Nintedanib ni iki: Ibikoresho, Uburyo bwo gufata imiti, Ingaruka zayo n'ibindi

Nintedanib ni umuti wandikirwa na muganga ufasha kugabanya imitsi y'ibihaha mu bantu bafite indwara zikomeye z'ibihaha. Yagenewe by'umwihariko kwibasira poroteyine zitera imitsi y'ibihaha mu buryo burenze urugero, bigaha umubiri wawe amahirwe yo guhumeka neza uko igihe kigenda gihita.

Uyu muti ugaragaza intambwe ikomeye mu kuvura indwara zari zifite agaciro ko kutavurwa. Nubwo utavura imitsi y'ibihaha, ushobora kugabanya cyane uko bigenda bikura kandi ugatuma ubuzima bwawe bukomeza kuba bwiza.

Nintedanib ni iki?

Nintedanib ni umuti uvura indwara wibanda ku cyo ugomba kuvura kandi ukaba mu cyiciro cy'imiti yitwa tyrosine kinase inhibitors. Tekereza nk'igikoresho cy'ukuri gihagarika poroteyine zihagarariye gukora imitsi y'ibihaha mu buryo burenze urugero.

Uyu muti uza mu buryo bw'ibinini byoroshye kandi ufashwa mu kanwa kabiri ku munsi. Yatejwe imbere by'umwihariko ku bantu ibihaha byabo byangizwa n'imitsi idasanzwe ituma guhumeka bigenda bigorana.

Bitandukanye n'imiti ya kera yafataga gusa ibimenyetso, nintedanib ifata neza indwara yihishe. Ibi bituma iba imiti ihindura indwara aho kuba umuti uvura gusa ibimenyetso.

Nintedanib ikoreshwa mu kuvura iki?

Nintedanib ikoreshwa cyane cyane mu kuvura idiopathic pulmonary fibrosis (IPF), indwara ikomeye y'ibihaha aho imitsi y'ibihaha isanzwe isimbuzwa n'imitsi. Yemerejwe kandi gukoreshwa mu zindi ndwara zimwe na zimwe ziterwa n'imitsi y'ibihaha.

IPF ifata abantu bagera ku 100,000 muri Leta Zunze Ubumwe z'Amerika kandi ikunda kugaragara ku bantu barengeje imyaka 50. Ijambo "idiopathic" risobanura ko abaganga batazi neza icyo bitera, ariko imitsi ituma ibihaha byawe bikakara kandi guhumeka bikagorana.

Muganga wawe ashobora no kugusaba nintedanib ku ndwara y’umwijima iterwa na systemic sclerosis-associated interstitial lung disease (SSc-ILD). Ibi bibaho iyo indwara y’ubwirinzi yitwa scleroderma yibasira ibihaha byawe, igatera ibibazo bisa n’ibyo gukomerera.

Mu bindi bihe, abaganga bashobora gukoresha nintedanib ku zindi ndwara ziterwa no gukomerera kw’ibihaha iyo gukomerera bikomeza kwiyongera nubwo hakoreshejwe izindi miti. Ariko, gukoresha ubu buryo bisaba isuzuma ryitondewe n’inzobere mu by’ibihaha.

Nintedanib ikora ite?

Nintedanib ikora ibuza imitsi itatu yihariye ikura ikoreshwa mu gukomerera mu bihaha byawe. Iyi mitsi isanzwe ifasha mu gukira, ariko mu gukomerera kw’ibihaha, irakabya kandi igakora uruhu rwinshi rwakomeretse.

Uyu muti ufatwa nk'umuti ukomeye wifuzwa kandi usaba gukurikiranwa neza. Si umuti woroshye, ariko akenshi urihanganirwa neza iyo ukoreshejwe hakurikijwe ubujyanama bw’abaganga.

Mu kubuza ibi bimenyetso bikabije, nintedanib ifasha kugabanya umuvuduko aho imitsi y’ibihaha ikora neza isimburwa n’uruhu rwakomeretse. Ibi bishobora gufasha kubungabunga imikorere y’ibihaha byawe n’ubushobozi bwo guhumeka igihe kirekire.

Uyu muti kandi ufite n’ingaruka zo kurwanya umubyimbirwe, bishobora gufasha kugabanya ibyangiritse bikomeza mu mitsi y’ibihaha byawe. Ariko, imbaraga zayo zibanze ziri mu guhagarika gukomerera aho gukura ibyangiritse byari bisanzweho.

Nkwiriye gufata nte nintedanib?

Nintedanib ikwiriye gufatwa nk'uko byategetswe na muganga wawe, akenshi 150 mg kabiri ku munsi, mu masaha nka 12. Kuyifata hamwe n’ibiryo ni ngombwa kuko ibi bigabanya cyane kuribwa mu gifu kandi bifasha umubiri wawe gukoresha neza uyu muti.

Minya ibinini byose hamwe n’ikirahure cyuzuye cy’amazi. Ntukagure, ukoremo agapfu, cyangwa urume ibinini, kuko ibi bishobora gutera umujinya mu kanwa kawe no mu muhogo kandi bishobora kugira ingaruka ku buryo uyu muti ukora.

Gufata nintedanib hamwe n'ifunguro cyangwa ifunguro rirambuye ni ngombwa kugira ngo wumve neza. Ibyo kurya ntibisabwa kuba byinshi, ariko kugira ikintu mu gifu cyawe bifasha kwirinda isesemi no guhungabana mu igogora bikunda kubaho iyo ufata uyu muti.

Gerageza gufata imiti yawe mu gihe kimwe buri munsi kugira ngo ugumane urwego ruzigama mu mubiri wawe. Abantu benshi babona ko bifasha gufata urugero rumwe hamwe na saftu n'urundi hamwe na dineri.

Niba uhuye no guhungabana gukabije mu gifu, muganga wawe ashobora kugabanya urugero rw'umuti by'agateganyo cyangwa akagusaba ibiryo byihariye bikora neza hamwe n'umuti. Ntukigere uhindura urugero rw'umuti wawe utabanje kugisha inama kwa muganga.

Nzagomba Gufata Nintedanib Igihe Kingana Gite?

Nintedanib akenshi ni uburyo bwo kuvura burambye ushobora gukenera gukomeza igihe cyose, igihe cyose bifasha kugabanya imitsi y'ibihaha byawe kandi ukaba ubasha kubyihanganira neza. Abantu benshi babifata imyaka aho kubifata amezi.

Muganga wawe azakurikiza iterambere ryawe binyuze mu bipimo bisanzwe by'imikorere y'ibihaha, ibipimo by'igituza, n'ibizamini by'amaraso. Ibi bifasha kumenya niba umuti ukora neza kandi niba ari byiza ko ukomeza.

Intego ni ukugabanya iterambere ry'imitsi y'ibihaha igihe gishoboka cyose. Guhagarika umuti akenshi bituma uburyo bwo kwangirika busubira ku muvuduko wabwo wari usanzweho, ni yo mpamvu kuvurwa buri gihe bikunze gushyirwaho.

Abantu bamwe bashobora gukenera guhagarika umuti igihe bafite ingaruka ziterwa n'umuti zikeneye igihe kugira ngo zikemuke. Muganga wawe azakorana nawe kugira ngo abone uburyo bukwiye hagati y'imikorere n'ubushobozi bwo kwihanganira.

Ni Izihe Ngaruka Ziterwa na Nintedanib?

Kimwe n'imiti yose, nintedanib ishobora gutera ingaruka ziterwa n'umuti, nubwo atari buri wese uzibona. Ingaruka zikunze kubaho zirashoboka kandi akenshi zikora neza uko umubiri wawe wimenyereza umuti.

Reka dutangire n'ingaruka ziterwa n'umuti ushobora guhura nazo cyane, zikora ku bantu benshi bafata uyu muti:

• Impiswi (bigera ku 60% by'abantu) - akenshi yoroheje kugeza hagati kandi igakemuka hakoreshejwe impinduka mu mirire
• Urugimbu n'igifu kitameze neza - gufata umuti hamwe n'ibiryo bifasha cyane
• Kugabanya ubushake bwo kurya no kugabanya ibiro - muganga wawe azabikurikirana hafi
• Urubavu cyangwa kuribwa mu nda - akenshi biragenda bikemuka uko igihe gihita kandi hakoreshejwe imirire ikwiye
• Kuruka - ntibisanzwe cyane nko kurugimbu ariko birashobora kubaho, cyane cyane mu byumweru bike bya mbere

Izi ngaruka zo mu rwungano rw'igogora ni zo zikunze kuvugwa cyane, ariko akenshi zirushaho gukemuka uko umubiri wawe umenyera umuti.

