Axitinib ni iki: Ibyo ikoreshwa, urugero rwo gufata, ingaruka ziterwa n'ibindi

Axitinib ni umuti uvura kanseri ugamije guhagarika umuvuduko wo gukura kw'uturemangingo twa kanseri yo mu mpyiko. Uyu muti ubarirwa mu itsinda ry'imiti yitwa tyrosine kinase inhibitors, ikora ibikorwa byo guhagarika poroteyine zihariye zikenewe n'uturemangingo twa kanseri kugira ngo dukure kandi twisanzarize mu mubiri wawe.

Uyu muti ni uburyo bw'ingenzi bwo kuvura abantu bafite kanseri yo mu mpyiko igeze kure, cyane cyane iyo izindi miti itakoze neza nk'uko byari byitezwe. Nubwo kumenya ko urwaye kanseri bishobora gutera ubwoba, kugira uburyo bwo kuvura neza nka axitinib bishobora gutanga icyizere no gufasha kongera ubuzima bwiza.

Axitinib ikoreshwa mu kuvura iki?

Axitinib ikoreshwa cyane cyane mu kuvura kanseri yo mu mpyiko igeze kure, ariyo bwoko bwa kanseri yo mu mpyiko bukunda kugaragara cyane. Muganga wawe azagusaba uyu muti iyo kanseri yo mu mpyiko yawe yafashe ibindi bice by'umubiri wawe cyangwa iyo imiti ya mbere itakoze neza.

Uyu muti wagenewe by'umwihariko abarwayi kanseri yabo yateye imbere nyuma yo gukoresha ubundi buryo bwo kuvura bugamije. Ifatwa nk'uburyo bwa kabiri bwo kuvura, bivuze ko ikoreshwa nyuma y'uko uburyo bwa mbere bwo kuvura butagikora neza.

Mu bindi bihe, abaganga bashobora gukoresha axitinib nk'igice cyo kuvura bafatanyije n'indi miti ivura kanseri. Ubu buryo rimwe na rimwe bushobora gukora neza kurusha gukoresha umuti umwe gusa, nubwo umuganga wawe w'inzobere mu kuvura kanseri azagena uburyo bwiza bujyanye n'uburwayi bwawe.

Axitinib ikora ite?

Axitinib ikora ihagarika poroteyine nyinshi zifite akamaro yitwa tyrosine kinases ifasha uturemangingo twa kanseri gukura no gukora imitsi mishya y'amaraso. Tekereza kuri izi poroteyine nk'amapompe y'ibitoro uturemangingo twa kanseri dukoresha kugira ngo tubone intungamubiri dukeneye kugira ngo tubashe kubaho no kwiyongera.

Uyu muti wibanda cyane ku kintu cyitwa VEGF receptors, zisa nk'ibimenyetso bibwira umubiri wawe gukora imitsi mishya y'amaraso. Ibimeme bya kanseri bikenera iyi mitsi y'amaraso kugira ngo bikure, bityo rero mu kubuza ibi bimenyetso, axitinib ishobora gufasha kwica ibimeme bya kanseri.

Ibi bifatwa nk'umuti wa kanseri ukomeye ku rugero ruciriritse ushobora kugira akamaro kanini ku bantu benshi. Ariko, ntibikaze nka chemotherapy ya gakondo kuko yibanda by'umwihariko ku ngendo za selile za kanseri aho kugira ingaruka ku ngingo zose zigenda zigabanuka mu mubiri wawe.

Nkwiriye gufata gute Axitinib?

Fata axitinib nk'uko muganga wawe abikwandikiye, akenshi kabiri ku munsi mu gihe cy'amasaha 12. Urashobora kuyifata hamwe cyangwa utayifatanije n'ibiryo, ariko gerageza kubikora buri gihe kugira ngo bifashe kugumana urugero ruzigama mu mubiri wawe.

Mimina ibinini byose hamwe n'ikirahure cy'amazi. Ntugasenya, ntugace cyangwa uhekenye, kuko ibi bishobora kugira ingaruka ku buryo umuti winjizwa kandi bishobora gutera ingaruka ziterwa n'umuti. Niba ugorwa no kumira ibinini, ganira n'ikipe yawe y'ubuzima ku bijyanye n'ingamba zishobora gufasha.

Nibyiza gufata axitinib mu gihe kimwe buri munsi kugira ngo bigufashe kwibuka no kugumana urugero ruzigama mu maraso yawe. Abantu benshi basanga bifasha gushyiraho ibyibutso kuri terefone cyangwa guhuza gufata imiti yabo n'ibikorwa bya buri munsi nk'ibiryo cyangwa igihe cyo kuryama.

