Crizotinib ni iki: Ibikoreshwa, Urutonde rw'imiti, Ingaruka zayo n'ibindi

Crizotinib ni umuti w'indwara ya kanseri ugamije gufasha kugabanya imikurire y'ubwoko bumwe bwa kanseri y'ibihaha. Ukora ubugizi bwa nabi mu guhagarika poroteyine zihariye zikenewe n'uturemangingo twa kanseri kugira ngo dukure kandi twisanzure mu mubiri wawe.

Uyu muti ugaragaza iterambere rikomeye mu kuvura kanseri hakurikijwe uko umuntu ameze. Muganga wawe akenshi azategeka ko hakorwa isuzuma rya genetike ry'igishyitsi cyawe mbere yo gutanga crizotinib kugira ngo yemeze ko ikwiriye ubwoko bwa kanseri yawe.

Crizotinib ni iki?

Crizotinib ni umuti wa kanseri unyobwa mu kanwa, ukaba mu cyiciro cy'imiti yitwa tyrosine kinase inhibitors. Igamije by'umwihariko uturemangingo twa kanseri mugihe itera ibyangiritse bike ku turemangingo twiza ugereranije na shimi ya kera.

Uyu muti uza mu buryo bwa capsule kandi ufata mu kanwa kabiri ku munsi. Yabanje kwemezwa na FDA mu 2011 kuva icyo gihe yafashije ibihumbi by'abarwayi bafite ubwoko bwihariye bwa kanseri y'ibihaha kubaho igihe kirekire, ubuzima bwiza.

Tekereza crizotinib nk'igikoresho gikora neza cyane gishobora kumenya no guhagarika ibimenyetso byihariye bibwira uturemangingo twa kanseri gukura. Ubu buryo bugamije akenshi busobanura ingaruka nke ugereranije n'imiti ya kanseri yagutse.

Crizotinib ikoreshwa mu iki?

Crizotinib ikoreshwa cyane cyane mu kuvura kanseri y'ibihaha idafite uturemangingo duto (NSCLC) ifite impinduka zihariye za genetike. Kanseri yawe igomba gupimwa neza kuri ALK gene rearrangements cyangwa ROS1 gene rearrangements kugira ngo uyu muti ugire akamaro.

Uyu muti akenshi utangwa iyo kanseri yageze mu bindi bice by'umubiri wawe cyangwa iyo kubagwa bidashoboka. Ifatwa nk'imiti ya mbere, bivuze ko akenshi ari umuti wa mbere muganga wawe azagerageza kuri ubwo bwoko bwihariye bwa kanseri.

Mu bindi bihe, crizotinib ishobora gukoreshwa ku bwoko bwa kanseri zidakunze kuboneka zifite impinduka za gene ya ALK, nka tumor ya myofibroblastic itera umubyimbirwe. Muganga wawe w’inzobere mu by’indwara z’umubiri azagena niba ubwoko bwa kanseri yawe n’imiterere yawe ya genetike bigutera kuba umukandida mwiza kuri ubu buvuzi.

Crizotinib ikora ite?

Crizotinib ikora ibuza poroteyine zidasanzwe zikoreshwa na selile za kanseri kugira ngo zikure kandi zigwize. By’umwihariko, yibanda kuri poroteyine za ALK na ROS1 zaba zarakabije kubera impinduka za genetike muri selile za kanseri yawe.

Uyu muti ufashwe nk'ubuvuzi bukomeye bwa kanseri burushaho kwibanda kurusha imiti gakondo ya shimi. Ibangamira ubushobozi bwa selile ya kanseri bwo kwakira ibimenyetso byo gukura, mu by'ukuri bigatuma selile za kanseri zicwa n'ibyo zikeneye kugira ngo zibaho kandi zikwire.

Ubushishozi bwa crizotinib buri mu buryo bwayo bwihariye. Mugihe imiti gakondo ya shimi igira ingaruka ku selile nzima n'iza kanseri, crizotinib yibanda cyane ku selile zifite ibitagenda neza bya genetike. Ubu buryo bwihariye akenshi butanga ibisubizo byiza bifite ingaruka nke zikomeye.

Nkwiriye gufata crizotinib nte?

