Icyo Azathioprine ari cyo: Ibyo ikoreshwa, urugero rwo gufata, ingaruka zayo n'ibindi

Azathioprine ni umuti ugabanya ubudahangarwa bw'umubiri ufasha gutuza ubudahangarwa bwawe iyo buri gukora cyane. Muganga wawe ashobora kukwandikira uyu muti niba ufite indwara aho ubudahangarwa bwawe butera umubiri wawe ubwawo, nk'indwara ya rheumatoid arthritis cyangwa indwara yo mu gifu. Tekereza nk'inzira yoroheje ariko ifite akamaro yo gufasha umubiri wawe kubona uburinganire buri hejuru.

Icyo Azathioprine ari cyo?

Azathioprine ni mu itsinda ry'imiti yitwa immunosuppressants, bivuze ko igabanya imikorere y'ubudahangarwa bwawe. Yabanje gukorwa mu myaka ya za 1950 kandi imaze gukoreshwa neza n'abantu babarirwa muri za miliyoni ku isi hose kuva icyo gihe. Uyu muti ukora ubuza uturemangingo tumwe na tumwe mu budahangarwa bwawe kwiyongera vuba cyane.

Uyu muti ufata nk'umuti uhindura indwara, bivuze ko ntuvura gusa ibimenyetso ahubwo ufasha guhindura uburyo indwara yawe igenda igenda uko igihe gishira. Bitandukanye n'imiti imwe na rimwe ufata gusa iyo wumva utameze neza, azathioprine ikunze gufatwa buri munsi nk'igice cy'umugambi wo kuvura igihe kirekire.

Azathioprine ikoreshwa mu iki?

Azathioprine ivura indwara nyinshi aho ubudahangarwa bwawe bukeneye kuyobozwa neza kugira ngo bukore neza. Muganga wawe ashobora kuyikwandikira indwara ziterwa n'ubudahangarwa bw'umubiri, zibaho iyo ubudahangarwa bwawe bwibeshye bugatera ibice by'umubiri wawe bifite ubuzima.

Indwara zisanzwe azathioprine ifasha gucunga zirimo rheumatoid arthritis, aho igabanya ububabare bwo mu ngingo no kubyimba. Ikoreshwa kandi kenshi mu ndwara zo mu gifu nka Crohn's disease na ulcerative colitis, ifasha gukiza inzira yawe yo mu gifu no gukumira ibibazo.

Ku bantu bafite impyiko zatewe, azathioprine igira uruhare rukomeye mu gukumira kwangwa kw'urugingo rushya, ikingira umubiri kwibasira urwo rugingo rushya. Byongeye kandi, irashobora gufasha mu kurwanya indwara zimwe na zimwe z'uruhu, indwara z'impyiko, n'izindi ndwara ziterwa n'umubiri ubwawo iyo izindi nshuti zitatanze umuti uhagije.

Azathioprine ikora ite?

Azathioprine ikora iteza imbere imikorere ya DNA mu ngirangingo z'umubiri zikora vuba. Iyo izo ngirangingo z'umubiri zikabije zigerageza kwiyongera, umuti uzibuza gukora ibikoresho byubaka bakeneye kugirango zikore.

Iyi nzira ibaho buhoro buhoro, niyo mpamvu ushobora kutabona impinduka ako kanya. Uyu muti wibanda cyane ku ngirangingo z'umubiri ziteza umubiri kubyimba no kwangirika, mugihe rusanzwe rurekerana n'izindi nshingano z'umubiri. Ifatwa nk'umuti ukomeye wo gukumira umubiri, ukomeye kurusha imiti imwe irwanya kubyimba ariko woroshye kurusha imiti ikomeye yo gukumira umubiri.

Ingaruka ziyongera mu mubiri wawe mu byumweru byinshi kugeza ku mezi menshi, bivuze ko azathioprine ikora neza nk'umuti urambye kuruta gukemura ibimenyetso byihuse.

Nkwiriye gufata azathioprine nte?

