Lapatinib ni iki: Ibikoresho, Urutonde rw'imiti, Ingaruka ziterwa n'iyo miti n'ibindi

Lapatinib ni umuti w'indwara ya kanseri ugamije gufasha kugabanya imikurire y'uturanduriro twa kanseri yo mu gituza. Uyu muti ubarizwa mu cyiciro cy'imiti yitwa tyrosine kinase inhibitors, ikora ibikorwa byo guhagarika poroteyine zihariye zifasha uturanduriro twa kanseri gukura no gukwirakwira mu mubiri wawe.

Uyu muti ukoreshwa cyane cyane hamwe n'izindi miti ivura kanseri kugira ngo ifashe abarwayi bafite kanseri yo mu gituza yateye imbere cyangwa yimuye. Kumva uko lapatinib ikora n'icyo witegura bishobora kugufasha kumva witeguye kandi ufite icyizere ku rugendo rwawe rw'ubuvuzi.

Lapatinib ni iki?

Lapatinib ni umuti wa kanseri unyobwa mu kanwa ugamije uturanduriro twa kanseri dufite poroteyine zihariye. Ikora ibikorwa byo guhagarika poroteyine ebyiri z'ingenzi zifasha uturanduriro twa kanseri gukura no kwiyongera, zikaba ari HER2 na EGFR.

Ubu buryo bugamije butuma lapatinib yibanda ku guhagarika uturanduriro twa kanseri mugihe muri rusange itangiza gusa uturemangingo twiza ugereranije na shimi ya gakondo. Uyu muti uza mu buryo bw'ibinini, bigatuma byoroha kuwufata mu rugo nk'igice cy'imikorere yawe ya buri munsi.

Muganga wawe azemeza niba lapatinib ikwiriye kuri wowe hashingiwe ku biranga uturanduriro twa kanseri yawe. Ubu buryo bwihariye bufasha kumenya neza ko wakira ubuvuzi bwiza cyane ku kibazo cyawe cyihariye.

Lapatinib ikoreshwa mu kuvura iki?

Lapatinib ikoreshwa cyane cyane mu kuvura kanseri yo mu gituza yateye imbere cyangwa yimuye ifite ibimenyetso bya poroteyine byitwa HER2-positive. Muri rusange itangwa iyo kanseri yimukiye mu bindi bice by'umubiri wawe cyangwa iyo izindi miti zitagize icyo zigeraho.

Uyu muti ubusanzwe uvangwa n'indi miti ya kanseri nka capecitabine cyangwa letrozole kugira ngo habeho uburyo bwo kuvura burambuye. Ubu buryo bwo kuvura buvanga imiti ishobora gufasha kugabanya ikwirakwira rya kanseri kandi rishobora gufasha kugabanya ibibyimba ku barwayi bamwe.

Umuvuzi wawe w’indwara z’umubiri ashobora kugusaba gufata lapatinib niba warabanje kuvurwa na trastuzumab (Herceptin) na chimiothérapie ishingiye kuri anthracycline. Ibi bituma lapatinib iba uburyo bw'ingenzi ku barwayi bakeneye ubundi buryo bwo kuvurwa.

Lapatinib ikora ite?

Lapatinib ikora ibyara ibintu bibiri byihariye kuri selile za kanseri byitwa HER2 na EGFR receptors. Izi poroteyine zisanzwe zohereza ibimenyetso bibwira selile za kanseri gukura no kwigabanya vuba.

Mugihe cyo kubuza ibi bimenyetso, lapatinib ishyira feri ku mikurire ya selile za kanseri. Tekereza nk'aho uca imirongo y'itumanaho selile za kanseri zikoresha kugirango zihuze imikurire yazo no gukwirakwira mumubiri wawe.

Uyu muti ufatanwa nk'uvura kanseri ukomeye cyane kandi usanzwe woroshye kuruta chimiothérapie gakondo. Nubwo ifite akamaro mugutera selile za kanseri, akenshi itera ingaruka nke zikomeye kuruta imiti imwe ya kanseri.

Nkwiriye gufata lapatinib nte?

Fata lapatinib nkuko umuganga wawe abitegeka, akenshi rimwe kumunsi mugihe kimwe buri munsi. Urutonde rusanzwe ni ibinini bitanu (1,250 mg yose) bifatwa hamwe, nubwo umuganga wawe ashobora kubihindura bitewe nibyo ukeneye.

Ukwiye gufata lapatinib munda itarimo ikintu, byibura isaha imwe mbere yo kurya cyangwa byibura isaha imwe nyuma yo kurya. Ibi bifasha umubiri wawe kwinjiza umuti neza kandi bigatuma ukora neza uko bishoboka kose.

