Mecasermine ni iki: Ibikoreshwa, Urutonde rw'imiti, Ingaruka ziterwa n'iyo miti n'ibindi

Mecasermine ni verisiyo ya sintetike ya insulin-like growth factor-1 (IGF-1) ifasha abana gukura iyo imibiri yabo itakora iyi hormone y'ingenzi mu buryo bwa kamere. Uyu muti wagenewe by'umwihariko abana bafite ikibazo gikomeye cya mbere cya IGF-1, ikibazo gike aho umubiri udashobora gukora hormone ikwiriye yo gukura cyangwa ngo uyisubize neza.

Niba umwana wawe yaranzweho kudakora neza kwa hormone ikura kandi ntiyagize icyo ageraho ku buryo busanzwe bwo kuvura hormone ikura, mecasermine irashobora kuba intambwe ikurikira umuganga wawe azatekereza. Itangwa nk'urushinge rwa buri munsi munsi y'uruhu, kimwe na insuline ya diyabete.

Mecasermine ni iki?

Mecasermine ni kopi yakozwe n'abantu ya insulin-like growth factor-1, poroteyine umubiri wawe ukora mu buryo bwa kamere kugirango ifashe selile gukura no kwiteza imbere. Iyo abana bafite ikibazo gikomeye cya mbere cya IGF-1, imibiri yabo ntikora IGF-1 ihagije cyangwa ntishobora kuyikoresha neza, bigatuma gukura bitinda cyane.

Uyu muti mu by'ukuri usimbuza icyo umubiri w'umwana wawe wagombye gukora wenyine. Tekereza nk'uko itanga igice cyaburaga gituma gukura no kwiteza imbere bisanzwe bibaho. FDA yemeye mecasermine by'umwihariko kuri iki kibazo gike, ikigira uburyo bwo kuvura bwihariye.

Bitandukanye na hormone isanzwe ikura, mecasermine ikora nk'uko IGF-1 ikora aho gutera umubiri gukora byinshi muri yo. Ibi bituma bifasha cyane abana imibiri yabo idashobora gusubiza mu buryo bwo kuvura hormone ikura.

Mecasermine ikoreshwa mu iki?

Mecasermine ivura ikibazo gikomeye cya mbere cya IGF-1 mu bana batagize icyo bageraho ku buryo bwo kuvura hormone ikura. Iki kibazo gifata hafi 1 kuri 100.000 y'abana, bigatuma biba bike ariko bikomeye iyo bibaye.

Muganga wawe akenshi azatekereza kuguha mecasermin igihe umwana wawe yujuje ibisabwa byihariye. Ibi birimo kugira urwego rwo hasi cyane rwa IGF-1 mu bipimo by'amaraso, kugaragaza imikurire micye nubwo afite imirire ihagije, kandi ntabwo yitabira nibura umwaka umwe w'imiti ikoreshwa mu mikurire.

Uyu muti ukoreshwa kandi ku bana bafite imikorere mibi y'imisemburo ikoreshwa mu mikurire cyangwa kutitabira cyane imisemburo ikoreshwa mu mikurire. Muri ibi bihe, imiti isanzwe ikoreshwa mu mikurire ntizakora neza kuko umubiri ntushobora gutunganya cyangwa kwitabira neza imisemburo ikoreshwa mu mikurire.

Mecasermin ikora ite?

Mecasermin ikora itanga mu buryo butaziguye umubiri w'umwana wawe IGF-1 ukeneye kugira ngo akure neza kandi yiteze imbere. Ibi bifatwa nk'umuti ukomeye cyane usaba gukurikiranwa neza no gutanga imiti neza.

Iyo yatewe mu ruhu, mecasermin yinjira mu maraso ikajya mu bice bitandukanye by'umubiri. Hanyuma ikifatanya n'ibice bya IGF-1 ku ngingo, igatangiza uburyo bwo gukura bugomba kuba mu buryo busanzwe mu bwana.

