Naldemedine ni iki: Ibyo ikoreshwa, urugero rwo gufata, ingaruka ziterwa n'iyo miti n'ibindi

Naldemedine ni umuti wandikirwa na muganga ufasha kuvura guhagarara k'umubiri guterwa n'imiti ikoreshwa mu kuvura uburibwe bwo mu ngingo. Niba urimo gufata imiti ikoreshwa mu kuvura uburibwe bwo mu ngingo burambye kandi ukaba ufite ikibazo cyo guhagarara k'umubiri, naldemedine ikora ibyo ikoresha ibice by'umubiri byakira imiti yo mu ngingo mu gihe itagira icyo ihindura ku buryo uburibwe bugabanyuka. Ubu buryo bwihariye butuma imyanda yo mu mubiri isubira mu buryo busanzwe mu gihe umuti w'uburibwe ukomeza gukora neza.

Naldemedine ni iki?

Naldemedine ni umuti wo mu bwoko bw'imiti yitwa opioid antagonists. Yagenewe by'umwihariko kurwanya ingaruka zo guhagarara k'umubiri ziterwa n'imiti yo mu ngingo itabangamiye inyungu zo kugabanya uburibwe. Bitekerezeho nk'umuti wihariye ukora gusa mu nzira y'igogora.

Uyu muti watejwe imbere kuko guhagarara k'umubiri guterwa n'imiti yo mu ngingo bigira ingaruka ku hafi ya buri wese ufata imiti yo mu ngingo buri gihe. Bitandukanye no guhagarara k'umubiri bisanzwe, ubu bwoko ntibusanzwe bwakira neza imiti isanzwe nk'ibyongerera imbaraga cyangwa imiti yo hanze yo kugurishwa.

Naldemedine ikoreshwa mu kuvura iki?

Naldemedine ivura guhagarara k'umubiri guterwa n'imiti yo mu ngingo ku bantu bakuru bafite uburibwe burambye buterwa na kanseri. Muganga wawe azagusaba uyu muti iyo umaze igihe ufata imiti yo mu ngingo kandi ukaba ufite guhagarara k'umubiri kudahinduka nk'ingaruka.

Uyu muti wagenewe by'umwihariko abantu guhagarara k'umubiri kwabo kutagize icyo guhinduka n'ubundi buryo bwo kuvura nk'imihindukire y'imirire, kongera kunywa amazi, cyangwa imiti yo hanze yo kugurishwa. Ni ngombwa gusobanukirwa ko naldemedine ikora gusa ku guhagarara k'umubiri guterwa n'imiti yo mu ngingo, atari izindi miterere yo guhagarara k'umubiri.

Naldemedine ikora ite?

Naldemedine ikora ibyo ikoresha ibice by'umubiri byakira imiti yo mu ngingo mu nzira y'igogora. Iyo ufata imiti yo mu ngingo, yifatira ku bice by'umubiri byakira imiti mu mubiri wawe, harimo no mu mara yawe, bigatuma igogora rigenda gahoro kandi bigatera guhagarara k'umubiri.

Uyu muti ukora nk'urufunguzo rwinjira muri izo reseptori zo mu mara yawe, ukabuza opioids guhuzwa nazo. Ariko, naldemedine ntijya mu bwonko bwawe cyangwa mu mugongo, bityo ntibuvangira uburyo bwo kugabanya ububabare. Iyi ngeso yihariye ituma iba igisubizo cyiza cyo gukomeza kugenzura ububabare mugihe isubiza imikorere isanzwe y'amara.

Nkwiriye Gufata Naldeemedine Nte?

Fata naldemedine nk'uko muganga wawe abikwandikiye, akenshi rimwe ku munsi hamwe n'ibiryo cyangwa utabifatanije. Urutonde rusanzwe rw'abantu bakuru ni 0.2 mg (ikibahasha kimwe) gifatwa ku gihe kimwe buri munsi. Mimina ikibahasha cyose hamwe n'amazi kandi ntukibice, ntukimenagure, cyangwa ngo ukimene.

