Icyo Istradefylline Arimara: Ibikoresho, Uburyo Bwo Gufata, Ingaruka Zishobora Kugaragara n'ibindi

Istradefylline ni umuti ufasha mu gucunga ibihe byo "kudakora" ku ndwara ya Parkinson igihe imiti yawe isanzwe itagikora neza nk'uko byagakwiye. Niba wowe cyangwa umuntu witaho arwaye indwara ya Parkinson, ushobora kuba warabonye ko rimwe na rimwe imiti y'ingenzi isa nk'aho irangira mbere y'uko doze ikurikira igera, bigatuma wumva umubiri wawe ugoye cyangwa ugahura n'ingorane zo kugenda neza.

Uyu muti ukora nk'umuti wongerwa ku miti yawe ya Parkinson isanzwe. Ugenewe kugufasha kugabanya ibyo bihe bisharira iyo ibimenyetso byawe bigaruka hagati ya doze, bikaguha ubufasha buhoraho umunsi wose.

Icyo Istradefylline Aricyo?

Istradefylline ni ubwoko bw'umuti witwa adenosine A2A receptor antagonist. Mu magambo yoroheje, ikora ibyara ibimenyetso bimwe na bimwe mu bwonko bwawe bishobora kubangamira imigendekere myiza n'imikoranire.

Tekereza nk'umuti ufasha ukora hamwe n'imiti yawe ya Parkinson y'ibanze. Mugihe umuti wawe w'ibanze (akenshi levodopa/carbidopa) utanga inyungu z'ibanze, istradefylline yinjira kugirango ifashe gukomeza izo nyungu mu buryo buhoraho umunsi wose.

Uyu muti uza mu buryo bw'ibinini kandi ufashwe mu kanwa. Byemerejwe by'umwihariko abantu bakuru barwaye indwara ya Parkinson bahura n'imihindagurikire y'imikorere, aribyo bihe ibimenyetso byawe bisa nk'aho biza bigenda mu buryo butunguranye.

Icyo Istradefylline Ikoreshwa?

Istradefylline ikoreshwa cyane cyane mu kuvura ibihe byo "kudakora" ku bantu barwaye indwara ya Parkinson. Ibi bihe byo kudakora ni ibihe imiti yawe ya Parkinson isanzwe isa nk'aho itagikora neza, kandi ibimenyetso byawe nk'umuturagaro, umubiri ugoye, n'imigendekere itinda bigaruka.

Abantu benshi barwaye indwara ya Parkinson bageza igihe bahura n'izo mpinduka uko indwara yabo ikomeza. Ushobora kubona ko imiti yawe ikora neza amasaha make nyuma yo kuyifata, ariko noneho ukatangira kumva umubiri wawe ukakaye cyangwa uhinda umushyitsi mbere yo gufata urundi rugero rw'umuti.

Uyu muti ukoreshwa buri gihe hamwe na levodopa/carbidopa, ntabwo ukoreshwa wenyine. Ugenewe gufasha kwongera igihe wumva umeze neza no kugabanya igihe umara mu bihe bitameze neza.

Ibyo Istradefylline Ikora

Istradefylline ikora ibungabunga imitsi ya adenosine A2A mu bwonko bwawe. Iyo mitsi isanzwe ituma imikorere ya dopamine igenda gahoro, umuti wo mu bwonko ufasha kugenzura imigendekere kandi ukaba ubura mu ndwara ya Parkinson.

Mugihe ibungabunga iyo mitsi, istradefylline yemerera dopamine gukora neza. Ibi bivuze ko imiti yawe ya Parkinson ishobora gutanga inyungu zihamye umunsi wose, igabanya ibyo bihe bigoye.

Ifatwa nk'umuti ukomeye wo hagati utanga ubufasha buhoraho aho gutanga impinduka zikomeye. Abantu benshi babona impinduka buhoro buhoro mu gihe cyabo cyo hanze y'imiti mu byumweru byinshi by'imiti, aho guhita bagira ingaruka zikomeye.

