Ni iki Dalbavancin: Ibyo ikoreshwa, urugero rwo gufata, ingaruka zabyo n'ibindi

Dalbavancin ni umuti ukomeye wa antibiyotike abaganga batanga banyujije mu muyoboro w'amaraso (IV) kugira ngo bavure indwara zikomeye ziterwa na mikorobe zo ku ruhu. Uyu muti ubarizwa mu itsinda ryitwa lipoglycopeptide antibiotics, zikora zihagarika mikorobe zangiza kubaka urukuta rwazo rurinda.

Igituma dalbavancin idasanzwe ni uko imara igihe kirekire mu mubiri wawe. Ibi bivuze ko ukeneye urugero rumwe cyangwa ebyiri gusa aho gufata antibiyotike buri munsi mu byumweru. Yagenewe abantu bakuru bafite indwara zikomeye zo ku ruhu n'imitsi yoroshye itarashoboye kuvurwa neza n'izindi nshuti.

Dalbavancin ikoreshwa mu kuvura iki?

Dalbavancin ivura indwara zikomeye ziterwa na mikorobe zo ku ruhu n'imitsi yoroshye (ABSSSI) mu bantu bakuru. Izi ni indwara zikomeye zirenga uruhu gusa kandi akenshi zikagera mu bice byo hepfo, harimo ibinure, imitsi, cyangwa imitsi ihujwe.

Umuvuzi wawe ashobora kugutera dalbavancin iyo ufite indwara nka cellulitis, ibibyimba bikomeye, cyangwa indwara ziterwa n'ibikomere. Ifite akamaro cyane cyane ku mikorobe ya gram-positive, harimo n'imwe irwanya izindi antibiyotike. Izi mikorobe zirimo Staphylococcus aureus (harimo MRSA), Streptococcus species, na Enterococcus faecalis.

Uyu muti ugenewe indwara zikomeye kuko ari antibiyotike ikomeye cyane. Umuvuzi wawe azahitamo dalbavancin iyo izindi antibiyotike zitagize icyo zikora cyangwa iyo indwara ikomeye bihagije kugira ngo bisabe kujyanwa mu bitaro.

Dalbavancin ikora ite?

Dalbavancin ni antibiyotike ikomeye cyane ikora igaba ibitero ku rukuta rw'uturemangingo twa mikorobe. Tekereza urukuta rw'uturemangingo twa mikorobe nk'igikonoshyo kirinda cy'igi - hatarimo, mikorobe ntishobora kubaho.

Uyu muti wibanda by'umwihariko ku rukururankurikizi rwitwa transglycosylase, rukenewe na bagiteri kugira ngo zubeho kandi zikomeze urukuta rwazo rw'uturemangingo. Iyo dalbavancin yabuza uru rukururankurikizi, bagiteri zirashwanyuka zikicwa. Ibi bituma abaganga bita uyu muti “bactericidal” ya antibiyotike, bivuze ko yica bagiteri aho kuzibuza gukura.

Ikintu gitangaje kuri dalbavancin ni igihe kirekire cyo kubaho, bivuze ko ikomeza gukora mu mubiri wawe mu gihe cy'iminsi 8-9 nyuma yo gufata urugero rumwe. Ibi bituma ikomeza kurwanya indwara nyuma y'igihe kinini umaze guhabwa urukingo rwa IV.

Nkwiriye Kufata Dalbavancin Nte?

Dalbavancin itangwa gusa binyuze mu rukingo rwa IV mu bitaro cyangwa muri kliniki. Ntushobora gufata uyu muti unywa mu rugo. Umuganga w'inzobere mu by'ubuzima azajya awutanga buri gihe kugira ngo yemeze ko urugero rutangwa neza kandi akurebe niba hari icyo waba ufite.

Urukingo ruzana iminota 30 kugira ngo rurangire. Umuforomo wawe azagutera gahoro gahoro binyuze mu urugingo rw'umuboko wawe. Mbere yo guterwa urukingo, ntugomba kwiyiriza cyangwa kwirinda kurya ibiryo byihariye, nubwo buri gihe ari byiza kuguma ufite amazi ahagije mu mubiri.

Abantu benshi bahabwa urugero rumwe rwa 1500 mg cyangwa urugero rwa kabiri rutangwa nyuma y'icyumweru (1000 mg mu ntangiriro, hanyuma 500 mg nyuma y'iminsi irindwi). Muganga wawe azagena gahunda ikora neza ku ndwara yawe yihariye n'ubuzima bwawe muri rusange.

Nkwiriye Kufata Dalbavancin Igihe Kingana Gite?

Icyiza cya dalbavancin ni uko ukeneye urugero rumwe cyangwa ebyiri gusa. Bitandukanye na antibiyotike zisanzwe zisaba ibinini bya buri munsi mu gihe cy'iminsi 7-14, ingaruka zirambye za dalbavancin zivuze ko kuvurwa bikunze kurangira nyuma yo gusura ibitaro rimwe cyangwa kabiri gusa.

Niba wakira urukingo rumwe, uzahabwa 1500 mg rimwe gusa. Mu gihe wakira inkingo ebyiri, uzahabwa urukingo rwa kabiri nyuma y'iminsi irindwi uvuye ku rwa mbere. Muganga wawe azahitamo uburyo bushingiye ku bintu nk'uburemere bw'ubwandu bwawe n'uburyo witwara ku miti.

Nubwo utari gufata imiti ya buri munsi, umuti wica mikorobe ukomeza gukora mu mubiri wawe mu byumweru nyuma yo guterwa urukingo. Iki gikorwa cyongereye ni cyo gituma uburyo bwo kuvura bugufi bugira akamaro kanini ku ndwara zikomeye z'uruhu.

Ni Ibihe Bikorwa Bigaragara ku Miti ya Dalbavancin?

Kimwe n'indi miti yose, dalbavancin ishobora gutera ibikorwa bigaragara, nubwo abantu benshi bayihanganira neza. Ibikorwa bigaragara cyane ni bike kandi birambye.

Dore ibikorwa bishobora kukubaho, dutangiriye ku bikorwa bisanzwe:

• Urugimbu no kuruka
• Impiswi
• Umutwe
• Urugero
• Urugo cyangwa gushishimura
• Urubavu, umutuku, cyangwa kubyimba ahaterwa urukingo

Ibi bimenyetso mubisanzwe birakira mu munsi umwe cyangwa ibiri kandi ntibisaba guhagarika imiti. Ariko, ugomba buri gihe kumenyesha ikipe yawe y'ubuzima niba wumva ububabare ubwo aribwo bwose.

Ibikorwa bikomeye ntibisanzwe ariko bishobora kuba harimo ibikorwa bikomeye bya allergie, umutima utagenda neza, cyangwa indwara yitwa C. diff colitis (uburwayi bukomeye bw'amara). Niba wumva ugorwa no guhumeka, ububabare bukomeye mu nda, cyangwa impiswi zidakama, shakisha ubufasha bw'ubuvuzi ako kanya.

Ninde Utagomba Gufata Dalbavancin?

Dalbavancin ntabwo ikwiriye kuri buri wese, kandi muganga wawe azasuzuma neza amateka yawe y'ubuvuzi mbere yo kuyandika. Ntugomba guhabwa uyu muti niba waragize allergie kuri dalbavancin cyangwa imiti isa nayo mu bihe byashize.

Abantu bafite indwara zimwe na zimwe z'umutima bagomba kwitonda cyane kuko dalbavancin ishobora kugira ingaruka ku mutima. Muganga wawe ashobora gukora isuzuma rya EKG mbere yo kuvurwa niba ufite amateka y'ibibazo by'umutima cyangwa ufata imiti igira ingaruka ku mutima wawe.

