Nafarelin ni iki: Ibyo ikoreshwa, urugero rwo gufata, ingaruka ziterwa n'ibindi

Nafarelin ni umuti wandikirwa wo mu mazuru ufasha mu kuvura indwara zifitanye isano n'imisemburo nk'indwara ya endometryose na puberté yo hambere ku bana. Uyu musemburo w'ubukorano ukora ugabanya by'agateganyo umubare w'imisemburo runaka y'ubuzima bw'imyororokere mu mubiri wawe, uha umubiri wawe amahirwe yo gukira cyangwa gusubiza ibintu mu buryo busanzwe.

Tekereza nafarelin nk'akabuto ko guhagarika imikorere y'imisemburo y'umubiri wawe. Nubwo bishobora kumvikana biteye inkeke, mu by'ukuri ni uburyo bugenzurwa neza abaganga bakoresha mu kuvura indwara zihariye aho kugabanya imisemburo bishobora gutanga ubufasha bukomeye no gukira.

Nafarelin ni iki?

Nafarelin ni verisiyo yakozwe n'abantu y'umusemburo witwa gonadotropin-releasing hormone (GnRH) ubwonko bwawe bwikorera. Iyo ukoresha nafarelin buri gihe, mu by'ukuri itegeka umubiri wawe guhagarika gukora imisemburo runaka y'imibonano mpuzabitsina nka estrogen na testosterone.

Uyu muti ubarirwa mu itsinda ryitwa GnRH agonists, bivuze ko yigana umusemburo wawe wa kamere ariko mu buryo butandukanye. Aho guteza imbere imikorere y'imisemburo nk'uko GnRH yawe ya kamere ikora, nafarelin amaherezo irayica nyuma yo kwiyongera by'agateganyo.

Uburyo bwo mu mazuru butuma bikoreshwa byoroshye mu rugo, kandi umuti winjizwa binyuze mu gice cyo mu mazuru yawe ukagera mu maraso yawe. Ubu buryo bwo gutanga bufasha kumenya urugero rw'imisemburo ruriho mu gihe cyose cyo kuvurwa kwawe.

Nafarelin ikoreshwa mu kuvura iki?

Nafarelin ahanini ivura indwara ya endometryose ku bagore na puberté yo hambere ku bana b'ibitsina byombi. Izi ndwara zungukirwa no kugabanya by'agateganyo urugero rw'imisemburo y'imibonano mpuzabitsina mu mubiri.

Ku ndwara ya endometryose, nafarelin ifasha kugabanya imikurire y'ibice by'uburwayi bibabaza bikura hanze y'inkondo y'umura. Iyo urugero rwa estrogen rugabanutse, ibi bice bya endometrial akenshi bigabanuka kandi ntibibabaza cyane, bikaguha ubufasha ku bimenyetso nk'ububabare bwo mu gatuza n'imihango iremereye.

Ku bana bafite ubugimbi bwihuse, nafarelin ituma imbere y’iterambere ry’imibonano mpuzabitsina ritinda. Ibi bituma abana babona igihe cyinshi cyo gukura no gukura mu byiyumvo mbere y’uko imibiri yabo itangira ubugimbi, ibyo bishobora kugora mu byiyumvo iyo bibaye kare.

Rimwe na rimwe abaganga bashobora kwandika nafarelin ku zindi ndwara zifitanye isano na hormone, nubwo izi nshingano zitamenyerewe. Umuganga wawe azagusobanurira neza impamvu bagusaba uyu muti ku kibazo cyawe.

Nafarelin ikora ite?

Nafarelin ikora itegeka imitsi yawe ya hormone, hanyuma ikayihagarika burundu. Ubu buryo bwitwa "downregulation" kandi ni nko guhagarika by'agateganyo uruganda rwa hormone mu mubiri wawe.

Iyo utangiye gukoresha nafarelin, ushobora kubona ibimenyetso byiyongeraho gato. Ibi bibaho kuko umuti utera mbere imikorere ya hormone mbere yo guhagarika ibintu byose. Ibi byiyongera bikunze kumara ibyumweru bike gusa.

Nyuma y'iki gihe cya mbere, urwego rwa hormone yawe ruragabanuka cyane, rugakora imiterere isa na menopause ku bagore cyangwa rugahagarika iterambere ry'ubugimbi ku bana. Iyi ngaruka ikomeye ku igabanuka rya hormone niyo itanga akamaro k'ubuvuzi ku ndwara yawe.