Nkwiriye Gufata Istradefylline Nte?

Fata istradefylline nk'uko muganga wawe abikwandikiye, akenshi rimwe ku munsi. Urashobora kuyifata urya cyangwa utarya, icyo wumva kigufitiye akamaro.

Nibyiza gufata urugero rwawe ku gihe kimwe buri munsi kugirango bifashe kugumana urwego ruzima mu mubiri wawe. Abantu benshi basanga bifasha kuyifata hamwe n'imiti yabo ya mugitondo nk'igice cy'ibikorwa byabo bya buri munsi.

Niba ugira ikibazo cyo kumira ibinini, urashobora gukanda ibinini bya istradefylline ukabivanga na pomme cyangwa pudding. Ariko, ntukomere cyangwa ucagagure ibinini keretse muganga wawe akubwiye ko byemewe.

Komeza gufata imiti yawe yose ya Parkinson uko yategetswe. Istradefylline igomba gukora hamwe n'imiti yawe ya none, ntabwo iyisimbuza.

Nzamara Mfata Istradefylline Igihe Kingana Gite?

Istradefylline akenshi ni imiti ifatwa igihe kirekire uzakomeza gufata igihe cyose ifasha kugenzura ibimenyetso bya Parkinson yawe. Abantu benshi bafashwa n'uyu muti bakeneye kuwufata iteka kugirango bagumane impinduka nziza.

Ushobora gutangira kubona ibyiza muminsi mike ya mbere, ariko birashobora gufata ibyumweru 12 kugirango ubone ingaruka zose. Iyi mpinduka buhoro buhoro ni ibisanzwe kandi ntibisobanura ko umuti utagikora.

Muganga wawe azagenzura buri gihe uko umuti ukora neza kuri wowe kandi ashobora guhindura gahunda yawe yo kuvurwa uko igihe kigenda. Ntukigere uhagarika gufata istradefylline ako kanya utabanje kubiganiraho n'umuganga wawe, kuko ibi bishobora gutuma ibihe byawe byo kutagira imiti bisubira cyangwa bikiyongera.

Ni Ibihe Bimenyetso Bigaragara Byatewe na Istradefylline?

Kimwe n'indi miti yose, istradefylline irashobora gutera ibimenyetso bigaragara, nubwo atari buri wese ubyumva. Kumva icyo witegura birashobora kugufasha kwitegura neza kandi ukamenya igihe wakwandikira muganga wawe.

Ibimenyetso bigaragara cyane akenshi biroroshye kandi akenshi birakosoka uko umubiri wawe wimenyereza umuti:

• Urugimbu cyangwa kuribwa munda
• Uruzi cyangwa umutwe
• Kugorwa no gusinzira cyangwa guhinduka kw'ibitotsi
• Kugara
• Kurota (kubona cyangwa kumva ibintu bitariho)

Ibi bimenyetso bigaragara akenshi biragabanuka nyuma y'ibyumweru bike byo kuvurwa. Gufata umuti hamwe n'ibiryo birashobora gufasha kugabanya urugimbu, kandi kuguma ufata amazi menshi birashobora gufasha kugabanya kugara.

Abantu bamwe bashobora guhura n'ibimenyetso bigaragara bikomeye bisaba ubufasha bw'abaganga. Nubwo ibi bidakunze kubaho, ni ngombwa kumenya icyo ugomba kwitaho:

• Ibyiyumvo bidasanzwe cyangwa imyitwarire (nk'urugero rwo gukunda gukina urusimbi, kugura cyane, cyangwa kurya cyane)
• Impinduka zikomeye mu myifatire cyangwa agahinda gakabije
• Kuzamuka cyane kw'imigendekere itunguranye
• Urubavu rubabaza cyangwa umutima utera nabi
• Urugero rwo kuribwa cyane cyangwa guta ubwenge

Niba ubonye bimwe muri ibi bintu bikomeye, vugana n'umuganga wawe vuba. Bashobora kugufasha kumenya niba imiti ikeneye guhindurwa cyangwa niba ukeneye ubufasha bwiyongera.