Urashobora gufata naldemedine hamwe n'ibiryo niba bigutera isesemi, nubwo ibiryo bitagira ingaruka zigaragara ku buryo umuti ukora. Gerageza gushyiraho gahunda yo kuyifata ku gihe kimwe buri munsi kugirango ikugireho urwibutso kandi ugumane urwego rwo hejuru mu mubiri wawe.

Niba ugira ikibazo cyo kumira ibibahasha, ganira na muganga wawe kubyerekeye izindi nzira. Ntuhagarike gufata imiti yawe igabanya ububabare ya opioid mugihe utangiye gufata naldemedine keretse muganga wawe akubwiye ko ubikora.

Nkwiriye Gufata Naldemedine Igihe Kingana Gite?

Ubusanzwe uzajya ufata naldemedine igihe cyose ufata imiti igabanya ububabare ya opioid kandi ufite ikibazo cyo kwituma. Abantu benshi bakomeza kuyifata mu gihe cyose bavurwa na opioid, bishobora kumara ibyumweru, amezi, cyangwa igihe kirekire bitewe n'uko ububabare bwawe bugomba kuvurwa.

Muganga wawe azagenzura uko witwara ku muti kandi ashobora guhindura gahunda yawe yo kuvurwa bitewe n'uko ukora neza. Abantu bamwe babona impinduka mu myitwarire yabo yo kwituma mu minsi mike, mugihe abandi bishobora kubatwara icyumweru kugirango babone inyungu zose.

Ntuhagarike gufata naldemedine ako kanya utabanje kuvugana na muganga wawe. Niba ukeneye guhagarika umuti, muganga wawe azakuyobora muri urwo rugendo kandi aganire nawe kubyerekeye ubundi buryo bwo kuvura ikibazo cyo kwituma giterwa na opioid.

Ibyo Bibazo biterwa na Naldemedine?

Kimwe n'imiti yose, naldemedine ishobora gutera ibibazo, nubwo atari buri wese ubyumva. Ibibazo byinshi biba byoroheje kandi bikagenda bikosoka uko umubiri wawe wimenyereza umuti.

Ibibazo bisanzwe ushobora guhura nabyo harimo kuribwa mu nda, guhitwa, isesemi, na gastroenteritis (ibimenyetso bimeze nk'ibicurane byo mu nda). Ibi bibazo byo mu nzira y'igogora birumvikana bitewe n'uko umuti ukora kugira ngo usubize imikorere isanzwe y'amara.

Dore ibibazo bisanzwe byo kumenya:

• Kuribwa mu nda cyangwa kuruka
• Guhitwa
• Isesemi
• Kuruka
• Ibimenyetso bya Gastroenteritis

Ibi bimenyetso mubisanzwe birambye kandi byoroheje. Ariko, niba guhitwa bikomeye cyangwa bigakomeza, vugana na muganga wawe kuko ushobora gukenera guhindura urugero rwawe cyangwa guhagarika umuti by'agateganyo.

Ibibazo bitavuka kenshi ariko bikomeye birashobora kubaho, nubwo bitavuka kenshi. Ibi birimo kuribwa cyane mu nda, ibimenyetso byo guhagarara kw'amara, cyangwa ibimenyetso by'uburwayi. Niba ufite kuribwa cyane mu nda, kuruka bikomeza, cyangwa ibimenyetso by'uburwayi nko kuribwa, guhumeka bigoye, cyangwa kubyimba, shakisha ubufasha bw'ubuvuzi ako kanya.

Ninde utagomba gufata Naldemedine?

Naldemedine ntabwo ikwiriye kuri buri wese. Ntugomba gufata uyu muti niba ufite ikibazo cyo guhagarara kw'amara cyangwa gufungana, kuko byakongera ibi bibazo.

Muganga wawe azasuzuma neza amateka yawe y'ubuvuzi mbere yo kugusaba naldemedine. Abantu bafite ibibazo bimwe na bimwe byo mu nzira y'igogora bashobora gukenera gukurikiranwa byihariye cyangwa ntibakwiriye uyu muti.

