Icyo Obeticholic Acid Aricyo: Ibikoresho, Uburyo Bwo Gukoresha, Ingaruka Ziterwa n'ibindi

Obeticholic acid ni umuti wandikirwa na muganga ufasha kuvura indwara zimwe na zimwe z'umwijima mu kwigana ikintu gisanzwe umubiri wawe ukora kugira ngo utunganye imisemburo ya bile. Uyu muti ukora by'umwihariko ku bantu bafite indwara ya primary biliary cholangitis, indwara idasanzwe yo mu rwego rwo kwirinda umubiri yangiza buhoro buhoro imiyoboro ya bile mu mwijima wawe.

Niba muganga wawe yaraguhaye uyu muti, birashoboka ko ufite ibibazo byerekeye uko ukora n'icyo witegura. Reka tunyuremo ibintu byose ukeneye kumenya kuri obeticholic acid mu magambo yoroshye kandi asobanutse.

Obeticholic Acid Ni Iki?

Obeticholic acid ni verisiyo ya sintetike ya aside ya bile isanzwe iboneka mu mubiri wawe. Igenzurwa mu cyiciro cy'imiti yitwa farnesoid X receptor agonists, ibyo byumvikana bigoye ariko bisobanura ko ikora imikorere yihariye mu mwijima wawe.

Umwijima wawe usanzwe ukora aside ya bile kugira ngo ifashe gutunganya amavuta no gukuraho imyanda. Iyo ufite indwara zimwe na zimwe z'umwijima, iyi mikorere ntikora neza. Obeticholic acid yinjira kugira ngo ifashe gusubiza mu buryo bumwe imikorere isanzwe mu kugaragaza umwijima wawe kugira ngo ugabanye ikorwa rya aside ya bile no kugabanya ububyimbirwe.

Uyu muti ni mushya ku isoko, wemerejwe na FDA mu 2016. Uvuga iterambere rikomeye mu kuvura indwara zidasanzwe z'umwijima zari zifite uburyo bwo kuvurwa butagira umubare.

Obeticholic Acid Ikoreshwa Kuri Iki?

Obeticholic acid ikoreshwa cyane mu kuvura primary biliary cholangitis (PBC), yahoze yitwa primary biliary cirrhosis. Iyi ni indwara idakira yo kwirinda umubiri aho urwego rwawe rwo kwirinda umubiri rukora amakosa rugatera imiyoboro mito ya bile mu mwijima wawe.

Muganga wawe ashobora kugutera umuti niba ufite PBC kandi niba utabasha kwihanganira aside ya ursodeoxycholic (umuti wa mbere ukoreshwa) cyangwa niba utarayisubiza neza. Intego ni kugabanya umuvuduko w’imikorere y’umwijima no kugabanya ibyago by’ingorane nka cirrhosis.

Ubu, aside ya obeticholic yemejwe by’umwihariko ku bantu bakuru bafite PBC. Abashakashatsi barimo kwiga uko yakoreshwa ku zindi ndwara z’umwijima, harimo na non-alcoholic steatohepatitis (NASH), ariko izi nshingano ziracyageragezwa.

Aside ya Obeticholic ikora ite?

Aside ya Obeticholic ikora mugihe ikoresha farnesoid X receptors mu mwijima wawe, mu mara, no mu mpyisi. Tekereza kuri izi receptors nk'ibishushanyo bigenzura uburyo umubiri wawe ukoresha aside ya bile n'uburwayi.

Iyo ufata uyu muti, ubwira umwijima wawe kugabanya umusaruro wa aside ya bile kandi ukagabanya gufata aside ya bile mu mara yawe. Ibi bifasha kugabanya ubwiyongere bwa aside ya bile bishobora kwangiza selile z'umwijima ku bantu bafite PBC.

Uyu muti kandi ufite ingaruka zirwanya ububyimbirwe, zishobora gufasha kugabanya uburyo bwo kurwanya umubiri wawe ku miyoboro ya bile. Ibi bifatwa nk'umuti ukomeye cyane ushobora kugira uruhare runini mu kugenzura imikorere y'umwijima, ariko ukora buhoro buhoro mu gihe cy'amezi aho gutanga ubufasha bwihuse.

Nkwiriye gufata aside ya Obeticholic nte?

Ukwiriye gufata aside ya obeticholic nk'uko muganga wawe abitegeka, akenshi rimwe ku munsi hamwe cyangwa nta funguro. Uyu muti uza mu buryo bw'ibinini ushira byose n'amazi.

Abantu benshi batangira n'urugero ruto rushobora kongerwa buhoro buhoro bitewe n'uko wihanganira umuti n'uko umwijima wawe witwara. Muganga wawe azagenzura ibizamini by'imikorere y'umwijima wawe buri gihe kugirango amenye urugero rukwiye kuri wewe.

Ushobora gufata uyu muti urya cyangwa utarya, ariko gerageza kuwufata ku gihe kimwe buri munsi kugira ngo urugero rwawo rugume mu mubiri wawe. Niba ugira ikibazo cyo kumira ibinini, ganira na muganga wawe ku buryo wabigenza, ariko ntukavunagure cyangwa ngo umene ibinini.

Mvura Nde Igihe Nzakoresha Umuti wa Obeticholic Acid?

Obeticholic acid akenshi ni umuti ukoreshwa igihe kirekire ugomba gukomeza gufata kugira ngo ugumane akamaro kawo. Kubera ko PBC ari indwara idakira, guhagarika umuti mubisanzwe bisobanura ko indwara izakomeza gutera imbere.

Muganga wawe azajya akurikirana uko witwara ku muti binyuze mu bipimo by'amaraso bigenzura imikorere y'umwijima wawe. Ibi bipimo bifasha kumenya niba umuti ukora neza kandi niba hakenewe guhindura urugero rwawo.

Igihe cyo kuvurwa gitandukanye ku muntu ku giti cye, ariko abantu benshi barwaye PBC bakeneye gufata imiti y'umwijima ubuzima bwabo bwose. Muganga wawe azaganira nawe ku gahunda yawe y'ubuvuzi bwite kandi agufashe gusobanukirwa icyo witegura mu miterere yawe yihariye.

Ni Iyihe Mbere Ibyo Gufata Obeticholic Acid Bitera?

Kimwe n'indi miti yose, obeticholic acid ishobora gutera ingaruka ziterwa n'imiti, nubwo atari buri wese uzihura. Ingaruka zisanzwe ni ubushye, bukaba bugira ingaruka ku bantu benshi bafata uyu muti.

Dore ingaruka zisanzwe ushobora guhura nazo:

• Ubushye bukaze (pruritus), cyane cyane nijoro
• Umunaniro cyangwa kumva unaniwe cyane
• Urubavu rurya cyangwa kutumva neza
• Uburibwe bw'ingingo
• Uburibwe mu muhogo
• Urugero
• Kugugara
• Urugo rw'uruhu

Ubushye bushobora kuba bukabije kandi bushobora kubangamira gusinzira. Niba ibi bibaye, muganga wawe ashobora guhindura urugero rwawo cyangwa agasaba imiti yo gufasha gucunga ubushye.

Ingaruka zitagaragara cyane ariko zikomeye zirimo:

• Uburwayi bw’umwijima burushaho kuba bubi (ntibibaho kenshi ariko birashoboka)
• Urugero rwo kwibasirwa n’umubiri cyane
• Impinduka zikomeye ku rugero rwa kolesteroli
• Ibibazo byo mu gifu cy’inyama

Vugana n’umuganga wawe ako kanya niba wumva uburibwe bukomeye mu nda, ibimenyetso by’ibibazo by’umwijima nk’uruhu rwawe cyangwa amaso yawe byihindura umuhondo, cyangwa urwo ari rwo rwose rwo kwibasirwa n’umubiri cyane.

Ninde utagomba gufata aside ya obeticholic?

Aside ya obeticholic ntikwiriye kuri buri wese, kandi umuganga wawe azasuzuma neza niba ikwiriye kuri wowe. Abantu bafite uburwayi runaka bagomba kwirinda uyu muti cyangwa bakawukoresha bitonze cyane.

Ntugomba gufata aside ya obeticholic niba ufite:

• Kubangamirwa kwuzuye kw’inzira z’igifu cy’inyama (inzira z’igifu cy’inyama zifunze)
• Uburwayi bukomeye bw’umwijima (icyiciro cya Child-Pugh B cyangwa C)
• Allergie izwi kuri aside ya obeticholic cyangwa ibindi biyigize
• Uburwayi bukomeye bw’impyiko

Umuganga wawe azitonda kandi mu gutanga uyu muti niba utwite, wonka, cyangwa uteganya gutwita, kuko nta makuru ahagije y’umutekano kuri ibi bihe.

Abantu bafite amateka y’indwara y’igifu cy’inyama, kolesteroli nyinshi, cyangwa izindi ndwara z’umwijima bashobora gukenera gukurikiranwa by’umwihariko mugihe bafata uyu muti. Buri gihe bwire umuganga wawe ibyerekeye uburwayi bwawe bwose n’imiti ufata mbere yo gutangira kuvurwa.

Amazina y’ubwoko bwa aside ya Obeticholic

Izina ry’ubwoko bwa aside ya obeticholic ni Ocaliva, ikorwa na Intercept Pharmaceuticals. Ubu nicyo gusa kiboneka muri Leta Zunze Ubumwe z'Amerika.

Ocaliva iza mu buryo bwa tablet muri ubushobozi butandukanye, mubisanzwe 5 mg na 10 mg. Umuganga wawe azandika ubushobozi bukwiye bushingiye ku byo ukeneye n’uburyo witwara ku buvuzi.

Ubwoko bwa rusange bwa aside ya obeticholic ntiburaboneka muri Leta Zunze Ubumwe z'Amerika, bityo Ocaliva nicyo gusa gishoboka ubu. Uyu muti ushobora guhenda cyane, bityo ganira na muganga wawe na farumasiye ku bijyanye n'ubwishingizi n'ubufasha ku barwayi.

Izindi nzira zo kuvura aside ya Obeticholic

Niba udashobora gufata aside ya obeticholic cyangwa niba itagukundira, hariho ubundi buryo bwo kuvura PBC. Uburyo busanzwe ni aside ya ursodeoxycholic (UDCA), akenshi ikoreshwa mbere.

Izindi nzira muganga wawe ashobora gutekereza zirimo:

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• Aside ya Ursodeoxycholic (Actigall, Urso) - akenshi igeragezwa mbere
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• Bezafibrate (ntiyemewe na FDA kuri PBC ariko ikoreshwa hanze y'icyemezo)
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• Budesonide (kubibazo bimwe na bimwe)
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• Guhindura umwijima (kubibazo byateye imbere)
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Muganga wawe azakorana nawe kugirango abone uburyo bwiza bwo kuvura bushingiye ku miterere yawe, izindi ndwara, n'uburyo wihanganira imiti itandukanye. Rimwe na rimwe guhuza imiti bitanga umusaruro kurusha umuti umwe.

Ese aside ya Obeticholic iruta aside ya Ursodeoxycholic?

Aside ya Obeticholic na aside ya ursodeoxycholic (UDCA) bikora mu buryo butandukanye kandi bifite uruhare rutandukanye mu kuvura PBC. UDCA akenshi ni umuti wa mbere abaganga bagerageza kuko imaze imyaka myinshi ikoreshwa mu buryo bwizewe.

Aside ya Obeticholic akenshi igenewe abantu batitabira neza UDCA cyangwa batayihanganira. Ubushakashatsi bwerekana ko aside ya obeticholic ishobora kugira akamaro kurusha UDCA yonyine mu kunoza ibizamini bimwe na bimwe by'imikorere y'umwijima.

Ariko,

Muganga wawe azareba ibisubizo byawe byihariye byo kwa muganga, ibimenyetso, n'uburyo wabyitwayemo ku zindi nshuti zivura kugira ngo afate icyemezo cy'umuti ukugirira neza. Rimwe na rimwe imiti ibiri ikoreshwa hamwe kugira ngo yongere imikorere.

Ibibazo Bikunze Kubazwa ku birebana na Obeticholic Acid

Ese Obeticholic Acid irakwiriye abantu barwaye diyabete?

Obeticholic acid irashobora gukoreshwa ku bantu barwaye diyabete, ariko bisaba gukurikiranwa neza. Uyu muti ushobora kugira ingaruka ku isukari yo mu maraso kandi ushobora guhura n'imiti ivura diyabete.

