Icyo Iobenguane I-123 ari cyo: Ibyo ikoreshwa, urugero rwa dose, ingaruka ziterwa n'ibindi

Iobenguane I-123 ni umuti wihariye ukoreshwa mu gushushanya mu buvuzi, cyane cyane mu kumenya ubwoko bumwe na bumwe bwa kanseri mu mubiri wawe. Iki kintu giterwa mu rushinge gikora nk'umuntu ushakisha, akagenda mu maraso yawe kugira ngo abone kandi atsindagirize selile zihariye zishobora gutera ibibazo by'ubuzima.

Ushobora kumva uhungabanye wumvise amakuru yerekeye imiti ikoresha imirasire, ariko iki kintu gishushanya kimaze imyaka myinshi gikoreshwa mu buryo bwizewe kugira ngo gifashe abaganga kubona amashusho asobanutse y'ibiri kuba mu mubiri wawe. Igice gikoresha imirasire ni gito cyane kandi cyateguwe kugira ngo kive mu mubiri wawe mu buryo busanzwe mu minsi mike.

Icyo Iobenguane I-123 ari cyo?

Iobenguane I-123 ni icyuma gikoresha imirasire gisa n'imiti isanzwe yitwa norepinephrine mu mubiri wawe. Iyo itewe mu maraso yawe, igenda mu bwoko bwihariye bwa selile z'imitsi na selile za kanseri zifata ubu bwoko bw'imiti.

Igice cya "I-123" kivuga iodine-123, uburyo bwa iodine bukoresha imirasire butanga imirasire ya gamma. Iyi mirasire irashobora kumenyekana na kamera zidasanzwe kugira ngo zikore amashusho arambuye y'ingingo zawe z'imbere n'ibice by'umubiri. Tekereza nk'uko uha abaganga itara ryihariye rishobora kureba mu mubiri wawe kugira ngo ribone ahantu hakeneye kwitabwaho.

Uyu muti utandukanye rwose n'ibyongerera iodine bisanzwe ushobora gufata kugira ngo ugire ubuzima bwiza bwa tiroyide. Iodine ikoresha imirasire ikoreshwa hano yateguwe by'umwihariko kugira ngo ikoreshwe mu gushushanya mu buvuzi kandi ifite igihe gito cyane cyo kubaho, bivuze ko itagikora vuba.

Icyo Iobenguane I-123 ikoreshwa

Abaganga bakoresha cyane cyane Iobenguane I-123 mu kumenya no gushaka pheochromocytomas na paragangliomas, ari kanseri idasanzwe ikura mu bwoko bumwe na bumwe bwa selile z'imitsi. Izi kanseri zirashobora gutanga imisemburo myinshi itera ibimenyetso nk'umuvuduko mwinshi w'amaraso, umutima utera vuba, no kubira ibyuya.

Uyu muti ufite akamaro kandi mu kumenya indwara ya neuroblastoma, ubwoko bwa kanseri ikunda gufata abana kandi ikava mu turemangingo tw'imitsi itarashyikira. Ikindi, ifasha mu gusuzuma tumor ya carcinoid, kanseri ikura gahoro ishobora kuboneka mu bice bitandukanye by'umubiri wawe.

Uretse kumenya tumor, uyu muti ukoreshwa mu isuzuma ryo kureba niba sisitemu yawe y'imitsi ifasha mu bikorwa by'umubiri ikora neza. Iyi sisitemu igenzura imikorere myinshi y'umubiri nk'umuvuduko w'umutima, umuvuduko w'amaraso, n'igogora. Iyo abaganga bakeneye kumenya niba inzira zimwe na zimwe z'imitsi zikora neza, iyi scan itanga amakuru y'ingenzi.

Ibyo Iobenguane I-123 ikora

Iobenguane I-123 ikora yigana norepinephrine, umuti kamere umubiri wawe ukoresha mu kuvugana hagati y'uturemangingo tw'imitsi. Iyo yatewe, igenda mu maraso yawe ikinjira mu turemangingo dusanzwe twakira norepinephrine.

