Icyo Fenfluramine ari cyo: Ibikoreshwa, Urutonde rw'imiti, Ingaruka ziterwa n'iyo miti n'ibindi

Fenfluramine ni umuti wandikirwa n'abaganga ukoreshwa cyane cyane mu kuvura ibibazo byo gufatwa n'indwara y'igicuri ku bantu bafite indwara ya Dravet, ubu bwoko bw'indwara y'igicuri bukaba ari ubwo gake kandi bukomeye. Uyu muti ukora mu kugabanya inshuro n'uburemere bwo gufatwa n'indwara y'igicuri, cyane cyane gufatwa n'indwara y'igicuri bigoye kuvura biranga iyi ndwara.

Mugihe fenfluramine yakoreshwaga mbere mu kugabanya ibiro mu myaka mirongo ishize, ubu ikoreshwa mu buvuzi yibanda gusa ku gucunga ibibazo byo gufatwa n'indwara y'igicuri. Uyu muti ushobora guhura nawo uyu munsi wateguwe by'umwihariko kandi wemerejwe kuvura indwara y'igicuri, ntabwo ukoreshwa mu kugenzura ibiro.

Fenfluramine ni iki?

Fenfluramine ni umuti usohora serotonin ugira ingaruka ku imikorere y'ubwonko kugirango ufashishe kugenzura ibibazo byo gufatwa n'indwara y'igicuri. Uyu muti ubarirwa mu cyiciro cy'imiti ikora mu kongera urwego rwa serotonin mu duce twihariye tw'ubwonko dushinzwe ibikorwa byo gufatwa n'indwara y'igicuri.

Uyu muti uza mu buryo bw'umuti unyobwa mu kanwa. Wateguwe by'umwihariko ku bantu bafite indwara ya Dravet, ubu bwoko bw'indwara y'igicuri butangira akenshi mu bwana kandi bushobora kugorana cyane kuvura n'indi miti ivura ibibazo byo gufatwa n'indwara y'igicuri.

Muganga wawe azagenzura neza uko witwara kuri uyu muti, kuko bisaba ko uza gusuzumwa kenshi kugirango wemeze ko ukora neza kandi mu buryo butekanye ku miterere yawe yihariye.

Fenfluramine ikoreshwa mu kuvura iki?

Fenfluramine ikoreshwa cyane cyane mu kugabanya inshuro zo gufatwa n'indwara y'igicuri ku bantu bafite indwara ya Dravet. Ubu bwoko bw'indwara y'igicuri bukunda kuboneka ku bantu 1 kuri 15,000 kugeza 20,000 kandi akenshi ntibusubiza neza ku miti isanzwe ivura ibibazo byo gufatwa n'indwara y'igicuri.

Uyu muti ufasha by'umwihariko mu guhangana no gufatwa n'indwara y'igicuri bikomeye biranga indwara ya Dravet. Uku gufatwa n'indwara y'igicuri bishobora kuba byateza akaga kandi bikabangamira imibereho ya buri munsi, bituma kuvurwa neza ari ngombwa ku mutekano no ku mibereho myiza.

Mu bindi bihe, abaganga bashobora no gutekereza gukoresha fenfluramine ku bundi burwayi bw’imitsi butavugwa cyane, ariko ibi byaba ari ukuyikoresha mu buryo butemewe, bisaba kugenzurwa na muganga neza no kuganira ku nyungu n’ibibazo bishobora kuvuka.

Fenfluramine ikora ite?

Fenfluramine ikora yongera urwego rwa serotonin mu bwonko bwawe, cyane cyane mu duce tugenzura imitsi. Tekereza serotonin nk'ubutumwa bw'imiti bufasha imitsi y'ubwonko kuvugana neza kandi ituje.

Uyu muti ufashwe nk'ukomeye ku rugero rwo kugenzura imitsi. Ntiukora kimwe n'indi miti myinshi ivura imitsi, niyo mpamvu ishobora gufasha iyo izindi nshuti zitatanze umusaruro uhagije wo kugenzura imitsi.

Kongera imikorere ya serotonin bifasha guhagarika imikorere y'amashanyarazi mu bwonko bwawe, bituma imitsi itabaho cyane. Iyi nzira ifata igihe kugira ngo yubake mu mubiri wawe, niyo mpamvu ushobora kutabona inyungu zose ako kanya.

Nkwiriye gufata fenfluramine nte?

