Mifepristone ni iki: Ibyo ikoreshwa, urugero rwo gufata, ingaruka zayo n'ibindi

Mifepristone ni umuti wandikirwa na muganga ubangamira imisemburo ya progesterone mu mubiri wawe. Ushobora kuyimenya neza nk'"umuti wo gukuramo inda" iyo ukoreshejwe hamwe n'undi muti witwa misoprostol, ariko kandi ifite izindi nshingano z'ubuvuzi z'ingenzi. Uyu muti ukora ubangamira imisemburo y'ingenzi mu kugumisha inda, ni yo mpamvu ifasha mu gukuramo inda hakoreshejwe imiti no mu zindi ngorane zimwe na zimwe.

Mifepristone ni iki?

Mifepristone ni umuti w'imiterere uhagarika imisemburo ubangamira progesterone mu mubiri wawe. Progesterone ni umusemburo ufasha mu kugumisha inda mu kugumisha urukuta rw'umura rworoshye kandi rushyigikiye. Iyo mifepristone ibangamiye progesterone, mu by'ukuri ibwira umubiri wawe guhagarika gushyigikira inda.

Uyu muti wemerejwe bwa mbere na FDA mu mwaka wa 2000 kandi ukoreshwa neza n'abantu babarirwa muri za miliyoni ku isi hose. Ubarirwa mu cyiciro cy'imiti yitwa antiprogestins, bivuze ko ikora ibinyuranye n'ingaruka zisanzwe za progesterone mu mubiri wawe.

Mifepristone ikoreshwa mu iki?

Mifepristone ifite inshingano ebyiri z'ubuvuzi z'ingenzi zemewe na FDA. Inshingano y'ibanze ni ugukuramo inda hakoreshejwe imiti mu ntangiriro z'inda, akenshi kugeza ku byumweru 10 uhereye ku gihe cy'imihango yawe iheruka. Ikoreshwa kandi mu gucunga isukari nyinshi mu maraso ku bantu bafite indwara ya Cushing's syndrome, indwara idasanzwe y'imisemburo.

Mu gukuramo inda hakoreshejwe imiti, mifepristone ikoreshwa hafi ya hose hamwe na misoprostol, undi muti utuma umura ugenda. Ubu buryo bufite akamaro kanini kandi bugufasha kurangiza inda udafashwe mu cyumba cy'ubuvuzi mu bihe byinshi.

Muri Cushing's syndrome, mifepristone ifasha mu kugenzura urugero rw'isukari mu maraso iyo izindi nshingano zitagize icyo zikora bihagije. Iyi nshingano isaba gukurikiranwa neza n'inzobere zifite ubumenyi kuri iyi ngorane igoye.

Mifepristone ikora ite?

Mifepristone ikora ibyo ikingira imitsi ya progesterone mu mubiri wawe. Tekereza progesterone nk'urufunguzo n'imitsi yayo nk'ibifunguzo - mifepristone mu by'ukuri ihindura ibifunguzo ku buryo urufunguzo rutagishobora gukora. Ibi bifatwa nk'inzira ikomeye kandi ifite akamaro kuko ituma itabangamira ubushobozi bwa hormone bwo gukora.

Iyo progesterone itashoboye gukora akazi kayo, ibintu byinshi bibaho mu mubiri wawe. Umurongo w'inda yawe utangira gusenyuka, kandi umuhogo wawe ushobora gutangira koroha no gufunguka gato. Izi mpinduka zitegura umubiri wawe ku muti wa kabiri, misoprostol, utera imitsi kugira ngo yirukane inda.

Umuti mubisanzwe utangira gukora mu masaha 24 kugeza kuri 48 nyuma yo kuwufata. Ariko, mubisanzwe uzakenera umuti wa kabiri kugira ngo urangize neza inzira.

Nkwiriye gufata gute Mifepristone?

Mifepristone ifatwa nk'urugero rumwe mu kanwa, mubisanzwe mu biro by'umuganga wawe cyangwa mu ivuriro. Uzamira urupapuro rwose hamwe n'amazi - ntukoreshe, ntukore, cyangwa urumenagure. Umuti urashobora gufatwa hamwe cyangwa udafite ibiryo, kuko kurya ntibigira ingaruka zikomeye ku buryo ukora neza.

Umuganga wawe azaguha amabwiriza yihariye yerekeye igihe cyo gufata umuti wa kabiri, misoprostol, niba ukoresha mifepristone mu gukuramo inda mu buvuzi. Iki gihe ni ngombwa kugira ngo ubuvuzi bukore neza kandi neza.

Ntabwo ukeneye kwirinda ibiryo byihariye mbere yo gufata mifepristone, ariko birafasha kurya ikintu gito niba wumva uteye ubwoba cyangwa niba inda yawe irimo ubusa. Abantu bamwe basanga kugira ifunguro rito bifasha kwirinda isesemi.

Mbwiriza gufata Mifepristone igihe kingana iki?

Ku gukuramo inda mu buvuzi, mifepristone mubisanzwe ifatwa nk'urugero rumwe. Ntabwo uzakenera kuyifata kenshi - urugero rumwe mubisanzwe ni byose bikenewe kuri iyi ntego. Ingaruka z'uru rugero rumwe zirashobora kumara iminsi myinshi uko umubiri wawe ukora umuti.

Niba ukoresha mifepristone kubera indwara ya Cushing, muganga wawe azagena igihe uzayimara ukoresha bitewe n'uburwayi bwawe bwihariye n'uburyo wabyitwayemo. Ibi bisaba gukurikiranwa no guhindurwa buri gihe.

Uzagirwa inama n'umuganga wawe ku bijyanye n'amasaha yo gusuzumwa kugira ngo yemeze ko imiti yakoze nk'uko byari byitezwe kandi ko urimo gukira neza.

Ni izihe ngaruka ziterwa na Mifepristone?

Kimwe n'indi miti yose, mifepristone irashobora gutera ingaruka, nubwo atari buri wese uzagira izo ngaruka. Ingaruka zisanzwe ziterwa n'imiti zifitanye isano n'ingaruka z'imiti ku myanya y'imyororokere n'imisemburo yawe.

Dore ingaruka ushobora guhura nazo cyane, wibuke ko nyinshi muri zo ziteganijwe iyo zikoreshwa mu gukuramo inda:

• Urugimbu no kuruka
• Impiswi cyangwa kuribwa mu nda
• Umutwe
• Urugero cyangwa kumva ureremba
• Kunanirwa cyangwa intege nke
• Urubavu
• Gusohoka amaraso mu gitsina (byitezwe mugihe cyo gukuramo inda)

Inyinshi muri izi ngaruka zoroheje kugeza hagati kandi zirakira muminsi mike. Ariko, abantu bamwe bashobora guhura n'ingaruka zikomeye zisaba ubufasha bwihuse bw'abaganga.

Ingaruka zitagaragara cyane ariko zikomeye zirimo kuva amaraso menshi arenze ibitambaro bibiri byinini kumwanya w'isaha mumasaha abiri akurikirana, ibimenyetso byo kwandura nko gushyuha umubiri no guhinda umushyitsi, cyangwa kuribwa cyane mu nda kutagabanuka n'imiti igabanya ububabare.

Mu bihe bidasanzwe, abantu bamwe bashobora guhura n'ibimenyetso byo kwibasirwa n'umubiri, amaraso avura, cyangwa ibibazo by'umutima. Izi ngorane zikomeye ntizisanzwe ariko zisaba ubufasha bwihuse bw'abaganga niba bibaye.

Ninde utagomba gufata Mifepristone?

Mifepristone ntirinzwe kuri buri wese, kandi hari ibintu byinshi by'ingenzi bituma uyu muti udakwiriye cyangwa ushobora guteza akaga. Muganga wawe azasuzuma neza amateka yawe y'ubuzima mbere yo kuwugushyiriraho.

Ntabwo ukwiye gufata mifepristone niba ufite kimwe muri ibi bintu, kuko bishobora kongera ibyago byo guhura n'ingorane zikomeye:

• Kumenya allergie kuri mifepristone cyangwa misoprostol
• Gukeka ko utwite hanze y'igitsina gore (gutwita hanze y'inkondo y'umura)
• Kunanirwa kw'imisemburo ya adrenal
• Indwara zo kuva amaraso cyangwa gukoresha imiti ituma amaraso ataguma
• Porphyria yarazwe (indwara idasanzwe y'amaraso)
• Ikibazo cyo kubona ubufasha bw'ubuvuzi bwihutirwa

Ibindi bintu bimwe na bimwe bisaba kwitonda cyane no gukurikiranwa neza. Ibi birimo asima ikomeye, indwara y'umutima, umuvuduko ukabije w'amaraso, ibibazo by'umwijima cyangwa impyiko, n'indwara y'amara yo gushya.

