Icyo Fedratinib Arimwo: Ibikoreshwa, Uburyo Bw'imiti, Ingaruka Zayo n'ibindi

Fedratinib ni umuti w'indwara ya kanseri ugamije gufasha kuvura kanseri zimwe na zimwe zo mu maraso binyuze mu kubuza proteyine zihutisha ikura ry'indwara. Uyu muti unyobwa mu kanwa wo mu cyiciro cyitwa JAK2 inhibitors, zikora zihagarika ibimenyetso bibwira selile za kanseri kwiyongera no gutera ibimenyetso nk'urwungano runini rw'umwijima no kunanirwa cyane.

Muganga wawe ashobora kugutera fedratinib igihe ufite myelofibrosis, kanseri idasanzwe yo mu maraso igira ingaruka ku bushobozi bw'umushongi w'amagufa bwo gukora selile z'amaraso nziza. Nubwo iyi diagnosis ishobora kumvikana nk'ikomeye, fedratinib itanga icyizere binyuze mu kugamisha ku mpamvu nyamukuru y'ibimenyetso byawe no gufasha gusubiza ubuzima bwawe mu buryo bwiza.

Fedratinib Ikoreshwa Kuri Iki?

Fedratinib ivura myelofibrosis, ubwoko bwa kanseri yo mu maraso aho umushongi w'amagufa yawe uhinduka ibibara kandi ntushobore gukora selile z'amaraso uko bisanzwe. Iyi ndwara ituma urwungano rw'umwijima wawe rwaguka uko rugerageza kwishyura rukora selile z'amaraso, bigatuma ibimenyetso bitari byiza bigira ingaruka ku buzima bwawe bwa buri munsi.

Muganga wawe yandika fedratinib by'umwihariko kuri intermediate-2 cyangwa high-risk primary myelofibrosis, cyangwa secondary myelofibrosis yatewe n'izindi ndwara zo mu maraso. Uyu muti ufasha kugabanya urwungano rw'umwijima wawe rwagutse kandi ugabanya ibimenyetso bikomeye nk'ukunanirwa cyane, ibyuya byo mu ijoro, no kumva wuzuye nyuma yo kurya ibintu bito.

Mu bihe bimwe na bimwe, fedratinib irashobora gushyirwaho niba wagerageje izindi JAK inhibitors nka ruxolitinib ariko ukagira ingaruka z'uruhande cyangwa imiti igahagarara gukora neza. Ibi biguha ubundi buryo bwo kuvura mugihe uhanganye n'iyi ndwara igoye.

Fedratinib Ikora Gute?

Fedratinib ikora ibuza proteyine za JAK2, zikora cyane muri myelofibrosis kandi zohereza ibimenyetso bihoraho kubw'umubiri wawe gukora selile z'amaraso zidasanzwe. Tekereza JAK2 nk'ikimuri cyashyizwe mu mwanya wa "on", gitera umushongi w'amagufa yawe gukora nabi n'urwungano rw'umwijima wawe rwaguka.

Uyu muti ufatwa nk'ubuvuzi bukomeye, bugamije guhangana n'impinduka za genetike ziteza myelofibrosis yawe. Mu kubuza ibyo bimenyetso, fedratinib ifasha kugabanya ubunini bwa seleni, kugabanya umubabaro w'ibimenyetso, kandi ishobora gutuma indwara itagenda vuba.

Uyu muti winjira mu maraso yawe nyuma yo kuwufata unywa, ugakwira mu mubiri wawe wose kugera ku turemangingo twagizweho ingaruka. Abantu benshi barabona impinduka nziza mu bimenyetso mu mezi make ya mbere yo kuvurwa, nubwo uko umuntu abyitwaramo bishobora gutandukana.

Nkwiriye gufata nte Fedratinib?

Fata fedratinib nk'uko umuganga wawe abikwandikiye, akenshi rimwe ku munsi ku gihe kimwe buri munsi. Urashobora kuyifata urya cyangwa utarya, ariko kuyifata urya birashobora kugufasha kugabanya ibibazo byo mu nda niba wumva isesemi.

Mimina ibinini byose hamwe n'ikirahure kinini cy'amazi - ntukabice, ntukayisye, cyangwa ngo uyifungure kuko ibi bishobora kugira ingaruka ku buryo umuti ukora. Niba ugira ibibazo byo kumira ibinini, ganira n'umuganga wawe ku bindi bisubizo aho kugerageza guhindura ibinini wenyine.

Mbere yo gutangira gufata fedratinib, umuganga wawe azagenzura urwego rwa thiamine (vitamine B1) yawe kandi ashobora kugusaba ibiyongera. Ibi ni ngombwa kuko fedratinib ishobora kugira ingaruka kuri thiamine mu mubiri wawe, kandi kugumana urwego rwo hejuru bifasha kwirinda ingaruka zikomeye.