Fata crizotinib nk'uko muganga wawe abitegeka, akenshi kabiri ku munsi ufite cyangwa udafite ibiryo. Mimina ibinini byose hamwe n'ikirahure kinini cy'amazi, kandi ntukoreshe, ntukore cyangwa ngo ubifungure.

Urashobora gufata crizotinib hamwe n'ibiryo niba bibabaza igifu cyawe, nubwo ibiryo bitakenewe kugirango byinjire. Abarwayi benshi basanga kubifata hamwe n'akaboga gato bifasha kugabanya isesemi, ikaba ari ingaruka zisanzwe.

Gerageza gufata imiti yawe mu gihe kimwe buri munsi, nka saa 12 zose. Ibi bifasha gukomeza urwego rwa medicament mu maraso yawe. Niba ufata indi miti, ganira n'umuganga wawe ku gihe cyo kuyifata kugirango wirinde guhura bishoboka.

Irinde pome na jus ya pome mugihe ufata crizotinib, kuko bishobora kongera umubare wa medicament mu maraso yawe kandi bishobora gutera izindi ngaruka.

Nzamara Crizotinib Mvuga Ryari?

Abantu benshi bakomeza gufata crizotinib igihe cyose ikiri gucunga kanseri yabo kandi ingaruka zikaba zigikora. Ibi bishobora kumara amezi cyangwa imyaka, bitewe n'uko kanseri yawe yitabira neza ubuvuzi.

Muganga wawe azakurikiza uko urimo utera imbere binyuze mu bipimo bisanzwe no mu bizami by'amaraso, akenshi buri mezi 2-3 mu ntangiriro. Ibi bizami bifasha kumenya niba umuti ukora neza kandi niba ugomba gukomeza kuvurwa.

Abantu bamwe bashobora gukenera guhagarika gufata crizotinib niba ingaruka zikomeye cyane, mu gihe abandi bashobora guhindurirwa imiti itandukanye niba kanseri yabo yigaragambije. Gahunda yawe y'ubuvuzi izahuzwa n'uburyo wabyitwayemo n'ubuzima bwawe muri rusange.

Ni Iyihe Ngaruka Ziterwa na Crizotinib?

Kimwe n'indi miti yose ya kanseri, crizotinib ishobora gutera ingaruka, nubwo atari buri wese uzibona. Ingaruka nyinshi zishobora gucungwa kandi akenshi zikagenda zikemuka umubiri wawe umaze kumenyera umuti.

Dore ingaruka zisanzwe ushobora guhura nazo:

• Isesemi no kuruka
• Impiswi cyangwa guhagarara k'amara
• Umunaniro no kunanuka
• Ukubura mu maguru, mu birenge, cyangwa hafi y'amaso
• Impinduka mu iyerekwa, harimo guhumirwa cyangwa kubona imirasire y'umucyo
• Urugero cyangwa guhumirwa
• Kugabanya ubushake bwo kurya
• Uruhu rurashya

Izi ngaruka zisanzwe akenshi ziba zoroshye kugeza ku gipimo cyo hagati kandi akenshi zishobora gucungwa no gufashwa cyangwa guhindura imiti.

Ingaruka zikomeye zirashobora kubaho, nubwo zitabaho kenshi. Ni ngombwa kubimenya kugirango ushobore gushaka ubufasha bw'ubuvuzi niba bibaye ngombwa:

• Ibibazo by'umwijima (uruhu cyangwa amaso y'umuhondo, inkari z'umukara, umunaniro ukabije)
• Uburwayi bwo mu bihaha (gukorora gushya cyangwa gukomera, guhumeka bigoranye, kuribwa mu gituza)
• Ibibazo by'umutima (umutima utera nabi, kuribwa mu gituza, kugwa igihumure)
• Ibibazo bikomeye by'impyiko (imihindukire mu kunyara, kubyimba)
• Urugero rukabije rw'uburwayi bwo mu mubiri (kubura umwuka, ibiheri bikabije, kubyimba mu maso cyangwa mu muhogo)

Vugana n'ikipe yawe y'ubuzima ako kanya niba ubonye izi ngaruka zikomeye. Bashobora gutanga ubujyanama no guhindura imiti yawe niba bibaye ngombwa.

Ninde utagomba gufata Crizotinib?

Crizotinib ntikwiriye kuri buri wese, kandi ibibazo by'ubuzima runaka cyangwa ibihe bishobora gutuma bitakugirira neza. Muganga wawe azasuzuma ubuzima bwawe muri rusange mbere yo kugutera uyu muti.

Ntabwo ugomba gufata crizotinib niba ufite allergie kuri uyu muti cyangwa ibikubiye muri wo. Byongeye kandi, abagore batwite bagomba kwirinda crizotinib kuko ishobora kwangiza umwana uri mu nda.

Abantu bafite ibibazo by'ubuzima runaka bakeneye kwitonda cyane cyangwa ntibashobora kuba bakwiriye guhabwa umuti wa crizotinib:

• Uburwayi bukomeye bw'umwijima cyangwa imikorere mibi y'umwijima
• Uburwayi bukomeye bw'impyiko
• Uburwayi bw'umutima cyangwa indwara zikomeye z'umutima
• Uburwayi bukomeye bw'ibihaha cyangwa ibibazo byo guhumeka
• Gusama cyangwa konsa

Muganga wawe azatekereza kandi ku yindi miti ufata, kuko crizotinib ishobora guhura n'imiti myinshi. Jya uhora utanga urutonde rwuzuye rw'imiti yose, ibyongerera imbaraga, n'ibicuruzwa by'ibyatsi ufata.

Amazina y'ubwoko bwa Crizotinib

Crizotinib igurishwa ku izina ry'ubwoko rya Xalkori muri Leta Zunze Ubumwe z'Amerika no mu bindi bihugu byinshi. Iri ni izina ry'ubwoko rya mbere ryakozwe na Pfizer, isosiyete ikora imiti yaremye uyu muti.

Ushobora kandi kubona crizotinib yitwa izina ryayo rusange mu nyandiko z'ubuvuzi cyangwa iyo uvugana n'ikipe yawe y'ubuzima. Amazina yombi yerekeza ku muti umwe ufite ibikoresho bifatika bimwe.

Ubwoko rusange bwa crizotinib bushobora kuboneka mu gihe kizaza, ariko ubu, Xalkori nicyo kirango cyibanze kiboneka ku masoko menshi.

Izindi nzira za Crizotinib

Imiti myinshi isimbura iraboneka mu kuvura kanseri y'ibihaha ya ALK-positive na ROS1-positive. Muganga wawe ashobora kubitekereza niba crizotinib itagukwiriye cyangwa niba kanseri yawe yigaragaza ko irwanya imiti.

Kubera kanseri y'ibihaha ya ALK-positive, izindi nzira zirimo alectinib (Alecensa), ceritinib (Zykadia), na brigatinib (Alunbrig). Iyi miti mishya rimwe na rimwe ikoreshwa nk'imiti ya mbere cyangwa iyo crizotinib ihagaritse gukora.

Ubuvuzi gakondo bwa chemotherapy buguma kuba uburyo, nubwo imiti igamije nka crizotinib akenshi itanga ibisubizo byiza hamwe n'ingaruka nkeya kubarwayi bafite ibimenyetso by'imiryango ikwiye. Umuganga wawe w'inzobere mu kuvura kanseri azagufasha kumenya uburyo bwiza bwo kuvura uburyo bwihariye.

Ese Crizotinib iruta Alectinib?

Crizotinib na alectinib ni imiti ikora neza mu kuvura kanseri y'ibihaha ya ALK-positive, ariko ubushakashatsi bwa vuba aha butanga ko alectinib ishobora kugira ibyiza nk'imiti ya mbere. Guhitamo hagati yabo biterwa n'ubuzima bwawe bwihariye n'amateka y'ubuvuzi.

Alectinib isa nkaho ikora neza mu kurinda kanseri gukwirakwira mu bwonko kandi ishobora gutera ingaruka nkeya kubarwayi bamwe. Ariko, crizotinib imaze igihe ikoreshwa kandi ifite uburambe bwinshi bw'isi yose bushyigikira imikorere yayo.

Umuganga wawe w'inzobere mu kuvura kanseri azatekereza ibintu nk'ubuzima bwawe muri rusange, izindi ndwara, ingaruka zishobora guterwa, n'ibyo ukunda wowe ubwawe mugihe uhitamo hagati yiyi miti. Byombi ni uburyo bwiza bwo kuvura kanseri y'ibihaha ya ALK-positive.