Abantu bamwe baragira ingaruka zitagaragara cyane ariko zikwiye kwitabwaho:

• Enzime z'umwijima zizamutse - zigaragazwa n'ibizamini by'amaraso, akenshi nta bimenyetso
• Umunaniro cyangwa gucika intege - bishobora gufitanye isano n'umuti cyangwa uburwayi bwawe bw'ibihaha
• Umutwe - akenshi woroheje kandi ukemurwa n'imiti igurishwa itagomba uruhushya rwa muganga
• Umuzungu - bikunze kubaho iyo utangiye gufata umuti cyangwa wongera urugero
• Uruhu rurashya cyangwa kurigata - akenshi byoroheje ariko bikwiye kumenyeshwa muganga wawe

Muganga wawe azagenzura imikorere y'umwijima wawe buri gihe kuko nintedanib ishobora kugira ingaruka ku nzima z'umwijima ku bantu bamwe.

Noneho, reka tuganire ku ngaruka zidakunze kubaho ariko zikomeye zisaba ubufasha bwihutirwa bwa muganga:

• Ibibazo bikomeye by'umwijima - ibimenyetso birimo umuhondo w'uruhu cyangwa amaso, inkari z'umukara, cyangwa kuribwa cyane mu nda
• Ibibazo by'umutima - kuribwa mu gituza, umutima utera nabi, cyangwa guhumeka nabi bidasanzwe
• Ibibazo byo gupfundika kw'amaraso - kuva amaraso bidasanzwe cyangwa gukomereka, cyane cyane niba bikomeye
• Ibibazo bikomeye by'ibihaha - gukorora gushya cyangwa gukomera, umuriro, cyangwa guhumeka bigoranye
• Uruhu rukomeye - uruhu rwakwiriye hose, guhura ibishyitsi, cyangwa gukuraho uruhu

Izi ngaruka zikomeye ntizisanzwe, ariko ni ngombwa kuzimenya kandi gushaka ubufasha bw'ubuvuzi ako kanya niba bibaye.

Ninde Utagomba Gufata Nintedanib?

Nintedanib ntibereye buri wese, kandi muganga wawe azagenzura neza niba bifitiye umutekano bitewe n'amateka yawe y'ubuzima n'ubuzima bwawe ubu.

Ntugomba gufata nintedanib niba ufite allergie yayo, soya, cyangwa ubunyobwa, kuko ibinini birimo soya lecithin. Abantu bafite hypersensitivity izwi ku kintu icyo aricyo cyose cy'umuti bagomba kuwureka rwose.

Indwara nyinshi zituma nintedanib ishobora kuba ikomeye cyangwa ikeneye ingamba zidasanzwe:

• Indwara ikomeye y'umwijima cyangwa ibibazo by'umwijima bikora - umuti ushobora gutuma imikorere y'umwijima irushaho kuba mibi
• Umutima warwaye vuba cyangwa indwara y'umutima idahagaze neza - nintedanib ishobora kugira ingaruka ku mutima
• Indwara zikora ziva amaraso - umuti ushobora kongera ibyago byo kuva amaraso
• Indwara ikomeye y'impyiko - impyiko zawe zigufasha gutunganya umuti
• Kubagwa gukomeye vuba - ibyago byiyongera byo kuva amaraso mugihe cyo gukira

Gusama no konsa ni ibintu bitagomba gukorwa, kuko nintedanib ishobora kwangiza abana bakiri bato kandi ishobora kujya mu mata y'ibere.

Abantu bamwe bakeneye gukurikiranwa by'umwihariko ariko bashobora gukomeza gufata nintedanib hamwe n'imivugurire:

• Ibibazo by'umwijima byoroheje kugeza hagati - bisaba guhindura urugero rwa dose no gukurikiranwa kenshi
• Amateka y'ibibazo by'umutima - bikeneye isuzuma ry'umutima no gukurikiranwa buri gihe
• Gufata imiti ituma amaraso ataguma - bisaba guhuza neza na muganga wawe
• Abantu bakuze - bashobora gukenera urugero ruto rwa dose bitewe no kwiyongera kw'ubwumvikane
• Abantu bafite ibisebe byo mu gifu - ibyago byinshi byo guhura n'ibibazo byo mu gihe cy'igogora

Muganga wawe azagereranya inyungu n'ibyago by'imimerere yawe yihariye kandi ashobora gushimangira ko hakoreshwa ubundi buvuzi niba nintedanib itagukwiriye.

Amazina y'ubwoko bwa Nintedanib

Nintedanib iboneka munsi y'izina ry'ubwoko rya Ofev mubihugu byinshi, harimo n'Amerika. Iri niryo zina ry'ubwoko rizwi cyane ry'uyu muti.

Mu turere tumwe na tumwe, ushobora guhura na nintedanib mu mazina y'ubwoko butandukanye, ariko Ofev iracyari izina rikuru rikoreshwa n'abavuzi benshi n'amavuriro.

Uyu muti ukorwa na Boehringer Ingelheim, isosiyete ikora imiti y'ubuvuzi yihariye mu miti y'ubuhumekero. Ingero rusange za nintedanib ntiziraboneka cyane mu masoko menshi.

Igihe uvugana n'abavuzi cyangwa abagurisha imiti ku bijyanye n'umuti wawe, ushobora kuwuvuga ukoresheje izina rusange (nintedanib) cyangwa izina ry'ubwoko (Ofev). Amazina yombi yerekeza ku muti umwe.

Uburyo bwo gusimbuza Nintedanib

Niba nintedanib itagukwiriye cyangwa idakora neza, hariho uburyo bwinshi bwo kuvura indwara ya pulmonary fibrosis. Muganga wawe azagufasha kumenya uburyo bwiza bushingiye ku burwayi bwawe bwihariye n'amateka yawe y'ubuvuzi.

Pirfenidone (izina ry'ubwoko Esbriet) ni undi muti wemewe na FDA wo kuvura idiopathic pulmonary fibrosis. Ikora mu buryo butandukanye na nintedanib mu kugabanya umubyimbire no gutinda imiterere y'igice cy'inyama zikomeretse binyuze mu nzira zitandukanye.

Ku bantu bamwe, imiti gakondo iracyakwiriye:

• Corticosteroids - ifasha kugabanya umubyimbire ariko ifite ingaruka nke kuri IPF
• Imiti igabanya ubudahangarwa - ishobora gukoreshwa mu bwoko bumwe na bumwe bwa pulmonary fibrosis
• Ubuvuzi bwa oxygen - bufasha mu bimenyetso byo guhumeka ariko ntibugabanya iterambere ry'indwara
• Urukurikirane rwa pulmonary - imyitozo na gahunda zo guhumeka kugira ngo bakomeze imikorere

Mu gihe indwara igeze kure, gushyirwa mu ngingo y'ibihaha bishobora gutekerezwa ku barwayi bemerewe batitabira imiti.

Abantu bamwe bungukirwa n'inzira zifatanyije, nko gukoresha imiti hamwe n'ubuvuzi bwa oxygen n'urukurikirane rwa pulmonary. Umuganga wihariye mu bijyanye n'ibihaha azakora gahunda yuzuye yo kuvura ijyanye n'ibyo ukeneye.

Ese Nintedanib iruta Pirfenidone?

Nintedanib na pirfenidone zombi ni imiti ikora neza mu kuvura indwara ya idiopathic pulmonary fibrosis, ariko zikora zinyuze mu buryo butandukanye kandi zifite ingaruka zitandukanye. Nta na imwe ifatwa nk'iy'"icyiza" kurusha iyindi ku barwayi bose.

Ubushakashatsi bwerekana ko imiti yombi ishobora gutuma imikorere y'ibihaha itagenda nabi cyane. Guhitamo hagati yazo akenshi biterwa n'ingaruka ushobora kwihanganira cyane n'ubuzima bwawe bwite.

Nintedanib ikunda gutera ingaruka zifitanye isano no mu nda nka diarée na mburugu, mugihe pirfenidone ikunda gutera uruhu gukabya ku zuba no kuribwa mu nda. Abantu bamwe bihangana n'imwe kurusha iyindi.

Muganga wawe azatekereza ibintu byinshi mugihe ahitamo hagati yiyi miti, harimo izindi ndwara ufite, imiti urimo gufata, n'imibereho yawe. Ihitamo "ryiza" ni irikora neza kubuzima bwawe bwihariye.

Mu bihe bimwe na bimwe, abaganga bashobora kubanza kugerageza umuti umwe hanyuma bakimukira ku wundi niba uwo bagerageje utihanganirwa neza cyangwa utagaragara ko ukora neza.

Ibibazo Bikunze Kubazwa Kuri Nintedanib

Q1. Nintedanib Irasa neza ku bantu barwaye indwara z'umutima?

Nintedanib irashobora gukoreshwa ku bantu bafite indwara z'umutima zidakomeye, ariko bisaba gukurikiranwa neza na muganga wawe. Uyu muti ushobora kugira ingaruka ku mutima no kongera ibyago by'ingaruka zifitanye isano n'umutima.

Niba ufite amateka y'ibibazo by'umutima, muganga wawe ashobora gushaka gukora ibizamini by'imikorere y'umutima mbere yo gutangira nintedanib no kugukurikirana cyane mugihe uvurwa. Abantu bafite ibitero by'umutima bya vuba cyangwa ibibazo by'umutima bidakomeye bashobora gukenera kwirinda uyu muti.

