Ni iki Neostigmine: Ibyo ikoreshwa, Urutonde rw'imiti, Ingaruka zayo n'ibindi

Neostigmine ni umuti wandikirwa na muganga ufasha kunoza imbaraga z'imitsi n'imikorere mu bantu bafite ibibazo by'intege nke z'imitsi. Ikora ibi ikingira enzyme isenya acetylcholine, ubutumwa bw'imirasire bufasha imitsi yawe kwikurura neza.

Uyu muti akenshi wandikirwa abafite myasthenia gravis, indwara aho umubiri w'abarwanya indwara ubangamira imikorere isanzwe y'imitsi. Muganga wawe ashobora no kuyikoresha ku zindi ndwara zigira ingaruka ku buryo imitsi yawe ivugana.

Neostigmine ni iki?

Neostigmine ni mu cyiciro cy'imiti yitwa cholinesterase inhibitors. Bitekereze nk'umufasha ureba ko imitsi yawe ibona ibimenyetso bikenewe kugira ngo ikore neza.

Iyo ufite ibibazo by'intege nke z'imitsi, umubiri wawe ugira ingorane zo kohereza ibimenyetso bikomeye bihagije kuva mu miyoboro yawe y'imitsi. Neostigmine yinjira kugira ngo yongere ibi bimenyetso ikingira isenyuka rya acetylcholine, umuti utwara ubutumwa hagati y'imitsi yawe n'imitsi.

Ubwoko bwa neostigmine bufatirwa mu kanwa akenshi bufatirwa mu nini cyangwa mu mvange, bituma byoroha kuvura igihe kirekire ibibazo by'intege nke z'imitsi.

Neostigmine ikoreshwa mu iki?

Neostigmine ahanini yandikirwa kuvura myasthenia gravis, indwara idakira y'umubiri w'abarwanya indwara itera intege nke z'imitsi no kunanirwa. Irashobora kunoza cyane ubushobozi bwawe bwo gukora ibikorwa bya buri munsi nk'urumwa, kumira, no kwimuka.

Muganga wawe ashobora no kukwandikira neostigmine ku zindi ndwara zigira ingaruka ku mikorere y'imitsi. Izi zirimo ubwoko bumwe na bumwe bw'intege nke z'imitsi nyuma yo kubagwa cyangwa izindi nzira z'ubuvuzi.

Mu bihe bimwe na bimwe, abaganga bakoresha neostigmine kugira ngo bafashe guhindura ingaruka z'imiti imwe n'imwe ishobora kubangamira imikorere y'imitsi, cyane cyane nyuma y'inzira z'ubuvuzi zisaba imiti iruhura imitsi.

Ni gute Neostigmine ikora?

Neostigmine ikora ibuza enzyme yitwa acetylcholinesterase. Iyi enzyme isanzwe isenya acetylcholine, umuti w'imiti ufasha imitsi yawe kwikurura igihe ubwonko bwawe butanze ibimenyetso.

Mugukingira uku gusenyuka, neostigmine yemerera ko acetylcholine nyinshi ziguma ziboneka ahantu hahuza imitsi yawe n'imitsi. Ibi bivuze ko imitsi yawe yakira ibimenyetso bikomeye kandi byumvikana neza byo kwikurura no gukora neza.

Uyu muti ufatwa nkukomeye ku rugero ruciriritse kandi akenshi utangira gukora nyuma y'iminota 30 kugeza ku masaha 2 nyuma yo kuwufata. Ibyo ukora bishobora kumara amasaha menshi, niyo mpamvu akenshi ufata inshuro nyinshi umunsi wose.

Nkwiriye gufata Neostigmine nte?

Fata neostigmine nkuko byategetswe na muganga wawe, akenshi inshuro 2 kugeza kuri 4 ku munsi hamwe n'ibiryo cyangwa amata. Kuwufata hamwe n'ibiryo bifasha kugabanya indwara zo munda kandi bigateza imbere uburyo umubiri wawe wunguka imiti.

Mimina ibinini byose hamwe n'ikirahure cyuzuye cy'amazi. Niba ufata urugero rw'amazi, koresha igikoresho cyo gupima cyatanzwe na farumasi yawe kugirango wemeze ko ubona urugero rukwiye.

Gerageza gufata urugero rwawe mu bihe bimwe buri munsi kugirango ugumane urugero rwawo ruzigama mumubiri wawe. Ibi bifasha kumenya imikorere yimitsi ihamye umunsi wose.

Birafasha kurya ifunguro ryoroheje cyangwa ifunguro rito mbere yo gufata neostigmine, kuko ibi bishobora kugabanya uburakari bushoboka bwo munda. Irinde kuwufata munda yuzuye keretse muganga wawe akubwiye byumwihariko kubikora.