Niba ufite igikoresho gishyirwa mu mura (IUD), kigomba gukurwaho mbere yo gufata mifepristone. Muganga wawe azabiganiraho nawe mu gihe cyo guhura kwanyu.

Amazina y'ubwoko bwa Mifepristone

Muri Leta Zunze Ubumwe z'Amerika, mifepristone iboneka munsi y'izina ry'ubwoko rya Mifeprex iyo ikoreshwa mu gukuramo inda mu buryo bw'ubuvuzi. Mu kuvura indwara ya Cushing, igurishwa munsi y'izina ry'ubwoko rya Korlym, nubwo iyi ari uburyo butandukanye n'urugero.

Imiti yombi ikubiyemo ikintu kimwe gikora - mifepristone - ariko itegurwa mu buryo butandukanye kandi ikoreshwa mu bintu bitandukanye. Farumasi yawe izatanga uburyo bwihariye muganga wawe yagushyiriyeho kubera ikibazo cyawe cyihariye.

Ubwoko bwa mifepristone bwa rusange buraboneka kandi mu bihe bimwe na bimwe, ariko muganga wawe azagena uburyo bwihariye bukwiye cyane kubyo ukeneye.

Uburyo bwo gusimbuza Mifepristone

Hari ubundi buryo bushobora gukoreshwa bitewe n'icyo urimo kuvura. Mu gihe cyo gukuramo inda hakiri kare, kubaga ni uburyo bukoreshwa cyane mu gihe cyo gukuramo inda hifashishijwe imiti ya mifepristone. Ibi bikubiyemo uburyo bugufi bukorerwa mu bitaro aho gutegereza gufata imiti.

Hariho n'ubundi buryo bwo gukuramo inda hifashishijwe imiti ariko ntibakunze gukoreshwa cyane muri Leta Zunze Ubumwe z'Amerika. Bumwe bukoresha imiti itandukanye cyangwa igihe kitandukanye, ariko mifepristone ihuzwa na misoprostol iracyari uburyo bwizwe cyane kandi bukoreshwa cyane.

Ku ndwara ya Cushing, ubundi buryo bwo kuvura burimo kubaga kugirango bakuremo ibibyimba, kuvurwa na radiyo, cyangwa indi miti ikora mu buryo butandukanye na mifepristone kugirango igenzure urugero rwa cortisol.

Umuvuzi wawe ashobora kuganira nawe kuri ubwo buryo kandi agafasha kumenya uburyo bwiza bukwiriye ubuzima bwawe n'ibyo wifuza.

Ese Mifepristone iruta Misoprostol yonyine?

Yego, guhuza mifepristone ikurikirwa na misoprostol biratanga umusaruro mwinshi ugereranije no gukoresha misoprostol yonyine mu gukuramo inda hifashishijwe imiti. Ubushakashatsi bwerekana ko ubu buryo bugira umusaruro mu byegeranyo bigera kuri 95-98%, mu gihe misoprostol yonyine igira umusaruro mu byegeranyo bigera kuri 85-90%.

Ubu buryo kandi bukunda gukora vuba kandi bushobora gutera kubabara no kuva amaraso bitinda ugereranije na misoprostol yonyine. Ibi nibyo bituma abaganga benshi bakunda uburyo bwo gukoresha imiti ibiri igihe zombi ziboneka.

Ariko, mu bice bimwe na bimwe by'isi aho mifepristone itaboneka, misoprostol yonyine iracyakoreshwa nk'uburyo bwizewe kandi bufite akamaro. Umuvuzi wawe azagusaba uburyo bwiza bushingiye ku byaboneka kandi bikwiriye ubuzima bwawe.

Ibibazo bikunze kwibazwa kuri Mifepristone

Ese Mifepristone irakwiriye abantu barwaye diyabete?

Mifepristone ikoreshwa mu buryo bwizewe n'abantu barwaye diyabete, ariko bisaba gukurikiranwa neza. Uyu muti ushobora kugira ingaruka ku isukari yo mu maraso, cyane cyane niba uwukoresha uvura indwara ya Cushing. Muganga wawe azashaka gukurikiranira hafi isukari yo mu maraso yawe mu gihe uvurwa.