Bika umuti wawe ku bushyuhe busanzwe kure y'ubushuhe n'ubushyuhe. Ubike mu gikoresho cyacyo cy'umwimerere kandi kure y'abana n'amatungo kugira ngo birinde impanuka.

Nkwiriye gufata Fedratinib igihe kingana iki?

Uzakenera gufata fedratinib igihe cyose ikomeje gufasha kugenzura ibimenyetso bya myelofibrosis yawe kandi umubiri wawe ukayihanganira neza. Abantu benshi bafata uyu muti mu mezi menshi kugeza ku myaka myinshi, kuko myelofibrosis ni indwara idakira isaba kuvurwa buri gihe.

Muganga wawe azakurikirana uko umubiri wawe witwara binyuze mu bipimo by'amaraso bya buri gihe no mu bizami by'umubiri kugira ngo asuzume niba umuti ukora neza. Bazapima ubunini bw'urwagashya rwawe kandi basuzume ibimenyetso byawe kugira ngo bamenye niba fedratinib ikomeza kugufasha.

Niba uhuye n'ingaruka zikomeye cyangwa umuti ukaba utagikora neza mu kugenzura ibimenyetso byawe, muganga wawe ashobora guhindura urugero rwawo cyangwa agatekereza ku zindi miti. Ntukigere uhagarika gufata fedratinib ako kanya utabanje kubiganiraho n'ikipe yawe y'ubuzima.

Ni izihe ngaruka ziterwa na Fedratinib?

Kimwe n'indi miti yose, fedratinib ishobora gutera ingaruka, nubwo atari buri wese uzihura. Ingaruka nyinshi zishobora gucungwa neza hakoreshejwe gukurikiranwa neza no gufashwa n'ikipe yawe y'ubuzima.

Dore ingaruka zisanzwe ushobora guhura nazo mugihe ufata fedratinib:

• Impiswi, zishobora kuva ku zoroshye kugeza ku zikomeye
• Isesemi no kuruka
• Anemiya (umubare muto w'uturemangingo dutukura tw'amaraso)
• Umubare muto wa platelet, ushobora kongera ibyago byo kuva amaraso
• Umunaniro no kunanuka
• Indwara z'inkari
• Imitsi y'umubiri
• Urugero

Izi ngaruka akenshi zinoza uko umubiri wawe wimenyereza umuti, kandi muganga wawe ashobora gutanga imiti yo gufasha kuzicunga neza.

Zimwe mu ngaruka zidakunze kubaho ariko zikomeye zisaba ubufasha bwihuse bwa muganga. Vugana na muganga wawe ako kanya niba uhuye n'urujijo, ibibazo byo kwibuka, kugorana kwibanda, cyangwa ibimenyetso byose byo kwandura nka umuriro cyangwa inkorora ihoraho.

Uburwayi bukomeye ariko butabaho cyane bita Wernicke encephalopathy bushobora kubaho niba urugero rwawe rwa thiamine rugabanutse cyane. Ibi nibyo bituma muganga wawe akurikirana urugero rwawe rwa thiamine kandi ashobora kwandika imiti yongera imbaraga - ni ingamba z'ingenzi zo kwirinda iyi ngorane.

Ninde utagomba gufata Fedratinib?

Fedratinib ntabwo ikwiriye buri wese, kandi muganga wawe azasuzuma neza niba ari umutekano kuri wowe bitewe n'amateka yawe y'ubuvuzi n'ubuzima bwawe bw'ubu. Ibyiciro bimwe na bimwe cyangwa ibihe bituma uyu muti ushobora kuba mubi.

Ntabwo ukwiriye gufata fedratinib niba ufite indwara ikomeye y'impyiko, kuko umubiri wawe ushobora kutabasha gutunganya neza uyu muti. Muganga wawe azagenzura imikorere y'impyiko zawe mbere yo kugusabira uyu muti.

Abantu bafite indwara zikomeye zikora, ntibagomba gutangira gufata fedratinib kuko ishobora gukandamiza ubudahangarwa bwawe kandi ikongera indwara. Muganga wawe azavura indwara zose mbere yo gutekereza kuri uyu muti.

Niba utwite cyangwa wonka, fedratinib ishobora kwangiza umwana wawe kandi ntibisabwa. Abagore bafite imyaka yo kubyara bakwiriye gukoresha uburyo bwo kuboneza urubyaro bukora neza mugihe bafata uyu muti no muminsi nibura mike nyuma yo kuwuhagarika.