Nkwiriye kumara igihe kingana iki mfata Neostigmine?

Igihe cyo kuvura neostigmine giterwa n'uburwayi bwawe bwihariye n'uburyo wunguka imiti. Kubijyanye na myasthenia gravis, ubu ni uburyo bwo kuvura burambye ushobora gukenera gukomeza igihe cyose.

Umuganga wawe azajya akurikirana uko umubiri wawe witwara ku muti, ashobora guhindura urugero rw'umuti cyangwa gahunda yo kuvura bitewe n'uko ibimenyetso byawe bigenda bikira cyangwa bihinduka uko iminsi igenda. Abantu bamwe basanga ibimenyetso byabo bigenda bigabanuka iyo bakoresha umuti buri gihe, mu gihe abandi bashobora gukenera guhindurirwa urugero rw'umuti.

Ntuzigere uhagarika gufata neostigmine mu buryo butunguranye utabanje kubiganiraho n'umuganga wawe. Guhagarika umuti mu buryo butunguranye bishobora gutuma ibimenyetso byo kunanirwa kw'imitsi bisubira cyangwa bikiyongera cyane, ibyo bishobora guteza akaga.

Ni Ibihe Bimenyetso Bigaragara Byatewe na Neostigmine?

Kimwe n'indi miti yose, neostigmine ishobora gutera ibimenyetso bigaragara, nubwo atari buri wese ubyumva. Ibimenyetso bigaragara byinshi bifitanye isano n'uko umuti ugira ingaruka ku mikorere y'imitsi yawe n'inzira yo mu gifu.

Dore ibimenyetso bigaragara bikunze kugaragara ushobora guhura nabyo:

• Urugaruka rwo kuruka no kuribwa
• Impiswi cyangwa kwituma impatwe
• Kuribwa mu nda cyangwa kubabara mu nda
• Kongera umusonga
• Kunyeganyega cyane kurusha uko bisanzwe
• Kunyeganyega kw'imitsi cyangwa kuribwa mu mitsi
• Umutwe
• Urugero

Ibi bimenyetso bigaragara bikunze koroha uko umubiri wawe wimenyereza umuti, akenshi mu byumweru bike bya mbere byo kuvurwa.

Ibimenyetso bikomeye ntibikunze kugaragara ariko bisaba ubufasha bw'ubuvuzi bwihuse. Ibi bishobora kuba harimo kuribwa mu nda cyane, kugorwa no guhumeka, umutima utera nabi, cyangwa ibimenyetso byo kwibasirwa n'umubiri nk'uruhu rurya, kurigata, cyangwa kubyimba.

Abantu bamwe bashobora guhura n'ibimenyetso bidasanzwe ariko bikomeye nko kunanirwa cyane kw'imitsi (bishobora kuba ikimenyetso cyo gufata umuti mwinshi), gufatwa n'ibihungabanyo, cyangwa kwibasirwa cyane n'umubiri. Niba ubonye ibimenyetso bidasanzwe, vugana n'umuganga wawe ako kanya.

Ni Bande Batagomba Gufata Neostigmine?

Neostigmine ntikwiriye kuri buri wese. Umuganga wawe azasuzuma neza amateka yawe y'ubuzima mbere yo kugutera uyu muti kugira ngo yemeze ko ari mutekano kuri wowe.

Ntugomba gufata neostigmine niba ufite indwara zimwe na zimwe zishobora gutuma umuti ugira akaga. Izi zirimo:

• Kubangamirwa mu mara cyangwa mu mpyisi
• Asima ikomeye cyangwa ibibazo byo guhumeka
• Umutima wateye vuba cyangwa umutima utagira umuvuduko uhamye
• Allergie izwi kuri neostigmine cyangwa imiti isa nayo
• Ubwoko bumwe na bumwe bwo kunanuka kw'imitsi bishobora kwiyongera n'uyu muti

Muganga wawe azitonda kandi mu gutanga neostigmine niba ufite ibibazo by'impyisi, indwara y'umwijima, cyangwa indwara zimwe na zimwe z'umutima, kuko ibi bishobora kugira ingaruka ku buryo umubiri wawe ukoresha umuti.

Abagore batwite cyangwa bonka bagomba kuganira ku byago n'inyungu n'umuganga wabo, kuko neostigmine ishobora kugira ingaruka ku mubyeyi n'umwana.

Amazina ya Neostigmine

Neostigmine iboneka mu mazina menshi y'ubwoko, Prostigmin ikaba ariyo izwi cyane. Farumasi yawe ishobora kugira ubwoko butandukanye, ariko zose zikubiyemo ikintu kimwe gikora.

Ubwoko bwa neostigmine rusange buraboneka kandi bukora neza nk'ubwoko bw'amazina. Muganga wawe cyangwa umufarumasiti ashobora kugufasha gusobanukirwa ubwoko bushobora kuba bwiza ku byo ukeneye.