Nafarelin ifatwa nk'umuti ukomeye kuko ihagarika burundu imikorere ya hormone karemano mu mubiri wawe. Ariko, izi ngaruka ziragaruka, kandi urwego rwa hormone yawe rukunze gusubira mu buryo busanzwe mu mezi make nyuma yo guhagarika ubuvuzi.

Nkwiriye gufata nafarelin nte?

Fata nafarelin nk'uko byategetswe, akenshi kabiri ku munsi ufite doze zishyizweho amasaha 12. Gahunda isanzwe ni rimwe mu gitondo na rimwe nimugoroba, ariko muganga wawe azaguha amabwiriza yihariye yo gukoresha.

Mbere yo gukoresha umuti uvuzwa mu mazuru, uhuhure neza amazuru yawe kugira ngo uvemo ibihaha. Fata icupa urishyire hejuru, ushyireho urutoki mu zuru rimwe, hanyuma uvuge umuti uhumeka buhoro. SImbuka amazuru buri dose kugira ngo wirinde kurakara.

Urashobora gufata nafarelin hamwe n'ibiryo cyangwa utabifite, kuko kurya ntiguhindura uburyo umuti ukora neza. Ariko, gerageza kuwukoresha mu gihe kimwe buri munsi kugira ngo ugumane igabanuka ry'imisemburo.

Irinde guhuhura amazuru yawe byibuze iminota 30 nyuma yo gukoresha umuti kugira ngo wemeze ko winjiye neza. Niba ufite ibicurane cyangwa amazuru yazibye, bimenyeshe muganga wawe, kuko ibi bishobora kugira ingaruka ku buryo umuti winjira neza.

Nzagufata Nafarelin Igihe Kingana Gite?

Abantu benshi bafata nafarelin amezi 6 mugihe bavura indwara ya endometriosis, nubwo bamwe bashobora gukenera igihe gito cyangwa kirekire cyo kuvurwa. Muganga wawe azagena igihe gikwiye hashingiwe ku bimenyetso byawe n'uburyo witwara neza ku buvuzi.

Ku bana bafite ubwangavu bwambere, igihe cyo kuvurwa gitandukanye cyane kandi giterwa n'imyaka y'umwana, urwego rw'iterambere, n'uburyo yitwara ku buvuzi. Abana bamwe bashobora gukenera kuvurwa imyaka myinshi kugeza igihe bageze mu gihe gikwiye cyo gukura mu buryo busanzwe.

Gufata nafarelin igihe kirekire kuruta uko byateganijwe bishobora kongera ibyago byo gutakaza ubucucike bw'amagufa n'izindi ngaruka ziterwa n'umuti. Muganga wawe azakugenzura buri gihe kandi ashobora kugusaba calcium na vitamine D kugira ngo urinde amagufa yawe mugihe uvurwa.

Ntuzigere uhagarika gufata nafarelin ako kanya utabanje kuvugana na muganga wawe. Nubwo muri rusange ari byiza guhagarika, umuganga wawe ashobora gushaka kukugenzura kugira ngo arebe ibimenyetso bisubira cyangwa ategure uburyo bwo kuvura butandukanye.

Ni Izihe Ngaruka Ziterwa na Nafarelin?

Ingaruka zikunze kugaragara za nafarelin zijyanye n'imisemburo mike kandi zirimo gushyuha cyane, guhinduka kw'amarangamutima, no kumuka kw'abagore. Ibi bimenyetso bisa na menopause kandi bigira ingaruka ku bantu benshi bakoresha uyu muti.

Kumenya ibyo witegura bishobora kugufasha kumva witeguye neza guhangana n'izi mpinduka:

• Gushyuha cyane no kubira ibyuya nijoro bibaho ku bantu bagera kuri 90% bakoresha uyu muti
• Kugabanyuka kw'irari ry'imibonano mpuzabitsina bigira ingaruka ku bantu benshi bari mu kuvurwa
• Guhererekana kw'amarangamutima, umujinya, cyangwa agahinda gato ni ibisanzwe
• Ubwuma bw'igitsina cy'abagore no kugabanyuka kw'amavangingo
• Umutwe no kuribwa kw'imitsi
• Uburibwe mu mazuru buturuka ku mvura y'umuti ubwayo
• Ibibazo byo gusinzira no kunanirwa

Izi ngaruka zikunda gucungwa neza kandi zikagaruka nyuma yo guhagarika ubuvuzi. Muganga wawe ashobora gutanga ibitekerezo byo kugabanya ibibazo mu gihe cyo kuvurwa.

Ingaruka zikomeye ariko zitabaho kenshi zisaba ubufasha bwihutirwa bw'abaganga. Nubwo bitabaho kenshi, ibi bishobora kuba birimo impinduka zikomeye mu marangamutima, gutekereza kwikomeretsa, cyangwa ibimenyetso byo gutakaza cyane amagufa nk'imvune idasanzwe.

Abantu bamwe bagira allergie kuri nafarelin, nubwo ibi bitabaho kenshi. Reba ibimenyetso nk'uruhu rwinshi, guhumeka bigoye, cyangwa kubyimba mu maso cyangwa mu muhogo, kandi ushake ubufasha bwihutirwa niba bibaye.

Ninde utagomba gufata Nafarelin?

Nafarelin ntabwo ari umutekano ku bagore batwite cyangwa abagerageza gusama, kuko ishobora gukomeretsa abana bakiri bato. Abagore bafite imyaka yo kubyara bagomba gukoresha uburyo bwo kuboneza urubyaro butari bwa hormone mu gihe cyo kuvurwa.

Abantu bafite indwara zimwe na zimwe bagomba kwirinda nafarelin cyangwa bakayikoresha bafite ubwitonzi bwinshi. Muganga wawe azasuzuma amateka yawe y'ubuzima neza mbere yo kwandika uyu muti.

Dore indwara zishobora kukubuza gukoresha nafarelin mu buryo bwizewe:

• Gusama cyangwa konsa
• Guhumeka mu gitsina kutumvikana
• Osteoporose ikomeye cyangwa amateka y'imvune z'amagufa
• Agahinda gakabije cyangwa indwara zo mu mutwe
• Allergie kuri nafarelin cyangwa imiti isa nayo
• Ubwoko bumwe na bumwe bwa kanseri zifite hormone

Niba ufite amateka y'ibibazo by'amagufa, muganga wawe ashobora gukomeza kugutera nafarelin ariko azagenzura ubucucike bw'amagufa yawe cyane. Ashobora kandi kugusaba izindi nshuti zo kurinda amagufa yawe mugihe cy'imiti.

Amazina y'ubwoko bwa Nafarelin

Nafarelin ikunze kugurishwa munsi y'izina ry'ubwoko rya Synarel muri Leta Zunze Ubumwe z'Amerika no mu bindi bihugu byinshi. Iri ni izina ry'ubwoko rya mbere abaganga benshi n'abacuruzi b'imiti bazamenya.

Ibindi bihugu bishobora kugira amazina y'ubwoko atandukanye ya nafarelin, ariko ibikoresho bikora biracyari kimwe. Buri gihe bwire abaganga bawe izina rusange "nafarelin" hamwe n'izina ry'ubwoko kugirango wirinde urujijo.

Ubwoko rusange bwa nafarelin bushobora kuboneka ahantu hamwe, nubwo bidakunze kugaragara kurusha ubwoko bw'izina. Umucuruzi wawe w'imiti ashobora kugufasha gusobanukirwa icyo gihari ahantu uherereye niba gusimbuza bikwiye.

Uburyo bwa Nafarelin

Imiti myinshi ishobora kuvura ibibazo bimwe na nafarelin, harimo n'izindi GnRH agonists nka leuprolide (Lupron) na goserelin (Zoladex). Izi nzira zikora kimwe ariko zishobora gutangwa nk'inkingo aho kuba imiti yo mu mazuru.

Kubera endometriosis, izindi nzira zo kuvura zirimo uburyo bwo kuboneza urubyaro, imiti ya progestin, cyangwa imiti irwanya ububyimbirwe. Abantu bamwe babona ubufasha hamwe n'imiti idakomeye mbere yo kugerageza GnRH agonists nka nafarelin.

Mugukira urubyiruko rwo hambere, izindi nzira zirimo izindi miterere ya GnRH agonists cyangwa, mubihe bimwe, gukurikiranwa neza hatarimo imiti niba ikibazo giciriritse. Muganga wawe azagufasha kumenya uburyo bwiza kubibazo byawe byihariye.

Guhitamo hagati ya nafarelin n'izindi nzira akenshi biterwa n'ibintu nk'uburyo bworoshye, kwihanganira ingaruka, n'ikiguzi. Abantu bamwe bakunda uburyo bwo mu mazuru, mugihe abandi bashobora gusanga inkingo zikwiriye.

Ese Nafarelin iruta Lupron?

Nafarelin na Lupron (leuprolide) byombi ni GnRH agonists bikora kimwe kandi bifite ubushobozi bungana bwo kuvura indwara ya endometriosis na precocious puberty. Itandukaniro rikuru riri mu buryo bitangwa kandi uburyo ukoresha.