Ninde utagomba gufata Istradefylline?

Istradefylline ntabwo ikwiriye kuri buri wese, kandi indwara zimwe na zimwe cyangwa imiti irashobora kuyigira itekanye. Umuganga wawe azasuzuma neza amateka yawe mbere yo kugutera uyu muti.

Ntabwo ugomba gufata istradefylline niba uyirwaye cyangwa niba ufite ibiyigize. Bwira umuganga wawe ibyerekeye ibyabayeho mbere byo kurwara imiti, n'iyo bisa nkaho bitajyanye.

Abantu bafite indwara zimwe na zimwe bashobora gukenera gukurikiranwa byihariye cyangwa ntibashobore gufata uyu muti mu buryo butekanye:

• Indwara ikomeye y'impyiko
• Indwara ikomeye y'umwijima
• Amateka y'ibibazo by'umutima
• Psychose ikora cyangwa indwara zikomeye zo mu mutwe
• Gusama cyangwa konsa

Imiti imwe na imwe irashobora guhura na istradefylline, ishobora kuyigira idakora neza cyangwa ikongera ingaruka ziterwa nayo. Wibuke kubwira umuganga wawe imiti yose urimo gufata, harimo imiti igurishwa itagomba kwandikwa na muganga n'ibyongerera imbaraga.

Izina ry'ubwoko bwa Istradefylline

Istradefylline igurishwa ku izina ry'ubwoko rya Nourianz muri Leta Zunze Ubumwe z'Amerika. Ubu ni bwo buryo busanzwe uzabona wanditswe kandi ugahabwa muri farumasi.

Igihe uvugana n'umuganga wawe cyangwa umufarumasiti, urashobora gukoresha izina rusange (istradefylline) cyangwa izina ry'ubwoko (Nourianz). Bazumva neza umuti uvuga.

Ubu, Nourianz nicyo gicuruzwa cyonyine kiboneka muri Amerika, nubwo ibindi bicuruzwa bya rusange bishobora kuboneka mu gihe kizaza igihe patenti zizaba zarangiye.

Izindi nzira zishobora gukoreshwa aho gukoresha Istradefylline

Niba istradefylline itagukwiriye, hari izindi miti ishobora kugufasha gucunga ibihe bibi bya indwara ya Parkinson. Muganga wawe ashobora kuganira kuri izi nzira bitewe n'uko ubuzima bwawe bumeze.

Ibindi byongerwa ku miti bikora kimwe no kugabanya igihe kibi birimo:

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• Safinamide (Xadago) - undi muti wongerwa
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• Rasagiline (Azilect) - umuti wa MAO-B
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• Selegiline (Eldepryl) - undi muti wa MAO-B
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• Entacapone (Comtan) - umuti wa COMT
\n

Muganga wawe ashobora kandi gutekereza guhindura gahunda yawe ya levodopa/carbidopa cyangwa guhindura ku yindi miti mbere yo kongeraho undi muti mushya. Guhitamo neza biterwa n'ibimenyetso byawe byihariye, izindi ndwara, n'uko wabyitwayemo ku miti yakoreshejwe mbere.

Ese Istradefylline iruta Rasagiline?

Istradefylline na rasagiline byombi bishobora gufasha kugabanya ibihe bibi bya indwara ya Parkinson, ariko bikora binyuze mu buryo butandukanye mu bwonko bwawe. Ntabwo hari igisubizo cyoroshye cyerekeye niba kimwe

Abantu barwaye indwara z'umutima akenshi bashobora gufata istradefylline neza, ariko bashobora gukenera gukurikiranwa cyane. Umuti rimwe na rimwe ushobora kugira ingaruka ku mutima, bityo muganga wawe azashaka gusuzuma ubuzima bw'umutima wawe neza mbere yo gutangira kuvurwa.