Uyu muti utuma amagufa akura, imitsi igakora, n'imikurire rusange y'umubiri. Ifasha kandi mu gukora poroteyine kandi ishobora kunoza imikorere y'umubiri. Kubera ko ikora ku rwego rw'uturemangingo, ntushobora kubona impinduka ako kanya, ariko imikurire igomba kuzamuka buhoro buhoro mu gihe cy'amezi menshi yo kuvurwa.

Nkwiriye gufata mecasermin nte?

Mecasermin igomba gutangwa nk'urushinge rwo munsi y'uruhu kabiri ku munsi, hafi iminota 20 mbere cyangwa nyuma yo kurya. Umuganga wawe azakwigisha uburyo bwo gutegura no gutanga izi nshinge mu buryo bwizewe mu rugo.

Jya uha mecasermin buri gihe hamwe n'ibiryo cyangwa ifunguro rito kugira ngo wirinde isukari nke mu maraso, ishobora kuba ingaruka ikomeye. Uyu muti ushobora gutuma urwego rw'isukari mu maraso rugabanuka cyane, cyane cyane ku bana batarya buri gihe cyangwa bafite ibibazo byo mu nda.

Hindura aho utera inshinge hagati y'amaboko, amaguru, n'inda kugira ngo wirinde ibibazo byo ku ruhu. Isuku aho utera inshinge ukoresheje alcool kandi ukoreshe urushinge rushya buri gihe. Bika amaviali atarakingurwa muri firigo, ariko uyareke agere ku bushyuhe busanzwe mbere yo kuyatera.

Ntuzigere uhuhura umuti, kuko ibyo bishobora kwangiza poroteyine. Niba ubonye uduce duto cyangwa umuti usa n'igicu, ntukawukoreshe kandi uvugishe farumasi yawe kugira ngo bagusimbuze undi.

Nzamara Mfata Mecasermin Igihe Kingana Gite?

Umwana wawe azakenera ubuvuzi bwa mecasermin mu myaka myinshi, akenshi kugeza ageze ku burebure bwe bw'abantu bakuru cyangwa igihe imitsi ye ifungana. Ibi bikunda kuba mu myaka y'ubugimbi, ariko igihe bitwara kiratandukana ku mwana ku wundi.

Muganga wawe azagenzura imikurire y'umwana wawe buri mezi atatu cyangwa atandatu kugira ngo amenye niba umuti ukora neza. Bazapima uburebure, uburemere, kandi bashobora gukora X-rays kugira ngo barebe imyaka y'amagufa n'imikurire y'imitsi.

Abana bamwe bashobora gukenera kuvurwa imyaka 5-10 cyangwa irenga, bitewe n'igihe batangiriye ubuvuzi n'uko umubiri wabo witwara. Intego ni ugufasha umwana wawe kugera ku bushobozi bwe bwo mu buryo bw'imiryungire ku burebure n'imikurire.

Ubuvuzi bukunze gukomeza igihe umwana wawe akiri gukura kandi umuti ufasha. Muganga wawe amaherezo azagusaba guhagarika igihe imikurire igabanutse cyane cyangwa igeze ku musozo.

Ni Ibihe Bikorwa Bigaragara Biterwa na Mecasermin?

Kimwe n'indi miti yose, mecasermin ishobora gutera ibikorwa bigaragara, nubwo atari buri wese ubyumva. Ikintu kigomba kwitabwaho cyane ni isukari nkeya mu maraso (hypoglycemia), ishobora kuba ikomeye niba itavuwe vuba.

Dore ibikorwa bigaragara bikunze kugaragara ushobora kubona, kandi ni ngombwa kumva ko byinshi muri ibi bishobora gucungwa neza bitewe n'ubuvuzi bukwiye:

• Ibimenyetso byo kugabanuka k'isukari mu maraso nk'umutwaro, ibyuya byinshi, urujijo, cyangwa umujinya
• Umutwe, cyane cyane mu byumweru bya mbere by'imiti
• Ibyangirika aho umuti utererwa nko gutukura, kubyimba, cyangwa kubabara gake
• Kubabara imitsi cyangwa ingingo uko umubiri uhinduka kugira ngo ukure
• Isesemi cyangwa kuruka, cyane cyane niba bitafashwe n'ibiryo
• Urugero cyangwa kumva urushye

Ibi bibazo bisanzwe bikunze gukira uko umubiri w'umwana wawe uhinduka ku muti. Ariko, ugomba guhora uvugana na muganga wawe niba bikomeye cyangwa biteye impungenge.

Ingaruka zikomeye ariko zitabaho kenshi zisaba ubufasha bwihuse bw'abaganga. Ibi bishobora kubaho bitarukanye harimo ibibazo bikomeye byo kwivumbura ku miti, kugabanuka k'isukari mu maraso idasubiza ku miti, cyangwa ibimenyetso byo kongera umuvuduko mu bwonko nk'umutwe ukabije hamwe n'impinduka mu mbono.

Abana bamwe bashobora kandi kugira amandazi manini cyangwa guhagarara guhumeka mu gihe basinziriye, cyane cyane abamaze kugira ibibazo byo guhumeka. Muganga wawe azagenzura ibi bibazo mu gihe cyo gusuzuma buri gihe.

Ninde utagomba gufata Mecasermin?

Mecasermin ntabwo ikwiriye kuri buri wese, kandi muganga wawe azasuzuma neza niba bifitiye umwana wawe umutekano. Abana bafite kanseri ikora cyangwa bakekwa ntibagomba guhabwa uyu muti, kuko IGF-1 ishobora gutera imikurire ya tumor.

Umwana wawe ntabwo akwiriye gufata mecasermin niba afite indwara ikomeye y'impyiko cyangwa umwijima, kuko ibi bibazo bishobora kugira ingaruka ku buryo umubiri ukoresha umuti. Abana bafite ibice byo gukura byafunzwe ntibazungukirwa n'imiti kuko amagufa yabo ntazongera gukura.

Dore ibintu by'ingenzi bishobora gutuma umwana wawe adakoresha mecasermin mu buryo butekanye:

• Kanseri irimo cyangwa yigeze kubaho
• Ibibazo bikomeye by'impyiko cyangwa umwijima
• Indwara ya diyabete cyangwa izindi ndwara zikomeye z'amaso
• Indwara zikomeye z'umutima
• Allergie izwi kuri mecasermin cyangwa ibindi bice byayo

Byongeyeho, abana bafite indwara zimwe na zimwe ziterwa n'imiryango cyangwa abafata imiti imwe na imwe bashobora gukenera imiti itandukanye. Muganga wawe azasuzuma amateka yose y'ubuzima bw'umwana wawe mbere yo kwandika mecasermin.

Amazina y'ubwoko bwa Mecasermin

Mecasermin iboneka munsi y'izina ry'ubwoko bwa Increlex muri Leta Zunze Ubumwe z'Amerika no mu bindi bihugu byinshi. Ubu ni bwo bwoko bumwe rukumbi bwa mecasermin bwemewe na FDA kubera kuvura kubura gukabije kwa IGF-1.

Increlex ikorwa na Ipsen Biopharmaceuticals kandi iza nk'igisubizo cyiza mu tubindi duto two guterwa inshinge. Agacupa kamwe gafite 40 mg ya mecasermin muri 4 mL y'igisubizo.

Ntabwo uzabona ubwoko bwa mecasermin kuko ari umuti w'ibinyabuzima bigoye bigoye kwigana neza. Ibi kandi bisobanura ko umuti ushobora guhenda cyane, ariko gahunda nyinshi z'ubwishingizi na gahunda zo gufasha abarwayi zishobora gufasha mu biciro.

Uburyo bwa Mecasermin

Kubana benshi bafite ikibazo cyo kubura imisemburo ikura, imiti gakondo y'imisemburo ikura (somatropin) ni uburyo bwa mbere bwo kuvura. Mecasermin akenshi yagenewe ibibazo aho imisemburo ikura itagikora cyangwa idashobora gukoreshwa.

Niba umwana wawe adashobora gufata mecasermin, izindi miteguro y'imisemburo ikura ishobora gutekerezwa, harimo ubwoko butandukanye cyangwa uburyo bwa somatropin. Abana bamwe bashobora kungukira mu miti ihuriweho cyangwa gahunda zitandukanye zo gutanga imiti.

Mu bihe bidasanzwe aho imisemburo ikura cyangwa mecasermin bidakwiye, abaganga bashobora gushishikariza inkunga y'imirire, imiti y'umubiri, cyangwa izindi miti ishyigikira kugirango iteze imbere imikurire n'iterambere mu byo umwana wawe ashoboye.

Ariko, ni ngombwa kumva ko nta mwanya wa mecasermin ku bana bafite ikibazo gikabije cya IGF-1. Uyu muti ukora uruhare rudasanzwe ko izindi miti itashobora gutanga.

Ese Mecasermin iruta imisemburo ikura?

Mecasermin ntabwo ari ngombwa ko ari “myiza” kurusha umusemburo ukura, ariko ikora mu buryo butandukanye kandi ifite icyo igamije. Ubuvuzi bwo gukoresha umusemburo ukura ni bwo bwa mbere buhitwamo ku bana benshi bafite ikibazo cyo kubura umusemburo ukura kuko muri rusange byoroshye gukoresha kandi bifite amateka maremare.

Ariko, mecasermin iba uburyo bwiza iyo ubuvuzi bwo gukoresha umusemburo ukura butagize icyo bugeraho cyangwa butashoboka. Ku bana bafite ikibazo gikomeye cya mbere cya IGF-1, mecasermin ishobora kuba ari yo miti yonyine ikora.

Umusemburo ukura utera umubiri gukora IGF-1, mugihe mecasermin itanga IGF-1 mu buryo butaziguye. Ibi bivuze ko mecasermin ishobora gufasha abana imibiri yabo itashobora gusubiza umusemburo ukura cyangwa gukora IGF-1 mu buryo busanzwe.

Gu hitamo hagati yiyi miti biterwa rwose n'uburwayi bwihariye bw'umwana wawe n'uburyo umubiri wabo witwara ku buvuzi. Muganga wawe azemeza uburyo bukwiye bushingiye ku bizami by'amaraso, uburyo bakura, n'amateka y'ubuvuzi.

Ibikunze Kubazwa Kuri Mecasermin

Ese Mecasermin irakwiriye ku bana barwaye diyabete?

Mecasermin isaba kwitonda cyane ku bana barwaye diyabete kuko ishobora kugabanya cyane urugero rw'isukari mu maraso. Niba umwana wawe arwaye diyabete, muganga wabo azakenera gukurikirana neza urugero rwa glucose mu maraso kandi ashobora guhindura imiti ya diyabete.

Uhuza mecasermin n'imiti ya diyabete birashobora kongera ibyago byo kugabanya cyane isukari mu maraso. Itsinda ry'ubuvuzi rizakorana nawe kugirango utegure gahunda yo gukurikirana neza kandi bakwigishe uburyo bwo kumenya no kuvura hypoglycemia vuba.

Gupima isukari mu maraso buri gihe birushaho kuba ngombwa iyo umwana wawe afata mecasermin. Uzakenera kureba urugero kenshi kandi ukagira amasoko y'isukari yihuta buri gihe.

Nigute nzagira niba mpanutse nkayiha mecasermin nyinshi?

Niba byabayeho ko uha umwana wawe mecasermin nyinshi, genzura neza ibimenyetso byo kugabanuka k'isukari mu maraso kandi uhamagare muganga wawe ako kanya. Ibyo bimenyetso birimo guhinda umushyitsi, kubira ibyuya, kuvurungana, umujinya, cyangwa imyitwarire idasanzwe.

