Colistimethate ni iki: Ibyo ikoreshwa, urugero, ingaruka ziterwa n'iyo miti n'ibindi

Colistimethate ni umuti ukomeye wica mikorobe abaganga bakoresha iyo izindi miti zitagize icyo zimarira abarwayi bafite indwara ziterwa na mikorobe zikomeye. Uyu muti ubarizwa mu itsinda ry'imiti yitwa polymyxins, ifatwa nk'imiti ikoreshwa nk'uburyo bwa nyuma bwo kuvura indwara ziterwa na mikorobe ziteje ubuzima akaga zidakira iyo zivuwe n'indi miti myinshi.

Uyu muti utangwa mu nshinge, haba mu urwungano rw'amaraso cyangwa mu mutsi, kuko ugomba gukora vuba kandi neza mu mubiri wawe wose. Nubwo ari umuti ukomeye ushobora kurokora ubuzima, ugira n'ingaruka zishobora guterwa n'iyo miti, kandi ikipe y'abaganga ikurikirana neza.

Colistimethate ikoreshwa mu kuvura iki?

Colistimethate ivura indwara zikomeye ziterwa na mikorobe zidakira iyo zivuwe n'indi miti. Muganga wawe azagusaba uyu muti iyo ufite indwara ikomeye kandi izindi miti zitagize icyo zimarira.

Indwara zisanzwe zivurwa na colistimethate zirimo umusonga, indwara zifata amaraso, indwara zifata mu nzira y'inkari, n'indwara zifata uruhu. Uyu muti ufitiye akamaro kanini kurwanya mikorobe nka Pseudomonas aeruginosa, Acinetobacter, n'ubwoko bumwe bwa E. coli bwanze gukira iyo zivuwe n'imiti myinshi.

Rimwe na rimwe abaganga bakoresha colistimethate mu gukumira indwara ku bantu bari mu kaga gakomeye, nk'abafite cystic fibrosis cyangwa abarwayi bari mu bitaro byita ku barwayi barembye. Ariko, ubu buryo bwo gukumira indwara ntibusanzwe kandi bisaba ko hazirikanwa neza inyungu n'ingaruka ziterwa n'iyo miti.

Colistimethate ikora ite?

Colistimethate ikora igaba ibitero ku rukuta rw'inyuma rw'uturemangingo twa mikorobe, bigatuma dusenyuka tugasenyuka. Bitekereze nk'aho utobora umupira - iyo urukuta rw'uturemangingo twa mikorobe rwangiritse, mikorobe ntizishobora kubaho.

Uyu ni umuti ukomeye wica mikorobe wagenewe kurwanya bagiteri zateje ubwihishwe ku yindi miti. Ni icyo abaganga bita "antibiyotike yica bagiteri", bivuze ko yica bagiteri aho kubuza gusa imikurire yazo.

Uyu muti uhindurwamo ishusho yawo ikora yitwa colistin iyo winjiye mu mubiri wawe. Iyi nzira yo guhindura ifasha kugabanya ingaruka zimwe na zimwe mu gihe igifite imbaraga zikomeye zo kurwanya bagiteri.

Nagomba Kufata Nte Colistimethate?

Uzakira colistimethate nk'urushinge mu bitaro cyangwa ahantu hakorerwa ibizamini, ntabwo ari nk'ipilule ufata mu rugo. Uyu muti utangwa unyuze mu muyoboro wa IV mu mitsi yawe cyangwa nk'urushinge mu mikaya yawe, bitewe n'uko ubuzima bwawe bumeze.

Itsinda ry'abaganga bazakubarurira urugero rw'umuti uzakoresha hashingiwe ku gipimo cy'uburemere bwawe, imikorere y'impyiko zawe, n'uburemere bw'ubwandu ufite. Ubuvuzi busanzwe bukubiyemo guhabwa umuti inshuro 2-4 ku munsi, buri rugero rutangwa buhoro buhoro mu gihe cy'iminota 30 kugeza ku masaha 2 niba binyuze muri IV.

Ntabwo ukeneye guhangayika ku bijyanye no gufata uyu muti hamwe n'ibiryo kuko utangwa nk'urushinge. Ariko, ni ngombwa kuguma ufite amazi ahagije mu gihe uvurwa, bityo unywe amazi menshi keretse muganga wawe akubwiye ibitandukanye.

