Olaparib (inzira yo kunywa)

Lynparza

Olaparib ikoreshwa nk'ubuvuzi bwo kubungabunga abarwayi bafite kanseri ya ovaire ikomeye, kanseri y'impyiko, cyangwa kanseri ya peritoneum y'ibanze ifite ubwoko runaka bwa gene ya BRCA idasanzwe irazwe (germline) cyangwa yabonetse (somatic). Muganga wawe azapima ubu bwoko bwa gene. Ikoreshwa ku barwayi bahawe ubuvuzi bwuzuye cyangwa bugufi bw'imiti yo kurwanya kanseri ifite platine. Olaparib ikoreshwa hamwe na bevacizumab nk'ubuvuzi bwo kubungabunga abarwayi bafite kanseri ya ovaire ikomeye, kanseri y'impyiko, cyangwa kanseri ya peritoneum y'ibanze ifite ubwoko runaka bwa gene ya BRCA idasanzwe cyangwa ikizamini cy'ibisebe by'umubiri kigaragaza kudakomera kwa genomic bitwa HRD. Muganga wawe azapima ubu bwoko bwa gene. Ikoreshwa ku barwayi bahawe ubuvuzi bwuzuye cyangwa bugufi bw'imiti yo kurwanya kanseri ifite platine. Olaparib kandi ikoreshwa mu kuvura kanseri ya ovaire, kanseri y'impyiko, cyangwa kanseri ya peritoneum y'ibanze ifite ubwoko runaka bwa gene ya BRCA idasanzwe irazwe (germline) cyangwa yabonetse (somatic) yasubiye. Muganga wawe azapima ubu bwoko bwa gene. Ikoreshwa ku barwayi bahawe ubuvuzi bwuzuye cyangwa bugufi bw'imiti yo kurwanya kanseri ifite platine. Olaparib kandi ikoreshwa mu kuvura kanseri y'ibere ya mbere idafite HER2 ku barwayi bahawe imiti yo kurwanya kanseri. Ikoreshwa niba uturemangingo twa kanseri dufite impinduka za germline BRCA. Muganga wawe azakoresha ikizamini kidasanzwe kugira ngo ashake izi mpinduka. Ihabwa abarwayi nyuma y'ubuganga bwo gukuraho umwimerere. Olaparib kandi ikoreshwa mu kuvura kanseri y'ibere ya metastasis (kanseri yikwiriye) idafite HER2 ku barwayi bahawe imiti yo kurwanya kanseri. Ikoreshwa niba uturemangingo twa kanseri dufite impinduka za germline BRCA. Muganga wawe azakoresha ikizamini kidasanzwe kugira ngo ashake izi mpinduka. Olaparib kandi ikoreshwa nk'ubuvuzi bwo kubungabunga abarwayi bafite kanseri ya pankirese ya metastasis (kanseri yikwiriye) ifite ubwoko runaka bwa gene ya BRCA idasanzwe irazwe (germline), indwara yabo itaratera imbere kandi bahawe imiti yo kurwanya kanseri ifite platine byibuze ibyumweru 16. Olaparib kandi ikoreshwa mu kuvura kanseri ya prostate ya metastasis idakira (kanseri ya prostate yikwiriye kandi idakira ubuvuzi cyangwa ubuvuzi bugabanya testosterone) ku barwayi bahawe imiti yo kurwanya kanseri (urugero, abiraterone, enzalutamide). Ikoreshwa niba uturemangingo twa kanseri dufite ubwoko runaka bwa gene ya HRR idasanzwe irazwe (germline) cyangwa yabonetse (somatic). Muganga wawe azapima ubu bwoko bwa gene. Olaparib ikoreshwa hamwe na abiraterone na prednisone cyangwa prednisolone mu kuvura kanseri ya prostate ya metastasis idakira (kanseri ya prostate yikwiriye kandi idakira ubuvuzi cyangwa ubuvuzi bugabanya testosterone) ifite ubwoko runaka bwa gene ya BRCA idasanzwe irazwe cyangwa yabonetse. Muganga wawe azapima ubu bwoko bwa gene. Uyu muti uboneka gusa ukurikije amabwiriza ya muganga wawe. Iyi miti iboneka mu buryo bukurikira:

Mu gufata icyemezo cyo gukoresha imiti, ibyago byo gufata iyo miti bigomba guhanurwa n'akamaro izagira. Iki ni icyemezo uzatanga hamwe na muganga wawe. Kuri iyi miti, ibi bikurikira bigomba kwitabwaho: Bwira muganga wawe niba wigeze ugira uburwayi budasanzwe cyangwa ubwoko bw'uburwayi buterwa na iyi miti cyangwa izindi miti. Nanone, bwira umuhanga mu by'ubuzima ufite andi moko y'uburwayi, nko ku biribwa, amabara, ibintu byongera ubuzima, cyangwa inyamaswa. Ku bicuruzwa bitagomba kwandikwa, soma witonze ibikubiye mu kinyamakuru cyangwa mu bipfunyika. Ubushakashatsi bukwiye ntabwo bwakozwe ku isano y'imyaka ku ngaruka za olaparib ku bana. Ubuziranenge n'ingaruka nziza ntibyarangiye. Ubushakashatsi bukwiye bwakozwe kugeza ubu ntabwo bwerekanye ibibazo byihariye by'abakuze byazagabanya ingaruka za olaparib ku bakuze. Nta bushakashatsi buhagije ku bagore bwo kumenya ibyago by'uruhinja mu gihe bakoresha iyi miti mu gihe cyo konsa. Pima inyungu zishoboka ugereranije n'ibyago bishoboka mbere yo gufata iyi miti mu gihe cyo konsa. Nubwo imiti imwe n'imwe idakwiye gukoreshwa hamwe na gato, mu bindi bihe imiti ibiri itandukanye ishobora gukoreshwa hamwe nubwo hariho isano ishobora kubaho. Muri uru rubanza, muganga wawe ashobora kwifuza guhindura umwanya, cyangwa izindi ngamba zishobora kuba ngombwa. Iyo ufashe iyi miti, ni ngombwa cyane ko umuhanga mu by'ubuzima azi niba ufashe imiti iri hasi. Ibi bikurikira byatoranijwe hashingiwe ku kamaro kabyo kandi si ngombwa ko ari byose. Gukoresha iyi miti hamwe n'imiti ikurikira ntibisanzwe bisabwa, ariko bishobora kuba ngombwa mubihe bimwe na bimwe. Niba imiti yombi yandikiwe hamwe, muganga wawe ashobora guhindura umwanya cyangwa ukuntu ukoresha imwe cyangwa imiti yombi. Imiti imwe n'imwe ntigomba gukoreshwa mu gihe cyo kurya cyangwa hafi yacyo cyangwa kurya bimwe mu bintu byo kurya kuko isano ishobora kubaho. Gukoresha inzoga cyangwa itabi hamwe n'imiti imwe na yo bishobora gutera isano. Ibi bikurikira byatoranijwe hashingiwe ku kamaro kabyo kandi si ngombwa ko ari byose. Gukoresha iyi miti hamwe n'ibikurikira ntibisanzwe bisabwa, ariko bishobora kuba bidashoboka mubihe bimwe na bimwe. Niba ikoreshwa hamwe, muganga wawe ashobora guhindura umwanya cyangwa ukuntu ukoresha iyi miti, cyangwa akaguha amabwiriza yihariye yerekeye ikoreshwa ry'ibiribwa, inzoga, cyangwa itabi. Kuba hari ibindi bibazo by'ubuzima bishobora kugira ingaruka ku ikoreshwa ry'iyi miti. Menya neza kubwira muganga wawe niba ufite ibindi bibazo by'ubuzima, cyane cyane: