Icyo Oliceridine ari cyo: Ibikoreshwa, Uburyo Bw'imiti, Ingaruka, n'ibindi

Oliceridine ni umuti mushya wandikirwa n'abaganga wo kugabanya ububabare ukoreshwa mu maraso (intravenous) kugira ngo uvure ububabare bwo hagati cyangwa bukomeye mu bitaro. Uyu muti ukora mu buryo butandukanye n'imiti gakondo yo kugabanya ububabare nka morufine, ushobora gutanga uburyo bwo kugabanya ububabare neza hamwe n'ibibazo bicye byo guhumeka n'ingaruka.

Niba uri mu gihe cyo kubagwa cyangwa ufite ububabare bukomeye busaba ubuvuzi mu bitaro, itsinda ryawe ry'abaganga rishobora gutekereza oliceridine nk'igice cy'uburyo bwawe bwo kuvura ububabare. Kumva uburyo uyu muti ukora birashobora kugufasha kumva witeguye kandi ufite icyizere ku buvuzi bwawe.

Oliceridine ni iki?

Oliceridine ni umuti wa sintetike wo kugabanya ububabare bwo mu gihe gito iyo izindi nshuti zitagikora. Igenzurwa mu cyiciro cy'imiti yitwa opioid agonists, bivuze ko ifatana n'uturemangingo twihariye mu bwonko bwawe n'umugongo kugira ngo ihagarike ibimenyetso by'ububabare.

Igituma oliceridine idasanzwe ni uburyo bwayo bwo gutoranya kuri utwo turemangingo. Mugihe imiti gakondo yo kugabanya ububabare igira ingaruka ku nzira nyinshi, oliceridine yibanda ku zihariye neza. Iki gikorwa cyibanda gishobora gufasha kugabanya zimwe mu ngaruka zisanzwe zo kugabanya ububabare mugihe igitanga uburyo bukomeye bwo kugabanya ububabare.

Uyu muti uboneka gusa mu bitaro no mu bigo by'ubuvuzi aho abaganga bashobora kugukurikiranira hafi. Ntabwo ari ikintu wakoresha mu rugo cyangwa ngo ukibone muri farumasi isanzwe.

Oliceridine ikoreshwa kubera iki?

Oliceridine ivura ububabare bwo hagati cyangwa bukomeye mu bantu bakuru bakeneye imiti yo kugabanya ububabare mu maraso mu bitaro. Muganga wawe ashobora kubikugiraho inama iyo imiti yo kugabanya ububabare yo kunywa itagikora cyangwa iyo udashobora gufata ibinini kubera kubagwa cyangwa indwara.

Ibyo oliceridine ishobora gukoreshwa harimo gukira nyuma yo kubagwa bikomeye, kubabara bikabije bitewe n'imvune, cyangwa ibihe by'ububabare bukomeye bisaba kwitabwaho byihutirwa mu bitaro. Bifasha cyane iyo ukeneye ubufasha bwihuse kandi bwiza bwo kugabanya ububabare bushobora gukurikiranwa no guhindurwa neza.

Uyu muti akenshi ugenewe gukoreshwa igihe gito uri mu bitaro. Itsinda ryawe ry'abaganga rizasuzuma niba oliceridine ari wo muti ukwiriye hashingiwe ku rwego rw'ububabare ufite, amateka yawe y'ubuzima, n'izindi nshuti urimo guhabwa.

Oliceridine ikora ite?

Oliceridine ikora yifatanya n'uturemangingo twa opioid mu bwonko bwawe no mu mugongo, by'umwihariko ikibanda ku icyo abahanga bita inzira ya G-protein. Uku kwifatanya guhitamo bifasha guhagarika ibimenyetso by'ububabare kugera mu bwonko bwawe, bitanga ubufasha ku bubabare bwo hagati cyangwa bukomeye.