Fata fenfluramine nk'uko muganga wawe abitegeka, akenshi kabiri ku munsi hamwe cyangwa hatariho ibiryo. Uyu muti uza mu buryo bw'umuti unyobwa mu kanwa upima neza ukoresheje igikoresho cyagenewe gupima.

Ushobora gufata uyu muti hamwe n'amazi, amata, cyangwa umutobe niba byoroshye kumira. Nta mbogamizi zihariye z'ibiryo, ariko kuwufata hamwe n'ibiryo bishobora gufasha kugabanya ibibazo byose byo mu nda ushobora guhura nabyo.

Ni ngombwa gufata imiti yawe ku gihe kimwe buri munsi kugira ngo ugumane urwego ruzigama mu maraso yawe. Shyiraho ibyibutsa niba bikenewe, kuko igihe gihamye gifasha umuti gukora neza.

Muganga wawe ashobora gutangira kukugaburira urugero ruto buhoro buhoro akarwongera bitewe n'uko wabyitwayemo neza n'ingaruka zose uhuye nazo. Ntukigere uhindura urugero rwawe utabanje kuvugana n'umuganga wawe.

Mbwiriza gufata fenfluramine igihe kingana iki?

Fenfluramine ikoreshwa akenshi mu gihe kirekire mu kuvura ibibazo byo gufatwa n'indwara ya Dravet. Abantu benshi bagomba gukomeza kuyifata igihe cyose kugira ngo bagumane uburyo bwo kugenzura gufatwa n'indwara, kuko kuyihagarika mu buryo butunguranye bishobora gutuma ibibazo byo gufatwa n'indwara byiyongera.

Muganga wawe azajya asuzuma buri gihe uko umuti ugufitiye akamaro, akenshi buri mezi make mbere na mbere, hanyuma bikagenda bigabanuka iyo ibibazo byawe byo gufatwa n'indwara bigenda bigabanuka. Ibi bizafasha kumenya niba fenfluramine ikomeje kuba igisubizo cyiza kuri wowe.

Niba wowe na muganga wawe mwafata icyemezo cyo guhagarika fenfluramine, iki gikorwa gisaba gutegura neza no kugabanya urugero rwawo buhoro buhoro. Guhagarika imiti ivura gufatwa n'indwara mu buryo butunguranye birashobora guteza akaga kandi bishobora gutera gufatwa n'indwara kenshi cyangwa bikomeye.

Ni Ibihe Bikorwa Bigaragara Biterwa na Fenfluramine?

Kimwe n'indi miti yose, fenfluramine ishobora gutera ibikorwa bigaragara, nubwo abantu benshi bayihanganira neza. Ibikorwa bigaragara bikunze kugaragara muri rusange biroroshye kandi akenshi birakosoka uko umubiri wawe wimenyereza umuti.

Dore ibikorwa bigaragara bishobora kukubaho cyane, wibuke ko abantu benshi bagira bike cyangwa nta ngaruka zibangamiye:

• Kugabanya ubushake bwo kurya no kugabanya ibiro
• Kugira umunaniro cyangwa kumva unaniwe cyane kurusha uko byari bisanzwe
• Gusinzira cyangwa gusinzira cyane
• Impiswi cyangwa kwituma bigenda byoroshye
• Kuguma mu nda
• Urubore
• Indwara zo mu nzira yo hejuru yo mu myanya y'ubuhumekero

Ibi bikorwa bigaragara bikunze kugabanuka nyuma y'ibyumweru bike uko umubiri wawe wimenyereza umuti. Ariko, menyesha muganga wawe niba bikomeje cyangwa bikaba bibangamiye.

Ibikorwa bimwe bitagaragara cyane ariko bikomeye bisaba ubufasha bwihutirwa bwa muganga. Nubwo ibi bidasanzwe, ni ngombwa kubimenya:

• Ibibazo by'imitsi y'umutima cyangwa imitsi y'umutima
• Umuvuduko mwinshi w'amaraso mu bihaha (umuvuduko mwinshi w'amaraso mu bihaha)
• Impinduka zikomeye z'amarangamutima cyangwa agahinda gakabije
• Urugero rukabije rw'uburwayi bwo mu mubiri
• Glaucoma cyangwa umuvuduko w'amaso wiyongera

Muganga wawe azagukurikiranira hafi ibi bibazo bikomeye binyuze mu kugusuzuma buri gihe kandi ashobora gutegeka ibizamini by'umutima bya hato na hato kugira ngo yemeze ko umuti ukomeza kuba mwiza kuri wowe.

