Bedaquiline ni iki: Ibikoreshwa, Urutonde rw'imiti, Ingaruka zayo n'ibindi

Bedaquiline ni umuti wihariye wa antibiyotike wagenewe kurwanya mikorobe ya igituntu (TB) idasubiza ku miti isanzwe ikoreshwa. Uyu muti ukora mu buryo butandukanye n'imiti ya kera ya TB, ukoresha ingufu zikorerwa imbere muri mikorobe ya TB, mu buryo bwo kuzibuza imbaraga.

Ushobora guhura na bedaquiline niba urwaye igituntu kirwanya imiti myinshi (MDR-TB) cyangwa igituntu kirwanya imiti myinshi cyane (XDR-TB). Izi ni indwara zikomeye za TB zarwanye imiti isanzwe ikoreshwa mu kuvura TB, bigatuma kuvurwa bigorana kandi bisaba uburyo bukomeye kandi bugamije.

Bedaquiline ikoreshwa mu kuvura iki?

Bedaquiline ivura igituntu kirwanya imiti myinshi mu muhogo mu bantu bakuru n'abana bafite imyaka 5 n'abarenzeho. Ibi bivuze ko igamije kurwanya indwara ya TB mu muhogo wawe itarasubije ku miti ibiri byibura ikoreshwa cyane mu kuvura TB nka isoniazid na rifampin.

Muganga wawe azandika bedaquiline gusa nk'igice cyo kuvura bifatanyije, ntabwo ari wenyine. Mikorobe ya TB ni umunyabwenge kandi irashobora kwirwanaho vuba, bityo gukoresha imiti myinshi hamwe birinda mikorobe gukoresha umuti umwe. Ubu buryo bwo gufatanya butanga umubiri wawe amahirwe meza yo gukuraho burundu indwara.

Uyu muti wihariye wagenewe gukoreshwa mu gihe izindi nzira zo kuvura zananiranye cyangwa zitakwemerwa. Itsinda ryawe ry'ubuzima rizaba ryaragerageje mikorobe yawe ya TB muri laboratwari kugirango bemeze ko imiti isanzwe itazakora mbere yo gutanga bedaquiline.

Bedaquiline ikora ite?

Bedaquiline ikora ibuza ATP synthase, uruganda rukenerwa na mikorobe ya TB kugirango ikore ingufu. Tekereza nk'aho ucika umuriro mu ruganda - nta ngufu, mikorobe ntishobora kubaho cyangwa kwororoka.

Ibi bituma bedaquiline ikomera cyane ku mikorobi ya TB, ariko si umuti ukora mu ijoro rimwe. Uyu muti uguma mu mubiri wawe igihe kirekire, ugakomeza kurwanya icyorezo kabone niyo hagati y'imiti. Ibi kuba uyu muti umaze igihe kirekire mu mubiri wawe bifasha mu kuvura icyorezo kandi ni ikintu muganga wawe azakurikiranira hafi.

Bitandukanye n'imiti imwe ya TB yica mikorobi vuba, bedaquiline ikora buhoro buhoro kandi idahindagurika. Ubu buryo buhoro bushobora gukora neza kurwanya ubwoko bwa TB bukomeye, butavurwa bumenyereye kubaho nyuma y'izindi nshingano.

Nkwiriye Gufata Bedaquiline Nte?

Fata bedaquiline nkuko muganga wawe abikwandikiye, akenshi rimwe ku munsi hamwe n'ibiryo. Uyu muti winjira neza cyane iyo ufashwe hamwe n'ifunguro, bityo ntukirengagize kurya mbere yo gufata umuti wawe. Ifunguro iryo ariryo ryose rizagufasha - ntugomba ikintu cyihariye.

Mimina ibinini byose hamwe n'amazi. Ntukabikore, ntukabumire, cyangwa ubimenagure, kuko ibi bishobora kugira ingaruka ku buryo umuti usohoka mu mubiri wawe. Niba ugira ikibazo cyo kumira ibinini, ganira n'umuganga wawe ku bindi bisubizo.