Iodine ya radioactive yashyizwe kuri iobenguane itanga imirasire ya gamma ishobora kumenyekana na camera zidasanzwe zizwi nka camera za gamma cyangwa SPECT scanners. Izi camera zikora amashusho arambuye yerekana neza aho umuti wakoreye mu mubiri wawe.

Ibi bifatwa nk'umuti woroshye wa radioactive ugereranije n'izindi nzira za nuclear medicine. Imirasire ihari ni mike kandi isa n'iyo wakira mu bindi bizami by'ubuvuzi nk'ibizamini bya CT. Radioactivity igabanuka mu buryo bwa kamere uko igihe kigenda, ibyinshi muri byo biva mu mubiri wawe mu minsi mike.

Nagomba gufata Iobenguane I-123 nte?

Iobenguane I-123 itangwa buri gihe nk'urushinge rutewe mu urwungano rw'amaraso, akenshi mu kuboko kwawe. Ntushobora gufata uyu muti unywa, kandi ugomba gutangwa n'abakozi b'ubuzima babihuguriwe mu kigo cy'ubuvuzi gifite ibikoresho bya nuclear medicine.

Mbere yo guterwa urushinge, muganga wawe ashobora kuguha potasiyumu yodide cyangwa undi muti wugurisha yodini kugira ngo urinde umusonga wawe. Ubusanzwe uzajya ufata uyu muti urinda umusonga uhereye amasaha 24 mbere yo guterwa urushinge ukomeza iminsi myinshi nyuma yaho.

Ntabwo bisaba kwiyiriza mbere y'iki gikorwa, ariko muganga wawe ashobora kukubwira kwirinda ibiryo bimwe na bimwe cyangwa imiti ishobora kubangamira ibisubizo by'isuzuma. Ni ngombwa kuguma ufite amazi ahagije unywa amazi menshi mbere na nyuma yo guterwa urushinge kugira ngo bifashe gukuramo umuti mu mubiri wawe.

Guterwa urushinge nyirizina bifata iminota mike gusa, ariko bizakenera gusubira mu masuzuma, akenshi amasaha 24 nyuma yo guterwa urushinge rimwe na rimwe bongera amasaha 48. Muri ibi biganiro by'isuzuma, uzaryama utuje ku meza mugihe camera zifata amafoto y'umubiri wawe.

Nzamara Igihe Kingana Gite Ndafatwa Iobenguane I-123?

Iobenguane I-123 itangwa nk'urushinge rumwe kuri buri cyegeranyo cy'isuzuma. Ntabwo ufata uyu muti buri munsi nkuko wabigenza n'ibinini bya buri munsi cyangwa imiti.

Ingaruka z'umuti zimara igihe gikenewe kugirango urangize isuzuma ryawe, akenshi amasaha 24 kugeza kuri 48 nyuma yo guterwa urushinge. Muri iki gihe, ibikoresho bya radioactive bigenda bigabanuka imbaraga kandi bikurwa mu mubiri wawe binyuze mu nkari no mu myanda.

Niba muganga wawe akeneye isuzuma ryinyongera cyangwa ibindi bisuzuma byo gukurikirana, bazategura gahunda y'ibindi biganiro bitandukanye hamwe n'urushinge rushya. Igihe kiri hagati y'amasuzuma yongera giterwa biterwa n'uburwayi bwawe bwihariye n'icyo muganga wawe akurikirana.

Ni Iyihe Ngaruka Ziterwa na Iobenguane I-123?

Abantu benshi bahura n'ingaruka nkeya cyane ziterwa na Iobenguane I-123, kandi ibisubizo bikomeye ni bike cyane. Ingaruka zisanzwe ni zoroshye kandi z'agateganyo, zibaho ku gice gito cy'abarwayi.

Ibi bikurikira ni bimwe mu ngaruka ushobora guhura nazo, ariko wibuke ko abantu benshi nta kibazo bagira:

• Urugimbu ruto cyangwa kumva uruka, akenshi bikaba bishira nyuma y'amasaha make
• Gucika intege guto cyangwa kumva umutwe nyuma yo guterwa urushinge
• Urubavu ruto cyangwa gusa n'uwakubiswe ahatewe urushinge
• Uburyohe bw'icyuma bw'agateganyo mu kanwa kawe
• Umutwe muto usanzwe ushira

Ingaruka zikomeye ntizisanzwe ariko zishobora kuba zirimo ibimenyetso by'uburwayi bw'umubiri nko kuribwa uruhu, kurigata, cyangwa guhumeka nabi. Niba ubonye ibimenyetso bikomeye nk'ububabare mu gituza, kuruka cyane, cyangwa ibimenyetso by'uburwayi bw'umubiri, genda kwa muganga ako kanya.

Abantu bamwe bahangayika ku bijyanye no kwegerana n'imirasire, ariko umubare w'imirasire uva muri ubu buryo uvugwaho ko utagira ingaruka kandi ukaba warabaruwe neza n'inzobere mu buvuzi bw'ibinyukliya. Kwegerana n'imirasire ni ukw'agateganyo kandi byinshi muri byo biva mu mubiri wawe mu masaha 24 ya mbere.

Ninde utagomba gufata Iobenguane I-123?

Abagore batwite ntibagomba guhabwa Iobenguane I-123 kuko ibikoresho bifite imirasire bishobora kwangiza umwana ukiri mu nda. Niba hari amahirwe yo kuba utwite, bwire muganga wawe mbere y'uko bakora ubu buryo kugira ngo bashobore kugukorera isuzuma ry'uko utwite.

Abagore bonsa bakeneye kwitabwaho by'umwihariko kuko ibikoresho bifite imirasire bishobora kujya mu mata y'ibere. Muganga wawe azaganira niba ukwiye guhagarika konsa by'agateganyo cyangwa niba inyungu zo gukora isuzuma zirenze ingaruka.

Abantu barwaye indwara zikomeye z'impyiko bashobora gukenera guhindurirwa urugero rw'umuti cyangwa uburyo bwo gukoresha amashusho andi kuko umuti usohoka binyuze mu mpyiko. Muganga wawe azareba imikorere y'impyiko zawe mbere yo gukomeza guterwa urushinge.

Niba ufite allergie kuri iyode cyangwa wigeze kugira ibibazo bikomeye byatewe n'ibintu bikoreshwa mu gukora amashusho, bimenyeshe ikipe yawe y'ubuvuzi. Nubwo ibibazo byatewe na Iobenguane I-123 bidasanzwe, muganga wawe ashobora gushaka gufata ingamba zidasanzwe cyangwa gutekereza ku buryo bwo gukora amashusho andi.

Amazina y'Ubwoko bwa Iobenguane I-123

Iobenguane I-123 iboneka mu mazina y'ubwoko butandukanye, AdreView ikaba ari yo ikoreshwa cyane muri Leta Zunze Ubumwe z'Amerika. Ubu bwoko bukorerwa cyane cyane mu gukoreshwa mu ishusho ry'ubuvuzi kandi bujyana n'ubuziranenge bukomeye mu bijyanye n'imiti ikoreshwa mu gukora ishusho.

Andi mazina y'ubwoko arimo MIBG I-123 n'uburyo butandukanye bwa rusange bufite umutekano n'imikorere bingana. Ubwoko bwihariye umuganga wawe akoresha buterwa n'ibiboneka mu kigo cyawe cy'ubuvuzi n'icyo bakunda gukoresha bashingiye ku bunararibonye.

