Icyo Danazol ari cyo: Ibyo ikoreshwa, urugero rwo gufata, ingaruka zayo n'ibindi

Danazol ni umuti w'imisemburo ikorwa mu buryo bwa gihanga ufasha kuvura indwara nyinshi zijyanye n'ubuzima bw'imyororokere n'indwara z'amaraso. Uyu muti ukora ugabanya imisemburo imwe n'imwe mu mubiri wawe, ibi bikaba byagabanya ibimenyetso bya endometriosis, indwara ya fibrocystic breast, n'indwara idasanzwe yo kuva amaraso yitwa hereditary angioedema.

Ushobora kuba wibaza uko uyu muti ujyana n'uburyo uvurwa. Danazol imaze imyaka myinshi ikoreshwa mu gufasha abantu guhangana n'indwara zikomeye zangiza ubuzima bwabo. Nubwo atariyo nzira ya mbere yo kuvura, irashobora kugira akamaro kanini iyo izindi nzira zitagize icyo zikora.

Danazol ni iki?

Danazol ni imisemburo ikorwa n'abantu, ikaba mu itsinda ry'imiti yitwa androgens. Yigana ingaruka zimwe na zimwe z'imisemburo y'abagabo mu mubiri wawe, ariko ntugire impungenge - ibi ntibisobanura ko bizateza impinduka zikomeye ku isura yawe cyangwa uko wumva.

Uyu muti ukora ugabanya umusaruro w'imisemburo imwe n'imwe iva mu ngingo yawe ya pituitary. Tekereza nk'aho ugabanya ijwi ry'ibimenyetso by'imisemburo bishobora gutera ibibazo mu ndwara nka endometriosis. Iyi ngaruka yo kugabanya imisemburo ifasha kugabanya umubyimbire no gukura kw'ibice bidasanzwe.

Danazol iza mu buryo bwa capsule kandi ifatirwa mu kanwa. Muganga wawe azayandika bitewe n'uburwayi bwawe bwihariye n'uko umubiri wawe witwara ku buvuzi. Uyu muti umazeho kuva mu myaka ya 1970, bityo abaganga bafite uburambe bwinshi bwo kuwukoresha mu buryo butekanye.

Danazol ikoreshwa mu kuvura iki?

Danazol ivura indwara eshatu zikomeye, buri imwe ikaba isaba uburyo butandukanye n'urugero rwo gufata. Muganga wawe azagena indwara ikureba kandi ahindure uburyo uvurwa uko bikwiye.

Ikoreshwa cyane ni ukurwanya indwara ya endometriosis, indwara ibabaza aho imitsi isa n'iy'umura w'umugore ikura hanze y'umura. Ibi bishobora gutera kubabara cyane mu gihe cy'imihango, kuva amaraso menshi, no kubabara mu gatuza. Danazol ifasha mu kugabanya urugero rwa estrogen, ibi bikagabanya ukuza kw'imitsi idasanzwe kandi bigatuma ibyimbirwa bigabanuka.

Uyu muti uvura kandi indwara ya fibrocystic y'ibere, itera amabere yuzuye, yoroshye akenshi yumva ababaza mbere y'imihango yawe. Mu kunoza urugero rwa hormone, danazol irashobora kugabanya kubabara kw'ibere no kugabanya ukuza kw'ibibyimba bishya.

Ku ndwara ya hereditary angioedema, indwara idasanzwe ya genetike, danazol ifite intego itandukanye. Iyi ndwara itera kubyimba mu buryo butunguranye mu maso yawe, mu muhogo, mu ntoki, cyangwa mu myanya ndangagitsina bitewe no kubura poroteyine. Danazol ifasha mu gukumira ibi bihe byo kubyimba by'akaga mu kongera umubiri wawe gukora poroteyine yaburaga.

Danazol ikora ite?

Danazol ifatwa nk'umuti ukomeye mu rugero ruciriritse utera impinduka zikomeye mu kuringaniza hormone yawe. Ikora mu guhagarika irekurwa rya hormone ziturutse mu ngingo ya pituitary yawe, cyane cyane luteinizing hormone (LH) na follicle-stimulating hormone (FSH).

Iyo izi hormone zigabanutse, imyanya y'intanga yawe ikora estrogen na progesterone nkeya. Iyi mpinduka ya hormone ifasha kugabanya imitsi ya endometrial kandi igabanya inzira z'uburwayi zitera kubabara no gukura bidasanzwe. Ku ndwara z'amabere, uku kugabanuka kwa hormone kumwe kugabanya impinduka zikora ibibyimba bibabaza.

Muri hereditary angioedema, danazol ikora mu buryo butandukanye mu kongera umubiri wawe gukora C1 esterase inhibitor. Iyi poroteyine ifasha kugenzura ibyimbirwa no gukumira ibihe byo kubyimba by'akaga bitunguranye biranga iyi ndwara.

Ingaruka z'uyu muti ziragaruka, bivuze ko urugero rwa hormone yawe ruzasubira mu buryo busanzwe umaze kureka kuwufata. Ariko, bishobora gufata amezi menshi kugira ngo umubiri wawe wose wongere kwisanisha.

Nkwiriye gufata danazol nte?

Fata danazol nk'uko umuganga wawe abikwandikiye, akenshi kabiri ku munsi hamwe n'ibiryo kugira ngo bigabanye kuribwa mu nda. Igihe cyo gufata imiti yawe kigomba gukwirakwizwa kimwe mu munsi, nk'uko bikorwa mu gitondo na nimugoroba.

Urashobora gufata danazol hamwe cyangwa utabana n'ibiryo, ariko kuyifata hamwe n'ifunguro cyangwa agafunguro gato akenshi bifasha kwirinda isesemi. Abantu bamwe basanga kuyifata hamwe n'amata cyangwa agafunguro gato bikora neza. Irinde kuyifata ku gifu cyuzuye niba ukunda kuribwa mu nda.

Mimina ibinini byose hamwe n'ikirahure cyuzuye cy'amazi. Ntugasenya, ntukore cyangwa ufungure ibinini, kuko ibi bishobora kugira ingaruka ku buryo umuti winjizwa. Niba ugira ikibazo cyo kumira ibinini, ganira n'umuganga wawe ku bindi bisubizo.

Gerageza gufata imiti yawe mu gihe kimwe buri munsi kugira ngo ugumane urwego ruzigama mu mubiri wawe. Gushyiraho ibyibutso kuri terefone cyangwa guhuza imiti n'ibikorwa bya buri munsi nk'amafunguro birashobora kugufasha kwibuka. Guhora bikora ni ngombwa kugira ngo umuti ukore neza.

Mbona Danazol Mugihe Kingana Gite?

Uburyo bwo kuvura na danazol butandukanye cyane bitewe n'uburwayi bwawe n'uburyo ubisobanukiramo. Abantu benshi babifata mu gihe cy'amezi 3 kugeza kuri 6 mbere na mbere, ariko bamwe bashobora gukenera igihe kirekire cyo kuvurwa.

Kubijyanye na endometriosis, kuvurwa akenshi bifata amezi 3 kugeza kuri 6. Umuganga wawe azagenzura ibimenyetso byawe kandi ashobora kongera kuvura niba ubona ibisubizo byiza nta ngaruka zikomeye. Abantu benshi bagira impinduka zigaragara mu mezi make ya mbere.

Indwara ya fibrocystic y'amabere akenshi isaba amezi 2 kugeza kuri 6 yo kuvurwa. Umuganga wawe ashobora gutangira kuri doze yo hejuru mbere na mbere, hanyuma akayigabanya uko ibimenyetso byawe bigenda birushaho. Abantu bamwe bakeneye amezi make gusa, mu gihe abandi bungukirwa no kuvurwa igihe kirekire.

Kubijyanye na hereditary angioedema, kuvurwa akenshi ni igihe kirekire kandi bishobora gukomeza imyaka myinshi. Intego ni ukwirinda ibyago byo kubyimba, bityo umuganga wawe azakorana nawe kugira ngo abone doze ntoya ikora neza kugira ngo irinde buri gihe.

Ni Ibihe Bikorwa Bigaragara Byatewe na Danazol?

Kimwe n'imiti yose igira ingaruka ku misemburo, danazol ishobora gutera ibikorwa bigaragara bitandukanye, nubwo atari buri wese ubyumva. Kumva icyo witegura bishobora kugufasha kwitegura neza no kumenya igihe cyo kuvugana na muganga wawe.

Ibikorwa bisanzwe bigaragara abantu benshi bahura nabyo birimo kongera ibiro, kubyimba, no guhinduka mu gihe cy'imihango yawe. Ushobora kubona imihango yawe iba mito, idahoraho, cyangwa ikahagarara burundu mugihe ukoresha danazol. Ibi ni kimwe mu buryo umuti ukora kandi akenshi bigaruka nyuma yo guhagarika kuvurwa.

Dore ibikorwa bigaragara byinshi byatangajwe:

• Kongera ibiro bya 5-10 pounds
• Kubyimba no kubika amazi
• Gushyuha cyane cyangwa ibyuya by'ijoro
• Guhinduka kw'amarangamutima cyangwa kurakara
• Uduheri cyangwa uruhu rurimo amavuta
• Kugabanyuka kw'amabere
• Kuribwa kw'imitsi

Ibikorwa bigaragara bitagaragara cyane ariko biteye impungenge birimo guhinduka kw'ijwi, gukura kw'umusatsi cyane, no guhinduka gukomeye kw'amarangamutima. Ijwi ryijimye rishobora kuba rirambye, bityo vugana na muganga wawe ako kanya niba ubonye ijwi ryawe ririmo guhumeka cyangwa ryijimye.