Bitandukanye na opioids gakondo zikoresha inzira nyinshi z'uturemangingo, oliceridine yibanda cyane ku nzira zihagarika ububabare mugihe igira ingaruka nkeya ku nzira zitera ibibazo byo guhumeka. Iki gikorwa gihitamo nicyo gituma gifatwa nk'umuti wa opioid "utabogamye".

Uyu muti ufashwe nk'ukomeye mu muryango wa opioid. Ufite imbaraga kurusha imiti nka codeine ariko ishobora kugira ingaruka zitandukanye nka morphine cyangwa fentanyl. Umubiri wawe akenshi usubiza kuri oliceridine muminsi mike nyuma yo kuyihabwa binyuze muri IV yawe.

Nkwiriye gufata oliceridine nte?

Oliceridine itangwa gusa n'abakora mu buvuzi binyuze mu muyoboro wa IV mu bitaro. Ntabwo bizakugora kuyifata wenyine cyangwa kwibuka doze, kuko itsinda ryawe ry'abaganga rizita ku miyoborere yose no gukurikirana.

Uyu muti utangwa nk'urushinge rutinda rutaziguye mu urwungano rwawe rw'amaraso. Umuforomo wawe cyangwa muganga azabara neza doze ikwiriye hashingiwe ku kuremera kwawe, urwego rw'ububabare, n'uko witwara ku muti. Bazagukurikirana neza mugihe cyose no nyuma ya doze imwe.

Kubera ko oliceridine itangwa binyuze mu maraso, ntugomba gutekereza ku mikoranire y'ibiryo cyangwa igihe cyo kurya. Ariko, itsinda ryawe ry'ubuvuzi rishobora guhindura igihe ubonera doze bitewe n'umugambi wawe wose wo kuvurwa, imiti indi, cyangwa ibikorwa byateganyijwe.

Nzamara Mfata Oliceridine Igihe Kingana Gite?

Oliceridine yagenewe gukoreshwa igihe gito, akenshi kimara amasaha make kugeza ku minsi myinshi bitewe n'uko ukeneye gucunga ububabare bwawe. Abantu benshi bayihabwa gusa mu gihe bari mu bitaro kubera ububabare bukomeye cyangwa nyuma yo kubagwa.

Itsinda ryawe ry'ubuvuzi rizasuzuma buri gihe urwego rw'ububabare bwawe kandi rihindure cyangwa rihagarike oliceridine uko ubuzima bwawe buzamuka. Bashobora kuguha imiti yo kunywa igabanya ububabare cyangwa izindi nshuti uko ukira kandi witegura gusohoka.

Igihe nyacyo giterwa n'ibintu nk'ubwoko bw'ubuganga bwawe, uko ukira, n'uko wemera imiti. Abaganga bawe bazakorana nawe kugirango bakore gahunda yo gucunga ububabare irimo kureka imiti itangwa mu maraso igihe bikwiye.

Ni Iyihe Mbere Ibyo Oliceridine Igira?

Kimwe n'indi miti yose ya opioid, oliceridine irashobora gutera ingaruka mbi, nubwo abantu benshi bahura n'ibibazo bicye byo guhumeka ugereranije na opioid zisanzwe. Kumva icyo witegura birashobora kugufasha kuvugana neza n'itsinda ryawe ry'ubuvuzi kubyerekeye uko wumva.

Ingaruka zikunze kugaragara ushobora guhura nazo zirimo isesemi, kuruka, isereri, n'umutwe. Izi ngaruka muri rusange ziracungwa kandi itsinda ryawe ry'ubuvuzi rishobora gutanga imiti yo gufasha kugabanya kutumva neza. Abarwayi benshi basanga izi ngaruka zigabanuka uko umubiri wabo wimenyereza imiti.