Uyu muti ntiwemerewe gukoreshwa ku bana bari munsi y'imyaka 18, kuko umutekano n'ubushobozi bwawo bitarashimangirwa ku barwayi bato. Byongeye kandi, niba utwite cyangwa wonka, muganga wawe azagereranya inyungu n'ibishobora guteza akaga mbere yo kugusaba dalbavancin.

Izina ry'ubwoko bwa Dalbavancin

Dalbavancin igurishwa ku izina ry'ubwoko rya Dalvance muri Leta Zunze Ubumwe z'Amerika. Iri ni ryo zina risanzwe ubona ku nyandiko zo mu bitaro no ku byapa by'imiti.

Uyu muti ukorwa na Allergan (ubu ni igice cya AbbVie) kandi umaze kuboneka kuva mu 2014. Mu gihe uvugana n'abaganga ku bijyanye n'ubuvuzi bwawe, bashobora kuwita izina iryo ari ryo ryose - dalbavancin cyangwa Dalvance.

Uburyo bwo gusimbuza Dalbavancin

Izindi nzitiramubiri nyinshi zishobora kuvura indwara zikomeye z'uruhu, nubwo buri imwe ifite inyungu zitandukanye n'ingengabihe yo gutanga imiti. Muganga wawe ashobora gutekereza ku buryo bwo gusimbuza bitewe n'agakoko kawe, amateka yawe y'ubuvuzi, n'ibyo ukunda mu kuvurwa.

Uburyo busanzwe bwo gusimbuza burimo vancomycin, isaba gutera imiti ya IV buri munsi mu minsi 7-10, cyangwa linezolid, iboneka mu buryo bwa IV n'ubwo kunywa. Telavancin ni ubundi buryo bukora igihe kirekire, nubwo bisaba gutera imiti buri munsi mu minsi 7-10 aho gutanga doze imwe cyangwa ebyiri za dalbavancin.

Uburyo bushya burimo oritavancin, nayo ni uburyo bumwe bwo kuvura, na tedizolid, ishobora gutangwa mu minsi 6 haba muri IV cyangwa kunywa. Umuganga wawe azahitamo uburyo bwiza bushingiye ku miterere y'indwara yawe n'ubuzima bwawe muri rusange.

Ese Dalbavancin iruta Vancomycin?

Dalbavancin na vancomycin zombi zombi antibiyotike nziza zo kuvura indwara zikomeye zifata uruhu, ariko zikora mu buryo butandukanye kandi zifite inyungu zihariye. Inyungu nyamukuru ya dalbavancin ni ukuboroherwa - ukeneye doze imwe cyangwa ebyiri gusa aho guhabwa imiti ya IV buri munsi mu gihe kirenga icyumweru.

Vancomycin yari isanzwe ikoreshwa mu myaka myinshi ishize kandi ifite ubushakashatsi bwinshi bushingiye ku mikorere yayo. Ariko, bisaba gukurikiranwa buri munsi urwego rwo mu maraso kandi bishobora gutera ibibazo byo mu mpyisi iyo bikoreshejwe igihe kirekire. Dalbavancin ntisaba iri kurikiranwa ryimbitse.

Mu bijyanye n'imikorere, ubushakashatsi bwerekana ko imiti yombi ikora neza kimwe mu kuvura indwara zikomeye zifata uruhu. Muganga wawe azahitamo bitewe n'ibintu nk'imikorere y'impyisi zawe, bagiteri zihariye zateye indwara yawe, niba wifuza kugabanya gusura ibitaro.

Ibikunze Kubazwa Kuri Dalbavancin

Ese Dalbavancin irinzwe ku ndwara z'impyisi?

