Icyo Baricitinib ari cyo: Ibyo ikoreshwa, urugero rwo gufata, ingaruka ziterwa n'iyo miti n'ibindi

Baricitinib ni umuti wandikirwa na muganga ufasha gutuza urwego rw'ubwirinzi burenze urugero. Ni kimwe mu cyiciro gishya cy'imiti yitwa JAK inhibitors, ikora ibyo ikingira poroteyine zihindura umubiri mu buryo butuma ubyimba.

Uyu muti wabaye uburyo bw'ingenzi bwo kuvura abantu bahanganye n'indwara ziterwa n'ubwirinzi aho urwego rw'ubwirinzi bw'umubiri rwibasira amaso y'umubiri azima. Tekereza nk'uburyo bugamije kugabanya umubyimbire aho guhagarika urwego rwawe rwose rw'ubwirinzi.

Baricitinib ikoreshwa mu iki?

Baricitinib ivura indwara nyinshi ziterwa n'ubwirinzi aho umubyimbire uhoraho utera ibimenyetso bihoraho. Uyu muti ufasha kugabanya kuribwa kw'ingingo, kubyimba, n'ibindi bimenyetso by'ububyimbire bishobora kugira ingaruka zikomeye ku buzima bwawe bwa buri munsi.

Muganga wawe ashobora kukwandikira baricitinib niba ufite indwara ya rheumatoid arthritis yo hagati kugeza ku ikomeye kandi izindi miti zitagufashije bihagije. Ikoreshwa kandi mu kuvura alopecia areata ikomeye, indwara aho urwego rwawe rw'ubwirinzi rwibasira imisatsi, bigatuma umusatsi ugenda.

Mu bihe bimwe na bimwe, abaganga bandikira baricitinib kubera atopic dermatitis (eczema) ikomeye mu bantu bakuru iyo izindi miti zitagize icyo zikora. Uyu muti ushobora kandi gukoreshwa mu kuvura ubwoko bumwe na bumwe bukomeye bwa COVID-19 mu barwayi barwariye mu bitaro, nubwo iyi mikoreshereze idakunze gukoreshwa.

Baricitinib ikora ite?

Baricitinib ikingira enzymes zihariye zifite izina rya JAK1 na JAK2, zisa nk'ibikoresho bya molekile bizimya umubyimbire mu mubiri wawe. Iyo ibi bikoresho bihora “byaka,” bitera umubyimbire uhoraho ugaragara mu ndwara ziterwa n'ubwirinzi.

Mugihe bikingira izi nzira, baricitinib ifasha kugabanya ibimenyetso by'ububyimbire bitera kwangirika kw'ingingo, ibibazo by'uruhu, n'ibindi bimenyetso. Ifatwa nk'umuti ukomeye wo hagati utanga uburyo bugamije bwo guhagarika ubwirinzi aho guhagarika urwego rwawe rwose rw'ubwirinzi.

Umuti ubusanzwe utangira gukora mu byumweru bike, nubwo bishobora gufata amezi atatu kugirango ubone inyungu zose. Bitandukanye n'ubundi buvuzi, baricitinib ntabwo isaba inshinge kandi irashobora gufatwa nk'ikibazo cyoroshye cyo kunywa.

Nkwiriye Kufata Baricitinib Nte?

Fata baricitinib nkuko muganga wawe abikwandikiye, ubusanzwe rimwe ku munsi hamwe n'ibiryo cyangwa nta biryo. Urashobora kuyifata n'ikirahure cy'amazi igihe icyo aricyo cyose cy'umunsi, ariko gerageza kuyifata ku gihe kimwe buri munsi kugirango ugumane urwego ruzigama mu mubiri wawe.

Mimina ikinini cyose utagikubise, ugikate, cyangwa ugicungura. Niba ugira ingorane zo kumira ibinini, ganira na muganga wawe kubyerekeye uburyo bushoboka cyangwa uburyo bushobora gufasha.

Ntabwo ukeneye gufata baricitinib n'amata cyangwa kwirinda ibiryo bimwe, ariko kuguma ufite amazi menshi ni byiza buri gihe. Niba ubonye inda itameze neza, kuyifata n'ibiryo birashobora gufasha kugabanya ibibazo byose byo mu gifu.

Ibizami by'amaraso bisanzwe ni ngombwa mugihe ufata baricitinib kugirango ukurikirane imibare yawe y'amaraso n'imikorere y'umwijima. Muganga wawe azategura ibi bizami kugirango yemeze ko umuti ukora neza kuri wewe.

Nkwiriye Kufata Baricitinib Igihe Kingana Gite?