Mimina ibinini byose hamwe n'ikirahure kinini cy'amazi. Ntukice, utahe cyangwa umene ibinini, kuko ibi bishobora kugira ingaruka kumubiri wawe uko ukoresha umuti. Niba ugira ikibazo cyo kumira ibinini, ganira n'ikipe yawe y'ubuzima kubijyanye n'uburyo bushobora gufasha.

Gerageza gufata umuti wawe mugihe kimwe buri munsi kugirango ufashwe kugumana urwego rwo hejuru mumaraso yawe. Abarwayi benshi basanga bifasha gushyiraho umwanya wo kwibutswa buri munsi cyangwa kubishyira mumurimo wabo wo mu gitondo cyangwa nimugoroba.

Mvure lapatinib igihe kingana iki?

Ubukure bw'imiti ya lapatinib butandukana cyane ku muntu ku muntu, bitewe n'uko kanseri yawe yitwara neza n'uko wihanganira umuti. Abantu bamwe barawufata amezi menshi, mu gihe abandi bashobora gukomeza umwaka cyangwa kurenzawo.

Umuhanga wawe mu by'ubuvuzi bw'indwara z'umwijima azakurikiza imikorere yawe binyuze mu gusuzuma buri gihe, ibizamini by'amaraso, no gukoresha ibikoresho by'isuzuma. Izo gahunda zifasha kumenya niba umuti ukora neza kandi niba ufite ingaruka ziteye inkeke.

Ntuzigere uhagarika gufata lapatinib mu buryo butunguranye utabanje kubiganiraho na muganga wawe. N'iyo wumva umeze neza, guhagarika mu buryo butunguranye byatuma selile za kanseri zongera gukura. Itsinda ryawe ry'ubuzima rizagufasha mu mpinduka zose ziri mu gahunda yawe y'imiti.

Ni izihe ngaruka ziterwa na Lapatinib?

Kimwe n'imiti yose ya kanseri, lapatinib ishobora gutera ingaruka, nubwo atari buri wese uzazibona. Ingaruka nyinshi zishobora gucungwa neza hakoreshejwe uburyo bwiza bwo kwita ku buzima no kuvugana n'itsinda ryawe ry'ubuzima.

Dore ingaruka zisanzwe ushobora guhura nazo mugihe ufata lapatinib:

• Impiswi (zifata abantu benshi ariko akenshi zicungwa neza)
• Uruhu rurashya cyangwa uruhu rwo mu ntoki no mu birenge ruma
• Umunaniro cyangwa kumva urushye kurusha uko bisanzwe
• Isesemi cyangwa kuribwa mu nda
• Kubura ubushake bwo kurya
• Ibisebe mu kanwa cyangwa impinduka mu buryohe

Izi ngaruka zisanzwe akenshi zikemura uko umubiri wawe wimenyereza umuti. Itsinda ryawe ry'ubuzima rishobora gutanga ingamba zihariye zo gufasha gucunga neza buri kimwe muri ibyo bimenyetso.

Abantu bamwe bashobora guhura n'ingaruka zikomeye zisaba ubufasha bwihutirwa bw'abaganga:

• Urubuto rukaze rudakira n'imiti
• Ibimenyetso by'ibibazo by'umwijima (uruhu cyangwa amaso y'umuhondo, inkari z'umukara)
• Ibibazo by'umutima (gucika intege bidasanzwe, kuribwa mu gituza)
• Uruhu rukaze cyangwa ibibara byinshi ku ruhu
• Ibibazo by'ibihaha (gukorora bidahagarara, guhumeka bigoranye)

Vugana n'ikipe yawe y'ubuvuzi ako kanya niba ubonye kimwe muri ibi bimenyetso bikomeye. Kuvugana vuba bifasha kumenya neza ko ibibazo byose bikemurwa vuba kandi mu buryo bwizewe.

Ingaruka zidakunze ariko zikomeye

Nubwo bitajyenda bibaho, abarwayi bamwe bashobora guhura n'ingaruka zidakunze ariko zishobora kuba zikomeye zisaba gukurikiranwa neza:

• Ibibazo bikomeye by'umutima harimo no kugabanuka kw'imikorere y'umutima
• Ukwangirika gukomeye kw'umwijima gushobora gutera urupfu
• Uburwayi bukomeye bw'ibihaha (pneumonitis)
• Uruhu rukaze rushobora gutuma umuntu ajyanwa mu bitaro
• Imikorere mibi ikomeye ya electrolyte iterwa n'urubuto rurerure

Muganga wawe azagukurikiranira hafi ibi bibazo bidasanzwe binyuze mu bipimo by'amaraso bisanzwe no kugenzura imikorere y'umutima. Kumenya no kuvura ibi bibazo hakiri kare birinda ko bikomera.

