Icyo Fecal Microbiota Live-jslm (Uburyo bwo mu rukururano): Ibikoreshwa, Urutonde rw'imiti, Ingaruka zayo n'ibindi

Fecal microbiota live-jslm ni umuti wandikirwa na muganga urimo bagiteri nziza ziva mu musaruro w'umuntu watoranyijwe neza. Ubu buvuzi bufasha gusubiza uburinganire busanzwe bwa bagiteri nziza mu mara yawe igihe bagiteri mbi zifashe ubutegetsi, cyane cyane nyuma y'indwara zikomeye nka C. difficile.

Bitekereze nk'uburyo bwo "gusubiza" umuryango wa bagiteri mu mara yawe mu buzima bwiza. Uyu muti utangwa unyuze mu rukururano nk'umuti, ukemerera bagiteri nziza kugera mu mara manini yawe aho zishobora kwishyiriraho no kwirukana bagiteri mbi zikuzanira indwara.

Fecal Microbiota Live-jslm ikoreshwa mu iki?

Uyu muti wagenewe by'umwihariko gukumira indwara ya C. difficile yisubiramo mu bantu bakuru. C. difficile ni bagiteri ikomeye ishobora gutera impiswi ikabije, colitis, n'ibibazo biteye ubuzima bw'akaga iyo yiyongereye mu mara yawe.

Ubu buvuzi buba ngombwa iyo imiti isanzwe yica mikorobe itashoboye gukumira C. diff kugaruka kenshi. Muganga wawe azasuzuma ubu buryo niba waragize ibibazo byinshi bya C. difficile nubwo warangije imiti yica mikorobe.

Uyu muti ukora uzana miliyoni za bagiteri nziza zirushanwa na C. difficile kubona umwanya n'intungamubiri mu mara yawe. Ibi bifasha urwego rw'amara yawe gusubira mu buzima bwayo busanzwe, burinda.

Fecal Microbiota Live-jslm ikora ite?

Uyu muti ukora usubiza microbiome y'amara yawe, ari umuryango ugoye wa bagiteri utuye mu mara yawe. Iyo indwara ya C. difficile ibayeho, akenshi zisenya bagiteri zawe nyinshi zirinda, zigatuma bagiteri mbi zikura.

Udukoko twiza twifashishwa muri ubu buvuzi dukora nk'ingabo ikingira amara yawe. Batanga ibintu bituma C. difficile itabasha kubaho no kwiyongera, mu gihe kandi bifasha urugingo rwawe rw'ubudahangarwa gukora neza.

Ibi bifatwa nk'ubuvuzi bwibanda ku cyo buri gukora ariko bukomeye. Nubwo atari umuti "ukomeye" mu buryo busanzwe, ni mwiza cyane kuko uvura ikibazo nyirizina cy'indwara zigaruka aho guhagarika ibimenyetso by'agateganyo.

Nkwiriye Gufata Nte Fecal Microbiota Live-jslm?

Uyu muti utangwa nk'urushinge rumwe rwo mu kibuno, akenshi rutangwa n'umuganga mu bitaro. Ubu buvuzi bukubiyemo gushyira umuti w'amazi mu kibuno ukoresheje urushinge rwihariye, nk'uko andi marushinge yo mu kibuno atangwa.

Mbere yo kuvurwa, muganga wawe ashobora kugusaba kurangiza umuti w'antibiotics kugira ngo ugabanye mikorobe ya C. difficile mu mubiri wawe. Uzaba ukeneye guhagarika gufata antibiotics byibuze amasaha 24 kugeza kuri 48 mbere yo guhabwa ubuvuzi bwa fecal microbiota.

Nta mbogamizi zidasanzwe z'imirire mbere yo kuvurwa, ariko kuguma ufite amazi ahagije bifasha buri gihe. Muganga wawe azaguha amabwiriza arambuye ku byo witegura no kwitegura.

Nyuma yo guhabwa urushinge, uzasabwa kuryama ku ruhande rwawe ukagerageza kubika umuti igihe kirekire gishoboka, byaba byiza byibuze iminota 15. Ibi bituma udukoko twiza tugira umwanya wo kwimuka mu mara yawe.

Mbwiriza Gufata Fecal Microbiota Live-jslm Igihe Kingana Gite?

Uku ni ubuvuzi bumwe gusa, si ikintu ufata kenshi nk'imiti isanzwe. Abantu benshi bakeneye urugero rumwe gusa kugira ngo birinde neza indwara za C. difficile mu gihe kizaza.

Mikobateri zifitiye akamaro ziva mu buvuzi zikora kugira ngo zishyireho itsinda rirambye kandi ryiza mu mara yawe. Iyo zimaze gushyirwaho, izo mikobateri zikomeza gukora kugira ngo zikurinde indwara zizaza zitagombye doze zindi.

Muganga wawe azakurikirana iterambere ryawe binyuze mu nama zo gukurikirana kugira ngo yemeze ko ubuvuzi bukora neza. Niba ibimenyetso bya C. difficile bisubiyeho, umuganga wawe ashobora gutekereza ku zindi nzira zo kuvura, nubwo ibyo bidakunze kubaho.

