Macimorelin ni iki: Ibikoreshwa, Urutonde rw'imiti, Ingaruka ziterwa n'ibindi

Macimorelin ni umuti wandikirwa na muganga ufasha abaganga kumenya niba abantu bakuru bafite ikibazo cyo kubura imisemburo ikura. Ukora utuma umubiri wawe usohora imisemburo ikura, abaganga bakabasha kuyipima binyuze mu bipimo by'amaraso kugira ngo barebe niba umusemburo wawe ukora neza.

Uyu muti uza mu buryo bw'umuti unyobwa, bigatuma uba uburyo bworoshye ugereranije n'ibizamini bya kera byasabaga guterwa inshinge. Muganga wawe azakoresha macimorelin nk'igice cy'isuzuma ryuzuye kugira ngo asobanukirwe niba umubiri wawe ukora imisemburo ikura ihagije mu buryo busanzwe.

Macimorelin ikoreshwa mu iki?

Macimorelin yagenewe by'umwihariko kumenya niba abantu bakuru bafite ikibazo cyo kubura imisemburo ikura (AGHD). Iyo abaganga bakeka ko ushobora kuba ufite iki kibazo, bakeneye uburyo bwizewe bwo gupima uburyo umusemburo wawe ukora imisemburo ikura neza.

Uyu muti ukora nk'igikoresho cyo kumenya indwara aho kuba umuti. Tekereza nk'ikizamini cy'umuvuduko ku musemburo wawe - uhatira umubiri wawe gukora imisemburo ikura kugira ngo abaganga babashe gupima uko witwara. Ibi bibafasha kumenya niba ibimenyetso byawe bifitanye isano no kubura imisemburo ikura cyangwa ikindi kibazo.

Kubura imisemburo ikura mu bantu bakuru bishobora gutera umunaniro, intege nke z'imitsi, kongera ibinure mu mubiri, no kugabanya ubuzima bwiza. Kugira icyemezo cy'indwara cy'ukuri ni intambwe ya mbere yo kubona ubuvuzi bukwiye niba koko ufite iki kibazo.

Macimorelin ikora ite?

Macimorelin ikora yigana imisemburo isanzwe yitwa ghrelin, itegeka umusemburo wawe gusohora imisemburo ikura. Ifatwa nk'imbaraga ikomeye yo gutuma imisemburo ikura isohoka, bivuze ko ifite akamaro kanini mu gutera iyi ngaruka.

Iyo ufata macimorelin, ifatana n'uturemangingo twihariye mu ngingo yawe ya pituitary na hypothalamus. Iki gikorwa cyo gufatana gituma habaho ikimenyetso gikomeye cyo kurekura imisemburo ikura mu maraso yawe. Umuti ugera ku gipimo cyiza mu minota nka 45 kugeza ku isaha umaze kuwufata.

Itsinda ry'abaganga bakwitaho bazafata icyitegererezo cy'amaraso mu bihe byihariye umaze gufata umuti kugira ngo bapime urugero rw'imisemburo ikura umubiri wawe ukora. Igisubizo gisanzwe kigaragaza ko ingingo yawe ya pituitary ikora neza, mugihe igisubizo gike gishobora gutanga icyerekezo cyo kubura imisemburo ikura.

Nkwiriye gufata macimorelin nte?

Uzafata macimorelin nk'urugero rumwe gusa mu biro bya muganga wawe cyangwa mu kigo cy'ubuvuzi, atari mu rugo. Uyu muti uza mu buryo bw'umuti unyobwa, kandi ubu buryo bwose busaba ubugenzuzi bwa muganga.

Mbere yo gufata macimorelin, uzakenera kwiyiriza byibuze amasaha 8 - ibi bivuze ko nta funguro, ariko mubisanzwe ushobora kunywa amazi. Muganga wawe azaguha amabwiriza yihariye yerekeye igihe cyo guhagarika kurya no kunywa mbere y'igeragezwa ryawe. Iki gihe cyo kwiyiriza ni ingenzi kuko ibiryo bishobora kubangamira ibisubizo by'igeragezwa.

Umuti ubwawo uryoha gato, kandi uzanywa urugero rwose icyarimwe. Umaze kuwufata, uzaguma mu kigo cy'ubuvuzi amasaha menshi mugihe abaganga bafata icyitegererezo cy'amaraso mu gihe gihariye kugirango bapime urugero rw'imisemburo ikura.

Mugihe cy'igeragezwa, uzakenera kuruhuka kandi wirinde imyitozo ngororamubiri, kuko imyitozo nayo ishobora kugira ingaruka ku rugero rw'imisemburo ikura. Itsinda ry'abaganga bakwitaho bazagukurikiranira hafi mugihe cyose kugirango barebe ko wumva umeze neza kandi ufite umutekano.