Gerageza gufata umuti wawe ku gihe kimwe buri munsi kugirango ugumane urwego ruzigama mu mubiri wawe. Gushyiraho umwibutso wa buri munsi birashobora kugufasha kuguma uhamye, ibi ni ngombwa mu kurwanya TB itavurwa neza.

Muganga wawe ashobora kwandika indi miti ya TB hamwe na bedaquiline. Fata yose uko yakabaye, kabone niyo utangiye kumva umeze neza. Guhagarika imiti kare kare birashobora korohereza mikorobi ya TB kugaruka no gukomera cyane.

Nkwiriye Gufata Bedaquiline Igihe Kingana Gite?

Abantu benshi bafata bedaquiline mu byumweru 24 (hafi amezi 6), ariko igihe nyacyo cyo kuvurwa giterwa n'uko ubuzima bwawe bumeze. Muganga wawe azatekereza ibintu nk'uko urimo witwara neza ku miti kandi n'indi miti urimo gufata.

Ibyumweru bibiri bya mbere ni iby'ingenzi cyane - uzajya ufata bedaquiline buri munsi muri iki gihe kugira ngo wihutishe kubaka urwego rwo hejuru mu mubiri wawe. Nyuma yaho, muganga wawe ashobora guhindura uburyo ubyakira bitewe n'uko urimo kwitwara.

Ntukareke gufata bedaquiline bitewe gusa n'uko wumva umeze neza. Bakiteri ya TB ishobora kwihisha mu mubiri wawe maze igasubira gukora igihe uvuye mu miti kare. Itsinda ryawe ry'ubuzima rizakoresha ibizamini nk'umuco w'amacandwe na X-ray y'igituza kugira ngo bamenye igihe byemewe guhagarika.

Abantu bamwe bakeneye imiti irambye, cyane cyane niba TB yabo ikaze cyane cyangwa bafite izindi ndwara zifite ingaruka ku gukira. Muganga wawe azakurikiza imiterere yawe neza kandi ahindure gahunda yawe y'imiti uko bikwiye.

Ni Ibihe Bikorwa Bigaragara bya Bedaquiline?

Kimwe n'imiti yose, bedaquiline ishobora gutera ibikorwa bigaragara, nubwo atari buri wese ubigeraho. Kumva icyo witeguye bishobora kugufasha kumva witeguye kandi ukamenya igihe wakwandikira umuganga wawe.

Ibikorwa bigaragara cyane ushobora kubona birimo isesemi, kubabara mu ngingo, kubabara umutwe, no guhinduka mu buryo wumva cyangwa unuka. Ibi bikorwa mubisanzwe biroroshye kandi akenshi birakosoka uko umubiri wawe wimenyereza umuti mu byumweru bya mbere.

Dore ibikorwa bigaragara abantu benshi bahura nabyo mugihe bavurwa:

• Isesemi no kurwara mu nda
• Kubabara mu ngingo cyangwa kubabara imitsi
• Umutwe
• Uruzi
• Guhinduka mu buryo wumva cyangwa unuka
• Kugira umunaniro cyangwa kumva unaniwe
• Uruhurirane rw'uruhu

Ibi bikorwa bigaragara bisanzwe mubisanzwe birashoboka kandi ntibisaba guhagarika umuti. Ariko, buri gihe menyesha itsinda ryawe ry'ubuzima ibimenyetso byose urimo guhura nabyo kugira ngo bagufashe kumva umeze neza.

Ibikorwa bigaragara bikomeye ntibisanzwe ariko bisaba ubufasha bwihuse bw'ubuvuzi. Ibi birimo ibibazo by'umutima, ibibazo bikomeye by'umwijima, cyangwa ibimenyetso byo kwibasirwa n'umubiri bikomeye.