Niba ufite amateka y'ibibazo by'umutima, muganga wawe ashobora gutegeka EKG (igeragezwa ry'umutima) mbere yo gutangira gufata istradefylline ndetse no mu gihe uvurwa. Ibi bifasha kumenya neza ko umuti utagira ingaruka ku mutima wawe.

Ntukemere impungenge z'umutima zikubuza kuganira kuri ubu buryo bwo kuvura na muganga wawe. Abantu benshi bafite ibibazo by'umutima bafata istradefylline neza bafashijwe no gukurikiranwa neza.

Q2. Nkwiriye gukora iki niba mfata istradefylline nyinshi ku buryo butunguranye?

Niba ufata istradefylline nyinshi ku buryo butunguranye kuruta uko byategetswe, vugana na muganga wawe cyangwa ikigo gishinzwe kurwanya ubumara ako kanya. Gufata nyinshi cyane bishobora kongera ibyago byo kugira ingaruka zirimo isesemi, isereri, cyangwa impinduka mu mutima.

Ntugerageze "gushyira mu gaciro" urugero rurenzeho urukurikiza urugero rukurikira. Ahubwo, kurikiza ubuyobozi butangwa n'umuganga wawe cyangwa ikigo gishinzwe kurwanya ubumara ku byo gukora.

Kugirango wirinde gufata imiti myinshi ku buryo butunguranye, tekereza gukoresha igikoresho cyo gutegura imiti cyangwa gushyiraho ibyibutso kuri terefone yawe kugirango bigufashe kumenya igihe wafatiye umuti wawe.

Q3. Nkwiriye gukora iki niba nirengagije urugero rwa istradefylline?

Niba wirengagije urugero rwa istradefylline, fata ako kanya wibuka, keretse igihe cyegereye urugero rukurikira rwateganyijwe. Muricyo gihe, reka urugero wirengagije ukomeze gahunda yawe isanzwe.

Ntuzigere ufata urugero rurenzeho rimwe kugirango ushyire mu gaciro urugero rwirengagijwe. Ibi bishobora kongera ibyago byo kugira ingaruka zitari ngombwa.

Niba ukunda kwibagirwa urugero, ganira na muganga wawe ku bijyanye n'uburyo bwo kugufasha kwibuka, nko gufata umuti mu gihe kimwe n'undi muti wa buri munsi cyangwa gushyiraho alarme kuri terefone yawe.

Q4. Ni ryari nshobora kureka gufata istradefylline?

Ugomba guhagarika gufata istradefylline uyobowe na muganga wawe. Kubera ko yagenewe gufasha mu gucunga ibimenyetso bya Parkinson bikomeza, kuyihagarika bishobora gutuma ibihe byawe byo kutumva neza bisubira.

Muganga wawe ashobora kugusaba guhagarika umuti niba urimo guhura n'ingaruka zikomeye zirenze akamaro, cyangwa niba indwara yawe ya Parkinson yarateye imbere ku buryo izindi nshuti zaba zikwiriye.

Niba wowe na muganga wawe mwemeje guhagarika istradefylline, mubisanzwe uzagabanya buhoro buhoro aho guhagarara ako kanya. Ibi bifasha kwirinda irushanwa ryongera ibimenyetso byawe.

Q5. Nshobora kunywa inzoga nkanwa istradefylline?

Mubisanzwe ni byiza kugabanya inzoga mugihe ufata istradefylline. Inzoga irashobora kongera ibyago byo kuribwa kandi irashobora kubangamira uburyo umuti ukora neza.

Niba uhisemo kunywa rimwe na rimwe, bikore mu rugero kandi witondere uko wumva. Abantu bamwe basanga n'inzoga nto zibatera kumva batameze neza cyangwa kuribwa iyo zivanzwe n'uyu muti.

Ganira na muganga wawe kubyerekeye imigenzo yawe yo kunywa inzoga kugirango batange ubuyobozi bwihariye bushingiye ku buzima bwawe muri rusange n'indi miti urimo gufata.