Cabazitaxel ni iki: Ibikoreshwa, Urutonde rw'imiti, Ingaruka ziterwa n'iyo miti n'ibindi

Cabazitaxel ni umuti ukomeye wa kanseri ukoreshwa mu kuvura kanseri ya prostate yateye imbere yageze no mu bindi bice by'umubiri. Uyu muti uterwa mu urugingo rw'imitsi ubarizwa mu cyiciro cy'imiti yitwa taxanes, ikora igihe ihagarika selile za kanseri kwigabanya no gukura.

Niba wowe cyangwa umuntu ukwitaho yarandikiwe cabazitaxel, birashoboka ko ufite ibibazo byinshi kuri ubu buvuzi. Kumva uko uyu muti ukora, icyo witegura, n'uko wacunga ingaruka zishobora guterwa n'iyo miti bishobora kugufasha kumva witeguye kandi ufite icyizere mu rugendo rwawe rwa kanseri.

Cabazitaxel ni iki?

Cabazitaxel ni umuti wa kanseri wagenewe kurwanya selile za kanseri ya prostate zanze gukira kubera izindi nshuti. Ni ikintu gikomoka ku kinyabutabire gisanzwe kiboneka mu gishishwa cy'igiti cya yew, cyahinduwe neza muri laboratori kugira ngo kigire akamaro kurwanya selile za kanseri zananiranye.

Uyu muti ufashwe nk'ubuvuzi bwa kabiri, bivuze ko abaganga basanzwe bawandika nyuma y'uko izindi nshuti z'imisemburo zihagaze gukora. Cabazitaxel ifite agaciro cyane kuko iracyashobora kurwanya selile za kanseri kabone niyo zaba zaramaze kwanga docetaxel, undi muti usanzwe wa kanseri.

Uyu muti buri gihe utangwa binyuze mu gutera urushinge mu urugingo rw'imitsi mu bitaro cyangwa ikigo cyihariye kivura kanseri. Ntabwo uzigera ufata uyu muti uri mu rugo, kuko bisaba gukurikiranwa neza no gutangwa n'abantu babifitiye ubuhanga kugira ngo umutekano wawe wizerwe.

Cabazitaxel ikoreshwa mu kuvura iki?

Cabazitaxel ikoreshwa cyane cyane mu kuvura kanseri ya prostate ya metastatic castration-resistant (mCRPC). Ibi bivuze ko kanseri yateye ikarenga urugingo rwa prostate kandi ntikigira icyo ikora ku nshuti zihagarika imisemburo igabanya urwego rwa testosterone.

Muganga wawe akenshi azagusaba cabazitaxel igihe kanseri ya prostate yawe yateye imbere nubwo wari umaze kuvurwa mbere na docetaxel-based chemotherapy. Yemerejwe by'umwihariko ku bagabo kanseri yabo yariyongereye nyuma yo guhabwa imiti ya hormone na docetaxel.

Mu bindi bihe, abaganga bashobora gutekereza cabazitaxel nk'uburyo bwa mbere bwo kuvura na chemotherapy, cyane cyane ku barwayi batabasha kwihanganira docetaxel cyangwa bafite ibimenyetso byihariye bya genetike byerekana ko cabazitaxel ishobora kuba ifite akamaro kurushaho. Umuganga wawe w'inzobere mu kuvura kanseri azasuzuma uko ubuzima bwawe buhagaze kugira ngo amenye niba ubu buvuzi bukugirira akamaro.

Cabazitaxel ikora ite?

Cabazitaxel ikora yibanda ku miterere y'imbere y'uturemangingo twa kanseri, cyane cyane ikabangamira utuyunguruzo duto twitwa microtubules dufasha uturemangingo kwigabanya. Tekereza kuri utu tuyunguruzo twa microtubules nk'ibishushanyo uturemangingo dukeneye kugira ngo bigabanemo utundi turemangingo tubiri dushya mugihe cyo kwikorera.