Vugana na muganga wawe ako kanya niba wumva ibi bimenyetso bikurikira:

• Umutima utera nabi cyangwa kubabara mu gituza
• Urugimbu rukabije, kuruka cyangwa kutagira ubushake bwo kurya
• Uruhu cyangwa amaso y'umuhondo (umwijima)
• Inkari z'umukara cyangwa imyanda y'umweru
• Umunaniro ukabije cyangwa intege nke
• Kugorana guhumeka cyangwa kumira
• Uruhu rurwara cyane cyangwa imyatsi

Itsinda ryawe ry'ubuvuzi rizagukurikiranira hafi mugihe cy'imiti hamwe n'ibizamini by'amaraso bisanzwe no gukurikirana umutima. Ibi bifasha gufata ibibazo byose bishoboka hakiri kare kandi bigashimangira ko imiti yawe iguma itekanye kandi ifite akamaro.

Ninde utagomba gufata Bedaquiline?

Bedaquiline ntabwo ikwiriye kuri buri wese, kandi muganga wawe azasuzuma neza niba ikwiriye kuri wewe. Abantu bafite indwara zimwe na zimwe z'umutima cyangwa abafata imiti yihariye bashobora gukenera imiti itandukanye.

Ntabwo ugomba gufata bedaquiline niba ufite allergie izwi ku muti cyangwa ibintu byawo byose. Muganga wawe azitonda kandi mu kuyandika niba ufite indwara zimwe na zimwe z'umutima cyangwa ufata imiti igira ingaruka ku bikorwa by'amashanyarazi by'umutima wawe.

Umuvuzi wawe azashaka kumenya ibi bintu mbere yo kwandika bedaquiline:

• Indwara z'umutima (arrhythmias)
• Indwara y'umwijima cyangwa imyunyu y'umwijima yazamutse
• Ibibazo by'impyiko
• Potasiyumu nkeya, kalisiyumu, cyangwa magnesium
• Amateka y'umutima wateye cyangwa kunanirwa k'umutima
• Amateka y'umuryango w'urupfu rutunguranye rw'umutima

Imiti imwe na imwe irashobora guhura nabi na bedaquiline, cyane cyane iyo igira ingaruka ku mutima cyangwa imikorere y'umwijima. Muganga wawe azasuzuma imiti yawe yose iriho, harimo imiti itangwa n'abaganga n'ibyongerera imiti, mbere yo gutangira imiti.

Niba utwite cyangwa wonka, muganga wawe azagerageza neza inyungu n'ibibazo. Mugihe kuvura igituntu bifite akamaro kuri wowe n'umwana wawe, gukoresha bedaquiline mugihe utwite bisaba gukurikiranwa neza no gutekereza ku zindi nzira.

Amazina ya Bedaquiline

Bedaquiline iboneka munsi y'izina ry'ubwoko rya Sirturo mubihugu byinshi, harimo na Leta Zunze Ubumwe. Ubu ni bwo buryo busanzwe uzabona yanditswe kandi yanditswe muri farumasi.

Ibindi bihugu bishobora kugira amazina y'ubwoko butandukanye cyangwa verisiyo rusange zihari. Umufarumasiti wawe ashobora kugufasha kumenya imiti yawe yihariye kandi akemeza ko wakira imiti ikwiye.

Buri gihe jya ureba umuganga wawe cyangwa umufarumasiti niba ufite ibibazo bijyanye n'imiti yawe cyangwa ibyanditswe. Ni ngombwa kumenya neza ko ufata neza icyo wandikiwe.

Izindi nzira za Bedaquiline

Niba bedaquiline itagukwiriye, izindi miti irashobora kuvura igituntu kirwanya imiti myinshi. Muganga wawe ashobora gutekereza ku miti nka linezolid, clofazimine, cyangwa ibintu bishya nka pretomanid, bitewe n'ubwoko bwawe bw'igituntu n'ubuzima bwawe.