Itsinda ry'abaganga bazakugenzura neza mu gihe uvurwa, bakora ibizamini by'amaraso buri gihe kugira ngo barebe niba umuti ukora neza kandi udatera ingaruka mbi.

Nzamara Igihe Kingana Iki Ndafata Colistimethate?

Ubusanzwe ubuvuzi bwa colistimethate bumara iminsi 7 kugeza kuri 14, ariko ibi birashobora gutandukana cyane bitewe n'ubwandu ufite n'uko witwara ku buvuzi. Muganga wawe azagena igihe nyacyo hashingiwe ku bintu bitandukanye.

Ku ndwara nyinshi ziterwa na mikorobe, uzakenera gukomeza kuvurwa kugeza igihe ibizamini byo muri laboratori byerekana ko mikorobe zashize kandi ibimenyetso byawe byarushijeho gukira. Indwara zimwe zikomeye zishobora gusaba igihe kirekire cyo kuvurwa, mu gihe izindi zishobora gukira vuba.

Itsinda ryawe ryita ku buzima rizakurikirana uko urimo urushaho gukira binyuze mu bizamini by'amaraso bya buri gihe, ibizamini byerekana ishusho y'umubiri, n'ibizamini by'umubiri. Bazareba kandi ibimenyetso byerekana ko indwara irimo irakira, nk'uko umuriro ugabanuka, guhumeka neza, cyangwa gukira kw'ibikomere byanduye.

Ni ngombwa kurangiza umuti wose nubwo watangira kumva urushijeho gukira. Guhagarika hakiri kare bishobora gutuma mikorobe zongera kugaruka zikomeye kandi zitarinda imiti.

Ni Ibihe Bimenyetso Bigaragara Byatewe na Colistimethate?

Kimwe n'imiti yose ikomeye, colistimethate ishobora gutera ibimenyetso bigaragara, nubwo atari buri wese ubigeraho. Ibimenyetso bigaragara cyane muri rusange birashobora gucungwa kandi itsinda ryawe ry'abaganga rizabikurikirana neza.

Dore ibimenyetso bigaragara ushobora guhura nabyo, dutangiriye ku bya kenshi bibaho:

• Ibibazo by'impyiko, harimo impinduka mu kunyara cyangwa kubyimba amaguru cyangwa ibirenge
• Kuribwa umutwe cyangwa kumva utameze neza, cyane cyane iyo uhagaze
• Kumva urugero cyangwa guhumeka mu ntoki, ibirenge, cyangwa hafi y'umunwa wawe
• Isesemi cyangwa kuribwa mu nda
• Urubavu cyangwa kurakara ahaterwa urushinge
• Umutwe cyangwa kumva uhuzagurika
• Ubugwari bw'imitsi cyangwa kugorana kw'imikorere

Ibyinshi muri ibi bimenyetso biroroshye kandi by'igihe gito, ariko itsinda ryawe ry'abaganga rizakurikirana neza kugira ngo ribone ibibazo byose hakiri kare. Bazagenzura buri gihe imikorere y'impyiko zawe n'uburyo imitsi yawe ikora mu gihe uvurwa.

Ibimenyetso bimwe na bimwe bidakunze kubaho ariko bikomeye birimo kwangirika gukomeye kw'impyiko, ibibazo byo guhumeka, cyangwa impinduka zikomeye mu miterere yawe yo mu mutwe. Itsinda ryawe ry'abaganga ryatojwe kumenya ibi bimenyetso kandi rizafata ingamba ako kanya niba bibaye.

Ni Bande Batagomba Gufata Colistimethate?

Colistimethate ntiribereye buri wese, kandi muganga wawe azasuzuma neza amateka yawe y'ubuzima mbere yo kukwandikira. Abantu bafite indwara zimwe na zimwe bashobora gukenera imiti itandukanye cyangwa gukurikiranwa by'umwihariko.

Ntabwo ukwiye guhabwa colistimethate niba ufite allergie kuri colistin, imiti ya polymyxin, cyangwa ibintu byose biri muri uyu muti. Bwira ikipe yawe y'ubuzima ku bijyanye n'uburwayi bwose bwa allergie bwigeze kubaho kuri antibiotike, n'iyo byasa nkaho bitajyanye.