Nafarelin itanga uburyo bwo gukoresha buri munsi mu rugo nk'umuti uvuzwa mu mazuru, mu gihe Lupron isaba inshinge buri kwezi cyangwa buri mezi make kwa muganga wawe. Abantu bamwe bakunda kugenzura imiti ya buri munsi, mu gihe abandi bakunda koroshya inshinge zitajyenda kenshi.

Ingaruka ziterwa n'imiti muri rusange zirasa hagati y'imiti yombi, nubwo abantu bamwe bashobora kwihanganira imwe kurusha iyindi. Uburibwe mu mazuru bwihariye kuri nafarelin, mu gihe ibisubizo byo guterwa inshinge byihariye kuri Lupron.

Itandukaniro ry'ibiciro rishobora kubaho bitewe n'ubwishingizi bwawe n'aho uherereye. Muganga wawe ashobora kugufasha gupima ibyiza n'ibibi bya buri kimwe hashingiwe ku mibereho yawe, ibyo ukunda, n'ibyo ukeneye mu buvuzi.

Ibikunze Kubazwa Kuri Nafarelin

Ese nafarelin irakwiriye abantu barwaye diyabete?

Nafarelin irashobora gukoreshwa neza ku bantu barwaye diyabete, nubwo bishobora kugira ingaruka ku isukari mu maraso ku bantu bamwe. Impinduka za hormone ziterwa na nafarelin rimwe na rimwe zishobora gutuma kugenzura isukari mu maraso bigorana.

Niba urwaye diyabete, muganga wawe azashaka gukurikirana urugero rw'isukari mu maraso yawe mugihe uvurwa na nafarelin. Ushobora gukenera guhindura imiti yawe ya diyabete cyangwa gupima glucose kenshi.

Nigute nzakora niba nanyweje nafarelin nyinshi?

Niba wanyweje urugero rwinshi rwa nafarelin, ntugahungabane. Nubwo bitari byiza, kunywa imiti nyinshi rimwe na rimwe ntibishoboka ko byateza ibibazo bikomeye kuko umuti ugamije guhagarika hormone buhoro buhoro.

Vugana na muganga wawe cyangwa umufarumasiti kugirango baguhe ubuyobozi, cyane cyane niba wanyweje nyinshi cyane kuruta uko byategetswe. Bashobora gusaba gukurikirana ingaruka zikomeye cyangwa guhindura igihe cyo kunywa urugero rwawe rukurikira.

Ninkora iki niba nirengagije urugero rwa nafarelin?

Niba wirengagije urugero rwa nafarelin, rufate uko wibuka vuba, keretse igihe cyegereje urugero rwawe ruteganyijwe. Muriyo manza, reka urugero wirengagije ukomeze gahunda yawe isanzwe.

Ntuzigere ufata urugero ebyiri icyarimwe kugirango usimbure urugero wirengagije, kuko ibyo bishobora kongera ingaruka ziterwa n'umuti. Niba ukunda kwibagirwa urugero, tekereza gushyiraho ibyibutso kuri terefone cyangwa ukoreshe porogaramu ikurikirana imiti.

Nshobora guhagarika ryari gufata nafarelin?

Ushobora guhagarika gufata nafarelin mugihe muganga wawe yemeje ko intego zawe zo kuvurwa zagezweho cyangwa niba uhuye n'ingaruka ziterwa n'umuti zirenga inyungu. Kubijyanye na endometriosis, ibi bikunze kuba nyuma y'amezi 6 yo kuvurwa.

Abantu benshi bashobora guhagarika nafarelin mu buryo bwizewe batagabanyije urugero buhoro buhoro, nubwo muganga wawe ashobora kwifuza kugukurikirana kubijyanye n'ibimenyetso bisubira. Urukoro rwawe rwemerewe rugomba gusubira muminsi mike nyuma yo guhagarika.

Nshobora gusama niba mfata nafarelin?

Gusama birashoboka cyane mugihe ufata nafarelin kuko umuti ubuzwa ovulation mu bagore. Ariko, ugomba gukoresha uburyo bwo kuboneza urubyaro butari bwa hormone nk'uburyo bwo kwirinda.

Niba utekereza ko ushobora kuba utwite mugihe ukoresha nafarelin, hagarika umuti ako kanya uvugishe muganga wawe. Nafarelin ishobora kwangiza umwana ukiri mu nda, bityo gusuzumwa kw'ubuvuzi byihuse ni ngombwa.