Guanidine ni iki: Ibikoresho, Urutonde rw'imiti, Ingaruka zayo n'ibindi

Guanidine ni umuti wandikirwa na muganga ukoreshwa cyane cyane mu kuvura indwara idasanzwe yo kunanuka kw'imitsi yitwa Lambert-Eaton myasthenic syndrome (LEMS). Iyi ndwara ifata umubano uri hagati y'imitsi yawe n'imitsi, bigatuma ibikorwa bya buri munsi nk'ukugenda, kuzamuka amategeko, cyangwa no gufata ibintu bigorana mu buryo butunguranye.

Nubwo guanidine atari izina risanzwe nk'indi miti myinshi, ifasha cyane mu kuvura abantu bafite indwara zidasanzwe zifata imitsi n'imitsi. Tekereza nk'igikoresho cyihariye gifasha kugarura umubano uri hagati y'imitsi yawe n'imitsi iyo uwo mubano utagenda neza.

Guanidine ni iki?

Guanidine ni umuti ukora by'umwihariko ku bimenyetso by'amashanyarazi biri hagati y'imitsi yawe n'imitsi. Ihereranye n'itsinda ry'imiti ifasha kunoza umubano uri hagati y'imitsi n'imitsi, cyane cyane iyo indwara zimwe na zimwe zifata ubwirinzi zivangira uyu murimo.

Uyu muti umaze gukoreshwa mu buvuzi mu myaka mirongo myinshi, nubwo ufatwa nk'ubuvuzi bwihariye aho kuba ubuvuzi bwa mbere. Muganga wawe azakoresha guanidine iyo ubundi buvuzi butatanze umuti uhagije cyangwa iyo indwara yawe yihariye ituma ari amahitamo akwiriye.

Guanidine ikoreshwa mu kuvura iki?

Guanidine ikoreshwa cyane cyane mu kuvura Lambert-Eaton myasthenic syndrome (LEMS), indwara idasanzwe ifata ubwirinzi ifata abantu hafi 1 kuri 100,000. Muri LEMS, ubwirinzi bwawe butera imikorere mibi ku miyoboro ya kalisiyumu iri mu mpera z'imitsi yawe, bigatuma ibimenyetso bibuza imitsi yawe kwikururira.

Rimwe na rimwe, abaganga bashobora no gutekereza gukoresha guanidine ku zindi ndwara zirimo intege nke z'imitsi, nubwo ibyo bidakunze kubaho. Ibyo bishobora kuba birimo ubwoko bumwe na bumwe bw'indwara z'imitsi aho umubano w'imitsi n'imitsi wangiritse, ariko gukoresha nk'uko bimeze bikunze gukorerwa mu bihe byihariye aho izindi nshuti zitagize icyo zigeraho.

Umuti ukora neza ku bantu intege nke z'imitsi zikunguka gato iyo bakoresheje imitsi ifite icyo kibazo inshuro nyinshi. Niba ubonye ko imbaraga zawe zigenda ziba nziza uko ukomeza kwimuka umunsi wose, guanidine ishobora kuba ifitiye akamaro kadasanzwe imiterere yawe.

Guanidine ikora ite?

Guanidine ikora yongera irekurwa ry'ubutumwa bw'imiti yitwa acetylcholine ku mfuruka iri hagati y'imitsi yawe n'imitsi. Tekereza acetylcholine nk'urufunguzo rufungura imitsi - iyo utagifite bihagije, imitsi yawe ntishobora gusubiza neza ibimenyetso by'imitsi.

Uyu muti mu by'ukuri ufasha iminsi yawe kurekura acetylcholine nyinshi, ikongera ikimenyetso kigera ku mitsi yawe. Bimeze nk'uko wazamura ijwi ku kimenyetso cya radiyo gicogora kugirango ushobore kumva umuzika neza.

Guanidine ifatwa nk'umuti ukomeye mu buryo bwo gukora. Ntabwo ikomeye nk'izindi nshuti zo gukiza intege nke z'imitsi, ariko irashobora gutanga impinduka zifite icyo zivuze ku bantu benshi bafite LEMS, cyane cyane iyo ihujwe n'izindi nshuti.