Nkwiriye gufata macimorelin igihe kingana iki?

Macimorelin ni igeragezwa rimwe ryo kumenya indwara, atari ubuvuzi burambye. Uzayifata rimwe gusa mugihe cyo gusura ikigo cy'ubuvuzi kugirango bapime kubura imisemburo ikura.

Ubusanzwe, igihe cyose cyo gupima gifata amasaha agera kuri 3-4 uhereye igihe ufatiye umuti kugeza igihe utorererejeho ibizamini byose by'amaraso. Igihe kinini muri iki gikorwa kirimo gutegereza hagati yo gufata amaraso aho gukora ikindi gikorwa cyo kuvura.

Niba muganga wawe akeneye gusubiramo ikizamini ku mpamvu iyo ari yo yose, bazategura gahunda yihariye. Ariko, abantu benshi bakenera gukora iki kizamini rimwe gusa kugira ngo babone ishusho isobanutse y'uko imisemburo yabo ikura imeze.

Ni Ibihe Bikorwa Bigaragara Biterwa na Macimorelin?

Abantu benshi bafata neza macimorelin, ariko nk'undi muti uwo ari wo wose, ushobora gutera ibikorwa bigaragara. Ibyo bikorwa bisanzwe bigaragara ni ibyoroshye kandi by'agateganyo, bibaho igihe cyangwa nyuma gato y'ikizamini.

Dore ibikorwa bigaragara ushobora guhura na byo igihe cyangwa nyuma yo gufata macimorelin:

• Kuribwa mu nda cyangwa kumva uruka
• Kuribwa umutwe
• Kumva unaniwe cyangwa ucogoye
• Inzara yiyongereye
• Impinduka mu buryohe
• Kutamererwa neza mu nda

Ibi bikorwa bisanzwe bigaragara bikunda gukira byonyine mu masaha make. Itsinda ry'abaganga rikora igenzura ry'ikizamini cyawe rizagenzura ibi bikorwa kandi rishobora kugufasha kumva umeze neza niba bibaye.

Nubwo bitaba kenshi, abantu bamwe bashobora guhura n'ibikorwa bigaragara bikomeye bisaba ubufasha bwihuse bw'abaganga. Ibi bikorwa bikomeye ntibisanzwe ariko ni ngombwa kubimenya:

• Kuribwa cyane umutwe cyangwa guta ubwenge
• Umutima utera cyane cyangwa mu buryo butari bwo
• Kugorwa no guhumeka
• Kuruka cyane
• Ibikorwa byo kwivumbura ku miti nk'uruhu rurya, gushyushye cyangwa kubyimba

Kubera ko uzaba uri mu kigo cy'ubuvuzi mu gihe cy'ikizamini, abaganga bashobora guhita bakemura ibimenyetso byose bishobora kuvuka. Iyi gahunda igenzurwa ituma umutekano wawe wose mu gihe cyo gukora isuzuma ry'uburwayi.

Ni Bande Batagomba Gufata Macimorelin?

Abantu bamwe bagomba kwirinda macimorelin kubera impungenge z'umutekano cyangwa ibyago byo kubona ibisubizo bitari byo by'ibizamini. Muganga wawe azasuzuma amateka yawe y'ubuvuzi neza mbere yo kugusaba iki kizamini.

Ntugomba gufata macimorelin niba ufite kimwe muri ibi bikurikira:

• Kumenyekana ko ufite allergie kuri macimorelin cyangwa ibiyigize
• Ibibazo bikomeye by'umwijima cyangwa indwara y'umwijima ikora
• Indwara ikomeye y'impyiko
• Umutima warwaye vuba cyangwa ibibazo by'umutima bitajegajega
• Umubyigisho mwinshi w'amaraso utagenzurwa
• Ibimeme bya pitwitori bikora

Gusama no konsa nabyo bisaba kwitonderwa byihariye, kuko umutekano wa macimorelin nturashyirwaho muri ibi bihe. Muganga wawe azaganira ku buryo bwo gupima ubundi niba utwite cyangwa konsa.

Imiti imwe n'imwe irashobora kubangamira imikorere cyangwa umutekano wa macimorelin. Wibuke kubwira muganga wawe imiti yose ufata, harimo:

• Ibiyobyabwenge byongera imisemburo ikura
• Corticosteroids
• Imiti igira ingaruka ku mutima
• Imiti igabanya umubyigisho w'amaraso
• Imiti ivura diyabete

Umuvuzi wawe azagufasha kumenya niba macimorelin ifite umutekano kandi ikwiriye kubera uko ubuzima bwawe bumeze. Barashobora kugusaba uburyo bwo gupima ubundi niba ufite ibintu byose bituma utayifata.