Dore ingaruka zishobora kugaragara cyane mugihe uvurwa:

• Isesemi no kuruka
• Isereri cyangwa kumva umutwe
• Umutwe
• Kugwiza umubiri
• Gusinzira cyangwa kunanirwa
• Umunwa wumye
• Kurya cyangwa ibikorwa byo ku ruhu

Ibyo bibazo bikunze kugaragara bikunda kuba by'igihe gito kandi bishobora guhangana nabyo hakoreshejwe ubufasha mu gihe uri mu bitaro.

Ingaruka zikomeye ziragabanuka ariko zisaba ubufasha bwihuse bw'abaganga. Itsinda ry'ubuvuzi rikugenzura neza kubera ibyo bibazo, bishobora kurimo ibibazo bikomeye byo guhumeka, igabanuka ry'amaraso ryangiza, cyangwa ibimenyetso byo kwibasirwa n'umubiri.

Ingaruka zidakunze kugaragara ariko zikomeye zisaba ubufasha bwihuse bw'abaganga zirimo:

• Ingorane zikomeye zo guhumeka cyangwa guhumeka gake cyane
• Igabanuka rikomeye ry'amaraso cyangwa umuvuduko w'umutima
• Kwibasirwa n'umubiri bikomeye hamwe n'imivumo, kubyimba, cyangwa ingorane zo guhumeka
• Urujijo rwinshi cyangwa ingorane zo gukomeza kuba maso
• Urubavu cyangwa umutima utagenda neza
• Ibimenyetso bya syndrome ya serotonin niba byavanzwe n'indi miti runaka

Kubera ko wakira oliceridine mu bitaro, itsinda ryawe ry'ubuvuzi rishobora guhita rikemura ibimenyetso byose biteye impungenge.

Ninde utagomba gufata Oliceridine?

Oliceridine ntirigenda neza kuri buri wese, kandi itsinda ryawe ry'ubuvuzi rizareba neza amateka yawe y'ubuvuzi mbere yo gutekereza kuri uyu muti. Ibyiciro runaka cyangwa ibihe bituma oliceridine idakwiriye cyangwa ishobora guteza akaga ku barwayi bamwe.

Ntabwo ugomba kwakira oliceridine niba ufite ibibazo bikomeye byo guhumeka, ibibazo by'umutima runaka, cyangwa allergie zizwi ku miti ya opioid. Muganga wawe azirinda kandi uyu muti niba ufite indwara ikomeye y'umwijima cyangwa impyiko ishobora kugira ingaruka ku buryo umubiri wawe ukoresha uwo muti.

Abantu bagomba kwirinda oliceridine harimo abafite:

• Kugabanuka gukomeye kw'ubuhumekero cyangwa indwara zo guhumeka
• Allergie izwi kuri oliceridine cyangwa imiti isa na opioid
• Indwara ikomeye y'umwijima cyangwa impyiko
• Uburwayi runaka bw'umutima
• Asthma ikaze cyangwa ikomeye ya bronchial
• Gusenyuka kwa gastrointestinal

Itsinda ryawe ry’abaganga rizagereranya ibyo bintu n’icyo ukeneye kugira ngo ubabare bike kugira ngo bafate icyemezo cyiza cyane ku buzima bwawe.

Ubwitange bwihariye bukenewe ku bantu bakuze, abagore batwite, n’abantu bafite amateka yo gukoresha ibiyobyabwenge. Itsinda ryawe ry’abaganga rizagenzura neza ibyo bintu kandi rishobora guhitamo uburyo bwo kuvura ububabare butandukanye niba oliceridine ifite ibyago byinshi.

Izina ry’ubwoko bwa Oliceridine

Oliceridine iboneka munsi y’izina ry’ubwoko rya Olinvyk muri Leta Zunze Ubumwe z’Amerika. Iri somo rifite izina ry’ubwoko nicyo gice cya oliceridine gihari ubu, kuko ibice bisanzwe bitaratezwa imbere.