Ni izihe ngaruka ziterwa na Fecal Microbiota Live-jslm?

Abantu benshi bakira neza ubu buvuzi, ingaruka zikaba zikunda kuba nto kandi z'agateganyo. Ibimenyetso bikunze kugaragara bibaho nyuma gato yo kwakira enema kandi bikunda gukemuka mu munsi umwe cyangwa ibiri.

Dore ingaruka ushobora guhura nazo, dutangiriye ku zikunze kugaragara:

• Kubabara mu nda cyangwa kutumva neza mu gihe cyangwa nyuma y'inzira
• Kuzana umwuka mubi cyangwa gushiraho igihe sisitemu yawe yo mu nda yihinduranya
• Isesemi rito, akenshi rishira vuba
• Impinduka z'agateganyo mu myitwarire y'amara cyangwa imiterere y'umwanda
• Kunanirwa ku munsi wo kuvurwa

Izi ngaruka muri rusange ni uburyo umubiri wawe uhinduranya n'ibidukikije bishya bya bagiteri. Abantu benshi basanga ko kutumva neza kwose ari guto cyane ugereranije n'ibyo bahuye nabyo hamwe n'indwara zabo za C. difficile.

Ingaruka zidakunze kubaho ariko zikomeye zirashobora kubaho rimwe na rimwe, nubwo bidakunze kubaho hamwe n'ubu buvuzi:

• Kubabara mu nda bikabije bitagira icyo bigeraho
• Urugohe rwinshi cyangwa ibimenyetso by'indwara
• Kuruka bidahagarara
• Uko umubiri wifatanya n'ibindi bintu, nubwo ibi bidasanzwe cyane

Niba uhuye n'ibimenyetso bikabije cyangwa biteye impungenge, hamagara umuganga wawe ako kanya. Bashobora gufasha kumenya niba ibyo urimo guhura nabyo bisanzwe cyangwa bisaba ubufasha bw'ubuvuzi.

Ninde utagomba gufata Fecal Microbiota Live-jslm?

Ubu buvuzi ntibukwiriye buri wese, cyane cyane abafite uburwayi bw'umubiri butuma udakora neza cyangwa abafite indwara zimwe na zimwe. Muganga wawe azasuzuma neza niba uyu muti ufitiye umutekano mu bihe byawe byihariye.

Abantu bagomba kwirinda ubu buvuzi barimo abafite:

• Uburwayi bukomeye butuma umubiri udakora neza cyangwa ibintu byangiza umubiri
• Ukuva amaraso gukabije mu gifu cyangwa indwara ikomeye yo mu mara
• Allergies zizwi ku bice byose by'umuti
• Ubwoko bumwe na bumwe bwa kanseri yibasira igifu
• Gusama cyangwa konsa (umutekano nturasobanuka)

Byongeye kandi, abantu bafata imiti imwe n'imwe igabanya imikorere y'umubiri bashobora gukenera ibitekerezo byihariye cyangwa ubuvuzi bundi.

Umuvuzi wawe azasuzuma amateka yawe yose y'ubuzima n'imiti ufata ubu kugira ngo amenye niba ubu buvuzi bukugirira akamaro. Bazatekereza kandi ku bintu nk'imyaka yawe, ubuzima bwawe muri rusange, n'uburemere bw'indwara yawe ya C. difficile.

Izina ry'ubwoko bwa Fecal Microbiota Live-jslm

Uyu muti uboneka ku izina ry'ubwoko rya Rebyota, ryari ryo rya mbere ryemewe na FDA ry'ibicuruzwa bya fecal microbiota mu kurinda indwara ya C. difficile yisubiramo. Rebyota ihagarariye iterambere rikomeye mu kuvura iyi ndwara igoye.

Uyu muti ukorwa hakurikijwe amategeko akomeye y'umutekano n'ubuziranenge, hamwe no gupima cyane ibikoresho by'abatanga kugira ngo umutekano n'ubushobozi byizurwe. Ubu buryo bukomeye bufasha kwemeza ko abarwayi bahabwa ubuvuzi buhoraho kandi bwiza.

Uburyo bwa Fecal Microbiota Live-jslm

Hariho ubundi buryo bwo kuvura bwo kurinda indwara ya C. difficile yisubiramo, nubwo bikora binyuze mu buryo butandukanye. Muganga wawe ashobora gutekereza kuri izi nzira zindi zishoboka bitewe n'ibihe byawe byihariye n'amateka yawe y'ubuzima.

Uburyo bwa kera bwa antibiyotike burimo:

• Imiti miremire ya vancomycin hamwe no kugabanya buhoro buhoro
• Fidaxomicin, ishobora kuba yoroshye ku mikorobe isanzwe yo mu mara yawe
• Ubuvuzi bwo guhuza imiti yica mikorobe

Ubuvuzi bundi bushingiye ku mikorobe nayo burimo kuboneka, harimo n'imiti yo mu kanwa y'ibinyabutabuzi bifitiye akamaro. Ubu buryo bushya bushobora koroha gukoreshwa kurusha enemas yo mu mpande z'inyuma.