Ninde utagomba gufata Fenfluramine?

Fenfluramine ntabwo ikwiriye kuri buri wese, kandi muganga wawe azasuzuma neza amateka yawe y'ubuzima mbere yo kuyandika. Ubuzima bumwe butuma uyu muti ushobora kuba utekanye cyangwa utagira akamaro.

Ntabwo ugomba gufata fenfluramine niba ufite kimwe muri ibi bibazo, kuko bishobora kongera ibyago byo guhura n'ibibazo bikomeye:

• Indwara y'umutima cyangwa umutima utera urusaku
• Umuvuduko ukabije w'amaraso mu bihaha
• Indwara ikomeye y'umwijima cyangwa impyiko
• Glaucoma cyangwa umuvuduko w'amaso wiyongereye
• Allergie izwi kuri fenfluramine cyangwa imiti isa nayo

Byongeye kandi, bwire muganga wawe ku byerekeye imiti yose urimo gufata, kuko fenfluramine ishobora guhura n'imiti imwe, cyane cyane indi miti ikora kuri serotoni na bimwe mu bitera umunezero.

Kugira inda no konsa bisaba kwitonderwa byihariye. Mugihe gucunga ibyago byo gufatwa n'indwara yo mu mutwe mugihe cyo gutwita ari ngombwa, muganga wawe azagomba gupima inyungu n'ibyago bishobora kwibasira umwana wawe.

Amazina y'ubwoko bwa Fenfluramine

Fenfluramine iboneka munsi y'izina ry'ubwoko bwa Fintepla muri Leta Zunze Ubumwe z'Amerika. Iyi ni formulation yihariye yemerejwe na FDA yo kuvura ibibazo byo gufatwa n'indwara yo mu mutwe bifitanye isano na syndrome ya Dravet.

Izina ry'ubwoko rya Fintepla rifasha gutandukanya uyu muti w'ubu wo kuvura ibibazo byo gufatwa n'indwara yo mu mutwe n'uburyo bwa kera bwa fenfluramine bwakoreshwaga mugihe cyo kugabanya ibiro ariko ntibigihari. Jya ukoresha buri gihe ubwoko bwihariye na formulation muganga wawe yandika.

Ubwoko bwa fenfluramine bwa rusange bwo kuvura ibibazo byo gufatwa n'indwara yo mu mutwe ntibiraboneka cyane, bityo ibyanditswe byinshi bizuzuzwa n'izina ry'ubwoko rya Fintepla.

Uburyo bwa Fenfluramine

Imiti myinshi yindi irashobora gufasha gucunga ibibazo byo gufatwa n'indwara ya Dravet, nubwo guhitamo neza biterwa n'uburyo wabyakiriye n'amateka yawe y'ubuvuzi. Muganga wawe ashobora gutekereza izi nzira niba fenfluramine itakwiriye cyangwa idakora neza kuri wowe.

Ubusanzwe izindi nzira zirimo stiripentol, clobazam, aside ya valproic, na topiramate. Buri kimwe gikora mu buryo butandukanye mu bwonko kandi gishobora gukora cyane cyangwa gake bitewe n'uburyo bwawe bwihariye bwo gufatwa n'indwara n'ibindi bibazo by'ubuzima.

Imiti ishingiye kuri Cannabis nka cannabidiol (CBD) nayo yemerejwe indwara ya Dravet kandi ishobora gutekerezwa nk'izindi nzira cyangwa kongerwa kuri fenfluramine, bitewe n'uko ubuzima bwawe bumeze.

Ntugasimbuze imiti utabiganiriyeho na muganga wawe, kuko imiti yo gufata indwara isaba kwitonda kugirango wirinde gufatwa n'indwara cyangwa ingaruka zo kuva mu miti.

Ese Fenfluramine iruta izindi miti yo gufata indwara?

Fenfluramine itanga inyungu zidasanzwe ku bantu barwaye indwara ya Dravet, cyane cyane kuko ikora ikoresha uburyo butandukanye n'indi miti myinshi yo gufata indwara. Ubu buryo butandukanye bushobora gufasha cyane iyo izindi nshuti zitatanze uburyo bwo gucunga neza indwara.

Inyigo za kliniki zerekana ko fenfluramine ishobora kugabanya cyane ubwinshi bwo gufatwa n'indwara ku bantu benshi barwaye indwara ya Dravet, akenshi itanga uburyo bwo gucunga neza kuruta imiti imwe isanzwe yo gufata indwara yonyine. Ariko,

Ese Fenfluramine irakwiriye gukoreshwa igihe kirekire?