Umuvuzi w'indwara z'umutima n'inzobere mu by'ibihaha bazakorana kugirango bamenye niba nintedanib ikwiriye kuri wowe kandi n'uburyo bwo kugukurikirana kugirango ukoreshe neza.

Q2. Nzakora iki niba mfashe nintedanib nyinshi ku buryo butunguranye?

Niba wanyoye nintedanib nyinshi kurusha uko byagutegetswe, vugana n'umuganga wawe cyangwa ikigo gishinzwe imiti ihumanya ako kanya. Ntuzategereze kureba niba ibimenyetso bigaragara, kuko gufata icyemezo vuba bifitiye akamaro umutekano wawe.

Kunywa nintedanib nyinshi bishobora kongera ibyago byo kugira ingaruka zikomeye, cyane cyane ibibazo by'umwijima n'ibibazo by'amaraso. N'iyo wumva umeze neza, isuzuma ryo kwa muganga ni ngombwa kugira ngo wemeze ko nta kibazo cyabaye.

Zana urupapuro rw'umuti hamwe nawe mu cyumba cy'abarwayi cyangwa urugireho igihe uhamagaye ukeneye ubufasha. Iri somo rifasha abaganga kumenya uburyo bwiza bwo gukora.

Q3. Ninkora iki niba nirengagije urugero rwa Nintedanib?

Niba wirengagije urugero rwa nintedanib, rinywe ako kanya wibuka, igihe cyose bitarenze amasaha make uhereye igihe cyari giteganijwe. Ariko, niba igihe cyo gufata urugero rukurikira kigeze, renga urugero wirengagije ukomeze gahunda yawe isanzwe.

Ntuzigere unywa urugero ebyiri icyarimwe kugira ngo usimbure urugero wirengagije, kuko ibi bishobora kongera ibyago byo kugira ingaruka. Biruta kurenga urugero rumwe kurusha kubikuba kabiri.

Niba ukunda kwibagirwa urugero, tekereza gukoresha igikoresho cyo gutegura imiti cyangwa gushyiraho ibyibutso kuri terefone. Kunywa imiti buri gihe bifasha kugumisha urugero rwawo mu mubiri wawe kugira ngo ukore neza.

Q4. Nshobora guhagarika kunywa Nintedanib ryari?

Ugomba guhagarika kunywa nintedanib gusa ukurikije ubuyobozi bw'umuganga wawe. Ubu ni uburyo bwo kuvura burambye, kandi kubihagarika mubisanzwe bituma uburyo bwo gukomera kw'ibihaha busubira ku murongo wabwo wa mbere.

Umuganga wawe ashobora kugusaba guhagarika kunywa nintedanib niba ugize ingaruka zikomeye zitagira icyo zihindura n'ubwo urugero rwahinduwe, niba imikorere y'ibihaha byawe ikomeza kugabanuka nubwo uvurwa, cyangwa niba utakibasha kwihanganira umuti.

Rimwe na rimwe, guhagarika imiti by'agateganyo birakenewe kugira ngo hacungwe ingaruka ziterwa nayo, ariko abantu benshi bongera kuyifata igihe ibibazo bikemutse. Buri gihe ganira ibikubangamiye n'ikipe yawe y'ubuvuzi mbere yo kugira impinduka izo ari zo zose ku buryo uvurwa.

Q5. Nshobora gufata Nintedanib hamwe n'indi miti?

Nintedanib irashobora gukururana n'indi miti myinshi, bityo ni ngombwa kubwira muganga wawe imiti yose wandikiwe, imiti itagurishwa ku gasoko, n'ibyongerera imiti urimo gufata. Imwe mu mibumbe irashobora guteza akaga cyangwa ikagabanya imikorere y'imiti uvurwa.

Imiti igabanya amaraso nka warfarin isaba kwitabwaho by'umwihariko kuko nintedanib ishobora kongera ibyago byo kuva amaraso. Muganga wawe azakenera gukurikiranira hafi uko amaraso yawe akama niba ufata iyo miti yombi.

Antibiyotike zimwe na zimwe, imiti irwanya imyungu, n'imiti ivura indwara zifata ubwonko zirashobora kugira ingaruka ku buryo umubiri wawe ukoresha nintedanib. Muganga wawe ashobora gukenera guhindura doze cyangwa agahitamo indi miti yo kwirinda gukururana gukomeye.