Fibrinogen (Uburyo bwo mu mitsi): Ibikoreshwa, Urutonde rw'imiti, Ingaruka ziterwa n'iyo miti n'ibindi

Fibrinogen ni poroteyine ikiza ubuzima ifasha amaraso gukama itangwa binyuze mu muyoboro w'amaraso iyo umubiri wawe utabasha kuyikora ku giti cyawo. Uyu muti ufasha amaraso yawe gukora ibikomere neza mugihe cyo kubagwa, nyuma yo kuvunika, cyangwa iyo ufite indwara zimwe na zimwe zituma amaraso ava cyane zishobora gushyira ubuzima bwawe mu kaga gakomeye.

Tekereza fibrinogen nk'imwe mu nkingi z'ingenzi z'umubiri wawe zo guhagarika kuva amaraso. Iyo utagifite bihagije, ndetse n'ibikomere bito bishobora kuba byateza akaga, niyo mpamvu abaganga rimwe na rimwe bakeneye kuyisimbuza mu maraso yawe.

Fibrinogen ni iki?

Fibrinogen ni poroteyine karemano umwijima wawe ukora buri munsi kugirango ifashe amaraso yawe gukama iyo wakomeretse. Iyo wagize igikomere, fibrinogen ihinduka imitsi ya fibrin ihuza nk'urushundura kugirango ihagarike kuva amaraso.

Uburyo bwa fibrinogen butangwa mu muyoboro w'amaraso ni verisiyo yibanda kuri iyi poroteyine imwe, akenshi ikorwa mu maraso y'abantu batanze. Iracungwa kandi irasukurwa kugirango ikuremo virusi n'ibindi bintu byangiza, bituma ikoreshwa mu buvuzi.

Umuvuzi wawe azagusaba ubu buvuzi gusa iyo urwego rwa fibrinogen rumanuka cyane. Urwego rusanzwe ruri hagati ya 200 na 400 mg / dL, ariko mugihe cyo kubagwa cyangwa indwara zikomeye, uru rwego rushobora kugabanuka vuba.

Fibrinogen ikoreshwa kubera iki?

Fibrinogen IV ikoreshwa cyane cyane mu kuvura cyangwa gukumira kuva amaraso iyo ubushobozi bw'umubiri bwo gukama amaraso bukomokeye. Ibi bibaho cyane cyane mugihe cyo kubagwa gukomeye, kuvunika bikomeye, cyangwa indwara zimwe na zimwe.

Dore ibintu by'ingenzi aho umuganga wawe ashobora gusaba ubuvuzi bwa fibrinogen:

• Kubagwa imibiri ikomeye aho utakaza amaraso menshi
• Ubukomere bukomeye cyangwa impanuka ziteza kuva amaraso menshi
• Kubura fibrinogen kuva umuntu avuka (indwara idasanzwe uvukana)
• Indwara y'umwijima ituma fibrinogen idakora neza
• Ibyago byo kubyara nk'ukuva amaraso menshi igihe cyo kubyara
• Ubwoko bumwe bwa kanseri cyangwa imiti ya chemotherapy igira ingaruka ku kuvura kw'amaraso

Itsinda ryawe ry'abaganga rizagenzura neza urwego rw'amaraso yawe kandi rizakoresha uyu muti gusa iyo inyungu ziruta ibyago. Ntabwo ikoreshwa mu bibazo bito byo kuva amaraso umubiri wawe ushobora kwikemurira.

Fibrinogen ikora ite?

Fibrinogen ikora isimbura mu buryo butaziguye poroteyine ivura amaraso umubiri wawe utagira cyangwa udashobora gukora vuba bihagije. Ibi bifatwa nk'ubuvuzi bw'ingirakamaro kandi bwiza ku byago byihutirwa byo kuva amaraso.

Iyo fibrinogen yinjira mu maraso yawe, ihita iboneka kugira ngo umubiri wawe ukore uburyo bwo kuvura amaraso. Amaraso yawe arimo enzyme yitwa thrombin ihindura fibrinogen ikaba imitsi ya fibrin, ikora imiterere isa n'urushundura ikora ibibumbe by'amaraso.

Umuti mubisanzwe utangira gukora mu minota mike nyuma yo kuwutanga. Ariko, itsinda ryawe ry'abaganga rizakomeza kugenzura urwego rw'amaraso yawe n'imikorere yo kuvura amaraso kugira ngo barebe niba ubuvuzi bukora neza kandi bamenye niba doze zindi zikenewe.

Nkwiriye gufata Fibrinogen nte?

