Icyo Dantrolene ari cyo: Ibyo ikoreshwa, Uburyo bwo kuyifata, Ingaruka zayo n'ibindi

Dantrolene ni umuti ugabanya imitsi ukora mu buryo butaziguye ku mikaya yawe kugira ngo ugabanye imitsi idashakaga no kwikanyabuka. Bitandukanye n'indi miti igabanya imitsi ikora binyuze mu mikoranire y'imitsi yawe, dantrolene yibanda ku mikaya ubwayo, bituma ikora neza mu buryo bwihariye ku bibazo bimwe na bimwe aho imitsi iba ikaze cyane cyangwa ikora cyane.

Uyu muti ugira uruhare runini mu kuvura indwara zikomeye zifitanye isano n'imitsi kandi ushobora guhindura ubuzima bw'abantu bahanganye no kwikanyabuka kw'imitsi. Reka dusuzume uko dantrolene ikora niba yaba ifitiye akamaro imiterere yawe yihariye.

Dantrolene ikoreshwa mu iki?

Dantrolene ivura indwara nyinshi zikomeye zifitanye isano n'imitsi aho imitsi yawe ikanyaruka cyane cyangwa kenshi. Uyu muti wandikirwa cyane kwikanyabuka kw'imitsi, bivuze ko imitsi yawe iguma ikaze kandi igoye, bigatuma kugenda bigorana kandi rimwe na rimwe bikababaza.

Muganga wawe ashobora kukwandikira dantrolene niba ufite kwikanyabuka kw'imitsi ku ndwara nka multiple sclerosis, cerebral palsy, imvune zo mu mugongo, cyangwa situroke. Izi ndwara zishobora gutuma imitsi yawe ikanyaruka ku buryo butunguranye, bigatuma ibikorwa bya buri munsi bigorana kandi bitaryoshye.

Dantrolene kandi ikora nk'umuti w'ubuzima ku ndwara ya malignant hyperthermia, igisubizo gike ariko giteje akaga ku miti imwe na imwe y'ububabare mu gihe cyo kubagwa. Muri iyi mimerere y'ubutabazi, uyu muti ushobora gukumira imitsi ikomeye ishobora kwica no gushyuha cyane.

Dantrolene ikora ite?

Dantrolene ikora ibuza calcium gusohoka muri selile zawe z'imitsi, ibyo bikaba ari ngombwa kugira ngo imitsi ikanyaruke. Tekereza calcium nk'urufunguzo rutangiza inzira yo gukanyaruka kw'imitsi - dantrolene mu by'ukuri ikura urwo rufunguzo, ikemerera imitsi yawe kuruhuka byoroshye.

Ibi bituma dantrolene iba umuti ucisha imitsi ku rugero ruringaniye, ariko itandukanye n'indi miti icisha imitsi kuko ikora mu buryo butaziguye ku gice cy'imitsi aho gukora binyuze mu bwonko bwawe cyangwa umugongo. Ubu buryo bwihariye busobanura ko bishobora kugira akamaro kanini ku bwoko bumwe bw'ibibazo by'imitsi mugihe bitera ingaruka nke ku mikorere y'imitsi yo hagati.

Uyu muti akenshi bifata ibyumweru byinshi kugirango ugere ku mikorere yawo yuzuye, bityo ntushobora kubona ihumure ako kanya. Imitsi yawe buhoro buhoro izagabanuka ubukana kandi ibashe gukorwa neza uko umuti wiyongera mu mubiri wawe.

Nkwiriye Gufata Dantrolene Nte?

Fata dantrolene nkuko muganga wawe abikwandikiye, akenshi utangira n'urugero ruto rugenda ruzamuka uko igihe kigenda. Abantu benshi batangira na 25 mg rimwe ku munsi hanyuma buhoro buhoro bakazamuka kugera ku rugero rukora neza, rushobora kuba hagati ya 100 na 400 mg ku munsi igabanyijemo ibice byinshi.

Ushobora gufata dantrolene hamwe n'ibiryo cyangwa utabifite, ariko kuyifata hamwe n'ibiryo bishobora gufasha kugabanya ibibazo byo mu nda niba hari icyo ubona. Mimina ibinini byose hamwe n'ikirahure cyuzuye cy'amazi - ntukabikoremo agahinda, ntukayarye, cyangwa ngo uyakingure keretse muganga wawe akubwiye byumwihariko.