Abantu bafite ibibazo by'impyiko basanzwe bakeneye kwitabwaho by'umwihariko, kuko colistimethate ishobora kugira ingaruka ku mikorere y'impyiko. Muganga wawe azagereranya inyungu n'ibibazo bishobora kuvuka kandi ashobora guhindura urugero rwawe cyangwa agahitamo undi muti niba impyiko zawe zitagikora neza.

Niba ufite myasthenia gravis (indwara yo kunanirwa kw'imitsi), ibibazo by'imitsi, cyangwa ibibazo byo kumva, muganga wawe azakenera kugukurikirana neza cyane. Izi ndwara zirashobora kwiyongera na colistimethate, nubwo kuvurwa bishobora kuba ngombwa niba ufite indwara ikomeye.

Abagore batwite kandi bonka bagomba kwitabwaho by'umwihariko, kuko hari amakuru make yerekeye umutekano wa colistimethate mugihe cyo gutwita. Muganga wawe azabikwandikira gusa niba inyungu zigaragara neza kurusha ibibazo bishobora kuvuka.

Amazina y'ubwoko bwa Colistimethate

Colistimethate iboneka munsi y'amazina menshi y'ubwoko, Coly-Mycin M ikaba ari imwe mu zisanzwe muri Leta Zunze Ubumwe z'Amerika. Andi mazina y'ubwoko arimo Colistin na Promixin, nubwo kuboneka bitandukanye bitewe n'igihugu.

Izina rusange

Iyo colistimethate idakwiriye cyangwa itaboneka, muganga wawe ashobora gutekereza ku zindi antibiyotike, nubwo amahitamo ya bagiteri zirwanya ari make. Ihitamo riterwa na bagiteri zirimo gutera ubwandu bwawe n'uburyo zihanganira imiti itandukanye.

Izindi nzira zirimo tigecycline, ikora ku bagiteri nyinshi zirwanya, cyangwa imiti ivanze ikoresha antibiyotike nyinshi icyarimwe. Imiti mishya nka ceftazidime-avibactam cyangwa meropenem-vaborbactam nayo ishobora kuba amahitamo yo mu bwoko bumwe bw'ubwandu.

Mu bihe bimwe na bimwe, muganga wawe ashobora kugerageza polymyxin B, ifitanye isano rya hafi na colistimethate kandi ikora kimwe. Ariko, ibyerekeye ingaruka zisa cyane, bityo iyi ntabwo buri gihe iba inzira nziza niba waragize ibibazo na colistimethate.

Ukuri ni uko ku bw'ubwandu bwinshi burwanya cyane, colistimethate ikomeza kuba imwe mu miti ikora cyane iboneka. Itsinda ryawe ry'abaganga rihora rigerageza gushaka uburyo bwiza kandi bukora neza ku miterere yawe yihariye.

Ese Colistimethate iruta izindi antibiyotike?

Colistimethate ntabwo ari ngombwa ko "iruta" izindi antibiyotike - ikora gusa ku bagiteri zititabira izindi miti. Tekereza nk'igikoresho cyihariye cy'ibihe byihariye aho kuba umuti usumba iyindi muri rusange.

Ku bw'ubwandu buterwa na bagiteri zihanganira izindi antibiyotike, abaganga bazakunda guhitamo izo zindi nzira mbere na mbere. Ibi ni uko colistimethate ifite ibyago byinshi by'ingaruka, cyane cyane ku mpyiko no ku mikorere y'imitsi.

Imbaraga za colistimethate ziri mu bushobozi bwayo bwo kurwanya bagiteri zirwanya imiti myinshi iyo izindi antibiyotike zananiranye. Muri ibi bihe biteye ubuzima bw'akaga, birashobora kuba bikiza ubuzima, bigatuma bitagaciro nubwo bifite ibyago.

Muganga wawe azahora agerageza gukoresha umuti wica mikorobe woroshye kandi ukora neza mbere na mbere, akajya ku bindi byemezo bikomeye nka colistimethate gusa igihe bibaye ngombwa. Ubu buryo bufasha kubungabunga imikorere y'iyo miti ikomeye igihe ikenewe rwose.