Dalbavancin irashobora gukoreshwa ku bantu barwaye indwara z'impyisi, ariko muganga wawe azahindura doze bitewe n'uburyo impyisi zawe zikora. Niba ufite ibibazo bikomeye by'impyisi, ushobora guhabwa doze ntoya cyangwa gukurikiranwa by'inyongera mugihe cyo kuvurwa.

Umuti ukurwa cyane cyane mu mpyisi zawe, bityo kugabanya imikorere y'impyisi bisobanura ko umuti uguma mu mubiri wawe igihe kirekire. Ibi ntibiba ngombwa ko biba byateje akaga, ariko bisaba ubugenzuzi bw'ubuvuzi bwitondewe kugirango wemeze ko ubona umubare ukwiye.

Nigute nzakora niba ngize allergie kuri Dalbavancin?

Niba ubonye ibimenyetso bya allergie mugihe cyangwa nyuma yo guterwa umuti, menyesha ikipe yawe y'ubuzima ako kanya. Ibimenyetso bishobora kuba birimo guhumeka bigoye, kubyimba mu maso cyangwa mu muhogo, uruhu ruruma cyane, cyangwa kumva urushye.

Kubera ko dalbavancin itangwa mu buryo bw'ubuvuzi, abakozi b'abahanga bashobora kwihutira gusubiza mu gihe habayeho ibimenyetso by'uburwayi bwo mu mubiri. Bafite imiti n'ibikoresho byiteguye kuvura ibimenyetso bikomeye. Ibimenyetso byinshi by'uburwayi bwo mu mubiri biterwa na dalbavancin biroroshye, ariko buri gihe ni byiza kwitonda no kuvuga niba hari ikintu kitagenda neza.

Nkwiriye gukora iki niba nciweho urukingo rwa dalbavancin?

Niba uteganyirijwe gahunda y'urukingo rw'ibice bibiri kandi ukaba waracikanwe n'iterabwoba rya kabiri, vugana n'umuganga wawe vuba bishoboka. Urukingo rwa kabiri rwaba rwiza rutanzwe nyuma y'iminsi irindwi nyuma y'urwa mbere, ariko akenshi habaho umwanya wo gukora ibintu.

Muganga wawe ashobora kongera kukugena mu gihe giteganyijwe cyangwa agahindura gahunda yawe yo kuvurwa bitewe n'uko wabyitwayemo ku rukingo rwa mbere. Ntukagerageze kubara cyangwa kwisubiraho wenyine - buri gihe ujye ufatanya n'ikipe yawe y'ubuvuzi.

Nshobora guhagarika ryari gufata dalbavancin?

Bitandukanye n'imiti isanzwe yica mikorobe, ntugomba "kureka" gufata dalbavancin kuko akenshi ni uburyo bwo kuvura urukingo rumwe cyangwa ebyiri. Umaze guhabwa urukingo rwawe rwategetswe, ubuvuzi burarangira.

Umuti ukomeza gukora mu mubiri wawe mu byumweru byinshi nyuma yo guterwa urukingo, bityo ntugomba gukora ikindi kintu. Muganga wawe azakurikirana uko icyorezo cyawe kigenda binyuze mu biganiro byo gukurikirana kandi ashobora gutumiza ibindi bizami kugirango yemeze ko ubuvuzi bukora neza.

Nshobora kunywa inzoga niba mvurwa na dalbavancin?

Nta kintu gihuriye na dalbavancin n'inzoga, ariko muri rusange ni ubwenge kwirinda kunywa mu gihe urwana n'icyorezo gikomeye. Inzoga zirashobora kubangamira urwego rwawe rw'ubudahangarwa kandi zikaba zateza imbere igihe cyo gukira.

Byongeye kandi, niba ufite ibimenyetso nk'isuka cyangwa kuribwa umutwe biturutse ku muti, inzoga zirashobora gutuma ibi bimenyetso birushaho kuba bibi. Ni byiza kwibanda ku kuruhuka, imirire myiza, no kuguma mu mazi mu gihe umubiri wawe urwanya icyorezo.