Gerageza gufata imiti yawe ku gihe kimwe buri munsi kugirango ugumane urugero rwo hejuru mu mubiri wawe. Niba ufata imiti myinshi ku munsi, yongeranya mu buryo bungana umunsi wose nkuko byategetswe n'umuganga wawe.

Nkwiriye Gufata Dantrolene Igihe Kingana Gite?

Igihe cyo kuvura na dantrolene giterwa n'uburwayi bwawe bwihariye n'uburyo wakiriye neza umuti. Kubijyanye n'uburwayi burambye bw'imitsi, abantu benshi bafata dantrolene amezi cyangwa imyaka nk'uburyo bwo kuvura igihe kirekire.

Muganga wawe ashobora gutangira ukoresha mu gihe cy'ibyumweru byinshi kugirango arebe uburyo umuti ukora neza kuri wowe. Niba utabonye impinduka zigaragara nyuma y'ibyumweru 6-8 ku rugero rwawe rwihariye, muganga wawe ashobora guhindura urugero cyangwa agatekereza ku zindi nshuti.

Ku bantu bamwe, dantrolene iba igice cy'iteka ry'ubuvuzi bwabo, mu gihe abandi bashobora kuyikoresha by'agateganyo mu gihe cy'uburwayi bukomeye cyangwa mu gihe imitsi yabo yiyongera gukomera. Ntukigere uhagarika gufata dantrolene ako kanya utabanje kubiganiraho na muganga wawe, kuko ibi bishobora gutuma ibimenyetso byawe bisubira vuba.

Ni izihe ngaruka ziterwa na Dantrolene?

Abantu benshi bagira ingaruka zimwe na zimwe iyo batangira gufata dantrolene, ariko nyinshi muri zo ziragenda zikira uko umubiri wawe wimenyereza umuti. Ingaruka zisanzwe ushobora kubona zirimo gusinzira, kuribwa umutwe, intege nke, no kunanirwa, cyane cyane mu byumweru bya mbere by'ubuvuzi.

Dore ingaruka ushobora guhura nazo cyane cyane iyo utangiye gufata umuti:

• Gusinzira no kunanirwa bishobora kugira ingaruka ku bikorwa byawe bya buri munsi
• Kuribwa umutwe, cyane cyane iyo uhagurutse vuba
• Intege nke rusange mu mubiri wawe wose
• Isesemi cyangwa kurwara inda
• Impiswi cyangwa impinduka mu myifatire y'amara
• Kuribwa umutwe bikunze kuba byoroheje cyangwa bikabije

Izi ngaruka zisanzwe akenshi zigenda zigabanuka uko umubiri wawe wimenyereza umuti mu byumweru bya mbere by'ubuvuzi.

Mu buryo butajegajega, abantu bamwe bagira ingaruka zikomeye zisaba ubufasha bwa muganga. Nubwo ibi bitabaho kenshi, ni ngombwa kubimenya:

• Intege nke zikomeye zibangamira kugenda cyangwa ibikorwa bya buri munsi
• Kugorwa no guhumeka cyangwa guhumeka nabi
• Kuribwa mu gituza cyangwa umutima gutera cyane
• Impiswi zikomeye zitera umwuma
• Uruhu rudasanzwe cyangwa kuva amaraso
• Uruhu cyangwa amaso y'umuhondo (jaundice)

Mu buryo butajegajega, dantrolene ishobora gutera ibibazo bikomeye by'umwijima, ni yo mpamvu muganga wawe azagenzura imikorere y'umwijima wawe akoresheje ibizamini by'amaraso bya buri gihe. Ibimenyetso by'ibibazo by'umwijima birimo isesemi ihoraho, kunanirwa bidasanzwe, inkari z'umukara, cyangwa uruhu cyangwa amaso y'umuhondo.

Vugana n'umuganga wawe niba ubonye ingaruka zidasanzwe, cyane cyane niba zirushaho cyangwa zikabangamira imibereho yawe ya buri munsi.

Ninde Utagomba Gufata Dantrolene?

Dantrolene ntibereye buri wese, kandi indwara zimwe na zimwe zituma bidatekanye kuyikoresha. Ntugomba gufata dantrolene niba ufite indwara y'umwijima ikora cyangwa niba waragize ibibazo by'umwijima biturutse ku gufata dantrolene mu gihe gishize.

Abantu bafite indwara zimwe na zimwe z'umutima, cyane cyane izangiza umuvuduko w'umutima, ntibashobora kuba abakandida beza ba dantrolene. Muganga wawe azasuzuma neza ubuzima bw'umutima wawe mbere yo kugusaba uyu muti.