Ubwoko bumwe na bumwe bushobora kuza mu mbaraga zitandukanye cyangwa mu buryo butandukanye, bityo ni ngombwa gukomeza gukoresha ubwoko bumwe n'uburyo bumwe umaze kubona ubukora neza kuri wowe, keretse muganga wawe abigushishikarije.

Uburyo bwo gusimbuza Neostigmine

Niba neostigmine itagukundiye cyangwa ikagutera ingaruka zikubangamiye, muganga wawe ashobora gutekereza ku zindi nzira zo kuvura. Pyridostigmine ni umuti usa n'uyu ukora mu buryo bumwe ariko ushobora kwihanganirwa neza n'abantu bamwe.

Izindi nzira zishobora kuba zirimo ubwoko butandukanye bw'imiti ishyigikira imikorere y'imitsi, nk'imiti ikumira ubudahangarwa ku ndwara ziterwa n'ubudahangarwa bw'umubiri, cyangwa izindi cholinesterase inhibitors zishobora gukwira neza ibyo ukeneye.

Umuvuzi wawe ashobora no kugusaba uburyo bwo kuvura bwunganira nk'imiti ivura imitsi, guhindura imirire, cyangwa guhindura imibereho kugira ngo bifashe mu kugenzura ibimenyetso byawe hamwe n'imiti.

Ese Neostigmine iruta Pyridostigmine?

Bombi neostigmine na pyridostigmine ni imiti ikora neza izwi nka cholinesterase inhibitors ikora kimwe kugira ngo iteze imbere imikorere y'imitsi. Guhitamo hagati yabo akenshi biterwa n'uburyo umubiri wawe wabyakiriye n'uburyo wihanganira buri muti.

Pyridostigmine ikunda kumara igihe kirekire ikora, bivuze ko ushobora gukenera kuyifata kenshi umunsi wose. Abantu bamwe kandi basanga itera ingaruka nke zo mu gifu kurusha neostigmine.

Ariko, neostigmine ishobora gukora neza ku bantu bamwe cyangwa ubwoko bwihariye bw'intege nke z'imitsi. Muganga wawe azatekereza ibintu nk'uburyo ibimenyetso byawe bimeze, imibereho yawe, n'uburyo wihanganira buri muti mugihe atanga inama.

Icyemezo

Ntugerageze kwivuza wenyine iyo wamaze gufata umuti mwinshi. Shakisha ubufasha bw'abaganga ako kanya, cyane cyane niba ufite ikibazo cyo guhumeka, kuribwa mu nda cyane, cyangwa kumva unaniwe cyane cyangwa uruka.

Nigute nzakora niba nirengagije gufata urugero rwa Neostigmine?

Niba wirengagije gufata urugero, rufate uko wibuka, keretse igihe cyo gufata urugero rukurikira kigeze. Muri icyo gihe, reka urugero wibagiwe ukomeze gahunda yawe isanzwe.

Ntuzigere ufata urugero rurenze rumwe kugirango wuzuze urwo wibagiwe, kuko ibyo bishobora kongera ibyago byo kugira ingaruka ziterwa n'umuti. Niba ukunda kwibagirwa gufata imiti, tekereza gushyiraho ibyibutso kuri terefone cyangwa gukoresha igikoresho cyo gutegura imiti kugirango bigufashe kuguma ku murongo.

Nshobora guhagarika ryari gufata Neostigmine?

Hagarika gufata neostigmine gusa igihe muganga wawe akubwiye ko byemewe. Kubantu benshi bafite myasthenia gravis, iyi ni imiti ikoreshwa igihe kirekire ifasha gucunga ibimenyetso bikomeza.

Muganga wawe azagenzura imiti yawe buri gihe kandi ashobora guhindura urugero rwawe cyangwa atekereze guhagarika umuti niba ubuzima bwawe burushaho gukomera cyane cyangwa niba izindi miti iba ikwiriye kurushaho kubera uko ubuzima bwawe bumeze.

Nshobora gutwara imodoka niba mfata Neostigmine?

Neostigmine ishobora gutera kuruka cyangwa ikagira ingaruka ku mikorere y'imitsi yawe, ibyo bishobora kugira ingaruka ku bushobozi bwawe bwo gutwara imodoka neza. Uko utangiye gufata uyu muti, irinde gutwara imodoka kugeza umenye uko bigufata.

Igihe umaze kumenyera imiti yawe kandi ibimenyetso byawe bigacungwa neza, abantu benshi bashobora gutwara imodoka neza. Ariko, jya ukoresha ubwenge bwawe kandi wirinde gutwara imodoka niba wumva uruka, unaniwe, cyangwa ufite ibimenyetso bibangamiye.