Lasmiditan ni iki: Ibikoresho, Uburyo bwo gukoresha, Ingaruka ziterwa nacyo n'ibindi

Lasmiditan ni umuti mushya wandikirwa abantu wagenewe kuvura kubabara umutwe bikabije mu bantu bakuru. Uyu muti ubarizwa mu cyiciro cy'imiti yitwa selective serotonin receptor agonists, ikora mu buryo butandukanye n'imiti gakondo ivura kubabara umutwe bikabije, ikora ku turemangingo twihariye two mu bwonko tugira uruhare mu kubabara umutwe bikabije.

Uyu muti utanga icyizere ku bantu batabonye umuti uvura kubabara umutwe bikabije cyangwa batabasha gufata imiti imwe n'imwe ivura kubabara umutwe bikabije bitewe n'indwara z'umutima. Kumva uko lasmiditan ikora n'icyo wakwitega bishobora kugufasha gufata ibyemezo bifitiye akamaro ku bijyanye no kwivuza kubabara umutwe bikabije.

Lasmiditan ni iki?

Lasmiditan ni umuti wandikirwa abantu uvura kubabara umutwe bikabije hamwe cyangwa hatarimo aura mu bantu bakuru. Bitandukanye n'imiti imwe n'imwe ya kera ivura kubabara umutwe bikabije, ntigira ingaruka ku miyoboro y'amaraso mu mutima wawe, bigatuma iba uburyo bwiza ku bantu bafite indwara zimwe na zimwe z'umutima.

Uyu muti ukora ukoresha imbaraga zo gukora ku turemangingo twihariye twa serotonin mu bwonko bwawe twitwa 5-HT1F receptors. Utu turemangingo tugira uruhare runini mu nzira zibabaza umutwe bikabije. Iyo lasmiditan yifatanyije n'utu turemangingo, bifasha kugabanya ububyimbirwe n'ibimenyetso by'ububabare bitera ibimenyetso byo kubabara umutwe bikabije.

Ushobora kumenya lasmiditan ku izina ry'ubucuruzi rya Reyvow. Yemejwe na FDA mu 2019 nk'umuti wa mbere mu cyiciro cyayo, ikaba igaragaza iterambere rikomeye mu buryo bwo kuvura kubabara umutwe bikabije.

Lasmiditan ikoreshwa mu kuvura iki?

Lasmiditan ikoreshwa by'umwihariko mu kuvura kubabara umutwe bikabije mu bantu bakuru. Ibi bivuze ko yagenewe guhagarika kubabara umutwe bikabije byatangiye, aho gukumira kubabara umutwe bikabije mu gihe kizaza.

Muganga wawe ashobora kukwandikira lasmiditan niba ufite kubabara umutwe bikabije ku rugero rwo hagati cyangwa rukomeye rubuza gukora imirimo yawe ya buri munsi. Ishobora gufasha ku kubabara umutwe, isesemi, no kumva urumuri n'urusaku.

Uyu muti ni ingirakamaro cyane ku bantu bafite indwara z'umutima, umuvuduko ukabije w'amaraso, cyangwa izindi ndwara zifitanye isano n'imitsi y'amaraso zituma imiti ya triptan isanzwe idatekanye. Ni n'uburyo bwo gufata umuti niba waragerageje izindi miti ivura migraine ntigire icyo itanga cyangwa wumvise ingaruka zikubangamiye.

Lasmiditan ikora ite?

Lasmiditan ikora yibanda ku dusoko twihariye twa serotonin mu bwonko bwawe twitwa 5-HT1F receptors. Iyo migraine itangiye, inzira zimwe na zimwe zibabaza zirarenga urugero, zohereza ibimenyetso by'ububabare bukaze mu mutwe wawe kandi bigatuma ibindi bimenyetso nk'isuka.

Muguhuza n'utu dusoko, lasmiditan ifasha gutuza inzira z'imitsi irenga urugero itera ububabare bwa migraine. Igabanya kandi umuvumo mu gice cy'ubwonko gitera ibimenyetso bya migraine. Ubu buryo bwihariye bufasha guhagarika inzira ya migraine igihe itangiye.