Igihe cyo kuvura baricitinib gitandukanye bitewe n'uburwayi bwawe n'uburyo wemera umuti. Abantu benshi bafite indwara ya rheumatoid arthritis bayifata igihe kirekire nk'igice cy'umugambi wabo wo kuvura urwego rwo hejuru.

Kubera alopecia areata, igihe cyo kuvura giterwa n'iterambere ry'umusatsi n'uburyo wihanganira umuti. Abantu bamwe barashobora kubona impinduka zikomeye mu mezi atandatu, mugihe abandi bashobora gukenera kuvurwa igihe kirekire.

Muganga wawe azagenzura buri gihe niba baricitinib ikomeje kuba amahitamo akwiriye kuri wewe. Bazatekereza ibintu nk'imikorere y'ibimenyetso, ingaruka ziterwa n'umuti, n'ubuzima bwawe muri rusange mugihe cyo gushyiraho igihe cyo kuvura.

Ntugasize gufata baricitinib mu buryo butunguranye utabanje kubiganiraho na muganga wawe, kuko ibyo bishobora gutuma indwara yawe yongera gukomera. Niba ukeneye guhagarika imiti, muganga wawe azakuyobora muri uwo murongo mu buryo butekanye.

Mbese ni izihe ngaruka ziterwa na Baricitinib?

Kimwe n'imiti yose igira ingaruka ku mikorere y'umubiri w'umuntu, baricitinib ishobora gutera ingaruka zinyuranye, nubwo atari buri wese uzigira. Kumenya ibyo ugomba kwitaho bifasha wowe na muganga wawe gucunga imiti yawe neza.

Ingaruka zisanzwe abantu benshi bahura nazo zirimo indwara zifata mu myanya y'ubuhumekero, isesemi, n'ibimenyetso byoroheje bisa n'ibikonjo. Ibi bikunda guterwa n'uko baricitinib igabanya imikorere y'umubiri w'umuntu, bigatuma wumva woroheje mu kwandura indwara ntoya.

Dore ingaruka zikunze kugaragara ushobora kubona:

• Ibimenyetso by'ibikonjo nk'amazuru asohoka cyangwa umuhogo urya
• Isesemi cyangwa kutumva neza mu nda
• Umutwe
• Kuzamuka kw'urugero rwa kolesteroli (bimenyekana mu bipimo by'amaraso)
• Kuzamuka guto kw'imisemburo imwe n'imwe yo mu mwijima

Izi ngaruka zisanzwe zikunda gucungwa kandi akenshi zigenda zikira uko umubiri wawe umenyera imiti. Ariko, ni ngombwa kumenyesha umuganga wawe ibimenyetso byose bihoraho cyangwa bibangamye.

Ingaruka zikomeye zisaba ubufasha bwihutirwa bw'abaganga, nubwo zitabaho kenshi. Izi zirimo ibimenyetso by'indwara zikomeye, amaraso avura, cyangwa impinduka zikomeye mu mubare w'amaraso yawe.

Witondere ibi bimenyetso byo kwitondera bisaba isuzuma ryihuse ry'abaganga:

• Urubavu, ibikonjo, cyangwa ibimenyetso bihoraho bisa n'ibya grip
• Umunaniro udasanzwe cyangwa intege nke
• Kugufuka umwuka cyangwa kuribwa mu gituza
• Ukuboko kubyimba cyangwa kuribwa bishobora kwerekana amaraso avura
• Gukomereka byoroshye cyangwa kuva amaraso bidasanzwe
• Uruhu cyangwa amaso y'umuhondo

Ibikomere bikomeye ariko bidasanzwe bishobora kwibandaho indwara zikomeye, amaraso mu bihaha cyangwa amaguru, n'imihindukire ikomeye mu mubare w'uturemangingo tw'amaraso. Nubwo izi ngaruka zitamenyerewe, gukurikirana buri gihe bifasha kumenya ibibazo byose hakiri kare.

Ninde utagomba gufata Baricitinib?

Abantu bamwe bagomba kwirinda baricitinib kubera ibyago byiyongereye by'ibibazo bikomeye. Muganga wawe azasuzuma neza niba uyu muti ufitiye umutekano mu miterere yawe yihariye.

Ntabwo ugomba gufata baricitinib niba ufite indwara ikomeye ikora, kuko umuti ushobora gutuma indwara zirushaho kuba mbi mugihe uhagarika ubudahangarwa bwawe. Ibi birimo bagiteri, virusi, fungus, cyangwa izindi ndwara zifata amahirwe.

Abantu bafite amateka y'amaraso bagomba gukoresha ubushishozi bukabije, kuko baricitinib ishobora kongera ibyago byo guteza amaraso mashya. Ibi birimo ibintu nka thrombosis yimitsi yimbitse, pulmonary embolism, cyangwa sitiroki.