Nubwo izina ry'ubwoko ryaba ari irihe, ubwoko bwose bwa Iobenguane I-123 bwemewe burimo ikintu kimwe gikora kandi gikora kimwe. Ibikubiye muri iodine ya radiyo n'ubushobozi bwo gukora ishusho byashyizweho mu buryo bumwe mu myiteguro yose yemewe y'imiti.

Uburyo bwa Iobenguane I-123 bwakoreshwa mu mwanya wayo

Uburyo butandukanye bwo gukora ishusho rimwe na rimwe bushobora gutanga amakuru asa, bitewe n'icyo umuganga wawe agerageza kumenya. Ibyuma bya CT bifite contrast bishobora kwerekana aho igituntu giherereye n'ubunini bwacyo, mugihe ibyuma bya MRI bitanga amashusho arambuye y'imyenda yoroshye itagira urugomo rwa radiyo.

Ku bwoko bwihariye bw'ibituntu, ibindi byuma by'ubuvuzi bwa nikleyeri bishobora kuba bikwiye. Ibyuma bya Octreotide (bikoresha In-111 cyangwa Ga-68) bishobora kumenya ibituntu bimwe bya neuroendocrine, mugihe ibyuma bya FDG-PET bishobora kumenya ubwoko butandukanye bwa kanseri bushingiye ku mikorere yabo ya metabolike.

Mu bihe bimwe na bimwe, abaganga bashobora gukoresha MIBG I-131 (uburyo bwo kuvura) mu mwanya wa I-123, cyane cyane iyo kuvura aho gukora ishusho gusa ari cyo kigamijwe. Ariko, I-131 itanga urugero rwo hejuru rwa radiyo kandi bisaba kwitonda kurushaho.

Umuganga wawe azahitamo uburyo bwiza bwo gukora ishusho bushingiye ku bimenyetso byawe byihariye, amateka yawe y'ubuvuzi, n'ubwoko bw'amakuru bakeneye kugirango bamenye neza indwara. Rimwe na rimwe uburyo bwinshi bwo gukora ishusho bukoreshwa hamwe kugirango babone ishusho yuzuye.

Ese Iobenguane I-123 iruta ubundi buryo bwo gukora ishusho?

Iobenguane I-123 irusha mu kumenya ubwoko bwihariye bwa kanseri izindi nzira zo kugaragaza ishusho zishobora kutabona. Ku birebana na pheochromocytomas, paragangliomas, na neuroblastomas, akenshi ifatwa nk'urwego rwa zahabu kuko ishobora kumenya ndetse na kanseri nto zitagaragara neza kuri CT cyangwa MRI.

Ugereranije na CT cyangwa MRI isanzwe, Iobenguane I-123 itanga amakuru yerekeye imikorere y'ibice by'umubiri, atari uko bisa gusa. Ibi bivuze ko ishobora kumenya ahantu hari ibibazo mbere yuko bigera ku bunini bwo kuboneka ku ishusho y'imiterere.

Ariko, iyi nzira yo kugaragaza ishusho ntabwo buri gihe iba nziza kurusha izindi. CT na MRI bitanga amakuru arambuye yerekeye imiterere y'umubiri kandi bishobora kumenya ubwoko bwinshi bw'indwara. Nanone ntibigira ingaruka ku mirasire, ibyo bikaba byiza gukoreshwa mu gukurikirana abantu bamwe na bamwe.

Guhitamo hagati y'inzira zo kugaragaza ishusho biterwa n'icyo muganga wawe akeka n'amakuru akeneye. Akenshi, Iobenguane I-123 ikoreshwa hamwe n'izindi nzira zo kugaragaza ishusho kugirango itange ishusho yuzuye y'ubuvuzi bushoboka.

Ibikunze Kubazwa Kuri Iobenguane I-123

Ese Iobenguane I-123 irakwiriye abantu barwaye diyabete?