Uyu muti ufashwe nk'ukomeye ku rugero ruciriritse kandi akenshi utangira gukora mu masaha abiri nyuma yo kuwufata. Bitandukanye n'imiti imwe na imwe ya migraine ifunga imitsi y'amaraso, lasmiditan ntigira ingaruka zigaragara ku mikorere y'imitsi yawe y'amaraso, bituma iba nziza ku bantu bafite indwara z'umutima.

Nkwiriye gufata lasmiditan nte?

Fata lasmiditan nk'uko muganga wawe abikwandikiye, akenshi nk'urugero rumwe gusa iyo wumva migraine itangiye. Urashobora kuyifata hamwe cyangwa udafite ibiryo, nubwo kuyifata hamwe n'ibiryo bishobora gufasha kugabanya isesemi niba uyigize.

Mimina urupapuro rwose hamwe n'ikirahure cyuzuye cy'amazi. Ntugasenye, uteme, cyangwa urume urupapuro, kuko ibi bishobora kugira ingaruka ku buryo umuti winjizwa. Urugero rusanzwe rwo gutangiriraho ni 50mg, nubwo muganga wawe ashobora kwandika 100mg niba bikenewe.

Ni ngombwa gufata lasmiditan ako kanya umaze kumenya ibimenyetso bya migraine bitangiye. Umuti ukora neza iyo ufashwe hakiri kare mu gihe cya migraine, mbere yuko ububabare bukomeza. Niba migraine yawe idakira nyuma y'amasaha abiri, ntukongere gufata undi muti utabanje kubaza muganga wawe.

Nzagomba Gufata Lasmiditan Igihe Kingana Gite?

Lasmiditan yagenewe gukoreshwa igihe gito mu kuvura ibitero bya migraine, atari ukuyirinda buri munsi igihe kirekire. Ugomba kuyifata gusa iyo urimo guhura na migraine nyayo, atari nk'uburyo bwo kuyirinda.

Umuti mubisanzwe utanga ubufasha mu gihe cy'amasaha abiri, kandi ingaruka zawo zirashobora kumara amasaha 24. Ntugomba gufata doze irenze imwe mu gihe cy'amasaha 24 keretse ubisabwe na muganga wawe. Kuyifata kenshi bishobora gutera kubabara umutwe bitewe no gukoresha imiti cyane.

Niba wibona ukenera lasmiditan inshuro zirenga 10 ku kwezi, ganira na muganga wawe ku bijyanye n'imiti yo kurwanya migraine. Gukoresha kenshi imiti ivura migraine ikaze rimwe na rimwe bishobora gutuma kubabara umutwe kurushaho uko igihe kigenda, bityo ni ngombwa kuyikoresha uko byategetswe.

Ni Iyihe Ngaruka Ziterwa na Lasmiditan?

Kimwe n'indi miti yose, lasmiditan ishobora gutera ingaruka, nubwo atari buri wese uzihura. Ingaruka zisanzwe zikunze kuba zoroshye kandi z'igihe gito, zigakira umuti umaze kuva mu mubiri wawe.

Dore ingaruka zikunze kuvugwa cyane ushobora guhura nazo:

• Kuribwa umutwe cyangwa kumva ureremba
• Gusinzira cyangwa kunanirwa
• Isesemi cyangwa kutumva neza mu nda
• Kugabanuka kw'imbaraga z'imitsi cyangwa kumva utameze neza
• Kumva urugero cyangwa guhumeka mu ntoki cyangwa mu birenge
• Umunwa wumye
• Kumva utandukanye cyangwa "mu kirere"

Ibi bimenyetso bigaragara kenshi bikunda kuvaho nyuma y'amasaha make umubiri wawe umaze gutunganya imiti. Kugira isereri no gusinzira cyane birashobora kugaragara cyane, ni yo mpamvu utagomba gutwara imodoka cyangwa gukoresha imashini nibura amasaha umunani umaze gufata lasmiditan.