Ibikorwa bigaragara bidakunze kubaho ariko bikomeye bisaba ubufasha bwihuse bwa muganga. Ibi birimo kuribwa cyane mu nda, guhinduka kw'uruhu cyangwa amaso umuhondo, kuribwa cyane mumutwe, cyangwa ibimenyetso by'amaraso yiziba nk'kuribwa kw'ukuguru gutunguranye cyangwa guhumeka nabi. Nubwo ibi bidakunze kubaho, bisaba isuzuma ryihuse.

Ninde Utagomba Gukoresha Danazol?

Amatsinda atandukanye y'abantu agomba kwirinda danazol kubera impungenge z'umutekano. Muganga wawe azasuzuma neza amateka yawe y'ubuzima mbere yo kwandika uyu muti.

Abagore batwite ntibagomba na rimwe gukoresha danazol, kuko ishobora gutera ubumuga bukomeye bw'ivuka, cyane cyane bugira ingaruka ku mikurire y'abana b'abakobwa. Niba ugerageza gusama cyangwa hari amahirwe yose ushobora kuba utwite, ganira ibi na muganga wawe ako kanya.

Abantu bafite indwara zimwe na zimwe bagomba kwirinda danazol cyangwa bakayikoresha bitonze cyane. Izi ndwara zongera ibyago iyo zifatanyije n'ingaruka za hormone z'uyu muti:

• Indwara ikomeye y'umutima cyangwa kunanirwa kw'umutima
• Indwara y'umwijima cyangwa imyunyu y'umwijima yiyongereye
• Indwara y'impyiko
• Amateka y'amaraso avurirana
• Umubyigano w'amaraso udakira
• Diabetes ikomeye
• Amateka ya stroke

Niba ufite amateka ya kanseri y'ibere cyangwa izindi kanseri zifite aho zihurira na hormone, muganga wawe azagomba gupima neza ibyago n'inyungu. Ingaruka za hormone z'uyu muti zishobora kugira ingaruka ku mikurire ya kanseri mu bihe bimwe na bimwe.

Amazina y'ubwoko bwa Danazol

Danazol iboneka mu mazina y'ubwoko butandukanye, nubwo verisiyo rusange ariyo ikoreshwa cyane uyu munsi. Izina ry'ubwoko rya mbere ryari Danocrine, ushobora gukomeza kubona ryandikwa mu turere tumwe na tumwe.

Andi mazina y'ubwoko arimo Danol na Azol, nubwo kuboneka bitandukanye bitewe n'igihugu n'akarere. Amavuriro menshi afite verisiyo rusange, ifite akamaro kimwe n'ubwoko bw'amazina kandi akenshi ihendutse.

Iyo ufata umuti wawe, icyapa kizerekana "danazol" cyangwa izina ry'ubwoko muganga wawe yanditse. Ubwoko bwose burimo ikintu kimwe gikora kandi gikora kimwe mu mubiri wawe.

Uburyo bwo gusimbura Danazol

Ubuvuzi butandukanye burahari kubera indwara danazol ivura, nubwo guhitamo neza biterwa n'uko ubuzima bwawe bumeze n'amateka yawe y'ubuvuzi. Muganga wawe ashobora kugufasha gushakisha izi nzira niba danazol itagukwiriye.

Kubera endometriosis, ibisubizo birimo ibinini bigenzura hormone, imiti ya progestin gusa, cyangwa GnRH agonists nka leuprolide. Ibi bikora mu buryo butandukanye na danazol ariko bishobora kugira akamaro kimwe mu gucunga ibimenyetso.

Indwara ya fibrocystic yo mu mabere ishobora gusubiza neza ku byongerera vitamine E, amavuta ya evening primrose, cyangwa kugabanya kunywa kafeine. Abantu bamwe babona ubufasha bakoresheje imiti yo kuboneza urubyaro ikoresha imisemburo cyangwa imiti irwanya ububyimbirwe.

Ku ndwara ya angioedema y'umurage, imiti mishya nka icatibant cyangwa ecallantide irashobora kuvura ibitero bikaze, mugihe imiti nka lanadelumab ishobora gukumira ibyorezo. Izi nzira nshya akenshi zigira ingaruka nke kurusha danazol.

Ese Danazol iruta izindi miti ikoresha imisemburo?

