Belinostat ni iki: Ibikoresho, Urutonde rw'imiti, Ingaruka zayo n'ibindi

Belinostat ni umuti w'indwara ya kanseri ugamije gufasha kuvura ubwoko bumwe na bumwe bwa kanseri y'amaraso mu kubuza proteyine zihariye selile za kanseri zikeneye gukura. Uyu muti uterwa mu maraso ungana n'itsinda ryitwa histone deacetylase inhibitors, ikora mu kwivanga mu bushobozi bwa selile ya kanseri bwo kwiyongera no kubaho.

Uyu muti uzawuhabwa unyuze mu muyoboro w'amaraso (IV) mu kigo kivurirwamo kanseri, aho ikipe y'ubuvuzi izagukurikiranira hafi. Nubwo belinostat ari igikoresho gikomeye mu kurwanya kanseri, gusobanukirwa uko ikora n'icyo witegura bishobora kugufasha kumva witeguye urugendo rwawe rw'ubuvuzi.

Belinostat ni iki?

Belinostat ni umuti wa kanseri wandikirwa ugamije enzymes zihariye imbere muri selile za kanseri kugirango ifashe guhagarika imikurire yazo. Uyu muti ukora mu kubuza histone deacetylases, ari proteyine zifasha selile za kanseri kubaho no kwiyongera mu buryo butagira umupaka.

Uyu muti uza mu ifu ivangwa n'amazi atagira mikorobe kandi itangwa unyuze mu muyoboro w'amaraso (IV) mu maraso yawe. FDA yemeye belinostat by'umwihariko mu kuvura peripheral T-cell lymphoma, ubwoko butavuka cyane ariko bukaze bwa kanseri y'amaraso igira ingaruka ku mikorere y'umubiri wawe.

Umuhanga wawe mu by'indwara ya kanseri azemeza niba belinostat ikwiriye kubera uko urwaye kanseri, ubuzima bwawe muri rusange, n'uburyo wabyitwayemo ku bundi buvuzi.

Belinostat ikoreshwa mu iki?

Belinostat ikoreshwa cyane cyane mu kuvura peripheral T-cell lymphoma (PTCL) ku barwayi bamaze kugerageza nibura ubundi buvuzi bumwe butakoze neza bihagije. PTCL ni itsinda rya kanseri zikaze z'amaraso zigaragara iyo selile zimwe zera z'amaraso zizwi nka T-cells zihindutse kanseri.

Muganga wawe ashobora kugusaba gukoresha belinostat niba lymphoma yawe yagarutse nyuma yo gukira cyangwa niba itarasubiza neza ku miti ya mbere ya chemotherapy. Uyu muti akenshi uzirikanwa iyo izindi miti isanzwe itagize icyo igeraho.

Rimwe na rimwe, abaganga bashobora gukoresha belinostat mu bushakashatsi ku zindi ndwara za kanseri, ariko gukoreshwa kwayo kwemewe cyane ni kuri ubu bwoko bwa lymphoma.

Belinostat ikora ite?

Belinostat ikora igamije enzymes yitwa histone deacetylases (HDACs) kanseri zishingiraho kugira ngo zikomeze kubaho no kwiyongera. Tekereza kuri izi enzymes nk'ibikoresho bya molekile kanseri zikoresha kugira ngo zihindure gene zimwe na zimwe zikore cyangwa zihagarare.

Iyo belinostat yabuza izi enzymes, ihungabanya ubushobozi bwa selile ya kanseri bwo kugenzura imikurire yayo n'uburyo bwo kubaho. Ibi bibangamira bituma selile za kanseri zihagarika kwigabanya kandi amaherezo zigapfa, mugihe muri rusange bitera ingaruka nke ku selile zifite ubuzima bwiza.

Uyu muti ufatanwa imbaraga ziringaniye, bivuze ko ushobora kugira akamaro ku kanseri zikaze ariko kandi ushobora gutera ingaruka zikomeye. Itsinda ryawe ryita ku buzima rizagereranya neza inyungu n'ibishobora guterwa n'ingaruka bitewe n'uko ubuzima bwawe bumeze.