Irinde imbuto za pome n'umutobe w'izo mbuto mugihe ufata uyu muti, kuko bishobora kongera umubare wa axitinib mu maraso yawe kandi bishobora gutera ingaruka ziterwa n'umuti. Izindi mbuto z'indimu nk'amacunga n'indimu muri rusange birashoboka kuzirya.

Nkwiriye kumara igihe kingana iki mfata Axitinib?

Uzakomeza gufata axitinib igihe cyose ifasha kugenzura kanseri yawe kandi ukaba uyihanganira neza. Ibi bishobora kumara amezi cyangwa imyaka, bitewe n'uko umubiri wawe witwara ku buvuzi.

Muganga wawe azakurikiza uko urugendo rwawe rugenda binyuze mu masikani n'ibizamini by'amaraso bya buri gihe kugira ngo arebe uko imiti ikora neza. Bazareba kandi n'ingaruka zose zishobora gusaba guhindura urugero rw'umuti cyangwa guhindurira ku buryo bwo kuvura butandukanye.

Abantu bamwe bashobora gukenera guhagarika imiti by'agateganyo niba bahuye n'ingaruka zikomeye. Itsinda ryawe ry'ubuvuzi rishobora kugabanya urugero rw'umuti cyangwa guhagarika kuvurwa mu byumweru bike kugira ngo umubiri wawe ukire, hanyuma bakongere gutangira iyo wumva umeze neza.

Ntuzigere uhagarika gufata axitinib ako kanya utabanje kuvugana na muganga wawe, kabone n'iyo wumva utameze neza. Guhagarara ako kanya bishobora gutuma kanseri yawe itangira kongera gukura vuba kuruta uko byari byitezwe.

Ni Izihe Ngaruka za Axitinib?

Kimwe n'imiti myinshi ya kanseri, axitinib ishobora gutera ingaruka, nubwo atari buri wese uzahura nazo. Ingaruka zisanzwe zikunze gucungwa neza n'ubufasha bukwiye buturuka mu itsinda ryawe ry'ubuvuzi.

Dore ingaruka zisanzwe ushobora guhura nazo mugihe ufata axitinib:

• Impiswi, rimwe na rimwe zishobora kuba zikomeye
• Umubyigano w'amaraso ushobora gukenera gukurikiranwa
• Umunaniro cyangwa kumva urushye kurusha uko bisanzwe
• Isesemi cyangwa kuribwa mu nda
• Kubura ubushake bwo kurya cyangwa kugabanya ibiro
• Syndrome y'intoki n'ibirenge, itera umutuku cyangwa ububabare ku ntoki n'ibirenge
• Ijwi ryumvikana cyangwa kuribwa mu muhogo
• Inkorora cyangwa guhumeka bigoranye

Inyinshi muri izi ngaruka zoroheje kugeza hagati kandi zirashobora gucungwa n'imiti cyangwa guhindura imibereho. Itsinda ryawe ry'ubuvuzi rizakorana nawe kugirango ribone uburyo bufasha wumva umeze neza uko bishoboka kose.

Nubwo bitari bisanzwe, abantu bamwe bashobora guhura n'ingaruka zikomeye zisaba ubufasha bw'ubuvuzi bwihuse:

• Umuvuduko ukabije w'amaraso utera kubabara umutwe cyangwa guhinduka kw'ibyo ubona
• Ibimenyetso by'ibibazo by'umwijima nk'uruhu ruhinduka umuhondo cyangwa inkari zikaba umukara
• Gushyira amaraso cyangwa gukomereka bidasanzwe
• Impiswi zikabije zitera kumuka amazi mu mubiri
• Amabuye y'amaraso ateza kubabara mu gituza cyangwa kubyimba kw'ukuguru
• Ibibazo by'umutima birimo kubabara mu gituza cyangwa umutima utera nabi

Ibi bibazo bikomeye biterwa n'imiti ni gake bibaho, ariko ni ngombwa kumenya ibimenyetso byo kuburira. Muganga wawe azagukurikiranira hafi kandi ahindure imiti yawe niba bikenewe kugirango akugumize mu mutekano kandi wumve neza.

Ninde utagomba gufata Axitinib?

Axitinib ntabwo ikwiriye kuri buri wese, kandi muganga wawe azasuzuma neza amateka yawe y'ubuzima mbere yo kuyandika. Abantu bafite uburwayi runaka bashobora gukenera kwirinda uyu muti cyangwa bakawukoresha bafite ubwitonzi bwinshi.

Ntabwo ugomba gufata axitinib niba ufite allergie kuri wo cyangwa kuri kimwe mu bigize wo. Ibimenyetso byo kwibasirwa n'allergie birimo uruhu rurya, kubyimba, cyangwa guhumeka bigoranye, kandi ibi bisaba ubuvuzi bwihutirwa.

Abantu bafite uburwayi runaka bashobora gukenera gukurikiranwa byihariye cyangwa guhindurirwa urugero rwawo rwa imiti iyo bafata axitinib:

• Umuvuduko ukabije w'amaraso utagenzurwa
• Uburwayi bw'umutima cyangwa amateka y'ibibazo by'umutima
• Uburwayi bw'umwijima cyangwa imyunyu y'umwijima yazamutse
• Ibibazo by'impyiko birenze kanseri ubwayo
• Amateka y'amabuye y'amaraso cyangwa sitiroke
• Uburwayi butuma amaraso ashira cyangwa kubagwa vuba
• Ibibazo bya tiroyide

Abagore batwite ntibagomba gufata axitinib kuko ishobora kwangiza umwana ukiri mu nda. Niba ushobora gutwita, uzakenera gukoresha uburyo bwo kuboneza urubyaro bukora neza mugihe uvurwa no mu gihe gito nyuma yaho.

Ababyeyi bonka bagomba kandi kwirinda uyu muti, kuko ushobora kwinjira mu mata y'ibere kandi ugashobora kwangiza umwana wonka. Itsinda ryawe ry'ubuvuzi rishobora kuganira ku zindi nzira zitunganye zo kugaburira niba bikenewe.

Izina ry'ubwoko bwa Axitinib

Axitinib igurishwa ku izina rya Inlyta na Pfizer. Ubu ni bwo bwoko bw'umuti buvuzwa cyane, kandi buza mu buryo bw'ibipimo bifite imbaraga zitandukanye.

Niba wakira izina ry'ubwoko cyangwa ubwoko rusange bishobora guturuka ku bwishingizi bwawe n'ubuvuzi. Ubu bwoko bwombi burimo ibintu bikora kimwe kandi bikora kimwe mu mubiri wawe.

Ubuvuzi bwawe bushobora gusimbuza axitinib rusange izina ry'ubwoko keretse muganga wawe yanditse by'umwihariko "izina ry'ubwoko gusa" ku byo wandikiwe. Niba ufite impungenge zo guhinduranya hagati y'ubwoko n'ubwoko rusange, ganira ibi n'ikipe yawe y'ubuzima.

Izindi nzira za Axitinib

Niba axitinib itagukorera neza cyangwa itera ingaruka zikomeye, hari ubundi buryo bwo kuvura buriho kubera kanseri y'impyiko. Umuganga wawe w'indwara z'umubiri ashobora gufasha kumenya uburyo bwiza bwo gufata umwanzuro wihariye.

Izindi nzira z'ubuvuzi ziganisha harimo imiti nka sunitinib, pazopanib, cyangwa cabozantinib, ikora mu buryo busa ariko ishobora kugira ingaruka zitandukanye. Abantu bamwe bakira umuti umwe neza kurusha undi, ndetse no mu rwego rumwe rw'imiti.

Imiti y'ubudahangarwa nka nivolumab cyangwa pembrolizumab yerekana ubundi buryo bwo kuvura bufasha urwego rwawe rw'ubudahangarwa kurwanya kanseri. Iyi miti ikora mu buryo butandukanye na axitinib kandi ishobora kugira akamaro niba ubuvuzi bwibanze butagize akamaro.

Muganga wawe ashobora kandi gutekereza ku buvuzi buhuza bukoresha ubwoko bubiri butandukanye bw'imiti hamwe. Ubu buhuza rimwe na rimwe bushobora kugira akamaro kurusha imiti imwe, nubwo bushobora kandi gutera ingaruka nyinshi.

Ese Axitinib iruta Sunitinib?

Axitinib na sunitinib ni imiti ifite akamaro kuri kanseri y'impyiko, ariko ikora mu buryo butandukanye gato kandi ifite ingaruka zitandukanye. Nta na kimwe "cyiza" kurusha ikindi - guhitamo neza biterwa n'uko umuntu ameze.

Axitinib akoreshwa akenshi nk'umuti wa kabiri nyuma y'imiti nk'isunitinib itagikora neza. Ubushakashatsi bumwe buvuga ko axitinib ishobora gufasha abantu kubaho igihe kirekire kanseri yabo itaratera imbere ugereranije n'ubundi buryo bwa kabiri.

Mu bijyanye n'ingaruka ziterwa n'umuti, axitinib ishobora gutera umunaniro muke n'ibibazo bike byo kubara amaraso ugereranije na sunitinib. Ariko, axitinib ishobora gutera umuvuduko w'amaraso mwinshi na diyare mu bantu bamwe.

Umuhanga wawe mu by'indwara z'umubiri azatekereza ibintu nk'ubuzima bwawe muri rusange, imiti wakoresheje mbere, n'ibyo ukunda ku giti cyawe mu gufata icyemezo cyo gukoresha iyi miti. Intego ni ukubona umuti ushobora kugufasha cyane mu gihe utera ibibazo bike ku buzima bwawe.

Ibibazo Bikunze Kubazwa Kuri Axitinib

Ese Axitinib irakwiriye ku bantu bafite umuvuduko mwinshi w'amaraso?

Axitinib irashobora gukoreshwa n'abantu bafite umuvuduko mwinshi w'amaraso, ariko bisaba gukurikiranwa neza kuko umuti ushobora kongera umuvuduko w'amaraso. Muganga wawe azashaka kumenya neza ko umuvuduko w'amaraso yawe ugenzurwa neza mbere yo gutangira kuvurwa.

Uzakeneye gupimisha umuvuduko w'amaraso buri gihe mu gihe uvurwa, kandi muganga wawe ashobora guhindura imiti yawe igabanya umuvuduko w'amaraso cyangwa urugero rwa axitinib niba bibaye ngombwa. Abantu benshi bashobora guhangana n'iyi ngaruka neza binyuze mu gukurikiranwa neza no guhindura imiti.

Nkwiriye gukora iki niba nanyweye axitinib nyinshi ku buryo butunguranye?

Niba unyweye axitinib nyinshi ku buryo butunguranye, vugana na muganga wawe cyangwa ujye mu cyumba cy'abarwayi vuba na bwangu. Ntukegere ngo urebe niba wumva urwaye, kuko kunywa umuti mwinshi bishobora kuba bikomeye nubwo utahita ubona ibimenyetso.

Zana icupa ry'umuti hamwe nawe kugira ngo abaganga bamenye neza icyo wanyoye n'ingano yacyo. Mu gihe utegereje ubufasha bw'ubuvuzi, ntugerageze kwivugisha umuriro keretse niba ubisabwe n'umuganga.

Nkwiriye gukora iki niba nirengagije urugero rwa axitinib?

Niba wibagiwe gufata urugero kandi hashize amasaha atarenga 6 uhereye igihe wagombaga kurufatiraho, fata urugero wibagiwe. Niba hashize amasaha arenga 6, reka urugero wibagiwe maze ufate urugero rukurikira ku gihe cyagenwe.

Ntuzigere ufata urugero ebyiri icyarimwe kugira ngo usimbure urugero wibagiwe, kuko ibyo bishobora kongera ibyago byo kugira ingaruka zidakunzwe. Niba ukunda kwibagirwa gufata imiti, tekereza gushyiraho ibyibutso kuri terefone cyangwa gukoresha agasanduku kagenewe imiti kugira ngo bigufashe gukurikiza gahunda.

Ni ryari nshobora kureka gufata Axitinib?

Ugomba kureka gufata axitinib gusa igihe muganga wawe akubwiye ko byemewe kubikora. Ibi bikunda kuba iyo kanseri yawe ikomeje nubwo uvurwa, niba ugize ingaruka zikomeye zidakunzwe, cyangwa niba wiyemeje guhindura uburyo bwo kuvurwa.

Muganga wawe azakoresha ibizamini bisanzwe n'amaraso kugira ngo akurikirane uko umuti ukora neza. Bazaganira nawe ku mpinduka zose ziri muri gahunda yawe yo kuvurwa kandi basobanure impamvu ziri inyuma y'ibyo bagusaba.

Nshobora kunywa inzoga nkanwa axitinib?

Muri rusange ni byiza kugabanya kunywa inzoga mugihe ufata axitinib, kuko byombi bishobora kugira ingaruka ku mwijima wawe. Inzoga ntoya mubisanzwe zirakwiriye kubantu benshi, ariko ugomba kuganira n'ikipe yawe y'ubuzima kubyerekeye uko ubuzima bwawe bumeze.

Niba uhisemo kunywa rimwe na rimwe, wite ku buryo wumva kandi urebe ibimenyetso bidasanzwe. Abantu bamwe basanga inzoga zibatera kumva barushye cyane cyangwa baruka mugihe bari kuvurwa kanseri, bityo ni ngombwa kumva umubiri wawe.