Muganga wawe azitondera kandi gusaba fedratinib niba ufite amateka y'ibibazo bikomeye by'umwijima, indwara zimwe na zimwe z'umutima, cyangwa wigeze ugira ibibazo bikomeye byatewe na JAK inhibitors.

Amazina ya Fedratinib

Fedratinib igurishwa munsi y'izina ry'ubucuruzi rya Inrebic muri Leta Zunze Ubumwe z'Amerika n'ibindi bihugu. Iri niryo zina ry'ibanze uzabona ku icupa ryawe ry'urukingo no ku gipfunyika cy'imiti.

Ubu, Inrebic nicyo kirango cy'ingenzi gihari, nubwo ubwoko bwa generic bushobora kuboneka mugihe kizaza mugihe patenti zirangiye. Kora buri gihe ukoresha ubwoko bwihariye cyangwa generic muganga wawe yaguteye, kuko ibintu bitandukanye bishobora kugira ingaruka zitandukanye.

Niba uri murugendo cyangwa ufite imiti yuzuzwa mumavuriro atandukanye, menya kuvuga izina rya generic (fedratinib) n'izina ry'ubucuruzi (Inrebic) kugirango wirinde urujijo.

Uburyo bwa Fedratinib

Imiti myinshi ishobora kuvura myelofibrosis niba fedratinib itagukwiriye cyangwa ikaba itagikora neza. Muganga wawe azareba uko ubuzima bwawe buhagaze, imiti wabanje gufata, n'ubuzima bwawe muri rusange mu gihe agushakira imiti.

Ruxolitinib (Jakafi) akenshi ni umuti wa mbere uvura myelofibrosis kandi ukora kimwe na fedratinib mu guhagarika poroteyine za JAK. Abarwayi benshi bagerageza ruxolitinib mbere yo gutekereza fedratinib, cyane cyane niba batarigeze bafata imiti ya JAK inhibitor.

Pacritinib (Vonjo) ni undi muti wa JAK inhibitor ushobora gukwira niba ufite umubare muto cyane wa platelet, kuko yagenewe abarwayi batabasha gufata izindi miti ya JAK inhibitor kubera thrombocytopenia ikomeye.

Ku barwayi bamwe, ibikorwa byo kubafasha nko kongera amaraso, imiti yo kugabanya ibimenyetso, cyangwa ndetse no kwimura umushongi w'amagufa bishobora gutekerezwa bitewe n'imyaka, ubuzima muri rusange, n'uburemere bw'indwara.

Ese Fedratinib iruta Ruxolitinib?

Bombi fedratinib na ruxolitinib ni imiti ya JAK inhibitor ikora neza mu kuvura myelofibrosis, ariko buri imwe ifite ibyiza byayo bitewe n'uko ubuzima bwawe buhagaze. Nta n'imwe iruta izindi - guhitamo biterwa n'uko ubuzima bwawe buhagaze n'amateka y'imiti wafashe.

Ruxolitinib akenshi yandikwa mbere kuko imaze igihe kinini iboneka kandi ifite uburambe bwinshi mu buvuzi. Ariko, fedratinib ishobora gukundwa niba warigeze ugerageza ruxolitinib ukagira ingaruka mbi cyangwa niba umuti utagikora neza kuri wowe.

Fedratinib ishobora gutanga ibyiza mu bihe bimwe na bimwe, nk'igihe ukeneye ingaruka zitandukanye cyangwa niba indwara yawe ifite ibiranga byihariye bituma fedratinib ikwira kurushaho. Abarwayi bamwe basubiza neza ku buryo fedratinib ikora.

Umuganga wawe azatekereza ku bintu nk'imibare y'amaraso yawe, imiti wakoresheje mbere, imikorere y'impyiko, n'ubuzima bwawe muri rusange mugihe afata icyemezo hagati y'iyi miti. Guhitamo "neza" ni kimwe kigenzura neza ibimenyetso byawe mugihe gitera ingaruka nke zikomeye kuri wowe ku giti cyawe.

Ibikunze Kubazwa Kuri Fedratinib

Ese Fedratinib iratekanye kubafite indwara y'impyiko?

Fedratinib isaba kwitonderwa niba ufite indwara y'impyiko, kuko impyiko zawe zifasha gutunganya no gukuraho uyu muti mu mubiri wawe. Umuganga wawe azasuzuma imikorere y'impyiko zawe binyuze mu bipimo by'amaraso mbere yo kwandika fedratinib.

Niba ufite ibibazo byoroheje kugeza hagati by'impyiko, umuganga wawe arashobora kwandika fedratinib ariko azakugenzura neza kandi ashobora guhindura urugero rwawe. Ariko, niba ufite indwara ikomeye y'impyiko, fedratinib irashobora kutagukwira kuko ishobora kwiyongera kugeza ku rwego ruteje akaga mu mubiri wawe.

Buri gihe menyesha umuganga wawe ibibazo byose by'impyiko, kandi bazagena uburyo butekanye kuri wowe. Kugenzura buri gihe bifasha kumenya neza ko umuti ukomeza kuba mutekanye kandi ukora neza kuri wowe.

Nigute nzakora niba nanyweye fedratinib nyinshi bitunguranye?

Niba utunguranye ukanywa fedratinib nyinshi kuruta uko byategetswe, vugana n'umuganga wawe cyangwa ikigo gishinzwe kugenzura uburozi ako kanya, kabone niyo wumva umeze neza. Kunywa nyinshi bishobora kongera ibyago byo kugira ingaruka zikomeye.

Ntugerageze "gukosora" kubera kunywa nyinshi ugasiba doze zizaza - ibi birashobora guteza akaga kandi bigahindura imikorere y'imiti yawe. Ahubwo, kurikiza ubuyobozi bw'umuganga wawe kubijyanye no gukomeza gahunda yawe yo kuvurwa mu buryo butekanye.

Ibimenyetso byo kunywa fedratinib nyinshi birashobora kuba isesemi ikabije, kuruka, impiswi, cyangwa umunaniro udasanzwe. Shakisha ubufasha bw'ubuvuzi ako kanya niba ubonye ibimenyetso bibangamiye nyuma yo kunywa imiti yinyongera.

Nigute nzakora niba nasibye doze ya Fedratinib?

Niba wibagiwe gufata urugero rwa fedratinib, rufate uko wibuka, keretse igihe cyo gufata urugero rwawe rukurikira kigeze. Muri urwo rubanza, reka urugero wibagiwe ukomeze gahunda yawe isanzwe.

Ntuzigere ufata urugero ebyiri icyarimwe kugirango wuzuze urugero wibagiwe, kuko ibyo bishobora kongera ibyago byo kugira ingaruka ziterwa n'umuti. Gufata imiti mu buryo burenze urugero bishobora kuba bibi kandi bishobora gutera ibibazo bikomeye.

Niba ukunda kwibagirwa gufata imiti, tekereza gushyiraho ibyibutso kuri terefone cyangwa gukoresha umuteguro w'imiti kugirango bigufashe kuguma ku murongo. Gufata imiti buri munsi mu buryo buhoraho ni ingenzi kugirango ugumane imikorere y'umuti mu kugenzura myelofibrosis yawe.

Ni ryari nshobora kureka gufata Fedratinib?

Ugomba kureka gufata fedratinib gusa ukurikije ubuyobozi bwa muganga wawe, kuko guhagarara mu buryo butunguranye bishobora gutuma ibimenyetso bya myelofibrosis yawe bisubira cyangwa bikarushaho. Muganga wawe azagenzura buri gihe niba umuti ukomeza kugufasha.

Muganga wawe ashobora kugusaba kureka gufata fedratinib niba ugize ingaruka zikomeye zitashobora gucungwa, niba umuti uhagaritse kugenzura ibimenyetso byawe neza, cyangwa niba ubuzima bwawe muri rusange buhinduka cyane.

Mbere yo guhagarara, muganga wawe azaganira ku buryo bwo kuvura bushoboka kugirango yemeze ko ukomeza kwakira ubuvuzi bukwiye bwa myelofibrosis yawe. Bashobora kandi kugabanya buhoro buhoro urugero rwawe aho guhagarara mu buryo butunguranye kugirango bagabanye ibibazo byose bishoboka.

Nshobora gufata Fedratinib hamwe n'indi miti?

Fedratinib irashobora guhura n'indi miti, bityo ni ngombwa kubwira muganga wawe imiti yose yanditswe, imiti itangwa nta cyangombwa, n'ibyongerera imbaraga ufata. Imvange zimwe zirashobora kongera ingaruka ziterwa n'umuti cyangwa zigatuma udakora neza.

Imiti imwe ikora ku bushobozi bw'umwijima bwo gutunganya imiti irashobora gusaba guhindura urugero cyangwa ubuvuzi bundi. Muganga wawe azasuzuma imiti yawe yose kugirango yemeze imvange zifite umutekano.

Banza uganire na muganga wawe cyangwa umufarumasiti mbere yo gutangira imiti mishya, harimo n’imiti ikoreshwa mu byatsi cyangwa vitamine, igihe urimo gufata fedratinib. Iki gikorwa cyoroshye gifasha kwirinda imikoranire y’imiti ishobora guteza akaga kandi kigafasha kumenya ko ubuvuzi bwawe bukomeza kuba bwiza kandi bugatanga umusaruro.