Iyo cabazitaxel yinjira mu turemangingo twa kanseri, yifatanya n'utu tuyunguruzo twa microtubules ikabuza guseneka neza. Ibi mu by'ukuri bituma uturemangingo twa kanseri dufata ahantu hamwe, bikabuza kwigabanya kandi amaherezo bigatuma dupfa.

Igituma cabazitaxel ifite akamaro cyane ni ubushobozi bwayo bwo kurenga inzitizi y'amaraso n'ubwonko no kwinjira mu turemangingo twa kanseri twateje ubwihishamo ku yindi miti ya chemotherapy. Ibi bifatwa nk'umuti wa chemotherapy ukomeye cyane, ufite imbaraga kurusha imiti ya hormone ariko yagenewe gucungwa neza n'ubufasha bw'ubuvuzi bukwiriye.

Nkwiriye gufata cabazitaxel nte?

Cabazitaxel ihabwa buri gihe nk'urukingo rwinjizwa mu maraso mu isaha imwe, akenshi buri byumweru bitatu. Uzahabwa ubu buvuzi mu bitaro, ikigo kivura kanseri, cyangwa ivuriro ryihariye aho abaganga bafite ubumenyi bazagukurikiranira hafi.

Mbere yo guterwa urushinge rw'umuti, uzahabwa imiti y'ibanze kugira ngo ifashe kwirinda ibimenyetso by'uburwayi bw'ubwivumbure n'ukugabanya isesemi. Iyi miti ikunze kuba irimo imiti irwanya ubwivumbure, imiti ya corticosteroid, n'imiti irwanya isesemi itangwa mbere y'iminota 30 mbere yo gutangira kuvurwa na cabazitaxel.

Ntabwo bisaba kwiyiriza mbere yo kuvurwa, ariko kurya ifunguro ryoroshye mbere bishobora gufasha kugabanya isesemi. Guma ufite amazi ahagije unywa amazi menshi mu minsi ibanza urushinge. Itsinda ryawe ry'ubuzima rizatanga amabwiriza yihariye yerekeye imiti iyo ari yo yose ugomba kwirinda mbere yo kuvurwa.

Mugihe cyo guterwa urushinge, abaforomo bazagenzura ibimenyetso byawe by'ingenzi buri gihe kandi barebe ibimenyetso byose by'ubwivumbure. Ahantu batera urushinge rwa IV hazagenzurwa neza kugirango barebe ko umuti utembera neza kandi ko utatera umuvuduko mu mitsi yawe.

Nzamara Igihe Kingana Iki Ndafata Cabazitaxel?

Igihe cyo kuvurwa na cabazitaxel gitandukana cyane ku muntu ku muntu, bitewe n'uburyo kanseri yitwara neza n'uburyo wihanganira umuti. Abantu benshi bakira ubuvuzi mu mezi menshi, akenshi kuva kuri 6 kugeza kuri 10.

Umuvuzi wawe w'indwara z'umutima azasuzuma uko witwara nyuma ya buri cyiciro cya 2-3 akoresheje ibizamini by'amaraso, ibizamini by'amashusho, no gusuzuma ibimenyetso byawe. Niba ubuvuzi bukora kandi ukaba ubona ibimenyetso by'inyongera neza, urashobora gukomeza mu bindi byiciro.

Ubuvuzi bukunze gukomeza kugeza igihe kimwe muri ibi bikurikira: kanseri ihagarika gusubiza umuti, ibimenyetso by'inyongera bigorana cyane kubicunga, cyangwa wowe n'umuganga wawe mwemeza ko inyungu zitarenze ibyago. Abarwayi bamwe bashobora guhabwa cabazitaxel umwaka cyangwa kurenza niba ikomeje kugenzura kanseri yabo neza.

Ni Ibihe Bimenyetso By'inyongera Bya Cabazitaxel?

Kimwe n'indi miti yose ya chemotherapy, cabazitaxel irashobora gutera ibimenyetso by'inyongera, nubwo atari buri wese ubyumva byose. Kumva icyo witegura birashobora kugufasha kwitegura no kumenya igihe cyo kuvugana n'itsinda ryawe ry'ubuzima.