Izindi ndwara nyinshi zisaba gutekerezwa neza mbere yo gutangira baricitinib:

• Ubukana bwa tuberculosis cyangwa amateka ya TB itavuwe neza
• Indwara ikomeye y'umwijima cyangwa imyunyu y'umwijima yazamutse cyane
• Umubare muto cyane w'uturemangingo tw'amaraso
• Inkingo ziheruka gukora (ugomba kwirinda inkingo zikora mugihe ufata baricitinib)
• Gusama cyangwa konka

Imyaka nayo ishobora kuba impamvu, kuko abantu barengeje imyaka 65 bashobora kugira ibyago byinshi byo kwandura indwara n'ibindi bibazo. Muganga wawe azagereranya inyungu n'ibyago bishoboka bitewe n'ubuzima bwawe bwite.

Amazina ya Baricitinib

Baricitinib igurishwa munsi yizina ry'ubwoko bwa Olumiant mumihanda myinshi, harimo na Leta Zunze Ubumwe. Iyi niyo miterere isanzwe yandikwa yumuti.

Ubwoko bwa baricitinib bushobora kuboneka mu turere tumwe na tumwe, ariko izina ry'ubwoko bwa Olumiant riguma kuba uburyo bwambere bwanditswe na ba muganga benshi. Jya ukoresha buri gihe ubwoko bwihariye cyangwa verisiyo rusange muganga wawe yandika.

Niba urimo uragenda cyangwa wimukira mu kindi gihugu, ganira n'umuganga wawe ku bijyanye n'uko imiti ihari muri ako gace ndetse n'itandukaniro riri mu mazina y'ubwoko bw'imiti cyangwa uko iteguye.

Izindi miti isimbura Baricitinib

Hariho izindi miti myinshi ikora kimwe na baricitinib mu kuvura indwara ziterwa n'ubwirinzi bw'umubiri. Iyi miti isimbura irashobora kuba ikwiriye kurushaho kubera uko ubuzima bwawe bumeze cyangwa amateka yawe y'ubuzima.

Izindi miti yitwa JAK inhibitors zirimo tofacitinib (Xeljanz) na upadacitinib (Rinvoq), zikora zinyuze mu buryo bumwe ariko zishobora kugira ingaruka zitandukanye. Umuganga wawe ashobora kubitekerezaho niba baricitinib itagukwiriye.

Imiti gakondo ivura indwara ziterwa n'ubwirinzi bw'umubiri (DMARDs) nka methotrexate cyangwa sulfasalazine iracyari uburyo bw'ingenzi bwo kuvura. Iyi miti imaze igihe kinini ikoreshwa kandi ishobora guhitwamo nk'imiti ikoreshwa bwa mbere.

Imiti ya biyolojiya nka TNF inhibitors (nka adalimumab cyangwa etanercept) itanga ubundi buryo bwo kuvura indwara ziterwa n'ubwirinzi bw'umubiri. Iyi miti isaba guterwa inshinge ariko ishobora kuba ikwiriye kurushaho ku bantu bamwe.

Ese Baricitinib iruta Methotrexate?

Baricitinib na methotrexate bikora mu buryo butandukanye kandi buri imwe ifite ibyiza byayo bitewe n'uko ubuzima bwawe bumeze. Nta n'imwe iruta indi, kuko guhitamo neza biterwa n'ibyo ukeneye n'amateka yawe y'ubuzima.

Methotrexate imaze imyaka myinshi ikoreshwa kandi ifite amateka meza y'umutekano, bituma akenshi ari yo ihitwamo bwa mbere mu kuvura indwara ya rheumatoid arthritis. Akenshi ntigora cyane kandi ishobora kugira akamaro kanini ku bantu benshi.

Baricitinib ishobora gukora vuba kurusha methotrexate kandi iroroshye gufata kuko ni ikinini gifatwa buri munsi aho guterwa urushinge buri cyumweru cyangwa gufata ibinini byinshi. Abantu bamwe batitabira methotrexate babona ibisubizo byiza kuri baricitinib.

Umuganga wawe azatekereza ku bintu nk'uburemere bw'indwara yawe, izindi ndwara ufite, uko wabanje kwitabira imiti, n'ibyo ukunda ubwo azatoranya imiti ikwiriye. Rimwe na rimwe bikoreshwa byombi kugira ngo bigire akamaro kurushaho.

Ibibazo Bikunze Kubazwa Kuri Baricitinib

Ese Baricitinib irakwiriye abantu barwaye indwara z'umutima?

Baricitinib isaba ko itekerezwaho cyane ku bantu barwaye indwara z'umutima, cyane cyane abashobora gufatwa n'amaraso. Muganga w'umutima wawe n'umuganga uvura indwara z'imitsi bagomba gufatanya kugenzura niba inyungu ziruta ibyago.