Ku byago bikomeye, abarwayi bamwe bashobora kungukira mu kwimurwa kw'imikorobe yo mu mara (FMT) bikorwa binyuze muri colonoscopy cyangwa izindi nzira. Umuganga wawe w'indwara z'igifu n'amara ashobora gufasha kumenya uburyo bushobora gukora neza ku miterere yawe.

Ese Kwimurwa kw'imikorobe yo mu mara biruta Vancomycin?

Ubu buvuzi bubiri bukora mu buryo butandukanye, bigatuma kugereranya mu buryo butaziguye bigorana. Vancomycin ni umuti wica mikorobe wica mikorobe ya C. difficile, mugihe kwimurwa kw'imikorobe yo mu mara gusubiza mikorobe zirinda kugirango zirinde indwara zizaza.

Vancomycin ikoreshwa cyane mugukiza indwara ya C. difficile ikiriho kandi irashobora gukora cyane muguhagarika ibimenyetso biriho. Ariko, ntigikemura ikibazo cy'ibanze cy'imikorobe yo mu mara yahungabanye ituma C. difficile igaruka.

Kwimurwa kw'imikorobe yo mu mara byateguwe by'umwihariko kugirango birinde indwara zigaruka binyuze mu kongera kubaka ubwirinzi bwawe bw'imikorobe. Ubushakashatsi butanga icyizere ko bishobora gukora neza kurusha imiti miremire yica mikorobe mugukumira ibyago bizaza.

Abarwayi benshi bakira ubuvuzi bwombi bukurikirana. Mbere, imiti yica mikorobe nka vancomycin ikiza indwara ikiriho, hanyuma kwimurwa kw'imikorobe yo mu mara bifasha kwirinda kugaruka binyuze mu gusubiza mikorobe nziza mu mara.

Ibikunze Kubazwa Ku Kwimurwa Kw'imikorobe yo mu mara

Ibibazo 1. Ese Kwimurwa kw'imikorobe yo mu mara birinzwe ku bantu barwaye diyabete?

Yego, kugira diyabete ntibisanzwe kukubuza kwakira ubu buvuzi. Ariko, muganga wawe azashaka kumenya niba isukari yo mu maraso yawe igenzurwa neza mbere na nyuma y'ubwo buryo, kuko ubuvuzi ubwo aribwo bwose bushobora kugira ingaruka ku micungire ya diyabete.

Abantu bafite diyabete ntibashyirwa mu kaga gakomeye ko kugira ingaruka ziterwa na fecal microbiota live-jslm by'umwihariko. Itsinda ryawe ry'ubuzima rizakugenzura neza kandi rishobora gutanga ubuyobozi bw'inyongera ku bijyanye no gucunga isukari yo mu maraso yawe mu gihe cy'ubuvuzi.

Q2. Nkwiriye gukora iki niba mbonye fecal microbiota live-jslm nyinshi mu buryo butunganye?

Ibi ntibisanzwe cyane kuko umuti utangwa n'abashinzwe ubuzima mu buryo bwo kuvura buri gihe. Ubuvuzi buza nk'urugero rumwe rukoreshwa rimwe rukoreshwa neza, rwakoreshejwe neza ku bw'umutekano n'imikorere.

Niba ufite impungenge ku buvuzi bwawe cyangwa ubonye ibimenyetso bitunguranye nyuma yo kwakira umuti, vugana n'umuganga wawe ako kanya. Bashobora gusuzuma uko uhagaze kandi bagatanga ubuyobozi bukwiye cyangwa kugenzura niba bikwiye.

Q3. Nkwiriye gukora iki niba ntasibye urugero rwanjye rwa fecal microbiota live-jslm?

Kubera ko ubu busanzwe ari ubuvuzi bumwe butangwa mu buryo bwo kuvura,

Utubakteri twiza dukomeza gukora kugira ngo turinde indwara ya C. difficile mu gihe kizaza, bitagombye gukoresha imiti yindi. Muganga wawe azakurikiza uko urimo urwara binyuze mu biganiro byo gukurikirana kugira ngo yemeze ko imiti ikora neza uko igihe kigenda.

Q5. Mbese nshobora gufata imiti ya probiyotike nkorera fecal microbiota live-jslm?

Muganga wawe akenshi azagusaba kwirinda probiyotike n'izindi nzego zishobora kubangamira imiti mu gihe mbere na nyuma yo gufata fecal microbiota live-jslm. Ibi bifasha kwemeza ko utubakteri twiza twaturutse mu miti twashobora kwishyiriraho neza.

Nyuma y'uko imiti imaze igihe gito ikora, akenshi ibyumweru byinshi, umuganga wawe ashobora kukugira inama yo kongera gufata probiyotike cyangwa izindi nzego niba bikenewe. Buri gihe jya ureba muganga wawe mbere yo gutangira izindi nzego nshya mu gihe urimo ufata imiti.