Ibrutinib (inzira yo kunywa)

Imbruvica

Ibrutinib ikoreshwa mu kuvura kanseri y'amaraso ya cronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL), kanseri y'amaraso ya chronic lymphocytic leukemia (CLL)/small lymphocytic leukemia (SLL) mu barwayi bafite 17p deletion, na Waldenström macroglobulinemia (WM). Ikoreshwa kandi mu kuvura chronic graft-versus-host disease (cGHVD) nyuma y'aho ubundi buryo bumwe cyangwa birenze bwo kuvura butabashije kugira icyo buhindura. Iratabara ubukura bw'uturemangingo twa kanseri, hanyuma umubiri ukabutsemba. Ibrutinib ni imiti irwanya kanseri (antineoplastic agent). Uyu muti uboneka gusa ufite ibaruwa y'umuganga. Uyu muti uboneka mu bwoko bukurikira bw'imiti:

Mu kwemerera gukoresha imiti, ibyago byo gufata imiti bigomba guhanurwa n'ibyiza bizakora. Iki ni cyemezo wowe na muganga wawe muzafatanya. Kuri iyi miti, ibi bikurikira bigomba kwitabwaho: Bwira muganga wawe niba wigeze ufite uburwayi budasanzwe cyangwa ubwo kwangirika kw'umubiri kuri iyi miti cyangwa izindi miti. Nanone, umenyeshe umuhanga mu by'ubuzima niba ufite izindi mubare z'ubwo kwangirika kw'umubiri, nko ku biribwa, amabara, ibintu byongera ubuzima, cyangwa inyamaswa. Ku bicuruzwa bitagomba kwandikwa, soma witonze ibikoresho biri ku gipfunyika cyangwa ku kimenyetso. Ubushakashatsi bukwiye ntabwo bwakozwe ku isano y'imyaka ku ngaruka za ibrutinib mu kuvura indwara ya graft-versus-host (cGHVD) mu bana bari munsi y'umwaka umwe, no kuvura kanseri y'amaraso (CLL) / lymphoma ntoya y'amaraso (SLL), kanseri y'amaraso (CLL) / lymphoma ntoya y'amaraso (SLL) ifite 17p deletion, na Waldenström macroglobulinemia (WM) mu bana. Ubuziranenge n'ingaruka nziza ntibyarangiye. Ubushakashatsi bukwiye bwakozwe kugeza ubu ntabwo bwerekanye ibibazo byihariye by'abakuze byagabanya ingaruka za ibrutinib mu bakuze. Ariko kandi, abarwayi bakuze bafite ibyago byinshi byo kugira ingaruka zitari nziza (urugero, anemia, pneumonia, ibibazo byo kuva amaraso, umuvuduko w'amaraso uri hejuru, ibibazo by'umutima), bishobora gusaba ubwitonzi mu barwayi bafata ibrutinib. Nta bushakashatsi buhagije ku bagore bwo kumenya ibyago by'uruhinja mu gihe bakoresha iyi miti mu gihe cyo konsa. Pima inyungu zishoboka ugereranije n'ibyago bishoboka mbere yo gufata iyi miti mu gihe cyo konsa. Nubwo imiti imwe n'imwe idakwiye gukoreshwa hamwe na gato, mu bindi bihe imiti ibiri itandukanye ishobora gukoreshwa hamwe nubwo hariho ikibazo gishobora kubaho. Muri uru rubanza, muganga wawe ashobora kwifuza guhindura umwanya, cyangwa izindi ngamba zishobora kuba ngombwa. Iyo ufata iyi miti, ni ngombwa cyane ko umuhanga mu by'ubuzima azi niba ufata imiti iri hasi. Ibi bikurikira byatoranijwe hashingiwe ku gaciro gashoboka kandi si ngombwa ko ari byose. Gukoresha iyi miti hamwe n'imiti iri hasi ntibyemerwa. Muganga wawe ashobora gufata icyemezo cyo kutakugira iyi miti cyangwa guhindura imiti imwe mu yindi ufata. Gukoresha iyi miti hamwe n'imiti iri hasi ntibisanzwe byemewe, ariko bishobora gusabwa mu bihe bimwe na bimwe. Niba imiti yombi yanditswe hamwe, muganga wawe ashobora guhindura umwanya cyangwa uko uyikoresha rimwe cyangwa imiti yombi. Gukoresha iyi miti hamwe n'imiti iri hasi bishobora gutera ibyago byiyongereye by'ingaruka zimwe na zimwe, ariko gukoresha imiti yombi bishobora kuba ubuvuzi bwiza kuri wowe. Niba imiti yombi yanditswe hamwe, muganga wawe ashobora guhindura umwanya cyangwa uko uyikoresha rimwe cyangwa imiti yombi. Imiti imwe n'imwe ntigomba gukoreshwa mu gihe cyo kurya cyangwa hafi yacyo cyangwa kurya ibiryo bimwe na bimwe kuko ibibazo bishobora kubaho. Gukoresha inzoga cyangwa itabi hamwe n'imiti imwe bishobora kandi gutera ibibazo kubaho. Ibi bikurikira byatoranijwe hashingiwe ku gaciro gashoboka kandi si ngombwa ko ari byose. Gukoresha iyi miti hamwe n'ibikurikira ntibisanzwe byemewe, ariko bishobora kuba bidashoboka kwirinda mu bihe bimwe na bimwe. Niba ikoreshwa hamwe, muganga wawe ashobora guhindura umwanya cyangwa uko uyikoresha iyi miti, cyangwa akaguha amabwiriza yihariye ku ikoreshwa ry'ibiryo, inzoga, cyangwa itabi. Kuba hari ibindi bibazo by'ubuzima bishobora kugira ingaruka ku ikoreshwa ry'iyi miti. Menya neza kubwira muganga wawe niba ufite ibindi bibazo by'ubuzima, cyane cyane: