Icyo Methylene Blue (inzira yo mu mitsi) ari cyo: Ibyo ikoreshwa, urugero rwo kuyifata, ingaruka zayo n'ibindi

Methylene blue ni irangi ry'ubururu ry'ubukorano abaganga bakoresha nk'umuti uterwa mu mitsi wo kuvura indwara zimwe na zimwe. Iyo itewe binyuze mu mitsi, uyu muti w'ubururu bwiza ukora nk'umuti ukomeye kandi ukoreshwa mu kumenya indwara mu bitaro no mu byumba by'abarwayi barembye.

Wenda watungurwa no kumenya ko uyu muti, ushobora guhindura inkari zawe ubururu n'icyatsi, umaze kurokora ubuzima mu myaka irenga ijana. Abaganga bakoresha cyane uyu muti mu kuvura methemoglobinemia, indwara ikomeye aho amaraso yawe adashobora gutwara umwuka neza.

Methylene Blue ni iki?

Methylene blue ni umuti wo mu cyiciro cy'imiti yitwa reducing agents. Ni umuti w'ubukorano ugaragara nk'ifu y'ubururu bwijimye, ihinduka umuti w'ubururu bwiza iyo uvanzwe n'amazi yo guterwa mu mitsi.

Uyu muti ukora ku rwego rw'uturemangingo kugira ngo ufashishe umubiri wawe kongera gukoresha umwuka neza. Uyu muti wabanje gukorwa nk'irangi rikoreshwa mu nganda mu myaka ya 1800, abaganga bavumbuye imikorere yawo mu buvuzi bitunguranye igihe babonaga ko ushobora kuvura ibibazo by'uburozi.

Ubwoko bwo guterwa mu mitsi bwateguwe by'umwihariko gukoreshwa mu bitaro, aho abaganga bashobora kugukurikiranira hafi mu gihe uvurwa. Si ikintu na rimwe wakoresha mu rugo, kuko bisaba gupima neza no kugenzurwa n'abaganga.

Methylene Blue ikoreshwa mu kuvura iki?

Methylene blue ivura methemoglobinemia, indwara aho uturemangingo tw'amaraso tutabasha gutwara umwuka neza mu bice by'umubiri wawe. Ibi bibaho iyo icyuma kiri muri hemoglobin yawe gihindutse, bigatuma amaraso yawe adashobora gutanga umwuka utuma ubaho mu mubiri wawe.

Reka turebe impamvu nyamukuru abaganga bashobora kwandika uyu muti. Ibi byose bisaba isuzuma ryitondewe no gukurikiranwa n'ikipe yawe y'abaganga.

• Methemoglobinemia iterwa n'imiti imwe n'imwe nka antibiyotike cyangwa imiti igabanya ububabare
• Guhumanywa n'ibinyabutabire bya nitrites cyangwa nitrates biboneka mu biribwa bimwe na amazi
• Methemoglobinemia yo mu buryo bw'umurage, uburwayi bwo mu bwoko bw'ibinyabuzima butavugwa cyane
• Guhura n'imiti ikoreshwa mu nganda cyangwa ibikoresho byo mu rugo
• Methemoglobinemia iterwa n'imiti ikoreshwa mu kubaga nka benzocaine

Mu bice bike bitavugwa cyane, abaganga bakoresha kandi methylene blue nk'igikoresho cyo gupima mu gihe cyo kubaga. Itsinda ryawe ry'abaganga rizasobanura neza impamvu bagusaba ubu buvuzi mu bihe byawe byihariye.

Methylene Blue ikora ite?

Methylene blue ikora ifasha uturemangingo twawe dutukura tw'amaraso guhindura hemoglobin yahindutse ikagaruka mu buryo bwayo busanzwe, butwara umwuka wa oxygen. Bitekereze nk'umufasha usubiza uturemangingo twawe tw'amaraso mu kazi kabyo gakuru ko gutanga umwuka wa oxygen mu mubiri wawe.

Iyo ufite methemoglobinemia, icyuma kiri muri hemoglobin yawe gifatirwa mu buryo budasanzwe. Methylene blue ikora nk'ikiraro, itanga electrons zifasha guhindura iyi hemoglobin idasanzwe igaruka muri hemoglobin isanzwe.