Guhitamo izindi nzira biterwa n'ibintu byinshi, harimo imiti mikorobe yawe y'igituntu irwanya, izindi ndwara zawe, n'imikoranire y'imiti ishoboka. Itsinda ryawe ry'ubuzima rizakorana n'inzobere mu gituntu kugirango zishake uburyo bwiza bwo guhangana n'ikibazo cyawe.

Abantu bamwe bashobora gukoresha bedaquiline hamwe n'izi nzira aho kuzisimbuza. Intego ni ukugira gahunda yo kuvura ishobora gukiza igituntu cyawe mugihe igabanya ingaruka ziterwa n'imiti n'ibibazo.

Ibyemezo byo kuvura igituntu kirwanya imiti biragoye kandi bigenda ku muntu ku giti cye. Muganga wawe azatekereza ku ngaruka za laboratori zerekana imiti ikora ku bwoko bwawe bw'igituntu, amateka yawe y'ubuvuzi, n'uburyo wihanganira imiti itandukanye.

Ese Bedaquiline iruta izindi miti y'igituntu?

Bedaquiline ntabwo ari ngombwa ko "iruta" imiti yindi ya TB - ifite icyo ikora gitandukanye. Mugihe imiti ya TB ikoreshwa bwa mbere nka isoniazid na rifampin ikora neza kubantu benshi barwaye TB, bedaquiline yibanda cyane kubwoko bwa mikorobe zirwanya imiti isanzwe ikoreshwa.

Kubantu barwaye TB irwanya imiti myinshi, bedaquiline yagaragaje inyungu zikomeye mubushakashatsi bwakozwe. Irashobora gufasha kugera ku kigero cyo gukira cyiza kandi irashobora gutuma imiti ivurwa mugihe ikoreshwa nkigice cyo kuvura hamwe.

Uburyo bwihariye bwiyi miti ikora bituma igirira akamaro kurwanya bagiteri ya TB yateje imbere ubwirinzi kuri iyindi miti. Ariko, akenshi yagenewe abantu barwaye indwara zirwanya imiti kubera ikiguzi cyayo, ingaruka zishobora kubaho, no gukurikiranwa neza.

Muganga wawe azahitamo imiti ikwiriye cyane bitewe nubwoko bwawe bwa TB, amateka yawe yubuzima, nibintu byawe bwite. Ubuvuzi "bwiza" ni bumwe buvura TB yawe neza kandi neza.

Ibikunze Kubazwa Kubijyanye na Bedaquiline

Ese Bedaquiline irakwiriye kubantu barwaye indwara z'umutima?

Bedaquiline bisaba kwitonderwa cyane kubantu barwaye indwara z'umutima kuko ishobora kugira ingaruka kumutima. Muganga wawe azasuzuma uko umutima wawe umeze, asuzume imiti ukoresha, kandi ashobora gutegeka gukurikiranwa k'umutima mbere na mugihe cyo kuvurwa.

Niba urwaye indwara z'umutima, ikipe yawe y'ubuzima irashobora gukora electrocardiogram (ECG) mbere yo gutangira bedaquiline no gukurikirana umutima wawe buri gihe mugihe uvurwa. Bazareba kandi urwego rw'amaraso yawe ya potasiyumu, kalisiyumu, na magnesiyumu, kuko kutaringana bishobora kongera ibyago byo guhagarara k'umutima.

Abantu benshi bafite indwara z'umutima barashobora gufata bedaquiline neza hamwe no gukurikiranwa neza. Muganga wawe azagereranya ibyago bikomeye bya TB irwanya imiti itavuwe n'ingaruka zishobora guterwa n'umutima ziterwa n'imiti.

Nigute nakora niba mfashe bedaquiline nyinshi bitunguranye?