Fata azathioprine nkuko muganga wawe abitegeka, akenshi rimwe cyangwa kabiri ku munsi hamwe n'ibiryo kugirango bifashe gukumira kuribwa mu gifu. Kuyifata hamwe n'ifunguro cyangwa ifunguro rito bifasha umubiri wawe gukurura umuti neza kandi bigabanya amahirwe yo kuruka.

Mimina ibinini byose hamwe n'ikirahure cyuzuye cy'amazi, kandi gerageza kubifata ku gihe kimwe buri munsi kugirango ugumane urwego ruzigama mu maraso yawe. Niba uyifata kabiri ku munsi, shyira intera ya hafi amasaha 12 hagati y'imiti. Abantu bamwe basanga bifasha kuyifata hamwe na saftu na dineri.

Irinda gukanda cyangwa gukata ibinini, kuko ibi bishobora kugira ingaruka ku buryo umuti ukora kandi bishobora gutera umujinya mu kanwa kawe cyangwa mu muhogo wawe. Niba ugira ikibazo cyo kumira ibinini, ganira na muganga wawe kubyerekeye ubundi buryo cyangwa uburyo bushobora gufasha.

Nzamara Mfite Azathioprine Igihe Kingana Gite?

Igihe cyo kuvura na azathioprine gitandukanye cyane bitewe n'uburwayi bwawe bwihariye n'uburyo wemera imiti. Abantu bamwe barayifata amezi menshi, mu gihe abandi bashobora kuyikeneye imyaka cyangwa ndetse igihe kirekire.

Kubijyanye n'indwara ziterwa n'umubiri w'umuntu, nka artrite ya reumatoide, ushobora gufata azathioprine umwaka umwe cyangwa ibiri mbere y'uko muganga wawe atekereza kugabanya urugero cyangwa guhindurira ku bundi buvuzi. Niba waragize igihe cyo kwimura urugingo, birashoboka ko uzakeneye kuyifata igihe cyose kugirango wirinde kwangwa.

Muganga wawe azagenzura buri gihe uko urimo utera imbere kandi ashobora guhindura gahunda yawe yo kuvura bitewe n'uko wumva umeze n'ibisubizo byawe byo gupima. Ntukigere ureka gufata azathioprine ako kanya utabanje kuvugana na muganga wawe, kuko ibi bishobora gutuma uburwayi bwawe bwiyongera.

Ni Ibihe Bikorwa Bigaragara bya Azathioprine?

Kimwe n'indi miti yose, azathioprine irashobora gutera ibikorwa bigaragara, nubwo abantu benshi bayihanganira neza. Kumva icyo witeguye bishobora kugufasha kumva ufite icyizere cyinshi kubijyanye n'ubuvuzi bwawe kandi ukamenya igihe wahamagara muganga wawe.

Ibikorwa bigaragara cyane mubisanzwe biroroshye kandi akenshi birakosoka uko umubiri wawe wimenyereza umuti:

• Uburwayi bwo mu nda cyangwa inda itameze neza, cyane cyane mugihe utangiye gufata umuti
• Kubura ubushake bwo kurya cyangwa guhinduka kw'uburyohe
• Kugira umunaniro muke cyangwa kumva urushye kurusha uko bisanzwe
• Umutwe ukunda gucungwa n'imiti irwanya ububabare itagurishwa
• Impiswi cyangwa imyanda idakomeye

Ibi bikorwa bisanzwe akenshi bigabanuka nyuma y'ibyumweru bike uko umubiri wawe umenyera umuti. Gufata azathioprine hamwe n'ibiryo birashobora gufasha kugabanya cyane ibikorwa bigaragara bifitanye isano n'inda.