Fibrinogen itangwa gusa mu maraso n'abakozi b'ubuzima babihuguriwe mu bitaro cyangwa ahantu hakorerwa ibizamini. Ntushobora gufata uyu muti mu rugo cyangwa unywa.

Itsinda ryawe ry'ubuzima rizashyira umuyoboro wa IV mu urugingo rw'umubiri, akenshi mu kuboko kwawe. Uwo muti ukoreshwa gahoro gahoro mu minota 5 kugeza kuri 10, bitewe na doze n'uko ubuzima bwawe bumeze.

Mbere yo guhabwa fibrinogen, muganga wawe azakora ibizamini by'amaraso kugira ngo amenye neza urugero ukeneye. Urugero rutangwa ruzitonderwa cyane hashingiwe ku rugero rwa fibrinogen ufite ubu, uburemere bwawe, n'uburemere bw'amaraso ava.

Ntabwo bisaba ko wiyiriza cyangwa wirinda kurya mbere yo kuvurwa. Ariko, itsinda ryawe ry'abaganga rizakugenzura cyane mu gihe cyo gutera umuti no nyuma yaho kugira ngo barebe niba hari ibintu byihuse cyangwa ingorane zigaragara.

Nzamara Igihe Kingana Iki Ndafashe Fibrinogen?

Fibrinogen akenshi itangwa nk'urugero rumwe cyangwa urugero ruto mu gihe cy'uburwayi bukomeye. Uyu si umuti w'igihe kirekire uzajya ufata buri munsi nk'ikindi kintu cyose ufata buri munsi.

Abantu benshi bahabwa fibrinogen gusa mu gihe cy'ikibazo cyihutirwa iyo amaraso atabasha guhagarara hakoreshejwe ubundi buryo. Iyo urugero rwa fibrinogen rwawe rugarutse ku rugero rwiza kandi amaraso agahagarara, kuvurwa birarangira.

Ariko, abantu bamwe bafite ubumuga bwa fibrinogen bw'umuvuko bashobora gukenera kuvurwa kenshi mu buzima bwabo bwose. Muganga wawe azakorana nawe kugira ngo ategure gahunda y'igihe kirekire niba ibi bireba uko ubuzima bwawe bumeze.

Ingaruka z'urugero rumwe akenshi zimara iminsi myinshi, ariko itsinda ryawe ry'abaganga rizakomeza kugenzura urugero rw'amaraso yawe kugira ngo bamenye niba hari uburyo bwo kuvura bwongereweho bukenewe.

Ni Iyihe Mbere Ingaruka Ziterwa na Fibrinogen?

Kimwe n'ibindi bikomoka ku maraso, fibrinogen ishobora gutera ingaruka, nubwo ingaruka zikomeye zitajyenda zibaho iyo zitanzwe n'abantu b'inzobere mu by'ubuvuzi bafite uburambe. Itsinda ryawe ry'ubuzima rizakugenzura cyane mu gihe cyo kuvurwa.

Ingaruka zisanzwe ushobora guhura nazo zirimo:

• Urubura cyangwa imbeho mu gihe cyangwa nyuma yo gutera umuti
• Isesemi cyangwa kuruka
• Umutwe
• Urugero rwo kumva ureremba cyangwa kumva umutwe
• Ingaruka nto zo kwivumbura nk'uruhu ruruma cyangwa kuribwa
• Urubavu cyangwa kubyimba ahantu umuti watewe

Ibi byangirika byoroheje akenshi bikira byonyine cyangwa hamwe n'imiti yoroheje nka acetaminophen yo kugabanya umuriro cyangwa antihistamines zo kurwanya ibibazo byo kuribwa.

Ingaruka zikomeye ariko zitabaho cyane zirimo:

• Urugero rukomeye rwo kwibasirwa n'umubiri (anaphylaxis) hamwe no guhumeka bigoranye cyangwa kubyimba
• Amaraso avura ahantu hatari hake nko mu maguru, mu muhaha, cyangwa mu bwonko
• Kwandura indwara (ntibibaho cyane hamwe n'imikorere ya none)
• Hemolysis (gusenya uturemangingo tw'amaraso atukura)
• Ibibazo by'impyiko mu bihe bitabaho cyane

Itsinda ryawe ry'abaganga ryatojwe kumenya no kuvura ibi byangirika bikomeye ako kanya. Ibyago byo guhura n'ibibazo bikomeye ni bike cyane, cyane cyane iyo bigereranyijwe n'akaga ko kuva amaraso atagabanijwe.

Ninde utagomba gufata Fibrinogen?

Fibrinogen ntibishoboka kuri buri wese, kandi muganga wawe azasuzuma neza amateka yawe mbere yo kugusaba ubu buvuzi. Ibihe bimwe na bimwe bishobora gutuma ibyago birenga inyungu.