Uyu muti ufashwe nk'ufite imbaraga zikomeye kandi ukora vuba. Abantu benshi batangira kumva barushaho kumera neza mu minota 30 kugeza ku isaha nyuma yo guterwa urushinge, nubwo gukira neza bishobora gufata amasaha menshi.

Ibara ry'ubururu uzabona mu nkari zawe ni ibisanzwe kandi birerekana ko umuti uri gukora mu mubiri wawe. Iri bara rihinduka ry'agateganyo kandi rizagabanuka uko umubiri wawe ukoresha umuti.

Nkwiriye gufata Methylene Blue nte?

Ntabwo uzifata methylene blue wenyine - buri gihe itangwa n'abakora mu buvuzi mu bitaro cyangwa ahantu ho kuvurira. Uyu muti uza mu buryo bw'urushinge rutangwa mu mitsi yawe unyuze mu muyoboro wa IV.

Itsinda ry'ubuvuzi ryawe rizategura umuti bawuvanga mu kintu cyera. Bazawutanga buhoro buhoro mu minota mike bakurikiranira hafi umuvuduko w'umutima wawe, umuvuduko w'amaraso, n'urugero rwa ogisijeni buri gihe.

Mbere yo guhabwa urushinge, ntugomba kwiyiriza cyangwa kwirinda ibiryo runaka. Ariko, ugomba kubwira itsinda ryawe ry'ubuvuzi imiti yose urimo gufata, harimo imiti igurishwa itagomba uruhushya rwa muganga n'ibyongerera imbaraga.

Aho urushinge ruterwa rushobora kumva hakonje gato igihe umuti winjira mu maraso yawe. Ibi ni ibisanzwe, kandi umuganga wawe azareba kugirango arebe neza ko IV ikora neza mu gihe cyose cy'ubuvuzi.

Nzamara Igihe Kingana Iki Ndafashe Methylene Blue?

Methylene blue akenshi itangwa nk'urugero rumwe cyangwa urugero ruto mu gihe gito, akenshi mu masaha 24. Bitandukanye n'imiti ushobora gufata buri munsi kubera indwara zidakira, ubu buvuzi bugamije gukemura ikibazo cy'ubuvuzi gikomeye.

Muganga wawe azemeza niba ukeneye urugero rwinshi bitewe n'urugero rwa ogisijeni mu maraso yawe n'uburyo urimo kwitwara neza ku buvuzi. Abantu benshi bakeneye urugero rumwe cyangwa ebyiri gusa kugirango basubize ubushobozi busanzwe bwo gutwara ogisijeni.

Nyuma yo guhabwa umuti, itsinda ryawe ry'ubuvuzi rizakomeza kugukurikiranira hafi amasaha menshi kugirango barebe neza ko ubuvuzi bukora neza. Bazareba urugero rwa ogisijeni mu maraso yawe barebe niba hari ibimenyetso byerekana ko ukeneye ubuvuzi bwiyongera.

Ingaruka za methylene blue zirashobora kumara amasaha menshi, kandi umubiri wawe uzagenda ukuraho umuti mu munsi umwe cyangwa ibiri bikurikira. Inkari zawe zirashobora kuguma zifite ibara ry'ubururu-icyatsi kugeza ku masaha 24 nyuma yo kuvurwa.

Ni Iyihe Ngaruka Ziterwa na Methylene Blue?

Kimwe n'imiti yose, methylene blue irashobora gutera ingaruka, nubwo abantu benshi bayihanganira neza iyo itanzwe neza. Ingaruka igaragara cyane ni ibara ry'ubururu-icyatsi ry'inkari zawe, ritarimo ingaruka kandi ry'igihe gito.

Ibi ni ibimenyetso bisanzwe bishobora kukubaho. Muri rusange, ibi bikemuka ubwabyo igihe umuti uva mu mubiri wawe.