Dore ibibazo bishobora kugutera kutafata naldemedine:

• Kumenyekana cyangwa gukekwa guhagarara kw'amara
• Ibibazo bikomeye by'umwijima
• Uburwayi kuri naldemedine cyangwa ibiyigize
• Indwara zimwe na zimwe zo mu nzira y'igogora zigira ingaruka ku mikorere y'amara

Abagore batwite cyangwa bonka bagomba kuganira ku byago n'inyungu na muganga wabo, kuko umutekano wa naldemedine mu gihe cyo gutwita no konsa utarashyirwaho neza. Muganga wawe azagereranya inyungu zishoboka n'ibyago byose bishoboka.

Amazina y'ubwoko bwa Naldemedine

Naldemedine iboneka munsi y'izina ry'ubwoko rya Symproic muri Leta Zunze Ubumwe z'Amerika. Iyi ni yo fomu ikoreshwa cyane y'umuti kandi iza mu nini za 0.2 mg.

Ubwoko rusange bwa naldemedine bushobora kuboneka mu gihe kizaza, ariko ubu, Symproic ni izina ry'ubwoko rya mbere uzahura naryo. Kora buri gihe ukoresha umuti nyawo muganga wawe yaguhaye kandi ntusimbuze n'andi moko atabiherewe uburenganzira na muganga.

Uburyo bwa Naldemedine

Niba naldemedine itagukundiye cyangwa ikaba yateza ingaruka zikomeye, indi miti myinshi ishobora kuvura guhagarara kw'amara guterwa na opioid. Muganga wawe ashobora gutekereza methylnaltrexone (Relistor) cyangwa naloxegol (Movantik), bikora kimwe na kimwe mu guhagarika imyanya yakira opioid mu gihe cyo gukora ibiryo.

Abantu bamwe babona intsinzi hamwe n'imiti isanzwe yo koroshya nk'ibinyabutabire bya polyethylene glycol (MiraLAX) cyangwa imiti ikangura, nubwo ibi muri rusange bidakora neza ku guhagarara kw'amara guterwa na opioid. Muganga wawe ashobora kandi kugusaba impinduka mu mibereho nk'iyongerwa ry'ifunguro ririmo fibre, imyitozo myinshi, n'amazi ahagije nk'inzira zunganira.

Guhitamo ubundi buryo biterwa n'imimerere yawe yihariye, indi miti urimo gufata, n'uburyo umubiri wawe witwara ku miti itandukanye. Ntukigere uhindura imiti utabanje kubaza umuganga wawe.

Ese Naldemedine iruta Methylnaltrexone?

Bombi naldemedine na methylnaltrexone bavura neza guhagarara kw'amara guterwa na opioid, ariko bafite inyungu zitandukanye. Naldemedine ifatwa mu kanwa rimwe ku munsi, bituma biba byoroshye ku bantu benshi, mugihe methylnaltrexone isanzwe itangwa nk'urushinge.

Gu hitamo hagati y'iyo miti akenshi biterwa n'ibyo ukunda, imibereho yawe, n'uko umubiri wawe witwara kuri buri muti. Abantu bamwe bakunda uburyo bworoshye bwo gufata ikinini buri munsi, mu gihe abandi bashobora kwitwara neza ku muti w'urushinge.

Muganga wawe azatekereza ku bintu nk'indi miti ufata, imikorere y'impyiko zawe, n'ibyo ukunda ku giti cyawe igihe afata icyemezo cy'umuti ukugirira neza. Imiti yombi ifite urugero rumwe rw'ubushobozi, bityo icyemezo akenshi kigashingira ku bintu bifatika n'uburyo umuntu ku giti cye yitwara.

Ibibazo Bikunze Kubazwa Kuri Naldemedine

Ese Naldemedine irakwiriye ku bantu barwaye indwara y'impyiko?