Ugomba kandi kwirinda dantrolene niba utwite cyangwa wonka, kuko uyu muti ushobora kujya ku mwana wawe kandi ugatera ingaruka mbi. Niba uteganya gutwita cyangwa ukamenya ko utwite ukoresha dantrolene, vugana n'umuganga wawe ako kanya kugira ngo muganire ku bindi bisubizo.

Byongeye kandi, abantu bafite indwara zikomeye z'ibihaha cyangwa ibibazo byo guhumeka ntibashobora gufata dantrolene neza, kuko uyu muti rimwe na rimwe ushobora gutera ibibazo byo guhumeka.

Amazina ya Dantrolene

Dantrolene iboneka ku izina rya Dantrium, rikaba ari ryo risabwa cyane mu buryo bwo kunywa uyu muti. Haboneka dantrolene isanzwe na Dantrium y'izina, zombi zikubiyemo ikintu kimwe gikora kandi zikora kimwe mu mubiri wawe.

Farumasi yawe ishobora gutanga verisiyo isanzwe cyangwa y'izina bitewe n'ubwishingizi bwawe n'uko ziboneka. Zombi zikora neza, nubwo hari abantu bahitamo gukoresha imwe kugira ngo bagire ubumwe.

Hariho kandi uburyo bwo guterwa rwa dantrolene bita Ryanodex, ariko ibi bikoreshwa gusa mu bitaro mu kuvura ibibazo byihutirwa bya malignant hyperthermia.

Uburyo bwo gusimbuza Dantrolene

Imiti indi myinshi irashobora kuvura imitsi yikora niba dantrolene itagukwiriye cyangwa itatanga imbaraga zihagije. Baclofen akenshi ifatwa nk'umuti wa mbere uvura ibibazo by'imitsi kandi ikora binyuze mu mugongo wawe kugirango igabanye imitsi.

Tizanidine ni ubundi buryo bukora ku mikorere y'imitsi yawe kugirango igabanye imbaraga zayo. Ikunda gutera gusinzira kurusha dantrolene ariko irashobora gukora neza kubantu bafite ubwoko butandukanye bw'imitsi.

Izindi nzira zirimo diazepam, ifite imbaraga zo kuruhura imitsi hamwe n'ingaruka zo kurwanya impungenge, no guterwa inshinge za botulinum toxin kubibazo by'imitsi byo mu gace kamwe. Muganga wawe ashobora kugufasha kumenya uburyo bwiza bushobora gukora neza kubibazo byawe byihariye.

Ese Dantrolene iruta Baclofen?

Dantrolene na baclofen bikora mu buryo butandukanye kandi buri kimwe gifite inyungu bitewe n'uburwayi bwawe bwihariye n'uburyo umubiri wawe witwara. Baclofen akenshi igeragezwa mbere kuko imaze igihe kinini ikoreshwa kandi ifite ingaruka zizwi cyane kubantu benshi.

Dantrolene irashobora kuba nziza kuri wewe niba baclofen itera gusinzira cyane cyangwa ingaruka zo mu mutwe, kuko dantrolene ikora ku mikorere y'imitsi aho gukora binyuze mu bwonko bwawe no mu mugongo. Abantu bamwe basanga dantrolene yihanganirwa kurushaho mugihe gikoreshwa igihe kirekire.

Ariko, baclofen irashobora gukora neza kubwoko bumwe bw'imitsi, cyane cyane iterwa no gukomereka k'umugongo. Guhitamo hagati yiyi miti biterwa n'uburyo wabyitwayemo, kwihanganira ingaruka, n'icyateye imitsi yawe.

Muganga wawe ashobora no kugusaba kugerageza imiti yombi mu bihe bitandukanye kugirango urebe iyikora neza kubibazo byawe byihariye.

Ibikunze Kubazwa Kuri Dantrolene

Ese Dantrolene irakwiriye kubafite indwara y'impyiko?

Dantrolene akenshi ifatwa nk'umuti utagira ingaruka ku bantu barwaye indwara z'impyiko ugereranije n'indi miti myinshi kuko ikorwa cyane mu mwijima aho gukorwa mu mpyiko. Ariko, ugomba kumenyesha muganga wawe ibibazo byose by'impyiko ufite.