Niba wanyoye bedaquiline irenze urugero rwanditswe, vugana n'umuganga wawe cyangwa ikigo gishinzwe gukurikirana uburozi ako kanya. Ntuzategereze ngo urebe niba wumva ibimenyetso, kuko kunywa bedaquiline irenze urugero bishobora gutera ibibazo bikomeye by'umutima.

Jya mu bitaro byihutirwa niba wumva ububabare mu gituza, umutima utera nabi, kuribwa cyane, cyangwa guhinda umushyitsi nyuma yo kunywa imiti myinshi. Zana icupa ry'umuti wawe kugira ngo abaganga bamenye neza icyo wanyoye n'ingano yacyo.

Kugira ngo wirinde kunywa imiti irenze urugero ku buryo butunguranye, bika bedaquiline mu gikoresho cyayo cy'umwimerere gifite ibirango bisobanutse. Tekereza gukoresha igikoresho cyo gutegura imiti cyangwa gushyiraho ibyibutsa kugira ngo bigufashe kwibuka niba umaze gufata urugero rwawe rwa buri munsi.

Nkwiriye gukora iki niba nciwe urugero rwa Bedaquiline?

Niba waciwe urugero rwa bedaquiline, rinywe ako kanya wibuka, ariko niba bitarenze amasaha 6 uhereye igihe wari uteganyirijwe. Niba hashize amasaha arenga 6, reka urugero waciwe, hanyuma unywe urugero rwawe rukurikira ku gihe gisanzwe.

Ntuzigere unywa urugero ebyiri icyarimwe kugira ngo usimbure urugero waciwe. Ibi bishobora kongera ibyago byo kugira ingaruka ziterwa n'umuti, cyane cyane ibibazo by'umutima. Ahubwo, komeza gahunda yawe isanzwe yo kunywa imiti.

Niba ukunda kwibagirwa kunywa imiti, vugana n'umuganga wawe kuri gahunda zagufasha kwibuka. Kunywa imiti buri gihe ni ngombwa kugira ngo urwanye igituntu kirwanya imiti neza kandi wirinde ko mikorobe yongera kurwanya imiti.

Nshobora kureka kunywa Bedaquiline ryari?

Ushobora kureka kunywa bedaquiline gusa igihe umuganga wawe akubwiye ko bitekanye kubikora. Iyi myanzuro ishingiye ku bizamini byo muri laboratori, isesengura ry'amashusho, n'uburyo umubiri wawe witwara ku miti, ntabwo bishingiye gusa ku buryo wumva.

Itsinda ryawe ry'abaganga rizakurikirana imico yawe y'amacandwe, imirasire ya X yo mu gituza, n'ibindi bizamini kugira ngo bamenye igihe icyorezo cyawe cy'igituntu kivuwe neza. Kureka kunywa imiti kare kare bishobora gutuma mikorobe igaruka kandi ikongera kurwanya imiti.

N'iyo umaze guhagarika gufata bedaquiline, birashoboka ko uzakomeza gufata imiti yindi ya TB no kujya kwa muganga buri gihe. Muganga wawe azashaka kumenya neza ko ubwandu butagaruka kandi ko wakize burundu.

Nshobora kunywa inzoga niba ndimo gufata Bedaquiline?

Ni byiza kwirinda inzoga igihe urimo gufata bedaquiline, kuko byombi bishobora kugira ingaruka ku mwijima wawe n'imikorere y'umutima. Inzoga irashobora kongera ibyago byo kurwara umwijima kandi ishobora kubuza umubiri wawe gukora neza imiti.

Niba uhisemo kunywa rimwe na rimwe, banza ubiganireho n'umuganga wawe. Bazakugira inama bitewe n'ubuzima bwawe bwihariye n'indi miti urimo gufata.

Wibuke ko umwijima wawe umaze gukora cyane kugira ngo ukore bedaquiline n'indi miti ya TB. Kongeraho inzoga bishobora gushyira igitutu cyinshi kuri uru rugingo rw'ingenzi kandi bikabangamira imikorere y'imiti yawe.