Ibibazo bikunze kubazwa kuri Colistimethate

Ese Colistimethate irakwiriye ku bantu barwaye indwara z'impyiko?

Colistimethate ishobora kugira ingaruka ku mikorere y'impyiko, bityo abantu bafite ibibazo by'impyiko basanzwe bakeneye ubufasha bwihariye no gukurikiranwa. Muganga wawe azahindura urugero rw'umuti ukurikije uko impyiko zawe zikora neza kandi azajya asuzuma imikorere y'impyiko zawe buri gihe mu gihe cy'ubuvuzi.

Niba ufite ibibazo byoroheje by'impyiko, ushobora gukomeza guhabwa colistimethate hamwe n'urugero rugabanutse no gukurikiranwa cyane. Ariko, niba imikorere y'impyiko zawe yarangiritse cyane, muganga wawe ashobora gukenera gutekereza ku zindi nshuti cyangwa gukoresha colistimethate gusa igihe bibaye ngombwa rwose.

Nkwiriye gukora iki niba ngize ingaruka zikomeye?

Kubera ko uzahabwa colistimethate mu bitaro cyangwa ahantu hakorerwa ibizamini, itsinda ry'abaganga bazaba bakurikirana hafi ingaruka zikubaho. Niba ubonye ibimenyetso bibangamiye nk'ingorane zo guhumeka, kuribwa cyane, cyangwa impinduka zikomeye mu kunyara, bimenyeshe umuforomo wawe cyangwa muganga ako kanya.

Ntugire impungenge zo kubuza abakozi b'ubuvuzi - barashaka kumenya ibimenyetso byose urimo guhura nabyo. Kumenya no kuvura ingaruka hakiri kare birashobora gukumira ibibazo bikomeye kurushaho.

Bikunda gute niba nciwe urugero rwa colistimethate?

Kubera ko colistimethate itangwa n'abakora mu buvuzi mu rwego rw'ubuvuzi, ntuzagomba guhangayika no gucikanwa n'urugero. Itsinda ryawe ry'ubuvuzi rizagufasha guhabwa imiti yawe ku gihe nk'igice cy'ubuvuzi bwawe.

Niba hari impamvu ituma urukingo rutinda kubera ibikorwa byo kwa muganga cyangwa izindi nshingano, itsinda ry'abaganga bazahindura igihe bikwiye. Bazakora uko bashoboye kugira ngo urugendo rwose rw'ubuvuzi rukenewe ku ndwara yawe rukorwe.

Ni ryari nshobora guhagarika gufata Colistimethate?

Ntabwo ugomba na rimwe guhagarika ubuvuzi bwa colistimethate ku bushake bwawe - iki cyemezo kigomba gufatwa n'itsinda ry'abaganga rishingiye ku buryo wabyakiriyeho mu buvuzi n'ibisubizo by'ibizamini. Guhagarika kare bishobora gutuma indwara igaruka ikomeye kurusha mbere.

Muganga wawe azagena igihe cyo guhagarika ubuvuzi ashingiye ku bintu bitandukanye: ibimenyetso byawe biragenda bikira, ibizamini by'amaraso byerekana ko indwara irimo gukira, no kwemeza ko umaze gufata imiti ihagije kugira ngo wirinde ko bagiteri zagaruka.

Ese Colistimethate ishobora guhura n'indi miti?

Yego, colistimethate ishobora guhura n'indi miti myinshi, ni yo mpamvu itsinda ryawe ry'abaganga rizasuzuma imiti yose ufata ubu mbere yo gutangira ubuvuzi. Uburyo bukunze kugaragara ni hamwe n'indi miti ishobora kugira ingaruka ku mpyiko cyangwa sisitemu y'imitsi.

Imiti nk'imiti yica mikorobe ya aminoglycoside, imiti imwe yo gukuramo amazi, n'imiti imwe yo kurwanya ububabare bishobora kongera ibyago byo kurwara impyiko iyo bivanzwe na colistimethate. Itsinda ryawe ry'abaganga rizakurikirana neza iyi mikoranire kandi rishobora guhindura doze cyangwa igihe cy'indi miti uko bikwiye.