Nkwiriye gufata guanidine nte?

Umuvuzi wawe azagutangira ku gipimo gito cya guanidine kandi agikureho buhoro buhoro bitewe n'uko ubyitwaramo. Abantu benshi batangira na 10-15 mg kuri kilogramme y'uburemere bw'umubiri buri munsi, igabanyijemo ibipimo bito bito umunsi wose.

Urashobora gufata guanidine hamwe cyangwa nta funguro, nubwo kuyifata hamwe n'amafunguro bishobora gufasha kugabanya inda niba hari icyo ubona. Ni byiza gutandukanya ibipimo byawe umunsi wose kugirango ugumane urwego ruzigama mu mubiri wawe.

Nubwo bimeze bityo, gukomeza gufata imiti ni ingenzi. Gerageza gufata imiti yawe ku gihe kimwe buri munsi, kandi ntukirengagize imiti niyo wumva umeze neza. Imbaraga z'imitsi yawe zishingiye ku gukomeza urugero rwo hejuru rw'umuti mu mubiri wawe.

Nzamara Igihe Kingana Iki Ndafata Guanidine?

Igihe cyo kuvura na guanidine gitandukanye cyane ku muntu ku muntu kandi biterwa n'uburwayi ufite. Ku ndwara ya Lambert-Eaton myasthenic syndrome, abantu benshi bakeneye gufata guanidine igihe kirekire kugira ngo bakomeze imbaraga z'imitsi yabo n'imikorere yayo.

Muganga wawe azagenzura uko witwara ku muti mu byumweru byinshi cyangwa amezi. Abantu bamwe babona impinduka mu minsi mike, mu gihe abandi bashobora gukenera ibyumweru byinshi kugira ngo babone inyungu zose.

Ibyo guhura na muganga buri gihe ni ingenzi kuko muganga wawe akeneye gusuzuma imikorere y'umuti no kureba niba hari ingaruka zishobora kubaho. Ntukareke gufata guanidine ako kanya utabanje kubiganiraho n'umuganga wawe, kuko ibi bishobora gutuma imitsi yongera kunanuka.

Ni Izihe Ngaruka Ziterwa na Guanidine?

Kimwe n'indi miti yose, guanidine ishobora gutera ingaruka, nubwo atari buri wese uzibona. Kumva icyo witegura bishobora kugufasha kumva witeguye kandi ukamenya igihe wahamagara muganga wawe.

Ingaruka zisanzwe zikunda kuba nto kandi akenshi zikagenda uko umubiri wawe umenyera umuti:

• Kuribwa mu nda cyangwa guhungabana
• Impiswi cyangwa kwituma byoroshye
• Kuribwa umutwe cyangwa kumva ureremba
• Uruhu ruruka cyangwa kuribwa
• Umutwe
• Kunanirwa cyangwa kumva unaniwe cyane

Izi ngaruka zisanzwe zikunda gushira mu minsi mike cyangwa ibyumweru uko umubiri wawe umenyera umuti. Niba zikomeje cyangwa zikaba zikakaye, muganga wawe akenshi ashobora guhindura urugero rwawo cyangwa igihe cyo gufata umuti kugira ngo agabanye izo ngaruka.

Ingaruka zikomeye ziterwa n'imiti ntizikunze kubaho ariko zisaba ubufasha bwihuse bw'abaganga. Izi zikubiyemo ibimenyetso bikomeye byo kwivumbura ku miti, impinduka zikomeye mu mutima, cyangwa ibimenyetso by'ibibazo by'impyiko nk'impinduka mu buryo umuntu anyariramo cyangwa kubyimba kw'amaguru n'ibirenge.

Abantu bamwe bashobora kandi guhura n'ingaruka zitari nyinshi ariko ziteye inkeke nk'ukuvugurana gukabije kw'imitsi, urujijo, cyangwa guhumeka bigoranye. Nubwo ibi bidakunze kubaho, ni ngombwa kumenya ko ubuvuzi bwihuse bushobora gukemura ibi bibazo neza.