Ntabwo ugomba guhabwa fibrinogen niba ufite:

• Ubwoko bukomeye bw'umubiri buzwi kuri fibrinogen cyangwa ibice byayo byose
• Amabara y'amaraso akora (thrombosis) keretse niba ibyago byo kuva amaraso biteye ubuzima bw'akaga
• Indwara ikomeye y'umutima aho gukora amaraso bishobora guteza akaga
• Amateka y'ibisubizo bikomeye ku bicuruzwa by'amaraso

Muganga wawe azakoresha ubushishozi bwihariye niba ufite:

• Amateka y'amaraso cyangwa ibibazo byo gukora amaraso
• Indwara y'umutima cyangwa ibyago byo guhura n'umuvundo
• Ibibazo by'impyiko cyangwa umwijima
• Kubagwa vuba cyangwa gukomereka
• Gusama cyangwa konsa

N'ubwo ufite ibi bihe, muganga wawe ashobora gukomeza kugusaba fibrinogen niba uhanganye n'ibibazo byo kuva amaraso biteye ubuzima bw'akaga. Umwanzuro uzahora ushingiye ku miterere yawe yihariye n'ibikenewe by'ubuvuzi bwihuse.

Amazina y'ubwoko bwa Fibrinogen

Fibrinogen iboneka mu mazina menshi y'ubucuruzi, nubwo ibikoresho by'ingenzi n'ingaruka rusange bisa kuri buri ruganda. Ibitaro byawe cyangwa ivuriro bizakoresha iryo bariho.

Amazina asanzwe y'ubucuruzi arimo RiaSTAP, Fibryga, na Clottafact. Ibikorwa bimwe na bimwe bishobora gukoresha verisiyo rusange zujuje ubuziranenge bumwe n'ubushobozi.

Ubusanzwe izina ryihariye ntacyo ritwaye ku musaruro w'ubuvuzi bwawe. Ikintu cy'ingenzi ni uko wakira urugero rukwiye ku gihe gikwiye kuva ku bahanga mu by'ubuvuzi bashobora gukurikirana uko witwara.

Uburyo bwo gusimbuza Fibrinogen

Iyo fibrinogen itaboneka cyangwa idakwiye, itsinda ryawe ry'ubuvuzi rifite ubundi buryo bwinshi bwo gufasha kugenzura amaraso no gushyigikira imikorere y'umubiri wawe.

Ubuvuzi busimbura bushobora kuba burimo:

\n
• Plasma nshya yafashwe, irimo fibrinogen hamwe n'ibindi bintu bifasha guhuza amaraso
\n
• Cryoprecipitate, umusaruro w'amaraso wibanda kuri fibrinogen
\n
• Asidi ya Tranexamic, umuti ufasha gukumira imikorere y'amaraso
\n
• Ibindi bintu byihariye bifasha guhuza amaraso
\n
• Kwohereza platelet kugirango byongere ubushobozi bwo guhuza amaraso
\n

Muganga wawe azahitamo uburyo bwiza bushingiye ku burwayi bwawe bwihariye, icyateye amaraso yawe, n'ibicuruzwa biboneka vuba. Rimwe na rimwe guhuza ubuvuzi bikora neza kuruta uburyo bumwe.

Ese Fibrinogen iruta Plasma nshya yafashwe?

Fibrinogen concentrate itanga ibyiza bimwe ugereranije na plasma nshya yafashwe (FFP), ariko icyemezo

FFP, ku rundi ruhande, irimo fibrinogen hamwe n'ibindi bintu byinshi bifasha amaraso gukama n'ibindi byose umubiri wawe ushobora gukenera. Akenshi ihitwamo iyo ufite ibibazo byinshi byo gukama kw'amaraso cyangwa iyo impamvu nyayo yo kuva amaraso itagaragara.

Itsinda ryawe ry'abaganga rizagereranya ibintu nk'uko amaraso yawe ameze ubu, ubuzima bwawe muri rusange, n'uburyo ibintu byihutirwa mu gihe cyo guhitamo hagati y'ibi byemezo. Byombi ni imiti ikora neza ishobora kurokora ubuzima mu bihe bikwiye.

Ibibazo Bikunze Kubazwa Kuri Fibrinogen

Ese Fibrinogen irakwiriye ku bantu barwaye indwara z'umutima?

Fibrinogen irashobora gukoreshwa witonze ku bantu barwaye indwara z'umutima, ariko bisaba gukurikiranwa byimazeyo no gusuzuma neza ibyago n'inyungu. Ikintu cy'ingenzi ni uko fibrinogen ishobora kongera ibyago byo gukora ibibumbe by'amaraso, bishobora kuba bibi ku muntu ufite ibibazo by'umutima.

