Eculizumab (inzira y'umutuku)
Amoko ahari
Bkemv, Epysqli, Soliris
Ibyerekeye uyu muti
Injeksiyon ya Eculizumab ikoreshwa mu kuvura indwara y'amaraso yitwa paroxysmal nocturnal hemoglobinuria (PNH). Iyi miti ifasha kugabanya kurimbuka cyangwa kwangirika kw'utubuto tw'amaraso atukura (hemolysis) mu barwayi bafite PNH. Iyi miti kandi ikoreshwa mu kuvura indwara ikomeye y'impyiko yitwa atypical hemolytic uremic syndrome (aHUS). Injeksiyon ya Eculizumab kandi ikoreshwa mu kuvura indwara y'imitsi n'imikaya yitwa generalized myasthenia gravis (gMG) mu barwayi bafite anti-acetylcholine receptor (AchR) antibody. Injeksiyon ya Eculizumab kandi ikoreshwa mu kuvura neuromyelitis optica spectrum disorder (NMOSD), indwara idakunze kugaragara itera ububabare bw'imitsi y'amaso n'umugongo. Ikoreshwa mu barwayi bafite anti-aquaporin-4 (AQP4) antibody. Injeksiyon ya Eculizumab ni imiti igizwe na antikororo imwe gusa ikora ku bukingo bw'umubiri. Iyi miti iboneka gusa muri gahunda y'ikwirakwizwa rigenzurwa yitwa Ultomiris® na Soliris® REMS (Risk Evaluation and Mitigation Strategy) Program. Iyi miti iboneka mu buryo bukurikira:
Mbere yo gukoresha uyu muti
Mu gufata icyemezo cyo gukoresha imiti, ingaruka mbi zo gufata iyo miti zigomba guhanurwa n'akamaro izagira. Iki ni icyemezo uzatanga hamwe na muganga wawe. Kuri iyi miti, ibi bikurikira bigomba kwitabwaho: Bwira muganga wawe niba warigeze ugira uburwayi budasanzwe cyangwa ubwandu bw'imiti kuri iyi miti cyangwa izindi miti. Nanone, bwira umuhanga mu by'ubuzima ufite andi moko y'uburwayi, nko ku biribwa, amabara, ibintu byongera ubuzima, cyangwa inyamaswa. Ku bicuruzwa bitagomba kwandikwa, soma witonze ibikoresho biri ku gipfunyika cyangwa ku kimenyetso. Ubushakashatsi bukwiye bwakozwe kugeza ubu ntabwo bwerekanye ibibazo byihariye by'abana byabuza ikoreshwa ry'urushinge rwa eculizumab mu kuvura indwara ya hemolytic uremic syndrome idasanzwe mu bana. Ariko kandi, umutekano n'ingaruka nziza z'urushinge rwa eculizumab mu kuvura izindi ndwara ntibyarangiye mu bana. Ubushakashatsi bukwiye bwakozwe kugeza ubu ntabwo bwerekanye ibibazo byihariye by'abakuze byabuza ikoreshwa ry'urushinge rwa eculizumab mu bakuze. Nta bushakashatsi buhagije ku bagore bwo kumenya ingaruka ku mwana mu gihe ukoresha iyi miti mu gihe cyo konsa. Pima inyungu zishoboka ugereranije n'ingaruka mbi zishoboka mbere yo gufata iyi miti mu gihe cyo konsa. Nubwo imiti imwe n'imwe idakwiye gukoreshwa hamwe na gato, mu bindi bihe imiti ibiri itandukanye ishobora gukoreshwa hamwe nubwo hariho ikibazo gishobora kubaho. Muri uru rubanza, muganga wawe ashobora kwifuza guhindura umwanya, cyangwa izindi ngamba zishobora kuba ngombwa. Iyo uhawe iyi miti, ni ngombwa cyane ko umuhanga mu by'ubuzima azi niba ufashe imiti iri hasi. Ibi bikurikira byatoranijwe hashingiwe ku kamaro kabyo kandi si ngombwa ko ari byose. Gukoresha iyi miti hamwe n'imiti ikurikira ntibisanzwe bisabwa, ariko bishobora kuba ngombwa mubihe bimwe na bimwe. Niba imiti yombi yandikiwe hamwe, muganga wawe ashobora guhindura umwanya cyangwa uko uyikoresha rimwe cyangwa imiti yombi. Imiti imwe n'imwe ntigomba gukoreshwa mu gihe cyo kurya cyangwa hafi yacyo cyangwa kurya imirire imwe n'imwe kuko hariho ikibazo gishobora kubaho. Gukoresha inzoga cyangwa itabi hamwe n'imiti imwe nabyo bishobora gutera ibibazo. Ganira n'umuhanga mu by'ubuzima ku gukoresha imiti yawe hamwe n'ibiribwa, inzoga cyangwa itabi. Kuba hari ibindi bibazo by'ubuzima bishobora kugira ingaruka ku ikoreshwa ry'iyi miti. Menya neza kubwira muganga wawe niba ufite ibindi bibazo by'ubuzima, cyane cyane:
Uburyo bwo gukoresha uyu muti
Umuforomokazi cyangwa undi wubatse ubumenyi mu buvuzi azaguha iyi miti. Iyi miti itangirwa mu buryo bwo kuyiterera mu mutsiko w'amaraso ukoreshwa mu gutera imiti (IV catheter) ushyirwa mu mubiri wawe. Igomba guterwa buhoro buhoro, bityo umutsiko wawe uzakenera kuguma aho uherereye nibura iminota 35 ku bakuru n'amasaha 1 kugeza kuri 4 ku bana. Ni ingenzi cyane ko ubwira ibijyanye na gahunda ya Ultomiris® na Soliris® REMS, kandi ukamenya neza amabwiriza ajyanye n'imiti ya Soliris®. Soma kandi ukurebereho aya mabwiriza neza. Baza muganga wawe niba ufite ikibazo icyo ari cyo cyose. Baza umuguzi w'imiti amabwiriza ajyanye n'imiti niba utayifite.