Danazol ntabwo ari ngombwa ko iruta cyangwa ngo irusheho izindi miti ikoresha imisemburo - iratandukanye, ifite inyungu zidasanzwe n'ibibi. Guhitamo neza biterwa n'uburwayi bwawe bwihariye, ibindi bintu by'ubuzima, n'uburyo usubiza ku miti.

Ugereranije n'ibinini byo kuboneza urubyaro cyangwa izindi miti ikoresha imisemburo, danazol akenshi ikora vuba kandi cyane. Abantu benshi babona impinduka mu mezi 2-3, mugihe izindi miti ishobora gutwara igihe kirekire kugirango igaragaremo ibisubizo.

Ariko, danazol akenshi itera ingaruka zigaragara kurusha imiti ikoresha imisemburo yoroshye. Ubusanzwe, guhinduranya ni ukubona ubufasha bwihuse kandi bwuzuye bw'ibimenyetso ugereranije n'ingaruka zicungwa neza hamwe n'izindi nzira.

Muganga wawe azatekereza ku myaka yawe, icyifuzo cyo gutwita, ubukana bw'ibimenyetso, n'uburyo wihanganira ingaruka mugihe asaba uburyo bwiza bwo kuvura.

Ibikunze Kubazwa Kuri Danazol

Q1. Ese Danazol irakwiriye abantu barwaye indwara z'umutima?

Danazol isaba gutekerezwa neza niba urwaye indwara y'umutima, kuko ishobora kugira ingaruka ku rwego rwa cholesterol kandi ikongera ibyago by'umutima n'imitsi. Muganga wawe ashobora gushaka gukurikirana ubuzima bw'umutima wawe neza niba ufata danazol hamwe n'indwara z'umutima zisanzweho.

Uyu muti ushobora kuzamura LDL (cholesterol mbi) no kugabanya HDL (cholesterol nziza), ibyo bitari byiza ku buzima bw'umutima. Ariko, kuburwayi bumwe nka endometriosis ikaze, inyungu zirashobora kurenga ibi byago hamwe no gukurikirana neza.

Q2. Nkwiriye gukora iki niramuka mfashwe danazol nyinshi ku buryo butunguranye?

Niba ufashwe danazol nyinshi ku buryo butunguranye kurusha uko byategetswe, vugana n'umuganga wawe cyangwa ikigo gishinzwe ubumara ako kanya. Gufata nyinshi bishobora kongera ingaruka mbi kandi bishobora gutera ibibazo bikomeye.

Ntugategereze ngo urebe niba ibimenyetso bigaragara - shakisha inama z'abaganga ako kanya. Zana urupapuro rw'umuti hamwe nawe niba ukeneye kujya mu bitaro, kugira ngo abakozi b'ubuvuzi babone neza icyo wafashe n'ingano yacyo.

Q3. Nkwiriye gukora iki niba nciwe urugero rwa danazol?

Niba waciwe urugero, rufate ako kanya wibukira, keretse igihe cyo gufata urugero rwawe rukurikira. Muri icyo gihe, reka urugero waciwe rugende ukomeze gahunda yawe isanzwe.

Ntuzigere ufata urugero ebyiri icyarimwe kugira ngo wuzuze urugero waciwe, kuko ibi bishobora kongera ibyago byo kugira ingaruka mbi. Niba ukunda kwibagirwa urugero, tekereza gushyiraho ibyibutso kuri terefone cyangwa ukoreshe umuteguro w'imiti.

Q4. Nshobora guhagarika ryari gufata danazol?

Hagarika gufata danazol gusa igihe umuganga wawe abikubwiye, kabone n'iyo wumva umeze neza. Guhagarika kare bishobora gutuma ibimenyetso byawe bisubira mbere yo kugera ku nyungu nyinshi.

Umuganga wawe ashobora gushaka kugabanya buhoro buhoro urugero rwawe aho guhagarika ako kanya. Ibi bifasha umubiri wawe kwisubiranya ku rwego rusanzwe rw'imisemburo neza kandi bigabanya amahirwe yo gusubira vuba kw'ibimenyetso.

Q5. Iminsi yanjye izasubira mu buryo busanzwe nyuma yo guhagarika danazol?

Yego, imihango yawe igomba gusubira mu buryo busanzwe mu mezi 2-3 nyuma yo guhagarika danazol. Abantu benshi basanga imihango yabo isubira buhoro buhoro ku buryo bwa mbere, nubwo bishobora gufata ibihe bike kugira ngo bisanzure rwose.

Niba imihango yawe itagarutse mu mezi 3, cyangwa niba ufite impungenge ku mpinduka mu gihe cyawe, vugana n'umuganga wawe. Rimwe na rimwe isuzuma ryinyongera rirakenewe kugira ngo ryemeze ko ibintu byose bisubira mu buryo busanzwe nkuko byitezwe.