• Urujyo rw'inkari rwa blue-green (ibi birategerejwe kandi ntacyo bitwaye)
• Uburwayi bwo mu nda cyangwa guhungabana gato kw'inda
• Kuribwa umutwe cyangwa kumva uruhuka
• Umutwe
• Kumva ushye gato aho batera urushinge
• Guhinduka uruhu rwa blue igihe gito aho batera urushinge

Ibyago bikomeye ntibisanzwe ariko bisaba ubufasha bwihuse bw'abaganga. Itsinda ryawe ry'ubuvuzi rizakurikirana neza ibi bishoboka.

• Kugorana guhumeka cyangwa guhumeka bigufi
• Uburibwe mu gituza cyangwa umutima wihuta
• Kuruka cyane cyangwa kuruka cyane
• Kuvurungana cyangwa guhinduka mu mutwe
• Kuribwa umutwe cyane cyangwa guta umutwe
• Urugero rw'ibimenyetso by'uburwayi nko kuribwa cyangwa kubyimba

Gahoro cyane, methylene blue ishobora gutera indwara yitwa serotonin syndrome ku bantu bafata imiti imwe yo kurwanya depression. Itsinda ryawe ry'ubuvuzi rizasuzuma imiti yawe neza mbere yo kuvurwa kugira ngo rigabanye iyi ngaruka.

Ninde utagomba gufata Methylene Blue?

Methylene blue ntabwo itekanye kuri buri wese, kandi itsinda ryawe ry'ubuvuzi rizasuzuma neza amateka yawe mbere yo gufata icyemezo niba bikwiriye kuri wewe. Abantu bafite indwara zimwe na zimwe cyangwa abafata imiti imwe na imwe bashobora gukenera uburyo bwo kuvurwa.

Indwara zikurikira zirashobora gutuma methylene blue itagutekana. Muganga wawe azatekereza ibi bintu mugihe ategura uburyo bwo kuvurwa kwawe.

• G6PD deficiency (indwara ya genetique igira ingaruka ku ngirangingo zitukura z'amaraso)
• Indwara ikomeye y'impyiko
• Indwara ikomeye y'umwijima
• Allergie izwi kuri methylene blue cyangwa ibintu bisa na byo
• Gusama cyangwa konsa (keretse inyungu zigaragara neza kurusha ibyago)
• Indwara zikomeye z'umutima

Imiti imwe n'imwe irashobora gukorana nabi na methylene blue, cyane cyane iyo igira uruhare ku rwego rwa serotonin. Itsinda ryawe ry'ubuvuzi rigomba kumenya imiti yose ufata.

• Inzitizi za MAO (imiti imwe yo kurwanya depression)
• SSRIs na SNRIs (imiti isanzwe yo kurwanya depression)
• Imiti imwe yo kurwanya ububabare nka tramadol
• Imiti imwe yo kurwanya migraine
• Antibiotics zimwe na imiti irwanya imyungu

Itsinda ryawe ry'ubuvuzi rizagereranya neza ibyago n'inyungu, cyane cyane niba ufite izi ndwara cyangwa ufata iyi miti. Rimwe na rimwe inyungu zo kurokora ubuzima ziruta ibyago bishobora kubaho.

Amazina y'ubwoko bwa Methylene Blue

Methylene blue iboneka mu mazina menshi y'ubwoko, nubwo akenshi yitwa gusa "methylene blue injection" mu bitaro. Izina risanzwe ry'ubwoko muri Amerika ni Provayblue, ikoreshwa by'umwihariko mu kuvura methemoglobinemia.

Andi mazina y'ubwoko ushobora kumva harimo Methylthioninium chloride, ikoreshwa mu bihugu bimwe hanze ya Amerika. Itsinda ryawe ry'ubuvuzi rizakoresha uburyo ubwo aribwo bwose buboneka kandi bukwiye kubera uko urwego rwawe rumeze.

Nubwo izina ry'ubwoko ryaba ari irihe, inshinge zose za methylene blue zikoreshwa mu nganda zifite ikintu kimwe gikora kandi zikora kimwe. Ikintu cy'ingenzi ni uko wakira uburyo bukwiye bwo mu rwego rw'ubuvuzi, atari amarangi yo mu rwego rw'inganda.