Ha umwana wawe ikintu kirimo isukari yo kurya cyangwa kunywa ako kanya, nk'umutobe w'imbuto, ibinini bya glucose, cyangwa ibiryo birimo isukari. Guma hafi ye kandi ukomeze gukurikirana ibimenyetso mu gihe utegereje ubujyanama bw'abaganga.

Ntugategereze ngo urebe niba ibimenyetso bigaragara. Kugabanuka k'isukari mu maraso biturutse kuri mecasermin nyinshi birashobora kuba bikomeye kandi bishobora gusaba ubuvuzi bwihutirwa. Hamagara umurongo wihutirwa wa muganga wawe cyangwa ujye mu cyumba cy'ubuvuzi bwihutirwa cyegereye niba utabashije kuvugana n'umuganga wawe.

Nkwiriye gukora iki niba nciwe urugero rwa Mecasermin?

Niba waciwe urugero rwa mecasermin, ruzi vuba na bwangu uko wibuka, ariko niba byabayeho mu masaha make nyuma y'igihe cyateganyijwe. Kora neza ko umwana wawe afata ikintu mbere cyangwa nyuma y'urukingo kugira ngo wirinde kugabanuka k'isukari mu maraso.

Niba igihe cyo gufata urugero rukurikira kigeze, reka urugero waciwe rugende hanyuma usubire ku gahunda yawe isanzwe. Ntukigere uha imiti ibiri icyarimwe kugira ngo usubize urugero waciwe, kuko ibyo bishobora gutera kugabanuka gukomeye k'isukari mu maraso.

Genzura urutonde rw'imiti waciwe kandi umenyeshe muganga wawe niba ufite ibibazo byo gukurikiza gahunda. Bashobora kuba bashobora gutanga ibitekerezo byo kugufasha kwibuka cyangwa guhindura igihe kugira ngo gihure neza n'imigenzo y'umuryango wawe.

Nshobora guhagarika ryari gufata Mecasermin?

Ntabwo ugomba na rimwe guhagarika mecasermin utabanje kubaza muganga w'umwana wawe. Igihe biterwa n'iterambere ry'umwana wawe, imyaka y'amagufa, n'imikurire muri rusange, ibyo ikipe yawe y'ubuvuzi ikurikirana buri gihe.

Abana benshi bashobora guhagarika mecasermin iyo ibice byabo byo gukura bifunze, akenshi mu gihe cy'ubugimbi. Muganga wawe azakoresha X-rays n'ingero z'imikurire kugira ngo amenye igihe ibi bibera niba gukomeza kuvurwa byaba bifitiye akamaro.

Abana bamwe bashobora gukenera gukomeza kuvurwa igihe kirekire niba bagikura kandi bafashwa n'umuti. Abandi bashobora guhagarara mbere niba ingaruka zibaye zikomeye cyangwa niba imikurire igeze ku rwego rwemewe.

Ese Mecasermin Ishobora Gutera Ibibazo by'Ubuzima by'igihe kirekire?

Ubushakashatsi bw'igihe kirekire kuri mecasermin buracyakorwa kuko ari umuti mushya. Ariko, ubushakashatsi buriho bwerekana ko iyo ikoreshejwe neza hakurikijwe ubuyobozi bwa muganga, inyungu muri rusange zirenga ibyago ku bana bafite ikibazo gikomeye cya IGF-1.

Muganga wawe azagenzura umwana wawe buri gihe kugira ngo arebe ingaruka zishobora kuba zirimo, harimo impinduka mu mikorere y'umubiri, imikurire y'amagufa, n'ubuzima muri rusange. Ibi bizamini bifasha kumenya ibibazo hakiri kare no guhindura uburyo bwo kuvura uko bikwiye.

Ikintu cy'ingenzi ni ugukomeza gahunda yo gusuzumwa buri gihe no gutanga raporo y'ibimenyetso byose biteye impungenge vuba. Ibi bituma ikipe yawe y'ubuzima yemeza ko umwana wawe abonye inyungu nyinshi ziva mu kuvurwa mugihe igabanya ibyago bishoboka.