Abantu bafite amateka yo gufatwa n'umutima, umutsi wo mu bwonko wazibye, cyangwa amaraso ashobora kugira ibyago byiyongereye iyo bafata baricitinib. Ariko, abantu bamwe bafite indwara z'umutima barashobora gukoresha uyu muti neza bafashijwe n'ubugenzuzi bukwiye.

Umuganga wawe azasuzuma ibyago byawe byihariye byo mu mutima kandi ashobora kugusaba gukurikiranwa cyangwa gufata ingamba zo kwirinda niba ufite indwara z'umutima kandi ukeneye kuvurwa na baricitinib.

Nzakora iki niba mfashe baricitinib nyinshi bitunguranye?

Niba utunguranye ufashe baricitinib nyinshi kuruta uko wategetswe, vugana n'umuganga wawe cyangwa ikigo gishinzwe kurwanya ubumara ako kanya. Guhora ufata nyinshi bishobora kongera ibyago byo kugira ingaruka zikomeye, cyane cyane indwara zandura n'ibibazo bifitanye isano n'amaraso.

Ntugerageze "gukosora" urugero rurenzeho urwanya urugero ruzaza, kuko ibi bishobora kubuza imiti yawe gukora neza. Ahubwo, kurikiza ubuyobozi bw'umuganga wawe ku buryo wakomeza neza.

Bika baricitinib mu gikoresho cyayo cy'umwimerere kandi uyibike neza kure y'abana n'amatungo kugira ngo wirinde gufata doze nyinshi bitunguranye. Niba ukunda kwibagirwa niba wamaze gufata urugero rwawe, tekereza gukoresha umuteguro w'imiti.

Nzakora iki niba nirengagije gufata urugero rwa baricitinib?

Niba wibagiwe gufata urugero rwa baricitinib, ifate ako kanya wibukiye, keretse igihe cyo gufata urugero rwawe rukurikira kigeze. Muri icyo gihe, reka urugero wibagiwe urukure ukomeze gahunda yawe isanzwe.

Ntugasuzume imiti ibiri icyarimwe kugira ngo usimbure doze wasibye, kuko ibyo bishobora kongera ibyago byo kugira ingaruka zidakurikira. Ni byiza gukomeza gahunda yawe isanzwe yo gufata imiti.

Niba ukunda kwibagirwa gufata imiti, gerageza gushyiraho alarume ya buri munsi cyangwa ukoreshe porogaramu ikwibutsa imiti. Guhora ufata imiti bifasha kugumana urugero rwawo ruhagije mu mubiri wawe kugira ngo ukore neza.

Ni ryari nshobora kureka gufata Baricitinib?

Ugomba kureka gufata baricitinib gusa ubisabwe na muganga wawe, kuko guhagarara ako kanya bishobora gutuma indwara yawe yongera gukomera. Muganga wawe azagufasha kumenya igihe cyiza cyo guhagarika bitewe n'ibimenyetso byawe n'ubuzima bwawe muri rusange.

Abantu bamwe bashobora kureka gufata baricitinib niba indwara yabo igenda ikira, mu gihe abandi bashobora gukenera kuvurwa igihe kirekire kugira ngo bagumane kugenzura ibimenyetso. Icyemezo nk'iki giterwa n'indwara yawe yihariye n'uburyo wemera neza ubuvuzi.

Niba ugize ingaruka zikomeye zidakurikira cyangwa indwara zandura, muganga wawe ashobora guhagarika baricitinib by'agateganyo kugeza ikibazo gikemutse. Bazakorana nawe kugira ngo bamenye niba byemewe kongera gufata umuti nyuma.

Nshobora guhabwa inkingo nteye imiti ya Baricitinib?

Inkingo nyinshi zisanzwe zifashwe neza mugihe ufata baricitinib, ariko ugomba kwirinda inkingo zikoresha virusi zikiriho mugihe uvurwa. Muganga wawe azatanga ubuyobozi bwihariye kubijyanye n'inkingo zisabwa n'igihe zizahabwa.

Inkingo zitagira ubuzima nka shoti y'ibicurane, urukingo rwa nyumoniya, n'inkingo za COVID-19 muri rusange zifashwe neza kandi zikaba z'ingenzi kubantu bafata baricitinib. Ariko, uburyo umubiri wawe witwara ku nkingo bushobora kugabanuka.

Gerageza gukingirwa inkingo zose zisabwa mbere yo gutangira gufata baricitinib niba bishoboka. Niba ukeneye gukingirwa byihutirwa mugihe ufata umuti, ganira n'umuganga wawe kubijyanye n'igihe n'ubwoko bw'urukingo.