Uburyo bwo gusimbuza Methylene Blue

Nubwo methylene blue ari uburyo bwiza bwo kuvura methemoglobinemia, hariho uburyo bumwe bwo gusimbuza umuganga wawe ashobora gutekereza mu bihe bimwe na bimwe. Ubu buryo bwo gusimbuza buterwa n'uburemere bw'indwara yawe n'imiterere yawe y'ubuvuzi.

Ku byerekeye methemoglobinemia yoroheje, rimwe na rimwe ubufasha gusa burashobora kuba buhagije. Ibi birimo gutanga umwuka mwinshi no gukurikirana neza uko urwego rwawe rumeze mugihe umubiri wawe ukira mu buryo busanzwe.

Mu gihe cyo kutabasha gukoresha methylene blue, abaganga bashobora kugerageza aside ya ascorbic (vitamin C) mu doze nyinshi, nubwo ibi bikora gahoro cyane. Guhindura amaraso, aho amaraso yawe asimburwa n'amaraso yatanzwe, ni uburyo bwa nyuma bukoreshwa mu gihe cy'indwara zikomeye.

Ubuvuzi bwa oxygen ya hyperbaric, aho uhumeka oxygen isukuye mu cyumba gishyirwamo umuvuduko mwinshi, bushobora gufasha mu bihe bimwe na bimwe. Ariko, methylene blue iracyakomeza kuba umuti mwiza cyane iyo ishobora gukoreshwa mu buryo butekanye.

Ese Methylene Blue iruta izindi miti?

Methylene blue ifatwa nk'umuti ukora neza kandi wihuta cyane wo kuvura methemoglobinemia. Ikora vuba kandi yizewe kurusha izindi miti nka vitamin C cyangwa ubufasha gusa.

Ugereranije n'indi miti, methylene blue akenshi itangira gukora mu minota 30 kandi ishobora kunoza cyane urwego rwa oxygen mu maraso yawe. Imiti itandukanye nka vitamin C yo mu doze nyinshi ishobora gufata amasaha cyangwa iminsi kugira ngo igaragaze impinduka zigaragara.

Inyungu nyamukuru za methylene blue ni umuvuduko wayo, ubushobozi bwayo, n'ukuri ko abantu benshi bayihanganira neza. Ariko, ntibisobanura ko ari "myiza" mu bihe byose - muganga wawe azahitamo uburyo bwo kuvura butekanye kandi bukwiye cyane kubera ibibazo byawe byihariye.

Mu bihe by'ubutabazi aho ubuzima bw'umuntu buri mu kaga kubera methemoglobinemia ikomeye, methylene blue akenshi ni yo hitamo ryiza kubera uburyo ikora vuba. Ubushobozi bwo guhindura iyi ndwara ikomeye vuba bituma iba igikoresho cy'agaciro gakomeye mu buvuzi bw'ubutabazi.

Ibikunze Kubazwa Kuri Methylene Blue

Ese Methylene Blue irakwiriye ku ndwara z'umutima?

Methylene blue irashobora gukoreshwa ku bantu barwaye indwara z'umutima, ariko bisaba kwitonda no gukurikiranwa cyane. Umuganga w'umutima wawe n'umuganga uvura bazakorana kugira ngo bamenye niba bikwiriye ku ndwara yawe y'umutima.

Abantu bafite uburwayi bukomeye bw'umutima cyangwa ibibazo bimwe na bimwe by'umuvuduko w'umutima bashobora gukenera gukurikiranwa byihariye mugihe bavurwa. Umuti rimwe na rimwe ushobora kugira ingaruka ku muvuduko w'umutima n'umuvuduko w'amaraso, bityo itsinda ry'abaganga bazabikurikiranira hafi.

Mu bihe by'ubutabazi aho methemoglobinemia iteye ubuzima mu kaga, inyungu za methylene blue akenshi ziruta ibyago by'umutima. Itsinda ryawe ry'abaganga rizafata iki cyemezo hashingiwe ku miterere yawe bwite.

Nkwiriye gukora iki niba mbonye methylene blue nyinshi bitunguranye?