Abantu bamwe bahura n'ibikorwa bigaragara bikomeye bisaba ubufasha bwa muganga, nubwo ibi bidakunze kubaho:

• Ibyago byiyongereye byo kwandura indwara ziterwa no kugabanuka kw'imikorere y'ubudahangarwa bw'umubiri
• Gukomereka cyangwa kuva amaraso byoroshye kuko umuti ushobora kugira ingaruka ku mikorere y'uturemangingo tw'amaraso
• Impinduka mu mikorere y'umwijima, ibyo muganga wawe akurikirana akoresheje ibizamini by'amaraso bya buri gihe
• Urugimbu rukabije cyangwa kuruka bikubuza kurya
• Umunaniro udasanzwe cyangwa intege nke zitagira icyo zihindukaho n'ikiruhuko

Mu buryo butajegajega, azathioprine ishobora gutera ibibazo bikomeye nk'uburwayi bukomeye bwo kwibasirwa n'umubiri, kugabanuka gukomeye kw'uturemangingo tw'amaraso, cyangwa ibibazo by'umwijima. Muganga wawe azakukurikirana cyane akoresheje ibizamini by'amaraso bya buri gihe kugira ngo amenye ibibazo byose hakiri kare.

Ninde utagomba gufata Azathioprine?

Azathioprine ntabwo ikwiriye kuri buri wese, kandi muganga wawe azatekereza neza amateka yawe mbere yo kuyandika. Ibyiciro bimwe na bimwe cyangwa ibihe bituma uyu muti ushobora kugira akaga cyangwa ntugire akamaro.

Ntabwo ugomba gufata azathioprine niba ufite allergie kuri wo cyangwa ku muti usa nawo witwa mercaptopurine. Abantu bafite indwara ikomeye y'umwijima cyangwa ibibazo bya genetike bigira ingaruka ku buryo umubiri ukoresha uyu muti nabo bagomba kuwukwepa.

Muganga wawe azitondera cyane mu kwandika azathioprine niba ufite indwara zikora, amateka ya kanseri, cyangwa utwite cyangwa ufite gahunda yo gutwita. Abantu bafite ibibazo by'impyiko bashobora gukenera guhindura urugero rw'umuti cyangwa uburyo bwo kuvura butandukanye.

Niba ufata indi miti imwe n'imwe, cyane cyane allopurinol yo kuvura gout, muganga wawe ashobora gukenera guhindura urugero rwa azathioprine cyane cyangwa agahitamo uburyo bwo kuvura butandukanye rwose.

Amazina y'ubwoko bwa Azathioprine

Azathioprine iboneka mu mazina y'ubwoko butandukanye, Imuran ikaba ariyo izwi cyane. Andi mazina y'ubwoko arimo Azasan, nubwo urugero rusanzwe rukoreshwa kandi rukora neza.

Niba wakira izina ry’uruganda cyangwa irivuguruye, ikintu gikora ni kimwe. Farumasi yawe ishobora gusimbuza kimwe n'ikindi keretse muganga wawe asabye by'umwihariko izina ry’uruganda.

Uburyo bwo gusimbuza Azathioprine

Niba azathioprine itagukwiriye cyangwa itatanga ubufasha buhagije, imiti myinshi isimbura ishobora kuvura indwara zisa. Muganga wawe ashobora gutekereza methotrexate, ikora mu buryo butandukanye ariko ikanahagarika imikorere y'umubiri irwanya indwara.

Imiti mishya ya biyolojiya nka adalimumab cyangwa infliximab itanga uburyo butandukanye bwo gukora kandi ishobora kuba amahitamo kuri zimwe mu ndwara. Sulfasalazine ni indi nzira isimbura, cyane cyane ku ndwara zifata urwungano rw'igifu.

Uburyo bwo guhitamo gusimbuza buterwa n'indwara yawe yihariye, amateka yawe y'ubuvuzi, n'uburyo witwaye ku zindi nshuti. Muganga wawe azakorana nawe kugirango abone amahitamo akwiriye niba azathioprine itariyo.

Ese Azathioprine iruta Methotrexate?