Nkwiriye gufata belinostat nte?

Uzahabwa belinostat nk'urushinge rwinjizwa mu maraso mu gihe cy'iminota 30 ku munsi wa 1 kugeza ku wa 5 w'uruziga rw'iminsi 21. Uyu muti ugomba gutangwa mu kigo kivura kanseri aho abaganga bafite ubumenyi bazawutegura kandi bawutange neza.

Mbere yo gutera urushinge, itsinda ryawe ryita ku buzima rizasuzuma imibare y'amaraso yawe n'ubuzima bwawe muri rusange kugira ngo barebe niba umubiri wawe witeguye gufata umuti. Ntabwo ukeneye gufata belinostat hamwe n'ibiryo kuko ijya mu maraso yawe, ariko kuguma ufite amazi ahagije mbere na nyuma yo kuvurwa bishobora gufasha umubiri wawe gukora umuti.

Umuforomo wawe azashyira umurongo wa IV mu kuboko kwawe cyangwa akoreshe icyambu cyawe niba ufite kimwe. Mu gihe cyo kuvomerwa, uzagenzurwa niba hari ibintu byihuse, kandi mubisanzwe urashobora gusoma, gukoresha ibikoresho bya elegitoroniki, cyangwa kuruhuka neza.

Nzagenda Mfata Belinostat Igihe Kingana Gite?

Ubugufi bwo kuvurwa na belinostat butandukanye cyane ku muntu ku muntu, bitewe nuko kanseri yawe yitwara neza kandi nuko umubiri wawe wihanganira imiti. Abantu benshi bakira ibizunguruka byinshi, buri kizunguruka kimara iminsi 21.

Umuvuzi wawe w’indwara z’umwijima azagenzura iterambere ryawe binyuze mu igeragezwa ry’amaraso risanzwe, isesengura ry’amashusho, n’ibizamini by’umubiri kugirango hamenyekane niba imiti ikora neza. Niba kanseri yawe yitwara neza kandi wihanganira imiti neza, urashobora gukomeza kuvurwa amezi menshi.

Ubuvuzi mubisanzwe burakomeza kugeza igihe kanseri yawe ihagarariye kwitwara neza ku miti, ingaruka zikaba zikomeye cyane ngo zigenzurwe, cyangwa kanseri yawe ikajya mu kiruhuko. Itsinda ryawe ry’ubuvuzi rizaganira kuri izi myanzuro nawe mu rugendo rwawe rw’ubuvuzi.

Ni Iyihe Ngaruka Ziterwa na Belinostat?

Kimwe n’imiti myinshi ya kanseri, belinostat irashobora gutera ingaruka ziva ku zoroshye kugeza ku zikomeye. Kumenya icyo witegura birashobora kugufasha kwitegura no kumenya igihe wahamagara itsinda ryawe ry’ubuvuzi.

Ingaruka zisanzwe ushobora guhura nazo zirimo umunaniro, isesemi, umuriro, no kugabanya ubushake bwo kurya. Abantu benshi kandi bagira umubare muto w’uturemangingo tw’amaraso, bishobora kongera ibyago byo kwandura, kuva amaraso, cyangwa anemia.

Ingaruka Zisanzwe

Izi ngaruka zibaho ku bantu benshi bafata belinostat kandi mubisanzwe birashoboka kubicunga neza hamwe n’ubuvuzi bukwiye no kugenzura:

• Kugira umunaniro mwinshi no kumva umubiri utagifite imbaraga bishobora kumara igihe hagati y'igihe cyo kuvurwa
• Urugimbu no kuruka, ibi bikaba bikunze gucungwa n'imiti igabanya urugimbu
• Urubore n'ubukonje, cyane cyane mu minsi ikurikira kuvurwa
• Kugabanyuka k'ipfa ry'ibiryo no guhinduka kw'uburyohe
• Impiswi cyangwa guhagarara k'umwanya
• Kugufuka umwuka igihe ukora imyitozo ngororamubiri
• Umutwe n'izunguzwa
• Uruhu rurya cyangwa gushishuka

Itsinda ry'abaganga bazatanga imiti n'uburyo bwo gufasha gucunga ibi bimenyetso no gukomeza ubuzima bwawe bwiza mu gihe cyo kuvurwa.