Ibyo bitera ingaruka mbi ariko bikomeye kandi bisaba ubufasha bwihuse bw'abaganga birimo:

• Kugira isereri rikomeye cyangwa kuruka
• Kubura umwuka cyangwa guhagarika igituza
• Kugabanuka gukomeye kw'imbaraga z'imitsi
• Urujijo cyangwa kutamenya aho uri
• Urugero rw'ibimenyetso by'uburwayi nka gusa, kurigata, cyangwa kubyimba

Niba ubonye kimwe muri ibyo bimenyetso bikomeye, vugana n'umuganga wawe ako kanya cyangwa ushake ubufasha bwihutirwa bw'ubuvuzi. Nubwo bidasanzwe, ibyo bimenyetso bishobora kwerekana igisubizo gikomeye gikeneye kuvurwa vuba.

Ninde utagomba gufata Lasmiditan?

Lasmiditan ntabwo ikwiriye kuri buri wese, kandi ibibazo by'ubuzima cyangwa ibihe runaka bituma bidatekanye kuyikoresha. Muganga wawe azasuzuma neza amateka yawe y'ubuzima mbere yo kwandika uyu muti.

Ntabwo ugomba gufata lasmiditan niba ufite indwara ikomeye y'umwijima, kuko umubiri wawe ushobora kutabasha gutunganya neza uwo muti. Abantu bafite amateka y'urugero, umutima wateye, cyangwa ibindi bibazo bikomeye by'umutima n'imitsi bagomba kwirinda uyu muti.

Dore ibibazo nyamukuru n'ibihe aho lasmiditan itasabwa:

• Indwara ikomeye y'umwijima cyangwa kunanirwa kw'umwijima
• Urugero rwa mbere cyangwa igitero cya ischemic gito (TIA)
• Amateka y'umutima wateye cyangwa ibibazo bikomeye by'umutima
• Umubyigano w'amaraso udagenzurwa
• Gusama cyangwa konsa
• Imyaka iri munsi y'imyaka 18
• Kumenya allergie kuri lasmiditan cyangwa ibiyigize

Muri ubundi buryo, ugomba kwitonda niba ufite ibibazo by'impyiko, ufata imiti imwe na imwe ivura umubabaro wo mu mutwe, cyangwa ufite amateka yo gukoresha ibiyobyabwenge. Ingaruka zo gutuza za lasmiditan zishobora kongerwa na alukolo cyangwa izindi miti ituma ubwonko butagira imbaraga, bityo wirinde izo mvange.

Izina ry'ubwoko bwa Lasmiditan

Lasmiditan igurishwa ku izina ry'ubwoko rya Reyvow muri Leta Zunze Ubumwe z'Amerika. Uyu muti w'izina ry'ubwoko ukorwa na Eli Lilly and Company kandi wemerejwe bwa mbere na FDA muri Ukwakira 2019.

Reyvow iboneka mu mbaraga ebyiri: ibinini 50mg na 100mg. Zombi zifite ikintu kimwe gikora, lasmiditan, ariko mu bwinshi butandukanye kugira ngo byorohereze gutanga imiti hakurikijwe ibyo ukeneye n'uburyo wakiriye imiti.

Kugeza ubu, nta miti ya lasmiditan iboneka, kuko uyu muti ukiri mu buryo bwo kurindwa na patenti. Ibi bivuze ko Reyvow ari ryo zina ryonyine riboneka, rishobora gutuma rihenda kurusha imiti ya kera ivura umutwe w'umutwe ifite izindi mpinduka.

Izindi miti isimbura Lasmiditan

Niba lasmiditan itagukwiriye cyangwa itatanga ubufasha buhagije, hari ubundi buryo bwo kuvura umutwe w'umutwe burahari. Muganga wawe ashobora kugufasha kubona igisubizo cyiza hashingiwe ku mateka yawe y'ubuzima n'ibyo ukeneye.