Yego, fenfluramine yagenewe gukoreshwa igihe kirekire ku bantu bafite indwara ya Dravet, kandi ubushakashatsi burashyigikira umutekano wayo iyo ikoreshejwe hakurikijwe ubugenzuzi bw'abaganga. Muganga wawe azajya akugenzura buri gihe akoresheje ibizamini bya buri gihe kugira ngo yemeze umutekano ukomeje.

Icy'ingenzi mu gukoresha neza igihe kirekire ni ugukurikiranwa buri gihe, cyane cyane ibizamini by'imikorere y'umutima, kuko fenfluramine ishobora rimwe na rimwe kugira ingaruka ku mitsi y'umutima. Ibi bizamini bifasha kumenya ibibazo byose bishoboka hakiri kare igihe bikiri byoroshye kuvura.

Nkwiriye gukora iki niba nanyweye fenfluramine nyinshi ku buryo butunganye?

Niba unyweye fenfluramine nyinshi ku buryo butunganye kuruta uko byategetswe, vugana n'umuganga wawe cyangwa ikigo gishinzwe kurwanya ubumara ako kanya, nubwo wumva umeze neza. Kunywa nyinshi bishobora kugira ingaruka ku mutima wawe, umuvuduko w'amaraso, n'imikorere y'ubwonko.

Ntugategereze ko ibimenyetso bigaragara mbere yo gushaka ubufasha, kuko zimwe mu ngaruka zo kunywa nyinshi ntizishobora kugaragara ako kanya. Bika urupapuro rw'imiti hamwe nawe igihe ushaka ubufasha bw'ubuvuzi kugira ngo abaganga bamenye neza icyo wanyoye n'ingano yacyo.

Nkwiriye gukora iki niba nciwe urugero rwa fenfluramine?

Niba waciwe urugero, unywe ako kanya wibuka, keretse igihe kigeze cyo gufata urugero rwawe ruteganyijwe. Muri icyo gihe, reka urugero waciwe ukomeze gahunda yawe isanzwe yo kunywa imiti.

Ntuzigere ufata urugero ebyiri icyarimwe kugira ngo usubize urugero waciwe, kuko ibi bishobora kongera ibyago byo kugira ingaruka ziterwa n'imiti. Niba ukunda kwibagirwa urugero, tekereza gushyiraho ibyibutso kuri terefone cyangwa ukoreshe umuteguro w'imiti kugira ngo bifashe gukomeza gukoresha imiti buri gihe.

Nshobora kureka kunywa fenfluramine ryari?

Ugomba kureka kunywa fenfluramine gusa ukurikije ubuyobozi n'ubugenzuzi bw'umuganga wawe. Guhagarika ako kanya bishobora gutuma ibikorwa byo gufatwa n'indwara y'igicuri byiyongera, ibyo bishobora guteza akaga ku bantu bafite indwara ya Dravet.

Niba wowe na muganga wawe mwafashe icyemezo cyo guhagarika fenfluramine, uburyo bwo kubikora busanzwe bukubiyemo kugabanya buhoro buhoro urugero rw'umuti ukoresha mu byumweru byinshi cyangwa amezi. Ubu buryo bwitondewe bufasha kugabanya ibyago byo kugira ibibazo byo gufatwa n'indwara mu gihe ukurikirana uko witwara ku mpinduka.

Nshobora gutwara imodoka nkorera fenfluramine?

Gutwara imodoka ukoresha fenfluramine biterwa n'uko ibibazo byawe byo gufatwa n'indwara bigenzurwa neza kandi n'uko umuti ukugiraho ingaruka ku giti cyawe. Uyu muti ushobora gutera gusinzira cyangwa kunanirwa ku bantu bamwe, ibyo bishobora kugira ingaruka ku bushobozi bwo gutwara imodoka.

Ganira ku mutekano wo gutwara imodoka na muganga wawe, kuko ashobora kugufasha gusobanukirwa imbogamizi zo gutwara imodoka zifitanye isano n'ibibazo byo gufatwa n'indwara mu karere kawe ndetse n'uko ingaruka ziterwa na fenfluramine zishobora kugira ingaruka ku bushobozi bwawe bwo gutwara imodoka neza. Abantu benshi bafite ibibazo byo gufatwa n'indwara bigenzurwa neza bashobora gutwara imodoka, ariko ibi bisaba isuzuma ry'ubuvuzi ku giti cyawe.