Ninde utagomba gufata Guanidine?

Abantu bamwe bagomba kwirinda guanidine cyangwa bakayikoresha bafite ubwitonzi bwinshi. Muganga wawe azasuzuma neza amateka yawe y'ubuzima mbere yo kugutera uyu muti kugirango yemeze ko ari mutekano kuri wewe.

Abantu bafite ibibazo bikomeye by'impyiko muri rusange bagomba kwirinda guanidine, kuko uyu muti ukoreshwa binyuze mu mpyiko. Niba urwaye indwara y'impyiko, muganga wawe azagomba kugukurikiranira hafi cyane cyangwa agashaka izindi miti.

Byongeye kandi, guanidine ntishobora gukwira niba ufite indwara zimwe na zimwe z'umutima, cyane cyane izo zirimo umuvuduko w'umutima utajegajega. Uyu muti rimwe na rimwe ushobora kugira ingaruka ku mikorere y'umutima, bityo muganga wawe azasuzuma ubuzima bwawe bw'umutima mbere yo gutangira kuvurwa.

Abagore batwite kandi bonka bagomba kuganira ku byago n'inyungu neza n'umuganga wabo, kuko hari amakuru make yerekeye umutekano wa guanidine mugihe cyo gutwita no konsa.

Amazina ya Guanidine

Guanidine iboneka munsi y'amazina atandukanye, nubwo iboneka bitewe n'igihugu. Mu turere tumwe na tumwe, urashobora kubona icuruzwa nka Guanidine HCl cyangwa munsi y'amazina yihariye ya farumasi.

Umunyamavuriro wawe ashobora kugufasha kumenya izina ryihariye cyangwa verisiyo rusange iboneka mu karere kawe. Ibikoresho bikora biracyari kimwe hatitawe ku mukora, nubwo abantu bamwe bashobora gusanga basubiza gato mu buryo butandukanye kuburyo butandukanye.

Uburyo bwo gusimbuza Guanidine

Niba guanidine itagukwiriye cyangwa itatanga ubufasha buhagije, hari izindi nzira zishobora gukoreshwa mu kuvura indwara ya Lambert-Eaton myasthenic syndrome n'izindi zisa nayo.

3,4-diaminopyridine (3,4-DAP) akenshi ifatwa nk'umuti wa mbere uvura LEMS kandi ishobora gukora neza kurusha guanidine ku bantu benshi. Uyu muti ukora kimwe ariko ukunze kugira ingaruka nke kandi ukorohera abawufata.

Imiti igabanya ubudahangarwa nk'uko prednisone, azathioprine, cyangwa mycophenolate nayo ishobora kuba igisubizo, cyane cyane niba uburwayi bwawe bufite uruhare rukomeye rw'ubwirinzi bw'umubiri. Iyi miti ikora igabanya uburyo ubudahangarwa bw'umubiri butera ibibazo ku mitsi n'imikoranire yayo.

Mu bindi bihe, gukuramo plasma cyangwa imiti yinjizwa mu maraso ya immunoglobulin (IVIG) bishobora gushyirwaho, cyane cyane mu gihe ibimenyetso byiyongera cyane.

Ese Guanidine iruta 3,4-Diaminopyridine?

3,4-diaminopyridine (3,4-DAP) muri rusange ifatwa nk'ikora neza kurusha guanidine mu kuvura indwara ya Lambert-Eaton myasthenic syndrome. Inama nyinshi z'abaganga zishyira 3,4-DAP ku mwanya wa mbere mu kuvura kuko akenshi itanga impinduka nziza mu bimenyetso hamwe n'ingaruka nke.

Ariko, guanidine iracyashobora kugira akamaro ku bantu batitabira neza 3,4-DAP cyangwa batabasha kwihanganira ingaruka zayo. Abantu bamwe bashobora gusubiza neza kuri guanidine, niyo mpamvu kugira uburyo bwinshi bwo kuvura ari ingenzi.