Imiti ya gakondo ya triptan nka sumatriptan (Imitrex), rizatriptan (Maxalt), na zolmitriptan (Zomig) akenshi igeragezwa mbere. Iyi miti ikora igabanya imitsi y'amaraso mu bwonko kandi ifasha abantu benshi, nubwo itakwiriye abafite indwara z'umutima.

Dore ibyiciro by'ingenzi byo kuvura umutwe w'umutwe:

• Triptans (sumatriptan, rizatriptan, eletriptan)
• Abanzi ba CGRP (ubrogepant, rimegepant)
• Ergot alkaloids (dihydroergotamine)
• Imiti irwanya isesemi (metoclopramide, ondansetron)
• Imiti igabanya ububabare (ibuprofen, naproxen, acetaminophen)
• Imiti ivanze (sumatriptanaproxen)

Uburyo bushya nka ubrogepant (Ubrelvy) na rimegepant (Nurtec ODT) bikora kimwe na lasmiditan mu kwerekeza ku byakira bitandukanye bifitanye isano n'ububabare bwa migraine. Izi CGRP antagonists zishobora kuba izindi nziza niba udashobora gufata lasmiditan ariko ukeneye uburyo bwizewe ku mutima.

Ese Lasmiditan iruta Sumatriptan?

Zose lasmiditan na sumatriptan ni imiti ikora neza mu kuvura migraine, ariko zikora mu buryo butandukanye kandi zifite inyungu zitandukanye bitewe n'uko umuntu ahagaze. Nta na rimwe riruta irindi, kuko guhitamo neza biterwa n'ubuzima bwawe bwihariye n'uburyo wakiriye imiti.

Sumatriptan imaze igihe kinini iboneka kandi ifite ubushakashatsi bwinshi bushingiye ku mikorere yayo. Akenshi igeragezwa mbere kuko iboneka mu buryo bwinshi (ibinini, inshinge, spray yo mu mazuru) kandi ifite ubwoko bwa generic butuma iba ihendutse. Ariko, sumatriptan ishobora kugabanya imitsi y'amaraso, bituma itakwemerera abantu bafite indwara z'umutima.

Inyungu nyamukuru ya Lasmiditan ni uko itagira ingaruka ku bantu bafite indwara z'umutima. Ntabwo igira ingaruka ku mitsi y'amaraso mu mutima, bituma iba nziza niba ufite indwara z'umutima, umuvuduko w'amaraso uri hejuru, cyangwa izindi ngaruka z'umutima. Irashobora kandi gutera ibibazo bike byo guhura n'umutwe ukabije iyo ikoreshejwe kenshi.

Gu hitamo hagati y'iyi miti akenshi biterwa n'ubuzima bwawe bwihariye. Niba ufite indwara z'umutima, lasmiditan ishobora kuba uburyo bwiza. Niba nta kibazo cy'umutima ufite kandi ikiguzi ari ikintu cy'ingenzi, sumatriptan ishobora kuba ifatika.

Ibibazo bikunze kubazwa kuri Lasmiditan

Ese Lasmiditan irakwiriye abantu bafite indwara z'umutima?

Yego, lasmiditan muri rusange ifatwa nk'inziza ku bantu bafite indwara z'umutima ugereranije n'imiti gakondo ya migraine nka triptans. Bitandukanye na triptans, lasmiditan ntigabanya cyane imitsi y'amaraso mu mutima, igabanya ibibazo by'umutima.

Ariko, ugomba kubanza kuganira n'umuganga wawe ku bijyanye n'uburwayi bw'umutima bwawe mbere yo gutangira gukoresha lasmiditan. Nubwo ari umutekano ku barwayi benshi b'umutima, uburwayi bukomeye bw'imitsi y'amaraso bushobora gutuma bitakwemerera. Umuganga wawe azasuzuma ibyago byawe byihariye hanyuma akemeza niba lasmiditan ikwiriye kubera uko urwaye.

Nkwiriye gukora iki niba nanyweye lasmiditan nyinshi bitunguranye?