Yego, Iobenguane I-123 muri rusange irakwiriye abantu barwaye diyabete. Uyu muti ntugira ingaruka zigororotse ku isukari yo mu maraso cyangwa ngo ugire icyo ukora ku miti myinshi ya diyabete. Ariko, ugomba gukomeza gufata imiti yawe ya diyabete nkuko byategetswe kandi ukanakurikiranira hafi isukari yo mu maraso yawe uko bisanzwe.

Niba ufata metformin ya diyabete, muganga wawe ashobora guhagarika by'agateganyo uyu muti mu gihe cyo gukora isuzuma ryawe. Iyi ngamba ntaho ihuriye na Iobenguane I-123 ubwayo, ahubwo ni ukugabanya ibibazo bishobora guterwa n'impyiko biturutse ku buryo bugaragara cyangwa indi miti ushobora guhabwa.

Nkwiriye gukora iki niba nkoresheje Iobenguane I-123 nyinshi mu buryo butunganye?

Guhitamo kubona urugero rwinshi rwa Iobenguane I-123 ntibishoboka cyane kuko umuti utangwa gusa n'abakozi b'ubuzima babihuguriwe mu bigo by'ubuvuzi bigenzurwa. Urugero rurabarwa neza hashingiwe ku gipimo cy'umubiri wawe n'ibisabwa byihariye byo gushushanya.

Niba ufite impungenge zo guhabwa umuti mwinshi cyane, wibuke ko amashami y'imiti ya nikleyeri afite amabwiriza akomeye yo gutegura no gutanga urugero. Urugero uhabwa rupimwa neza kandi rugenzurwa mu gihe cyose cy'inzira.

Niba ubonye ibimenyetso bidasanzwe nyuma yo guterwa urushinge, vugana n'umuganga wawe ako kanya. Barashobora gusuzuma niba ibimenyetso byawe bifitanye isano n'umuti kandi bagatanga ubufasha bukwiriye niba bibaye ngombwa.

Nkwiriye gukora iki niba ntasibye urugero rwa Iobenguane I-123?

Kubera ko Iobenguane I-123 itangwa nk'urushinge rumwe rukoreshwa mu bushakashatsi bwihariye bwo gushushanya, ntakintu nk'icyo cyo

Radioactivite nyinshi izaba yavuye mu mubiri wawe mu masaha 24 kugeza kuri 48 nyuma yo guterwa urushinge. Ushobora gufasha kwihutisha iyi nzira unywa amazi menshi kandi unyara kenshi, ibi bifasha gukuramo imiti mu mubiri wawe.

Muganga wawe azatanga amabwiriza arambuye yerekeye ingamba zose ugomba gufata mu minsi mike nyuma yo guterwa urushinge, nko kugabanya umubano wa hafi n'abagore batwite cyangwa abana bato nk'ingamba zo kwirinda.

Nshobora gutwara imodoka nyuma yo guhabwa Iobenguane I-123?

Abantu benshi bashobora gutwara imodoka neza nyuma yo guhabwa Iobenguane I-123, kuko uyu muti akenshi ntutera ingaruka zateza ikibazo cyo gutwara imodoka. Ariko, abantu bamwe bashobora kugira isereri ryoroheje cyangwa isesemi nyuma yo guterwa urushinge.

Ni byiza kugira umuntu ugutwara akakuzana kandi akakujyana mu gihe cyo kwisuzumisha, cyane cyane niba wumva uhangayitse kubera ubu buryo cyangwa niba ugize izo ngaruka zose. Ibi kandi bituma ugira umutuzo kandi bikagufasha kuruhuka niba bibaye ngombwa.

Niba wumva umeze neza rwose nyuma yo guterwa urushinge no gupimwa, gutwara imodoka muri rusange biratekanye. Ariko, buri gihe ukurikize amabwiriza yihariye ya muganga wawe kandi ntugatware niba wumva urwaye isereri, isesemi, cyangwa ubundi burwayi.