Ingaruka zikomeye

Nubwo bitajyenda bibaho kenshi, hariho ingaruka zimwe na zimwe zisaba ubufasha bwihuse bw'abaganga no gukurikiranwa neza mu gihe cyose uvurwa:

• Kugabanuka gukomeye kw'umubare w'uturemangingo tw'amaraso (neutropenia, thrombocytopenia, anemia)
• Indwara zikomeye ziterwa n'ukugabanuka k'ubudahangarwa bw'umubiri
• Ukuva amaraso cyangwa gukomeretsa bikomeye
• Ibibazo by'umwijima, harimo no kwiyongera kw'imisemburo y'umwijima
• Uburwayi butunguranye bw'umutima cyangwa ibindi bibazo by'umutima
• Urugero rukomeye rw'uburwayi bw'umubiri mu gihe cyangwa nyuma yo guterwa imiti
• Tumor lysis syndrome, aho uturemangingo twa kanseri twangirika vuba cyane

Itsinda ry'abaganga bazakurikirana ibi bibazo binyuze mu bipimo by'amaraso bisanzwe n'ibizamini, kandi bazahindura gahunda yawe yo kuvurwa niba bibaye ngombwa.

Ingaruka zidakunze ariko zikomeye

Mu gihe kitajyenda kibaho, belinostat ishobora gutera ibibazo bikomeye bisaba ubufasha bwihuse bw'abaganga:

• Ukwangirika gukomeye kw'umwijima cyangwa kunanirwa kw'umwijima
• Indwara ziteje ubuzima bw'umuntu cyangwa sepsis
• Ibibazo bikomeye by'umutima cyangwa kunanirwa kw'umutima
• Kanseri zikurikira zishobora kwigaragaza nyuma y'imyaka myinshi
• Urugero rukomeye rw'uruhu cyangwa kwangirika kw'imitsi

Nubwo ibi bibazo bidakunze kubaho, itsinda ry'abaganga rizakomeza kuba maso ku bimenyetso byo kuburira kare kandi bazafata ingamba zikwiye niba bibayeho.

Ninde utagomba gufata Belinostat?

Belinostat ntibereye buri wese, kandi muganga wawe azasuzuma neza niba uyu muti ufitiye umutekano mu bihe byawe byihariye. Ibyiciro by'ubuzima cyangwa ibihe bishobora gutuma ubu buvuzi butekanye.

Ntabwo ukwiye guhabwa belinostat niba ufite allergie izwi ku muti cyangwa ibice byawo. Byongeye kandi, niba ufite indwara ikomeye y'umwijima, muganga wawe ashobora kwirinda ubu buvuzi kuko belinostat ishobora kugira ingaruka ku mikorere y'umwijima.

Abantu bafite ibibazo bikomeye by'umutima, indwara zikomeye zikora, cyangwa umubare muto cyane w'uturemangingo tw'amaraso ntibashobora kuba abakandida beza bo kuvurwa na belinostat. Umuganga wawe w'indwara z'umwijima azagereranya ibi bintu n'inyungu zishoboka z'ubuvuzi.

Ibitekerezo Bidasanzwe

Amatsinda amwe y'abantu asaba isuzuma ryihariye n'ikurikirana niba ubuvuzi bwa belinostat burimo gutekerezwa:

• Abagore batwite cyangwa bonka (belinostat ishobora gukomeretsa abana bakiri bato)
• Abantu bafite ibibazo by'umwijima cyangwa hepatite
• Abarwayi bafite indwara z'umutima cyangwa indwara z'umutima
• Abafite ibibazo by'impyiko cyangwa imikorere y'impyiko yagabanutse
• Abantu bafata imiti ituma amaraso ataguma cyangwa bafite indwara zo kuva amaraso
• Abarwayi bafite ubudahangarwa bw'umubiri butameze neza buturutse ku zindi mpamvu

Itsinda ryawe ry'ubuzima rizasuzuma neza amateka yawe y'ubuvuzi n'ubuzima bwawe bwa none mbere yo kugusaba kuvurwa na belinostat.

Amazina ya Belinostat Brand

Belinostat iboneka munsi y'izina rya Beleodaq muri Leta Zunze Ubumwe z'Amerika. Iyi ni yo formulation imwe gusa ya belinostat yemerwa na FDA.

Beleodaq iza nk'ifu ya lyophilized abaganga bayisubiza amazi atagira mikorobe mbere yo kuyitanga. Uyu muti ukorwa na Acrotech Biopharma kandi uboneka gusa binyuze muri farumasi zidasanzwe n'ibigo bivura kanseri.

Ntabwo urabona imiti ya belinostat isanzwe, kuko uyu muti ukirinda n'amategeko ya patenti. Ibi bivuze ko Beleodaq ariyo yonyine ihari ubu yo kuvura belinostat.

Izindi miti isimbura Belinostat

Niba belinostat itagukwiriye cyangwa ikaba itagikora neza, muganga wawe ufite ubushobozi afite izindi nzira zo kuvura lymphoma ya T-cell yo ku mpande. Izi nzira zikora mu buryo butandukanye kandi zishobora gukwira neza uko ubuzima bwawe buteye.

Izindi miti yica HDAC nka romidepsin (Istodax) ikora kimwe na belinostat kandi ishobora gutekerezwa niba udashobora kwihanganira belinostat. Byongeye kandi, imiti mishya igamije kuvura indwara n'uburyo bwo gukingira umubiri birimo kuboneka ku miti ya T-cell lymphoma.

Uburyo bwa kera bwo kuvura kanseri, kwimura uturemangingo tw'umubiri, cyangwa kwitabira igeragezwa ry'imiti mishya bishobora kuba inzira bitewe n'ubuzima bwawe muri rusange n'amateka y'imiti wahawe.

Ese Belinostat iruta Romidepsin?

Zombi belinostat na romidepsin ni imiti yica HDAC ikoreshwa mu kuvura lymphoma ya T-cell yo ku mpande, ariko ntibiba ngombwa ko iruta cyangwa ngo irushwe n'indi. Buri muti ufite inyungu zawo n'ingaruka zishobora gutuma umwe ukwira neza uko ubuzima bwawe buteye.

Belinostat itangwa nk'urushinge rugufi mu minota 30 mu minsi itanu ikurikirana, naho romidepsin isaba urushinge rurerure ku minsi runaka y'uruziga. Abantu bamwe bihangana n'umuti umwe kurusha undi mu bijyanye n'ingaruka.

Muganga wawe ufite ubushobozi azatekereza ibintu nk'ubuzima bwawe muri rusange, imiti wahawe mbere, uko imiti ishobora guhura, n'ibyo wifuza mu gihe cyo guhitamo hagati y'izi nzira. Guhitamo

Belinostat isaba kwitonda cyane ku bantu bafite ibibazo by'umwijima kuko uyu muti ushobora kugira ingaruka ku mikorere y'umwijima. Muganga wawe azagomba gusuzuma ubukana bw'indwara yawe y'umwijima no gupima inyungu zishoboka n'ibibazo bishobora kuvuka.

Niba ufite ibibazo byoroheje by'umwijima, muganga wawe ashobora gukomeza gutekereza kuri belinostat ariko akoresheje gukurikirana kenshi ibizamini by'imikorere y'umwijima wawe. Ariko, niba ufite indwara ikomeye y'umwijima cyangwa hepatite ikora, belinostat ntishobora kuba umutekano kuri wowe.

Itsinda ryawe ry'ubuvuzi rizakora ibizamini by'imikorere y'umwijima mbere yo gutangira kuvurwa kandi rikazabikurikirana buri gihe mu gihe uvurwa kugira ngo ryemeze ko umwijima wawe ukoresha umuti neza.

Nagomba gukora iki niba mbonye belinostat nyinshi ku buryo butunguranye?