Ingaruka zikunze kugaragara ushobora guhura nazo zirimo umunaniro, isesemi, impiswi, no gutakaza umusatsi by'agateganyo. Abantu benshi barwara kandi babona impinduka mu rwego rw'amavuta kandi bashobora kugira uburyaryate cyangwa kumva ibintu bimeze nk'ibishashagu mu ntoki no mu birenge byabo.

Dore ingaruka zikunze kugaragara zikora ku barwayi benshi:

• Umunaniro n'intege nke bishobora kumara iminsi myinshi nyuma yo kuvurwa
• Isesemi no kuruka, akenshi bigenzurwa n'imiti irwanya isesemi
• Impiswi, rimwe na rimwe zishobora kuba zikomeye kandi zigasaba ubufasha bwa muganga
• Gutakaza umusatsi, akenshi bitangira nyuma yo kuvurwa bwa mbere
• Kugabanya ubushake bwo kurya no guhindura uburyohe
• Umubare muto w'uturemangingo tw'amaraso, wongera ibyago byo kwandura indwara
• Uburyaryate cyangwa kumva ibintu bimeze nk'ibishashagu mu ntoki no mu birenge (peripheral neuropathy)
• Uburibwe mu mikaya no mu ngingo

Izi ngaruka muri rusange ni iz'agateganyo kandi zikagenda zikira hagati y'ibihe byo kuvurwa. Itsinda ryawe ry'ubuvuzi rizatanga imiti n'uburyo bwo gufasha kugenzura ibi bimenyetso neza.

Mu buryo butajegajega, abantu bamwe barwara bashobora guhura n'ingaruka zikomeye zisaba ubufasha bwa muganga bwihutirwa. Nubwo ibi bibaho ku bantu bake, ni ngombwa kubimenya.

Dore ingaruka zidakunze kugaragara ariko zikomeye zo kwitondera:

• Urugero rukomeye rw'uburwayi bw'uburwayi mugihe cyangwa nyuma gato yo guterwa urushinge
• Indwara zikomeye ziterwa n'umubare muto cyane w'uturemangingo twera tw'amaraso
• Ibibazo by'impyiko, harimo impinduka mu kunyara cyangwa kubyimba
• Impiswi zikomeye zikugeza ku kumuka amazi mu mubiri
• Ingorane zo guhumeka cyangwa inkorora ihoraho
• Ukuva amaraso kudasanzwe cyangwa gukomeretsa
• Uburibwe bukomeye mu nda cyangwa kuruka bihoraho

Niba ubonye kimwe muri ibi bimenyetso bikomeye, hamagara umuganga wawe w'indwara z'umwijima ako kanya cyangwa ushake ubufasha bw'ubuvuzi bwihutirwa. Itsinda ryawe ry'ubuvuzi rizakugenzura neza hamwe n'ibizamini by'amaraso bisanzwe kugirango bamenye ibibazo byose hakiri kare.

Ninde utagomba gufata Cabazitaxel?

Cabazitaxel ntibereye buri wese, kandi muganga wawe azasuzuma neza niba ubu buvuzi bukugirira neza. Ibyiciro by'ubuzima runaka cyangwa ibihe bishobora gutuma cabazitaxel iba iy'akaga cyane cyangwa idakora neza.

Ntabwo ukwiye guhabwa cabazitaxel niba ufite allergie ikomeye kuri uyu muti cyangwa ibintu byose bigize wo, harimo polysorbate 80. Abantu bafite uburyo bwo kwirinda bukomeye cyane cyangwa umubare muto cyane w'uturemangingo twera tw'amaraso nabo bashobora gukenera kwirinda ubu buvuzi.

Muganga wawe azitondera cyane mu gutanga cabazitaxel niba ufite kimwe muri ibi bibazo:

• Ibibazo bikomeye by'umwijima cyangwa imyunyu y'umwijima yazamutse
• Indwara zikomeye zitagenzurwa
• Kubagwa bikomeye bya vuba cyangwa ibikomere bikira bigurumuka
• Indwara zikomeye z'impyiko
• Ibibazo by'umutima cyangwa umutima wateye vuba
• Amateka y'allergie ikomeye ku miti ya taxane
• Ubuzima bubi muri rusange

Imyaka yonyine ntigutera kuba utabona cabazitaxel, ariko abantu bakuze bashobora gukurikiranwa cyane kubera ingaruka ziterwa. Umuganga wawe w'indwara z'umwijima azagereranya inyungu zishoboka n'akaga gashingiye ku buzima bwawe bwite.