Niba unyweye lasmiditan nyinshi kuruta uko byategetswe, vugana n'umuganga wawe cyangwa ikigo gishinzwe kurwanya ubumara ako kanya. Kunywa nyinshi bishobora kongera ibyago byo kugira ingaruka zikomeye nk'izindi zikomeye, kurara cyane, cyangwa kugorwa no guhumeka.

Ntugerageze kwitwara kugira ngo ubone ubufasha, kuko umuti ushobora gutera kurara cyane no kuribwa umutwe. Reka undi muntu akujyane mu cyumba cy'abarwayi b'igitaraganya niba bigizwe n'umuganga wawe. Zana icupa ry'umuti kugira ngo abaganga babone neza icyo wanyweye n'ingano yacyo.

Ibimenyetso byo kunywa umuti mwinshi bishobora kuba birimo kunanirwa cyane, urujijo, kugorwa no gukomeza kuba maso, cyangwa ibibazo byo guhuza ibice by'umubiri. N'iyo wumva umeze neza mbere na mbere, ni ngombwa gushaka ubufasha bw'abaganga, kuko izindi ngaruka zishobora kutagaragara ako kanya.

Nkwiriye gukora iki niba nirengagije urugero rwa lasmiditan?

Lasmiditan ifatwa gusa iyo ufite umutwe ukabije, ntabwo ifatwa ku gihe giteganijwe, bityo ntushobora rwose

Niba utazi neza niba wakoresha lasmiditan ku migraine imaze igihe, vugana n'umuganga wawe kugira ngo akugire inama. Ashobora kugufasha gufata icyemezo niba bikwiye gukoreshwa cyangwa niba izindi nshuti zishobora kuba zikwiriye kurushaho icyo gihe.

Ni ryari nshobora kureka gukoresha Lasmiditan?

Ushobora kureka gukoresha lasmiditan igihe icyo aricyo cyose, kuko atari umuti usaba guhagarikwa buhoro buhoro. Kubera ko ikoreshwa gusa ku gitero cya migraine kimwe aho gukumira buri munsi, nta kaga ko kugira ibimenyetso byo kuva mu miti iyo uhagaritse.

Ushobora guhitamo kureka gukoresha lasmiditan niba ubona izindi nshuti zikora neza, niba ugira ingaruka zibabaje, cyangwa niba migraine yawe igabanuka kenshi cyangwa ikaba idakaze. Abantu bamwe kandi bareka iyo batangira imiti yo gukumira migraine igabanya icyifuzo cyabo cyo gukoresha imiti ikaze.

Mbere yo guhagarika, ganira ku cyemezo cyawe n'umuganga wawe, cyane cyane niba lasmiditan yarafashaga migraine yawe. Bashobora gufasha kumenya neza ko ufite uburyo bwo kuvura bundi kandi bashobora gutanga ibitekerezo byo gucunga indwara yawe ya migraine.

Nshobora gufata Lasmiditan hamwe n'indi miti?

Lasmiditan irashobora guhura n'imiti imwe n'imwe, bityo ni ngombwa kubwira umuganga wawe imiti yose yanditswe, imiti itangwa nta cyangombwa, n'ibyongerera imbaraga ukoresha. Imvange zimwe zirashobora kongera ingaruka cyangwa zigatuma itagira akamaro.

Umuti urashobora kongera ingaruka zo gusinziriza za alukolo, ibinini bisinziriza, imiti igabanya impungenge, na zimwe muri antidepressants. Iyi mvange irashobora gutuma usinzira cyane cyangwa ugahungabana, bikongera ibyago byo kugwa cyangwa impanuka. Umuganga wawe ashobora kugusaba kwirinda izi mvange cyangwa guhindura doze.

Banza uganire n'umuganga wawe mbere yo gutangira imiti mishya iyo ari yo yose ukoresha lasmiditan. Bashobora gusuzuma uko imiti ishobora gukorana kandi bakagufasha gukoresha imiti yawe yose neza. Bika urutonde rw'imiti yose ukoresha kugira ngo urusangize umuganga uwo ari we wese ubonana nawe.