Niba uri mu bitaro, itsinda ryawe ry'abaganga rizafata icyemezo cyose kijyanye n'urugero rw'umuti - ntugomba kubyitaho wenyine. Abaganga babara kandi bagakurikirana neza urugero rwa methylene blue kugirango birinde kwiyongera k'umuti.

Ibimenyetso bya methylene blue nyinshi harimo isesemi ikabije, kuribwa mu gituza, guhumeka bigoranye, cyangwa kuribwa cyane. Niba ubonye kimwe muri ibi bimenyetso, itsinda ryawe ry'abaganga rizatanga ubufasha no gukurikirana.

Ubuvuzi bwa methylene blue nyinshi mubisanzwe burimo ubufasha, harimo amazi ya IV, umwuka wa oxygen, no gukurikiranwa hafi kw'ibimenyetso byawe by'ingenzi. Umuti uzagenda usohoka mu mubiri wawe uko igihe kigenda.

Nkwiriye gukora iki niba nciwe urugero rwa methylene blue?

Kubera ko methylene blue itangwa mu bitaro n'abaganga, ntugomba guhangayika kubera gucikanwa n'urugero rw'umuti. Itsinda ryawe ry'abaganga rizagena igihe n'umubare w'urugero ukeneye.

Niba urugero rwinshi rukenewe, itsinda ryawe ry'abaganga rizarutegura hashingiwe ku rwego rwa oxygen mu maraso yawe n'uko witwara ku buvuzi. Bazagukurikirana buri gihe kugirango bamenye niba umuti mwinshi ukenewe.

Igihe cyo gufata urugero rwa methylene blue gishingiye ku miterere yawe y'ubuzima, ntabwo ari gahunda isanzwe nk'imiti ya buri munsi. Itsinda ryawe ry'abaganga rizafata ibyemezo byose bijyanye n'igihe n'urugero rw'umuti ukeneye.

Nshobora kureka gufata methylene blue ryari?

Ntugomba gufata icyemezo cyo guhagarika umuti wa methylene blue - iki cyemezo gifatwa n’ikipe yawe y’ubuvuzi ishingiye ku kigero cy’umwuka wa ooxygeni mu maraso yawe ndetse n’uburyo urimo koroherwa. Abantu benshi bakeneye doze imwe cyangwa ebyiri gusa.

Muganga wawe azahagarika umuti igihe ikigero cy’umwuka wa ooxygeni mu maraso yawe gisubiye mu buryo busanzwe kandi kigahoraho. Ibi bikunda kuba nyuma y’amasaha make cyangwa umunsi umwe nyuma yo gutangira kuvurwa.

Nyuma yo kurangiza kuvurwa, ikipe yawe y’ubuvuzi izakomeza kugukurikiranira hafi kugira ngo barebe ko methemoglobinemia itagaruka. Bazanakemura icyateye iyo ndwara, nk’uguhagarika imiti ishobora kuba yarateye iyo ndwara.

Ese Methylene Blue izabangamira ibindi bizami by’ubuvuzi?

Yego, methylene blue ishobora kubangamira ibizamini bimwe na bimwe by’ubuvuzi, cyane cyane ibipima ikigero cy’umwuka wa ooxygeni mu maraso yawe. Ikipe yawe y’ubuvuzi izabizirikana igihe isobanura ibisubizo by’ibizamini.

Uwo muti ushobora kugira ingaruka ku bipimo bya pulse oximetry, bipima ikigero cy’umwuka wa ooxygeni binyuze mu rutoki rwawe. Ikipe yawe y’ubuvuzi izakoresha ubundi buryo bwo gukurikiranira hafi ikigero cy’umwuka wa ooxygeni mu maraso yawe igihe uwo muti uri mu mubiri wawe.

Ibizami by’amaraso bishobora kandi kugaragaza ibara ry’ubururu mu gihe gito nyuma yo kuvurwa. Ibi ntibigira ingaruka ku bisubizo by’ibizamini byinshi, ariko ikipe yawe y’ubuvuzi izavuga ko wakiriye methylene blue igihe isobanura ibintu bidasanzwe byagaragaye.