Kubera ko belinostat itangwa n'abantu b'inzobere mu buvuzi ahantu hacungwa, kwiyongera kw'imiti ku buryo butunguranye ni gake cyane. Ariko, niba ucyeka ko wakiriye umuti mwinshi, menyesha umuforomo wawe cyangwa muganga wawe ako kanya.

Nta muti wihariye wo kuvura kwiyongera kwa belinostat, bityo kuvura byibanda ku gucunga ibimenyetso byose byagaragara. Itsinda ryawe ry'ubuvuzi rizagukurikiranira hafi ibimenyetso by'ingaruka ziyongereye, cyane cyane kugabanuka kw'umubare w'uturemangingo tw'amaraso cyangwa ibibazo by'umwijima.

Uburyo bwo gutanga imiti bucungwa neza no kubara neza imiti bifasha kwirinda ibibazo byo kwiyongera kw'imiti, ariko itsinda ryawe ry'ubuvuzi ryiteguye gusubiza vuba niba hari amakosa yo gutanga imiti yabayeho.

Nagomba gukora iki niba nciweho urugero rwa belinostat?

Niba ucikanwe no guterwa belinostat, vugana n'ikipe yawe y'ubuvuzi bw'indwara z'umwijima ako kanya kugira ngo utegure bundi bushya. Ntugerageze gusubiza urugero rwatanzweho inyungu ukubye kabiri cyangwa guhindura gahunda yawe utabanje kugisha inama z'abaganga.

Muganga wawe azagena uburyo bwiza bwo gukomeza ashingiye ku mpamvu yatumye ucikanwa n'urugero n'aho uri mu cyiciro cyawe cyo kuvurwa. Rimwe na rimwe, bashobora guhindura gahunda yawe cyangwa guhindura gahunda yawe yo gutanga imiti.

Kutabona imiti yose bishobora kugira ingaruka ku mikorere y'imiti yawe, bityo ni ngombwa kubahiriza gahunda zose z'ibitaramo byawe kandi ukavugana n'ikipe yawe niba ufite ibibazo byo kwitabira imiti.

Ni ryari nshobora guhagarika gufata Belinostat?

Ugomba guhagarika gusa imiti ya belinostat uyobowe na muganga wawe w'indwara z'umubiri. Umwanzuro wo guhagarika imiti biterwa n'ibintu byinshi, harimo uburyo kanseri yawe iri gusubiza, ingaruka z'uruhande urimo guhura nazo, n'ubuzima bwawe muri rusange.

Muganga wawe ashobora kugusaba guhagarika belinostat niba kanseri yawe igiye mu kiruhuko, niba ingaruka z'uruhande zikomeye cyane ku buryo bidashoboka kuzicunga, cyangwa niba imiti itagikora neza ku kanseri yawe.

Ntuzigere uhagarika imiti ya belinostat ku giti cyawe, kabone niyo wumva umeze neza cyangwa ufite ingaruka z'uruhande. Muganga wawe w'indwara z'umubiri akeneye gusuzuma uko umeze neza kandi ashobora gukenera kuguha izindi miti cyangwa ubufasha.

Nshobora gufata izindi miti nkanwa belinostat?

Urashobora gufata izindi miti zimwe na zimwe mugihe ufata belinostat, ariko ikipe yawe y'ubuzima ikeneye gusuzuma ibyo ufata byose kugirango wirinde guhura n'ibibazo bishobora guteza akaga. Imwe mu miti ishobora kongera ingaruka z'uruhande rwa belinostat cyangwa ikabangamira imikorere yayo.

Buri gihe menyesha muganga wawe w'indwara z'umubiri ku miti yose yanditswe, imiti itangwa nta cyangombwa, vitamine, n'ibyongerera imiti ufata. Bazamenya icyo gukomeza gufata kandi icyo gikeneye guhindurwa cyangwa guhagarikwa.

Umunyamiti wawe n'ikipe yawe y'indwara z'umubiri bazakorana kugirango barebe ko imiti yawe yose ihuye kandi ko urimo kubona imiti ifite umutekano kandi ikora neza.