Amazina y'ubwoko bwa Cabazitaxel

Cabazitaxel iboneka munsi y'izina ry'ubwoko rya Jevtana, ikorwa na Sanofi. Iyi ni verisiyo y'umwimerere kandi ikoreshwa cyane ya cabazitaxel iboneka mu bihugu byinshi.

Verisiyo rusange ya cabazitaxel ishobora kuboneka mu turere tumwe na tumwe, nubwo zikubiyemo ibintu bikora kimwe kandi zigakora kimwe na verisiyo y'izina ry'ubwoko. Farumasi yawe n'ikigo cy'ubwishingizi bizafasha kumenya verisiyo uzabona.

Bitewe n'ubwoko wabona, umuti ubwawo usa neza mu bijyanye n'imikorere n'ingaruka ziterwa. Itandukaniro rikuru rishobora kuba mu gupakira, imiterere, cyangwa igiciro, ariko inyungu zivura ziracyahari.

Uburyo bwa Cabazitaxel

Niba cabazitaxel itagukwiriye cyangwa ikaba itagikora neza, hari ubundi buryo bwo kuvura kanseri ya prostate igeze kure. Umuganga wawe w’inzobere mu kuvura kanseri azagufasha gushakisha izo nzira zindi zishingiye ku bibazo byawe byihariye.

Ubwoko bundi bwo kuvura na sima burimo docetaxel, akenshi igeragezwa mbere ya cabazitaxel, na mitoxantrone, ishobora gutekerezwa mu kugenzura ibimenyetso. Ubuvuzi bushya bwibanda ku ntego nka enzalutamide, abiraterone, na darolutamide butanga uburyo butandukanye bwo gukora.

Uburyo bwongereweho umuganga wawe ashobora gutekereza burimo:

• Radium-223, ubuvuzi bukoresha imirasire ku gice cy’amagufa cyateweho n’indwara
• Sipuleucel-T, ubuvuzi bwo gukoresha imbaraga z’umubiri
• Olaparib cyangwa rucaparib ku barwayi bafite impinduka zidasanzwe za genetike
• Lutetium-177 PSMA ku bwoko bumwe bwa kanseri ya prostate igeze kure
• Igeragezwa ryo kuvura rishya rigeragezwa

Uburyo bwiza bushingiye ku buvuzi wahawe mbere, ibisubizo byo gupima genetike, ubuzima bwawe muri rusange, n'ibyifuzo byawe bwite. Itsinda ryawe ry’ubuvuzi rizakorana nawe kugira ngo ribone intambwe ikwiriye ikurikira.

Ese Cabazitaxel iruta Docetaxel?

Cabazitaxel na docetaxel zombi ni imiti ikora neza ya sima ya kanseri ya prostate, ariko akenshi zikoreshwa mu byiciro bitandukanye by’ubuvuzi. Docetaxel akenshi ni uburyo bwa mbere bwo kuvura na sima, mu gihe cabazitaxel yagenewe igihe docetaxel itagikora.

Ubushakashatsi bwerekana ko cabazitaxel ishobora gukora neza niyo docetaxel yanze gukora, bigatuma iba uburyo bwiza bwo gukoresha kuva ku murongo wa kabiri. Ariko, ibyo ntibisobanura ko cabazitaxel “iruta” docetaxel - bakora ibintu bitandukanye mu rugendo rwawe rw’ubuvuzi.

Cabazitaxel ishobora gutera ingaruka zitandukanye na docetaxel, kandi abarwayi bamwe babyihanganira kurusha abandi. Umuganga wawe w’inzobere mu kuvura kanseri azahitamo umuti ukwiriye cyane bitewe n’amateka yawe y’ubuvuzi, uko ubuzima bwawe buhagaze ubu, n’imiterere yihariye ya kanseri.