Ninde utagomba gufata Lapatinib?

Lapatinib ntikwiriye kuri buri wese, kandi muganga wawe azagenzura neza niba ari umutekano kuri wowe. Uburwayi runaka cyangwa ibihe bishobora gutuma uyu muti ugira akaga gakabije.

Ntugomba gufata lapatinib niba ufite allergie izwi kuri uyu muti cyangwa ibikoresho byawo. Byongeye kandi, niba ufite indwara ikomeye y'umwijima cyangwa ibibazo bikomeye by'umutima, muganga wawe ashobora kugusaba imiti yindi.

Abagore batwite cyangwa bonka ntibagomba gufata lapatinib, kuko ishobora gukomeretsa abana bakiri bato. Niba uri mu gihe cyo kubyara, uzakenera gukoresha uburyo bwo kuboneza urubyaro bukora neza mugihe uvurwa no mu gihe gito umaze guhagarika imiti.

Muganga wawe azitonda kandi mu gutanga lapatinib niba ufite amateka y'indwara z'umutima, ibibazo by'umwijima, cyangwa indwara z'ibihaha. Ibi bibazo bisaba gukurikiranwa neza kandi bishobora kugira uruhare muri gahunda yawe y'ubuvuzi.

Amazina ya Lapatinib

Izina ry'ubucuruzi rya lapatinib ni Tykerb muri Leta Zunze Ubumwe z'Amerika no mu bindi bihugu byinshi. Uturere tumwe dushobora kurumenya ku izina ry'ubucuruzi rya Tyverb, nubwo byombi bikubiyemo umuti umwe ukora.

Ubwoko bwa lapatinib bwa rusange burimo kuboneka mu bihugu bimwe na bimwe, bishobora gutanga uburyo bwo kuzigama amafaranga mugihe bitanga inyungu zimwe zo kuvura. Farumasi yawe cyangwa ikipe y'ubuzima irashobora kugufasha gusobanukirwa ubwoko buboneka mu karere kawe.

Tutitaye ku izina ry'ubucuruzi, ubwoko bwose bwa lapatinib burimo umuti umwe ukora kandi ukora kimwe. Muganga wawe azatanga ubwoko bukwiye kandi buboneka kubera uko umubiri wawe umeze.

Uburyo bwa Lapatinib

Imiti myinshi isimbura iraboneka mu kuvura kanseri y'ibere ya HER2-positive, bitewe n'uko umubiri wawe umeze n'amateka y'ubuvuzi. Ibi bisimbura bikora binyuze mu buryo butandukanye ariko bigamije kugera ku ntego zimwe.

Trastuzumab (Herceptin) akunda gukoreshwa nk'ubuvuzi bwa mbere bwa kanseri y'ibere ya HER2-positive. Izindi mpuzankano zirimo pertuzumab (Perjeta), T-DM1 (Kadcyla), n'imiti mishya nka tucatinib (Tukysa) cyangwa neratinib (Nerlynx).

Umuvuzi wawe w'indwara z'umubiri azatekereza ibintu nk'ubuvuzi bwawe bwa mbere, uko ubuzima bwawe buhagaze ubu, n'imiterere yihariye ya kanseri mugihe asaba ibindi bisimbura. Buri muti ufite inyungu zawo n'ingaruka zishobora kuba zigaragara zigomba kuzirikanwa neza.

Uburyo bwo kuvura ni umuntu ku giti cye cyane, kandi icyo gikora neza kuri umwe gishobora kutaba uburyo bwiza kuri undi. Wizere ikipe yawe y'ubuzima kugirango ikuyobore ku buryo bukwiye bw'uko umubiri wawe umeze.

Ese Lapatinib iruta Trastuzumab?

Lapatinib na trastuzumab bikora mu buryo butandukanye kandi akenshi bikoreshwa mu byiciro bitandukanye by'ubuvuzi, bigatuma kugereranya mu buryo butaziguye bigorana. Byombi ni imiti ikora neza ku kanseri y'ibere ya HER2-positive, ariko buri kimwe gifite inyungu zidasanzwe.

Trastuzumab akenshi ikoreshwa nk'ubuvuzi bwa mbere kandi ishobora gutangwa mu maraso, mu gihe lapatinib akenshi yagenewe ubuvuzi bwo mu byiciro bya nyuma kandi iza mu buryo bw'umuti unyobwa. Lapatinib ishobora kuba ingirakamaro cyane ku barwayi kanseri yabo yafashe mu bwonko, kuko ishobora kurenga inzitizi iri hagati y'amaraso n'ubwonko neza.