Abantu bafite ibibazo by'impyiko byoroheje kugeza ku birenzeho, akenshi bashobora gufata naldemedine neza, ariko muganga wawe ashobora gukenera kugukurikiranira hafi. Niba urwaye indwara y'impyiko ikomeye, muganga wawe azatekereza neza inyungu n'ingaruka mbere yo kugusaba uyu muti.

Imikorere y'impyiko zawe igira uruhare mu buryo umubiri wawe ukoresha naldemedine, bityo guhindura urugero rw'umuti bishobora kuba ngombwa. Buri gihe menyesha muganga wawe ibibazo byose by'impyiko mbere yo gutangira uyu muti, kandi witabire gahunda zose zagenwe zo gukurikiranwa.

Nzakora iki niba mfata naldemedine nyinshi ku buryo butunguranye?

Niba ufata naldemedine nyinshi ku buryo butunguranye kuruta uko byategetswe, vugana na muganga wawe cyangwa ikigo gishinzwe kurwanya ubumara ako kanya. Gufata nyinshi bishobora gutera impiswi ikabije, kumuka amazi mu mubiri, cyangwa izindi ngorane zikomeye zo mu nzira y'igogora.

Ntugerageze kwivuza wenyine igihe wamazeho umuti mwinshi. Mu gihe utegereje inama ya muganga, komereza amazi mu mubiri wawe kandi wigenzure niba hari ibimenyetso nk'ububabare bukomeye mu nda, kuruka bidahagarara, cyangwa ibimenyetso byo kumuka amazi mu mubiri. Bika urupapuro rw'umuti hamwe nawe igihe ushaka ubufasha bwa muganga kugira ngo abaganga bamenye neza icyo wafashe n'ingano yacyo.

Nzakora iki niba nirengagije gufata urugero rwa naldemedine?

Niba wibagiwe gufata urugero rwa naldemedine, rufate uko wibukije, keretse igihe cyo gufata urugero rwawe rutaha rwegereje. Muri urwo rubanza, reka urugero wibagiwe, maze ufate urugero rwawe rutaha ku gihe cyagenwe.

Ntuzigere ufata urugero ebyiri icyarimwe kugira ngo usimbure urugero wibagiwe, kuko ibi bishobora kongera ibyago byo kugira ingaruka mbi. Niba ukunda kwibagirwa gufata imiti, tekereza gushyiraho alarme ya buri munsi cyangwa gukoresha umuteguro w'imiti kugira ngo bikugiremo urwibutso.

Ni ryari nshobora kureka gufata Naldemedine?

Ubusanzwe, ushobora kureka gufata naldemedine igihe utakigomba imiti igabanya ububabare ya opioid cyangwa igihe muganga wawe yemeje ko bitakiri ngombwa. Abantu benshi bareka naldemedine igihe barangije kuvurwa na opioid cyangwa bahinduye uburyo bwo kugabanya ububabare butari bwa opioid.

Buri gihe jya inama na muganga wawe mbere yo kureka naldemedine, kabone n'iyo wumva umeze neza. Muganga wawe azatekereza gahunda yawe yose yo kugabanya ububabare kandi ashobora kwifuza kugukurikiranira kugaruka kw'ibimenyetso byo guhagarara kw'amara mbere yo guhagarika rwose umuti.

Nshobora gufata Naldemedine hamwe n'indi miti igabanya guhagarara kw'amara?

Muri rusange, ntugomba gukenera indi miti igabanya guhagarara kw'amara mugihe ufata naldemedine, kuko yibanda by'umwihariko ku guhagarara kw'amara guterwa na opioid. Ariko, muganga wawe ashobora rimwe na rimwe gutanga inama yo guhuza imiti niba ufite izindi mpamvu zitera guhagarara kw'amara.

Ntuzigere wongerera indi miti igabanya guhagarara kw'amara mu buryo bwawe butagishije inama na muganga wawe mbere, kuko ibi bishobora gutera imyitwarire y'amara y'umurengera cyangwa izindi ngorane. Niba naldemedine yonyine itatanga ubufasha buhagije, ganira ibi n'umuganga wawe aho kwivura wenyine ukoresheje indi miti.