Amazina y'ubwoko bwa Macimorelin

Macimorelin iboneka munsi y'izina ry'ubwoko rya Macrilen muri Leta Zunze Ubumwe z'Amerika. Ubu nicyo gice kimwe gihari kigurishwa cy'uyu muti.

Macrilen ikorwa na Aeterna Zentaris kandi yatejwe imbere by'umwihariko kugirango isuzume kubura imisemburo ikura mu bantu bakuru. Muganga wawe azayita izina iryo ariryo ryose - macimorelin cyangwa Macrilen - kandi bisobanura umuti umwe.

Kubera ko iyi ari imiti yihariye yo gupima indwara, iboneka gusa mu bigo by’ubuvuzi bikora ibizamini bya hormone ikura. Ntuzayisanga muri farumasi zisanzwe kuko bisaba kugenzurwa na muganga igihe itangwa.

Uburyo bwo gusimbuza Macimorelin

Ibindi bizamini byinshi bishobora kumenya kubura kwa hormone ikura, nubwo buri kimwe gifite ibyiza byacyo n'intege nke zacyo. Muganga wawe azahitamo uburyo bwiza bushingiye ku miterere yawe yihariye n'amateka yawe y'ubuvuzi.

Ikizamini cyo kwihanganira insuline (ITT) gifatwa nk'ikizamini cyiza cyo kumenya kubura kwa hormone ikura. Ariko, bisaba kugenzurwa neza kuko bikubiyemo kumanura isukari yo mu maraso yawe, ibyo bishobora kutaryoha kandi bikaba bishobora guteza akaga ku bantu bamwe.

Ikizamini cyo gushishikariza arginine ni ubundi buryo bwo gusimbuza busanzwe butekanye kurusha ITT. Arginine ni aside ya amino ikangura irekurwa rya hormone ikura, ariko ntigira imbaraga nka macimorelin kandi ntishobora gukora neza ku barwayi bose.

Ikizamini cyo gushishikariza glucagon gitanga ubundi buryo, cyane cyane ku bantu badashobora gukorerwa ikizamini cyo kwihanganira insuline. Glucagon ni hormone ituma irekurwa rya hormone ikura, nubwo bishobora gutera isesemi kenshi kurusha macimorelin.

Muganga wawe azatekereza ibintu nk'imyaka yawe, ubuzima muri rusange, izindi ndwara, n'ibisubizo by'ibizamini byabanje mugihe ahitamo uburyo bukwiye bwo kugupima.

Ese Macimorelin iruta izindi bizamini bya hormone ikura?

Macimorelin itanga ibyiza byinshi kurusha ibizamini bisanzwe bya hormone ikura, bituma ihitamo ryiza mu bihe byinshi. Muri rusange birinda kandi biraryoha kurusha ubundi buryo bwo gusimbuza mugihe bitanga ibisubizo byizewe.

Ugereranije n'igerageza ryo kwihanganira insuline, macimorelin ni nziza cyane kuko ntishobora gutera isukari yo mu maraso igabanuka cyane. Igerageza rya insuline rishobora guteza akaga cyane cyane ku bantu barwaye indwara z'umutima, indwara zifitanye isano no gufatwa n'ibicurane, cyangwa diyabete, mugihe macimorelin ari nziza ku bantu benshi.

Macimorelin kandi iroroshye kurusha igerageza rishingiye ku nshinge. Unywa gusa umuti aho guhabwa inshinge, ibintu benshi babona ko bishimishije. Uburyo bwo kunywa kandi bukuraho impungenge zerekeye ibisubizo byo guterwa inshinge cyangwa impungenge zifitanye isano n'urushinge.

Igerageza ritanga ibisubizo byizewe kimwe n'uburyo gakondo. Ubushakashatsi bwerekana ko macimorelin yerekana neza kubura kwa hormone ikura hamwe n'ubushobozi bwo hejuru no gushimangira, bivuze ko yerekana neza abantu bafite iyo ndwara n'abatayifite.

Ariko, macimorelin ntabwo ari nziza kuri buri wese. Abantu bamwe barashobora gukenera ibindi bigeragezo bishingiye ku ndwara zabo zihariye cyangwa niba ibisubizo byambere bitumvikana. Muganga wawe azagufasha kumenya igerageza rikwiye cyane kubera uko umerewe.

Ibikunze Kubazwa Kuri Macimorelin

Ese Macimorelin ni nziza ku bantu barwaye diyabete?

Macimorelin muri rusange irashobora gukoreshwa neza ku bantu barwaye diyabete, ariko bisaba gukurikiranwa neza. Bitandukanye no kugerageza kwihanganira insuline, macimorelin ntishobora gutera isukari yo mu maraso igabanuka cyane.