Muganga wawe ashobora gushaka gukurikirana imikorere y'impyiko zawe cyane igihe urimo gufata dantrolene, cyane cyane niba ufite indwara y'impyiko yo hagati cyangwa ikomeye. Urutonde rw'imiti akenshi ntirukeneye guhindurwa kubera ibibazo by'impyiko, ariko ubuzima bwawe muri rusange buzagira uruhare mu gufata icyemezo.

Nkwiriye gukora iki niba nanyoye dantrolene nyinshi ku buryo butunguranye?

Niba unyweye dantrolene nyinshi ku buryo butunguranye kuruta uko byategetswe, vugana n'umuganga wawe cyangwa ikigo gishinzwe kurwanya ubumara ako kanya, kabone n'iyo wumva umeze neza. Kunywa dantrolene nyinshi bishobora gutera intege nke zikomeye mu mikaya, guhumeka bigoranye, n'ibibazo by'umutima.

Ntugategereze ngo urebe niba ibimenyetso bigaragara - shaka ubufasha bw'ubuvuzi ako kanya. Zana icupa ry'umuti hamwe nawe mu cyumba cy'ubutabazi kugira ngo abaganga bamenye neza icyo wanyoye n'ingano yacyo.

Ibimenyetso byo kurenza urugero rwa dantrolene birimo intege nke zikomeye mu mikaya, guhumeka bigoranye, umuvuduko w'umutima utinda, no gutakaza ubwenge. Ibi bimenyetso bisaba ubufasha bw'ubuvuzi bwihutirwa.

Nkwiriye gukora iki niba nanyimye urugero rwa dantrolene?

Niba wanyimye urugero rwa dantrolene, unywe ako kanya wibuka, keretse igihe cyegereje urugero rwawe ruteganyijwe. Muri icyo gihe, reka urugero wanyimye ukomeze gahunda yawe isanzwe yo kunywa imiti.

Ntuzigere unywa urugero rwa kabiri icyarimwe kugira ngo usubize urugero wanyimye, kuko ibi bishobora gutera ingaruka mbi. Niba ukunda kwibagirwa urugero, tekereza gushyiraho ibyibutso kuri terefone yawe cyangwa ukoreshe umuteguro w'imiti.

Kunyima urugero rimwe na rimwe ntizatera ingaruka ako kanya, ariko gerageza kugumana uburyo bumwe kugira ngo ugire ingaruka nziza z'ubuvuzi. Niba wanyimye urugero rwinshi rukurikirana, vugana n'umuganga wawe kugira ngo akuyobore uko wasubira kunywa imiti mu buryo bwizewe.

Nshobora Kureka Gufata Dantrolene Ryari?

Ugomba kureka gufata dantrolene gusa ubisabwe na muganga wawe, kuko guhagarara ako kanya bishobora gutuma imitsi yawe yongera kugira ibibazo ako kanya kandi bikaba byakiyongera. Muganga wawe akenshi azagusaba kugabanya urugero ufata mu byumweru byinshi.

Igihe cyo kureka gufata dantrolene giterwa n'uburwayi ufite n'intego z'ubuvuzi. Abantu bamwe bafite indwara zigenda ziyongera bashobora gukenera kuyifata iteka, mu gihe abandi bashobora kuyihagarika nyuma yo gukira imvune cyangwa mu gihe cy'ituze.

Muganga wawe azakorana nawe kugira ngo amenye igihe cyiza cyo gutekereza kureka imiti bitewe n'ibimenyetso byawe, ubuzima bwawe muri rusange, n'uburyo uvuzwa.

Nshobora Gutwara Imodoka Ndafata Dantrolene?

Dantrolene ishobora gutera gusinzira, isereri, no kunanuka kw'imitsi, bishobora kugira ingaruka ku bushobozi bwawe bwo gutwara neza, cyane cyane iyo utangiye kuyifata. Ugomba kwirinda gutwara kugeza umenye uko umuti ukugiraho ingaruka ku giti cyawe.

Abantu benshi basanga izi ngaruka zikemuka nyuma y'ibyumweru bike by'ubuvuzi, kandi bashobora gusubira mu gutwara bisanzwe igihe bahagaze neza ku rugero bafata. Ariko, abantu bamwe bakomeza kugira ibimenyetso byo gusinzira cyangwa kunanuka bituma gutwara bidatekanye.

Ba umunyakuri kuri wowe ku bijyanye no kumenyera no gukora vuba igihe ufata dantrolene. Niba wumva ko hari ikiguhungabanya, ni byiza gutegura uburyo bwo gutwara butandukanye kugeza igihe ushobora kuganira n'umuganga wawe kuri iyo ngingo.