesteroli. Inzira nyinshi zo kuvura diyabete zishyiraho neza imiti ya statin kubantu bakuru benshi barwaye diyabete.

Ariko, statin harimo atorvastatin irashobora kongera gato urugero rwa isukari mu maraso kubantu bamwe. Iyi ngaruka akenshi iringaniye kandi ntigahungabanya inyungu za cardiovascular kubantu benshi barwaye diyabete. Muganga wawe azagenzura urugero rwa isukari mu maraso yawe buri gihe kandi ashobora guhindura imiti yawe ya diyabete niba bibaye ngombwa.

Ninkora iki niba mfashe atorvastatin nyinshi bitunguranye?

Niba wanyoye atoruvastatine nyinshi kuruta uko wategetswe, ntugahagarike umutima, ariko uvugishe muganga wawe cyangwa umufarumasiti kugira ngo baguhe ubujyanama. Kunywa doze y'inyongera rimwe na rimwe ntibishobora guteza ingaruka zikomeye, ariko ni ngombwa kubona inama z'inzobere ku cyo gukora gikurikira.

Ntugerageze "gusubiza" doze y'inyongera wirinda doze yawe iteganyijwe ikurikira. Ahubwo, garuka ku gahunda yawe isanzwe yo kunywa imiti nk'uko byagizwe inama n'umuganga wawe. Niba wanyoye nyinshi cyane kuruta doze wategetswe cyangwa urimo kugira ibimenyetso nk'ububabare bukomeye bw'imitsi, isesemi, cyangwa intege nke, shakisha ubufasha bw'ubuvuzi vuba.

Nkwiriye gukora iki niba nciwe doze ya Atoruvastatine?

Niba waciwe doze ya atoruvastatine, yinywe ako kanya wibuka, keretse igihe kigeze cyo kunywa doze yawe iteganyijwe ikurikira. Muri icyo gihe, irengagize doze waciwe unywe doze yawe ikurikira ku gihe gisanzwe. Ntukanywe doze ebyiri icyarimwe kugira ngo usubize doze waciwe.

Kutanywa doze rimwe na rimwe ntizitera ibibazo byihuse, ariko gerageza kunywa imiti yawe buri gihe kugira ngo ubashe kubona ibisubizo byiza. Niba ukunda kwibagirwa doze, tekereza gushyiraho umwibutso wa buri munsi kuri terefone yawe cyangwa ukoreshe umuteguro w'imiti kugira ngo ugufashe kuguma ku murongo.

Nshobora guhagarika ryari kunywa Atoruvastatine?

Wagombye guhagarika kunywa atoruvastatine gusa ukurikije ubujyanama bw'umuganga wawe. Cholesterol nyinshi akenshi ni indwara y'ubuzima bwose isaba gukurikiranwa buri gihe, bityo abantu benshi bagomba gukomeza kunywa imiti yabo ya statin igihe kirekire kugira ngo bagumane inyungu.

Muganga wawe ashobora gutekereza guhagarika atoruvastatine niba ugize ingaruka zikomeye zitashobora gucungwa, niba intego zawe za cholesterol zihinduka cyane, cyangwa niba izindi ndwara zishobora gutuma gukomeza kuyikoresha bidakwiriye. Bashobora kandi gusuzuma kongera icyo ukeneye iyo miti niba ukoze impinduka zikomeye mu mibereho yawe zigaragara cyane mu gukemura urugero rwa cholesterol yawe.

Nshobora kunywa inzoga nkanwa Atoruvastatine?

Ushobora kunywa inzoga mu rugero ruciriritse mugihe ufata atorvastatin, ariko ni ngombwa kwitonda. Zose inzoga na atorvastatin bikorwa numwijima wawe, bityo kunywa cyane bishobora kongera ibyago byo kurwara umwijima. Abaganga benshi basaba kugabanya inzoga ntirenze kimwe kumunsi kubagore na kabiri kumunsi kubagabo.

Niba ufite amateka yo kurwara umwijima cyangwa muganga wawe akurikirana imikorere yumwijima wawe neza, bashobora kugusaba kwirinda inzoga rwose. Buri gihe ganira kubyerekeye kunywa inzoga kwawe ukuri numuganga wawe kugirango batange ubujyanama bwihariye bushingiye kubuzima bwawe bwihariye.