Ariko, ugomba kwirinda kurya mbere y'igerageza, ibyo bishobora kugira ingaruka ku kugenzura isukari yo mu maraso yawe. Muganga wawe azakorana nawe kugirango ahindure imiti yawe ya diyabete neza mu gihe cyo kugerageza. Barashobora kugusaba gupima isukari yo mu maraso yawe kenshi mbere na nyuma y'igerageza.

Icyo usabwa ni ukwirinda kurya amasaha 8, ibyo bikaba bishoboka ku bantu benshi barwaye diyabete. Itsinda ryawe ryita ku buzima rizagukurikirana neza mu gihe cyose cyo kugerageza kugirango rimenye ko isukari yo mu maraso yawe iguma mu ntera nziza.

Ninkora iki numva ndwaye mu gihe cyo gukora isuzuma rya Macimorelin?

Niba wumva uruka, uruka, cyangwa utameze neza mu gihe cyo gukora isuzuma, bimenyeshe ikipe yawe y'ubuzima ako kanya. Batojwe guhangana n'ibihe nk'ibi kandi barashobora kugufasha kumva umeze neza.

Kubera kuruka gake, bashobora kuguha imiti irwanya kuruka cyangwa bagatanga ibitekerezo byo guhindura imyanya bishobora gufasha. Niba wumva uruka, birashoboka ko bazagushyira hasi bakagenzura umuvuduko w'amaraso yawe n'umuvuduko w'umutima.

Wibuke ko uri mu kigo cy'ubuvuzi mu gihe cyose cy'isuzuma, bityo ubufasha bw'umwuga buraboneka buri gihe. Ntugatinye kuvuga ku bijyanye n'uburyo ubwo aribwo bwose - ikipe yawe y'ubuzima irashaka kumenya ko uri umutekano kandi umeze neza uko bishoboka kose.

Nshobora gutwara imodoka nyuma yo gufata Macimorelin?

Ugomba gutegura undi muntu kugutwara nyuma yo gukora isuzuma rya macimorelin. Umuti urashobora gutera isereri, kandi wari umaze kwiyiriza, bishobora kugira ingaruka ku maso yawe n'igihe cyo gusubiza.

Ibikorwa byinshi by'ubuvuzi byemeza ko ugira inshuti cyangwa umuryango bakugenda, cyangwa gukoresha serivisi yo gutwara aho kwitwara. Iki ni ingamba zo gukingira umutekano wawe n'abandi batwara imodoka mu muhanda.

Muri rusange uzasubira mu buryo busanzwe mu masaha make nyuma yo gukora isuzuma, ariko biruta kwitonda. Teganya koroshya umunsi wose hanyuma usubire mu bikorwa bisanzwe umunsi ukurikira.

Nzamenya ryari ibisubizo byanjye by'isuzuma?

Muganga wawe akenshi azagira ibisubizo by'ibanze mu minsi mike kugeza ku cyumweru nyuma yo gukora isuzuma ryawe. Icyitegererezo cy'amaraso kigomba gusesengurwa muri laboratori, kandi ibisubizo bisaba gusobanura neza.

Umutanga serivisi z'ubuzima azategura gahunda yo gukurikirana kugirango baganire ku bisubizo n'icyo bisobanura ku buzima bwawe. Bazatangariza niba urugero rwawe rw'imisemburo ikura ari ibisanzwe cyangwa niba hari irindi suzuma cyangwa kuvurwa bishobora gukenerwa.

Niba ibisubizo byerekana ko umubiri udafite imisemburo ikura, muganga wawe azaganira nawe ku buryo bwo kuvura n'intambwe zikurikira. Niba ibisubizo ari ibisanzwe, bazagufasha gushakisha izindi mpamvu zishobora gutera ibimenyetso byawe.

Uburyo Isuzuma rya Macimorelin Rikorwa neza?

Isuzuma rya macimorelin rikoreshwa cyane mu kumenya niba umubiri udafite imisemburo ikura mu bantu bakuru. Ubushakashatsi bwakozwe bwerekana ko rimenya neza iyi ndwara mu byegeranyo biri hagati ya 92-96%.

Iri suzuma rifite ubushobozi bwo kumenya neza (rifata abantu benshi bafite ikibazo cyo kutagira imisemburo ikura) kandi rifite ubushobozi bwo kumenya neza (ntirisuzuma nabi abantu badafite icyo kibazo). Ibi bituma riba igikoresho cyizewe cyo gupima indwara.

Ariko, nk'isuzuma iryo ariryo ryose ryo kwa muganga, ntiriri 100% neza. Muganga wawe ashobora kugusaba izindi nzira zo gupima cyangwa gusuzuma niba ibimenyetso byawe bitajyana n'ibisubizo byawe by'isuzuma, cyangwa niba bakeneye andi makuru kugira ngo bamenye neza indwara ufite.