Ibibazo Bikunze Kubazwa Kuri Crizotinib

Ese Crizotinib Ifitiye Umutekano Abantu Barwaye Indwara z'Umutima?

Crizotinib ishobora kugira ingaruka ku mutima, bityo abantu bafite indwara z'umutima basanzwe barwaye bakenera gukurikiranwa neza. Muganga wawe ashobora gutuma ukorerwa ikizamini cya electrocardiogram (EKG) mbere yo gutangira kuvurwa no mu gihe cyose uvurwa.

Niba urwaye indwara y'umutima, umuganga w'umutima wawe n'umuganga w'indwara z'umubiri bazakorana kugira ngo bamenye niba crizotinib ifitiye umutekano. Bashobora guhindura imiti y'umutima wawe cyangwa bakagukurikiranira hafi, ariko abarwayi benshi bafite indwara z'umutima barashobora gufata crizotinib mu buryo bw'umutekano.

Nkwiriye Gukora Iki Niba Nifashe Crizotinib Nyinshi Mu buryo Butunganye?

Niba ufata crizotinib nyinshi mu buryo butunganye kuruta uko byategetswe, vugana n'umuganga wawe cyangwa ikigo gishinzwe kugenzura uburozi ako kanya. Ntugasubize inyuma ngo utegereze ibimenyetso, kuko kwitabwaho n'abaganga vuba ni ingenzi.

Ibimenyetso byo kurenza urugero bishobora kuba birimo isesemi ikabije, kuruka, impiswi, cyangwa isereri. Bika urupapuro rw'imiti hamwe nawe igihe ujya kwa muganga kugira ngo abaganga bamenye neza icyo wafashe n'ingano yacyo.

Nkwiriye Gukora Iki Niba Nsibye Dosi Ya Crizotinib?

Niba usibye dosi kandi hashize amasaha arenga 6 mbere yuko ufata dosi ikurikira, fata dosi wasibye ako kanya wibukira. Niba hasigaye amasaha atageze kuri 6 mbere yuko ufata dosi ikurikira, reka dosi wasibye ukomeze gahunda yawe isanzwe.

Ntuzigere ufata dosi ebyiri icyarimwe kugira ngo usimbure dosi wasibye. Ibi birashobora kongera ibyago byo kugira ingaruka ziterwa n'imiti utagize akamaro kongeraho. Niba ukunda kwibagirwa dosi, tekereza gukoresha umuteguro w'imiti cyangwa gushyiraho ibyibutso kuri terefone yawe.

Nshobora Kureka Gufata Crizotinib Ryari?

Reka gusa gufata crizotinib mugihe muganga wawe akubwiye ko ari umutekano kubikora. N'iyo wumva urimo gukira, imiti irashobora kuba igikora kugira ngo igenzure kanseri yawe, kandi guhagarara ako kanya byatuma kanseri yongera gukura.

Muganga wawe azakoresha ibizamini bisanzwe byo mu mashini n'ibizamini by'amaraso kugira ngo akurikirane uko urugero rwawe rwitwara ku miti. Niba kanseri ikomeje cyangwa ingaruka zikaba zidakwirakwiza, muganga wawe azakorana nawe kugira ngo aguhindurire uburyo bwo kuvurwa mu buryo bwizewe.

Nshobora Kugenda Ndi Gukoresha Crizotinib?

Yego, muri rusange urashobora kugenda ukoresha crizotinib, ariko bisaba gutegura. Zana imiti yinyongera mu gihe habayeho gutinda, kandi ubike imiti yawe mu gikapu cyawe cyo mu ntoki niba ugenda mu ndege kugira ngo wirinde kuyitakaza.

Menyesha ikipe yawe y'ubuzima ku bijyanye n'ingendo, cyane cyane niba ugiye mu mahanga aho kwitabwaho n'ubuvuzi bwihuse bishobora kugorana kubona. Bashobora gutanga ubuyobozi ku bijyanye no gucunga ingaruka ziterwa n'imiti mugihe ugenda kandi bakemeza ko ufite imiti ihagije.