Niba urwaye diyabete kandi ukeneye mifepristone mu gukuramo inda kwa muganga, gukoresha uyu muti mu gihe gito ntibisanzwe bitera ibibazo bikomeye byo kugenzura isukari yo mu maraso. Ariko, ugomba kumenyesha muganga wawe ibyerekeye diyabete yawe kugira ngo ashobore gutanga ubufasha bukwiriye no kugukurikiranira hafi.

Ninkora iki niba mfashe mifepristone nyinshi ku buryo butunguranye?

Niba ufata mifepristone nyinshi ku buryo butunguranye kuruta uko byategetswe, vugana na muganga wawe cyangwa ikigo gishinzwe kurwanya ubumara ako kanya. Gufata nyinshi bishobora kongera ibyago byo kugira ingaruka ziterwa n'uyu muti n'ibibazo.

Ntugerageze kwisuka uruka keretse niba ubitegetswe na muganga. Bika uruziga rw'imiti hamwe nawe kugira ngo ushobore gutanga amakuru nyayo y'icyo wafashe n'ingano yacyo.

Ibimenyetso byo kurenza urugero bishobora kuba harimo isesemi ikabije, kuruka, impiswi, cyangwa ibimenyetso byo kutagira ubushobozi bwo mu ngingo zikora imisemburo nk'intege nke zikabije n'umuvuduko muke w'amaraso. Gana ubufasha bw'ubuvuzi ako kanya niba ubonye ibimenyetso bibangamiye.

Ninkora iki niba nirengagije gufata urugero rwa mifepristone?

Mu gukuramo inda kwa muganga, mifepristone isanzwe itangwa nk'urugero rumwe, bityo kurengagiza urugero ntibisanzwe bigira ikibazo. Ariko, niba ugomba gufata undi muti wa kabiri nka misoprostol ukarengagiza igihe cyo kuwufata, vugana na muganga wawe ako kanya kugira ngo akugire inama.

Niba ufata mifepristone uvura indwara ya Cushing kandi ukarengagiza urugero, fata ako kanya wibuka keretse igihe cyo gufata urugero rukurikira kigeze. Ntukafate urugero rwa kabiri icyarimwe kugira ngo usimbure urugero warengagije.

Umuvuzi wawe w'ubuzima azaguha amabwiriza yihariye yerekeye igihe, ayo akaba ari ingenzi ku mutekano wawe no kugira ngo imiti ikore neza.

Nshobora Kureka Gufata Mifepristone Ryari?

Mugukora icyuma cyo gukuramo inda, mubisanzwe ufata mifepristone rimwe gusa, bityo ntakindi uvurwa ugomba guhagarika. Ariko, uzakenera gahunda zo gukurikiranwa kugira ngo wemeze ko ubuvuzi bwagenze neza kandi ko urimo gukira neza.

Niba ufata mifepristone kubera indwara ya Cushing, ntuzigere uhagarika kuyifata ako kanya utabanje kuvugana n'umuvuzi wawe w'ubuzima. Guhagarika ako kanya bishobora gutera ibibazo bikomeye bifitanye isano n'imitsi yawe y'imisemburo ya adrenal na cortisol.

Muganga wawe azagenzura uko witwara ku buvuzi kandi azemeza igihe bizaba byemewe kugabanya urugero rw'umuti cyangwa guhagarika rwose imiti. Iyi myanzuro ishingiye ku buzima bwawe bwihariye n'uko witwara ku buvuzi.

Nshobora Kongera Kugira Inda Nyuma yo Gufata Mifepristone?

Yego, mifepristone ntigira ingaruka ku bushobozi bwawe bwo kubyara mu gihe kizaza cyangwa ubushobozi bwo kugira inda. Igihe cyawe cyo mu gihe cy'imihango mubisanzwe kizagaruka mu byumweru 4-8 nyuma yo gukoresha mifepristone mugukuramo inda hakoreshejwe imiti.

Mu byukuri, ushobora kongera kugira inda vuba nyuma yo gufata mifepristone, mbere yuko imihango yawe ya mbere igaruka. Niba udashaka kongera kugira inda ako kanya, ni ngombwa gutangira gukoresha uburyo bwo kuboneza urubyaro mugihe cyose witeguye gusubukura imibonano mpuzabitsina.

Umuvuzi wawe w'ubuzima ashobora kuganira nawe kubijyanye n'uburyo bwo kuboneza urubyaro kandi akagufasha guhitamo uburyo bukwiye ubuzima bwawe n'ibyo ukunda.