Umuvuzi w'indwara z'umutima n'itsinda ry'abaganga bavura bazakorana kugira ngo bagereranye ibyago byo kuva amaraso ako kanya n'ibishobora gutera ibibazo by'ibibumbe. Mu bihe byo kuva amaraso biteye ubuzima bw'akaga, inyungu akenshi ziruta ibyago, ariko uzahabwa uburyo bwo gukurikiranwa neza mu gihe cyo kuvurwa no nyuma yaho.

Nkwiriye gukora iki niba ngize allergie kuri Fibrinogen?

Niba ubonye ibimenyetso byose byo kwibasirwa n'allergie mu gihe uvurwa na fibrinogen, menyesha itsinda ryawe ry'abaganga ako kanya. Batojwe kumenya no kuvura ibi byiyumvo vuba kandi neza.

Ibimenyetso byoroheje nk'ibicurane cyangwa uruhu rworoshye akenshi bishobora kuvurwa n'imiti irwanya allergie mu gihe ugikomeza kuvurwa. Ibimenyetso bikomeye bisaba guhagarika imiti no gutanga ubufasha bwihutirwa, harimo epinephrine, steroids, n'ibindi bikoresho byunganira nk'uko bikwiye.

Itsinda ryawe ry'ubuzima rizagena ibimenyetso byose mu nyandiko zawe z'ubuvuzi kugira ngo bifashe kuyobora ibyemezo byo kuvura mu gihe kizaza. Abantu benshi bafite ibimenyetso byoroheje barashobora kongera guhabwa fibrinogen niba bibaye ngombwa, hamwe n'imiti ikwiriye mbere yo kuvurwa.

Fibrinogen itangira gukora vuba gute?

Fibrinogen itangira gukora hafi ako kanya nyuma yo kwinjira mu maraso yawe, akenshi mu minota 5 kugeza kuri 10 nyuma yo kurangiza gutera urushinge. Ariko, ingaruka zose ku bushobozi bwawe bwo gupfuka amaraso birashobora gufata iminota 15 kugeza kuri 30 kugirango bigaragarire.

Itsinda ryawe ry'abaganga rizakurikirana uko witwara binyuze mu bipimo by'amaraso no kureba ibimenyetso. Bazareba ibimenyetso byerekana ko kuva amaraso bigenda bigabanuka kandi ko amaraso yawe apfuka neza.

Ingaruka z'umuti zirashobora kumara iminsi myinshi, ariko urwego rwawe rwa fibrinogen ruzasubira buhoro buhoro ku rwego rwari ruriho mbere keretse ikibazo cyateye ikibazo na cyo kivuwe.

Nshobora gutwara imodoka nyuma yo guhabwa Fibrinogen?

Ntugomba gutwara imodoka ako kanya nyuma yo guhabwa fibrinogen, kuko umuti ushobora gutera isereri, kandi birashoboka ko wari ufite ikibazo gikomeye cy'ubuzima gisaba igihe cyo gukira.

Abantu benshi bahabwa fibrinogen baba mu bitaro kugirango babarebe. Itsinda ryawe ry'abaganga rizakumenyesha igihe bizaba byemewe gusubira mu bikorwa bisanzwe, harimo no gutwara imodoka, bitewe n'ubuzima bwawe muri rusange n'imikurire yawe.

Muri rusange, ugomba gutegereza kugeza igihe ingaruka zose zikemukiye kandi ukumva umeze neza kandi utekanye mbere yo kwicara inyuma y'uruziga.

Fibrinogen ikorwa mu maraso y'abantu?

Yego, ibicuruzwa byinshi bya fibrinogen bikorwa mu maraso y'abantu yatanzwe, ariko banyuzwa mu buryo bwo kubitunganya kugirango bikoreshwe neza. Ibi birimo intambwe zo gukuraho cyangwa guhagarika virusi n'ibindi bintu bishobora kuba byangiza.

Uburyo bwo gupima no gutunganya bukoreshwa uyu munsi bufite akamaro kanini mu gukumira indwara. Ibyago byo kwandura indwara ziva mu bicuruzwa bya fibrinogen bya none ni bike cyane, bito cyane kurusha ibyago bifitanye isano no kuva amaraso atavuwe.

Hari ibicuruzwa bishya bya fibrinogen biri gukorwa hakoreshejwe ikoranabuhanga rishya, ritishingiye ku gutanga amaraso y'abantu, ariko ibi biracyigwaho kandi ntibiraboneka hose.