Ibibazo Bikunze Kubazwa ku bijyanye na Cabazitaxel

Ese Cabazitaxel ifitiye umutekano abarwayi ba diyabete?

Muri rusange, Cabazitaxel ishobora gukoreshwa neza ku bantu barwaye diyabete, nubwo urugero rw'isukari mu maraso yawe rushobora gukenera gukurikiranwa cyane mugihe uvurwa. Imiti uhabwa mbere yo kuvurwa, cyane cyane imiti ya corticosteroid, ishobora kuzamura urugero rw'isukari mu maraso by'agateganyo.

Korana bya hafi n'abaganga bavura kanseri yawe ndetse n'ikipe ikuvura diyabete kugirango uhindure imiti yawe ya diyabete niba bibaye ngombwa. Gerageza urugero rw'isukari mu maraso yawe kenshi kuruta uko bisanzwe, cyane cyane ku munsi wo kuvurwa no muminsi mike nyuma yaho.

Nigute nzakora niba nirengagije urugero rwa Cabazitaxel?

Kubera ko cabazitaxel itangwa mu kigo cy'ubuvuzi, ntuzirengagiza urugero rwawo mu rugo. Niba ukeneye gusubika kuvurwa kwateganyijwe kubera uburwayi, umubare muto w'uturemangingo tw'amaraso, cyangwa izindi mpungenge z'ubuzima, vugana n'umuganga wawe uvura kanseri vuba bishoboka.

Ikipe ikuvura izagena igihe bizaba byemewe kongera kuvurwa kwawe. Rimwe na rimwe gutinda birakenewe kugirango umubiri wawe ukire, kandi ibi ntibizahungabanya ibisubizo byo kuvurwa kwawe.

Nshobora guhagarika ryari gufata Cabazitaxel?

Umwanzuro wo guhagarika cabazitaxel biterwa n'ibintu byinshi, harimo uburyo ubuvuzi buri kugenzura kanseri yawe neza n'uburyo urimo guhangana n'ingaruka ziterwa n'umuti. Umuganga wawe uvura kanseri azagenzura buri gihe uko urimo witwara akoresheje ibizamini by'amaraso n'ibizamini by'amashusho.

Ushobora guhagarika kuvurwa niba kanseri ikomeje nubwo uvurwa, niba ingaruka ziterwa n'umuti zikomeje kuba zikomeye cyane, cyangwa niba wowe n'umuganga wawe mwemeza ko inyungu zitagihwanye n'ibibazo. Ntukigere uhagarika kuvurwa utabanje kubiganiraho n'ikipe ikuvura.

Nshobora gukora nkorera mugihe mvurwa na Cabazitaxel?

Abantu benshi barashobora gukomeza gukora mugihe bakira cabazitaxel, nubwo bishobora kuba ngombwa ko uhindura gahunda yawe cyangwa inshingano zawe. Umunaniro ni ibisanzwe kandi ushobora kumara iminsi myinshi nyuma ya buri cyiciro cyo kuvurwa.

Tekereza gutegura imirimo yoroheje nyuma yo guterwa imiti, kandi witegure gufata ikiruhuko niba ugize indwara zandura cyangwa izindi ngorane. Ganira n'abakugenzura ubuzima kugira ngo mutegure gahunda ifatika.

Ese Cabazitaxel izagira ingaruka ku bushobozi bwanjye bwo kubyara?

Cabazitaxel ishobora kugira ingaruka ku burezi mu bagabo kandi ishobora guteza ibibazo bya genetike ku ntanga. Niba uteganya kubyara mu gihe kizaza, ganira n'umuganga wawe w'indwara z'umwijima mbere yo gutangira kuvurwa ku bijyanye n'uburyo bwo kubungabunga uburezi.

Koresha uburyo bwo kuboneza urubyaro neza mu gihe uvurwa no mu mezi make nyuma yaho, nk'uko byategetswe n'abakugenzura ubuzima. Umuti ushobora kuguma mu mubiri wawe igihe gito nyuma yo gufata urugero rwawo rwa nyuma.