Muganga wawe azatekereza ku bimenyetso byawe byihariye, amateka yawe y'ubuvuzi, n'uburyo witwara ku bindi byavuweho mugihe cyo guhitamo hagati yiyi miti. Rimwe na rimwe, guhuza imiti yombi ku bipimo bike bishobora gukora neza kurusha gukoresha imwe gusa.

Ibikunze Kubazwa Kuri Guanidine

Ese Guanidine irakwiriye ku bantu barwaye diyabete?

Guanidine irashobora gukoreshwa ku bantu barwaye diyabete, ariko bisaba gukurikiranwa neza. Uyu muti ushobora kugira ingaruka ku isukari mu maraso ku bantu bamwe, nubwo ibi bitajyenda kenshi.

Umuvuzi wawe azashaka gukurikirana isukari yo mu maraso yawe neza cyane iyo utangiye gufata guanidine, cyane cyane niba urwaye diyabete. Wibuke kubwira umuganga wawe ibyerekeye impinduka zose zigaragara ku isukari yo mu maraso yawe cyangwa imiti ya diyabete.

Nkwiriye gukora iki niba mfashwe n'impanuka nkafata guanidine nyinshi cyane?

Niba ufashwe n'impanuka ukafata guanidine nyinshi kurusha uko byategetswe, vugana n'umuganga wawe cyangwa ikigo gishinzwe kurwanya ubumara ako kanya. Gufata nyinshi cyane bishobora gutera ingaruka zikomeye zirimo isesemi ikabije, kuruka, guhinda umushyitsi kw'imitsi, cyangwa ibibazo by'umutima.

Ntugerageze kwivugisha keretse ubitegetswe n'umuganga. Bika urupapuro rw'umuti hamwe nawe igihe ushaka ubufasha bw'ubuvuzi kugirango abaganga bamenye neza icyo wafashe n'ingano yacyo.

Nkwiriye gukora iki niba nirengagije urugero rwa guanidine?

Niba wirengagije urugero rwa guanidine, ifate ako kanya wibuka, keretse igihe cyegereye urugero rwawe ruteganyijwe. Muri icyo gihe, reka urugero wibagiwe ukomeze gahunda yawe isanzwe.

Ntuzigere ufata urugero rurenzeho kugirango wuzuze urwo wibagiwe, kuko ibyo bishobora kongera ibyago byo kugira ingaruka. Niba ukunda kwibagirwa urugero, tekereza gushyiraho ibyibutso kuri terefone cyangwa ukoreshe umuteguro w'imiti kugirango ugufashe kuguma ku murongo.

Nshobora guhagarika ryari gufata guanidine?

Wagombye guhagarika gufata guanidine gusa ubikoresheje ubuyobozi bw'umuganga wawe. Kubantu benshi barwaye indwara ya Lambert-Eaton myasthenic syndrome, guhagarika umuti bizatuma intege nke z'imitsi zisubira.

Umuganga wawe ashobora gutanga igitekerezo cyo kugabanya buhoro buhoro urugero rwawe aho guhagarara ako kanya. Ubu buryo bufasha kugabanya ibyago byo kugira ibimenyetso byo guhagarika umuti kandi bikagufasha gukurikirana uko umubiri wawe witwara ku rugero ruto.

Nshobora gutwara imodoka niba mfata guanidine?

Guanidine irashobora gutera isereri cyangwa umunaniro kubantu bamwe, ibyo bishobora kugira ingaruka ku bushobozi bwawe bwo gutwara neza. Igihe utangira gufata umuti, ni byiza kwirinda gutwara kugeza umenye uko bigutera.

Umaze igihe ukoresha urugero ruzwi kandi utagize isereri cyangwa izindi ngaruka ziteye inkeke, abantu benshi bashobora gutwara imodoka uko bisanzwe. Ariko, jya ukoresha ubwenge bwawe kandi ntugatware imodoka niba wumva utameze neza cyangwa warushye cyane.