Abantu barwaye bamwe bashobora kungukirwa no guhabwa imiti yombi yaba mu buryo bukurikirana cyangwa mu buryo buhuriweho. Muganga wawe w'inzobere mu by'indwara z'umubiri azagena uburyo bwiza bushingiye ku miterere ya kanseri yawe, amateka y'ubuvuzi bwawe, n'ubuzima bwawe muri rusange.

Aho gutekereza ko imwe ari

Niba wanyoye lapatinib nyinshi kuruta uko wagombaga, vugana n'umuganga wawe cyangwa ikigo gishinzwe ubumara ako kanya. Kunywa nyinshi bishobora kongera ibyago byo kugira ingaruka zikomeye, cyane cyane ibibazo by'umutima na diarhee ikaze.

Ntugategereze ngo urebe niba wumva ibimenyetso mbere yo gushaka ubufasha. N'iyo wumva umeze neza mbere na mbere, kunywa nyinshi bishobora gutera ingaruka zitinda zikeneye ubuvuzi. Gira urupapuro rw'umuti ruri kumwe nawe igihe uhamagaye kugira ngo ubone ubufasha.

Kugira ngo wirinde kunywa nyinshi bitunguranye, koresha agasanduku kagenewe imiti cyangwa ushyireho ibyibutso kuri terefone yawe. Ntukigere wongera doze niba wibagiwe imwe, kuko ibi bishobora gutuma unywa imiti myinshi icyarimwe.

Nkwiriye gukora iki niba nibagiwe doze ya lapatinib?

Niba wibagiwe doze ya lapatinib, yinywere ako kanya wibukire, ariko niba hashize amasaha atarenze 12 uhereye igihe wari uteganyirijwe kuyinywera. Niba hashize amasaha arenga 12, reka doze wibagiwe hanyuma unywe doze ikurikira ku gihe gisanzwe.

Ntuzigere unywa doze ebyiri icyarimwe kugira ngo usimbure doze wibagiwe, kuko ibi bishobora kongera ibyago byo kugira ingaruka. Aho kubikora, komeza gahunda yawe isanzwe yo kunywa imiti kandi umenyeshe ikipe yawe y'ubuvuzi ku bijyanye na doze wibagiwe.

Tekereza gushyiraho ibyibutso bya buri munsi kuri terefone yawe cyangwa ukoreshe agasanduku kagenewe imiti kugira ngo bigufashe kwibuka imiti yawe. Kwihangana mu kunywa lapatinib bifasha kugumisha urwego ruri hejuru mu maraso yawe kugira ngo bikore neza.

Nshobora guhagarika ryari kunywa lapatinib?

Wagombye guhagarika kunywa lapatinib gusa uyobowe na oncologiste wawe, kabone niyo wumva umeze neza cyangwa ufite ingaruka. Guhagarika kare bishobora gutuma selile za kanseri zongera gukura.

Muganga wawe azagena igihe byemewe guhagarika bishingiye ku buryo umuti ukora neza, ingaruka zikugiraho, n'ubuzima bwawe muri rusange. Iyi myanzuro irimo kwitondera ibintu byinshi byihariye ku miterere yawe.

Niba ingaruka zikomeye zo gukemura, ganira n'ikipe yawe y'ubuzima ku bijyanye no guhindura urugero rw'umuti cyangwa ingamba zo gufasha mbere yo gutekereza guhagarika umuti. Ingaruka nyinshi zishobora gukemurwa neza no kwitabwaho neza.

Nshobora kunywa inzoga niba mfata Lapatinib?

Nubwo nta tegeko rihana kunywa inzoga hamwe na lapatinib, muri rusange birasabwa kugabanya cyangwa kwirinda inzoga mugihe cyo kuvurwa kanseri. Inzoga ishobora gutera ingaruka zimwe na zimwe zikaba mibi kandi ishobora kubuza umubiri wawe gukora umuti.

Kubera ko lapatinib ishobora kugira ingaruka ku mikorere y'umwijima, kongeramo inzoga byongera umuvuduko ku mwijima wawe. Niba uhisemo kunywa rimwe na rimwe, ganira ibi n'ikipe yawe y'ubuzima kugirango usobanukirwe icyo gishobora kuba gitekanye kubibazo byawe byihariye.

Shyira imbaraga mu kuguma ufite amazi menshi n'ibindi byoroshye mugihe cyo kuvurwa. Umubiri wawe ukeneye imirire myiza n'amazi kugirango afashe gukemura ingaruka zo kuvurwa no gushyigikira ubuzima bwawe muri rusange.