Azathioprine na methotrexate ni imiti ikora igabanya imikorere y'umubiri irwanya indwara, ariko ikora mu buryo butandukanye kandi ifite inyungu zitandukanye. Guhitamo

Azathioprine irashobora gukoreshwa ku bantu barwaye indwara z'impyiko, ariko muganga wawe azagomba guhindura urugero rwawe rwa imiti bitewe n'uko impyiko zawe zikora neza. Uyu muti ukorwa igice na impyiko, bityo kugabanya imikorere y'impyiko bisobanura ko umuti uguma mu mubiri wawe igihe kirekire.

Muganga wawe azagenzura imikorere y'impyiko zawe buri gihe akoresheje ibizamini by'amaraso kandi ashobora gutangira kugutera urugero ruto kuruta urusanzwe. Mu bihe bimwe na bimwe, azathioprine ikoreshwa mu kuvura indwara zimwe na zimwe z'impyiko, ariko ibi bisaba ubugenzuzi bw'abaganga b'umwuga.

Nkwiriye gukora iki niba nanyweye azathioprine nyinshi ku buryo butunganye?

Niba unyweye azathioprine nyinshi ku buryo butunganye, vugana n'umuganga wawe cyangwa ikigo gishinzwe kugenzura uburozi ako kanya, n'iyo wumva umeze neza. Kunywa nyinshi bishobora kongera ibyago byo kugira ingaruka zikomeye, cyane cyane indwara zandura n'ibibazo by'uturemangingo tw'amaraso.

Ntugerageze gusubiza urugero rwawe rwa imiti ukoresheje urugero rukurikira. Ahubwo, kurikiza amabwiriza ya muganga wawe hanyuma usubire kuri gahunda yawe isanzwe yo kunywa imiti nk'uko byasabwe. Genzura ibyabaye kugirango wirinde amakosa nk'ayo mu gihe kizaza.

Nkwiriye gukora iki niba nanyimye urugero rwa azathioprine?

Niba wanyimye urugero rwa azathioprine, nywe ako kanya wibuka, keretse igihe cyegereye urugero rwawe rukurikira. Muricyo gihe, reka urugero wanyimye hanyuma ukomeze gahunda yawe isanzwe.

Ntunyweho urugero rwa kabiri icyarimwe kugirango usubize urugero wanyimye, kuko ibi bishobora kongera ibyago byo kugira ingaruka zikomeye. Niba ukunda kwibagirwa urugero rwawe rwa imiti, tekereza gushyiraho ibyibutso kuri terefone cyangwa ukoreshe umuteguro w'imiti kugirango ugufashe kuguma ku murongo.

Nshobora kureka kunywa azathioprine ryari?

Reka kunywa azathioprine gusa mugihe muganga wawe akubwiye ko bitekanye kubikora. Igihe biterwa n'uburwayi bwawe, uko witwara neza ku buvuzi, niba wimukiye ku rundi rugero rwa imiti.

Muganga wawe akenshi azagabanya urugero rw'umuti buhoro buhoro aho guhagarara ako kanya, ibyo bikaba bifasha kwirinda ko uburwayi bwawe bwongera gukomera. Iyi nzira ishobora kumara ibyumweru byinshi cyangwa amezi menshi, kandi uzakenera gukurikiranwa buri gihe muri iki gihe.

Nshobora kunywa inzoga nkanwa Azathioprine?

Ni byiza kugabanya kunywa inzoga mugihe ukoresha azathioprine, kuko imiti yombi n'inzoga bishobora kugira ingaruka kumwijima wawe. Kunywa rimwe na rimwe bisanzwe biba byiza kubantu benshi, ariko kunywa inzoga buri gihe cyangwa nyinshi bishobora kongera ibyago byo kurwara umwijima.

Ganira na muganga wawe kubyerekeye ibigukwiriye, kuko ibi biterwa n'ubuzima bwawe muri rusange, izindi miti urimo gufata, n'uburyo umwijima wawe ukora neza. Muganga wawe ashobora kugufasha gusobanukirwa urwego rwo kunywa inzoga, niba ruriho, rukwiriye imiterere yawe.