Muganga wawe azakurikirana isukari yo mu maraso yawe neza iyo utangiye gufata obeticholic acid, cyane cyane niba ufata insuline cyangwa indi miti ivura diyabete. Abantu bamwe bashobora gukenera guhindura gahunda yabo yo kuvura diyabete.

Buri gihe menyesha muganga wawe ibyerekeye diyabete yawe n'imiti yose ya diyabete ufata. Bashobora kugufasha gucunga ibibazo byombi mu buryo bwizewe kandi neza.

Nkwiriye gukora iki niba nanyweye obeticholic acid nyinshi mu buryo butunganye?

Niba unyweye obeticholic acid nyinshi mu buryo butunganye, vugana na muganga wawe cyangwa ikigo gishinzwe kurwanya uburozi ako kanya. Kunywa nyinshi bishobora gutuma ingaruka zikomeza cyangwa zigateza ibibazo by'umwijima.

Ntugerageze kwivugisha umuriro keretse niba ubitegetswe n'umuganga. Bika icupa ry'umuti hamwe nawe igihe ushakisha ubufasha bwa muganga kugira ngo abaganga bamenye neza icyo wanyoye n'ingano yacyo.

Reba ibimenyetso by'ingaruka zikomeye nk'uburibwe bukomeye, kuribwa cyane mu nda, cyangwa impinduka mu ruhu rwawe cyangwa ibara ry'amaso. Shakisha ubufasha bwa muganga ako kanya niba ubonye ibimenyetso bibangamiye.

Nkwiriye gukora iki niba nirengagije urugero rwa obeticholic acid?

Niba wibagiwe urugero rwa obeticholic acid, rinywe ako kanya wibukiye, keretse igihe cyegereye urugero rwawe rukurikira. Muri icyo gihe, reka urugero wibagiwe ukomeze gahunda yawe isanzwe.

Ntugasuzume imiti ibiri icyarimwe kugira ngo usimbure urugero rwasibye, kuko ibyo bishobora kongera ibyago byo kugira ingaruka ziterwa n'imiti. Niba ukunda kwibagirwa imiti, tekereza gushyiraho alarme ya buri munsi cyangwa gukoresha umuteguro w'imiti.

Niba usibye imiti myinshi cyangwa ufite impungenge zerekeye imiti wasibye igira ingaruka ku kuvurwa kwawe, vugana na muganga wawe kugira ngo akuyobore. Gukoresha imiti buri munsi bihoraho ni ngombwa kugira ngo imiti ikore neza.

Ni ryari nshobora kureka gufata aside ya obeticholic?

Ntabwo ugomba kureka gufata aside ya obeticholic utabanje kubiganiraho na muganga wawe. Kubera ko PBC ari indwara ihoraho, kureka kuvurwa mubisanzwe bisobanura ko indwara izakomeza gutera imbere.

Muganga wawe ashobora gutekereza kureka cyangwa guhindura imiti yawe niba ugize ingaruka zikomeye ziterwa n'imiti zitashobora gucungwa, niba imikorere y'umwijima wawe irushijeho kuba mibi cyane, cyangwa niba ugize ibibazo.

Gukurikiranwa buri gihe hamwe n'ibizamini by'amaraso bifasha muganga wawe kumenya niba imiti ikigufitiye akamaro kandi itagutera ibibazo. Bazafata icyemezo icyo aricyo cyose cyo kureka cyangwa guhindura uburyo uvurwa ukurikije uko wowe ubwawe witwara n'ubuzima bwawe muri rusange.

Nshobora kunywa inzoga nkanwa aside ya obeticholic?

Mubisanzwe ni byiza kwirinda inzoga mugihe ufata aside ya obeticholic, cyane cyane niba ufite indwara y'umwijima. Inzoga irashobora gutera umwijima kwangirika kandi ishobora kubangamira imikorere y'imiti.

Kubera ko aside ya obeticholic yandikirwa indwara z'umwijima, umwijima wawe umaze guhangana n'umuvuduko watewe n'indwara. Kongeraho inzoga birashobora gushyira umuvuduko wiyongera ku mwijima wawe kandi bishobora gutuma urushaho kuba mubi.

Niba ubu unywa inzoga, ganira ukuri na muganga wawe ku bijyanye no kunywa inzoga. Barashobora gutanga inama zihariye zishingiye ku ndwara y'umwijima wawe n'ubuzima bwawe muri rusange.