Iyo itsinda ryawe ry’abaganga rivuga ku kuvurwa na oliceridine, bashobora kuyivuga bakoresheje izina iryo ariryo ryose. Amagambo yombi yerekeza ku muti umwe ufite ingaruka zimwe n’ibitekerezo by’umutekano.

Olinvyk ikorwa na Trevena, Inc., kandi yemejwe na FDA by’umwihariko gukoreshwa na IV mu bitaro. Uyu muti uza mu macupa y’urugero rumwe itsinda ryawe ry’abaganga rizategura kandi rikayatanga.

Uburyo bwo gusimbuza Oliceridine

Imiti myinshi ya IV opioid ishobora kuvura ububabare bwo hagati kugeza ku bukomeye mu bitaro. Itsinda ryawe ry’abaganga rishobora gutekereza kuri izo nzira zisimbura hashingiwe ku byo ukeneye, amateka yawe y’ubuvuzi, n’uburyo wihanganira imiti itandukanye.

Opioids ya IV ya gakondo nka morphine, fentanyl, na hydromorphone ziguma kuba imiti isanzwe yo kuvura ububabare bukomeye. Iyi miti ifite amateka maremare kandi ubushakashatsi bwagutse bushyigikira imikoreshereze yayo, nubwo ishobora kugira ingaruka zitandukanye.

Uburyo busanzwe bwo gusimbuza umuganga wawe ashobora gutekereza harimo:

• Morphine - ikoreshwa cyane kandi yigwaho neza mu kurwanya ububabare bwihuse
• Fentanyl - ikora vuba kandi ikomeye mu kurwanya ububabare bukomeye
• Hydromorphone - ifasha mu kurwanya ububabare buringaniye kugeza bukomeye
• Oxycodone IV - igihe bibonetse, mu bihe bimwe na bimwe by'ububabare
• Pompe za patient-controlled analgesia (PCA) zifite ubwoko butandukanye bwa opioids
• Imiti itari ya opioid IV nka ketorolac yo mu bwoko bumwe na bumwe bw'ububabare

Itsinda ryawe rishinzwe ubuzima rizagena uburyo bukwiye bushingiye ku miterere yawe bwite n'intego zo gucunga ububabare.

Ese Oliceridine iruta Morphine?

Oliceridine na morphine zombi zikora neza mu kuvura ububabare buringaniye kugeza bukomeye, ariko zikora mu buryo butandukanye gato mu mubiri wawe. Niba imwe ari "nziza" biterwa n'ibyo ukeneye, amateka yawe y'ubuvuzi, n'uko witwara kuri buri muti.

Oliceridine ishobora gutera ibibazo bicye byo guhumeka kurusha morphine bitewe n'uko ikora ku buryo batoranijwe kuri reseptori za opioid. Ubushakashatsi bumwe buvuga ko abantu bahura no guhagarara guhumeka guke hamwe na oliceridine mugihe bagihabwa imiti igabanya ububabare neza. Ibi bishobora kuba ingirakamaro cyane kubarwayi bari mu kaga gakomeye ko guhura n'ibibazo byo guhumeka.

Ariko, morphine ifite imyaka myinshi y'ubushakashatsi n'uburambe bwo kuvura bushyigikira imikoreshereze yayo. Akenshi ihendutse kandi iraboneka kurusha oliceridine. Itsinda ryawe rishinzwe ubuzima rizagereranya ibintu nk'indwara zawe zihariye, indi miti urimo gufata, n'ibintu byawe byihariye by'akaga mugihe uhitamo hagati y'izi mpuzamiti.

Umuti "mwiza" ni umwe utanga imiti igabanya ububabare neza hamwe n'ingaruka nke kuri wowe. Itsinda ryawe ry'ubuvuzi rizakurikirana uko umuti wose ukora neza kuri wowe kandi rigahindura imiti uko bikwiye.

Ibikunze Kubazwa Kuri Oliceridine

Ese Oliceridine irakwiriye abantu barwaye indwara z'impyiko?

Oliceridine bisaba kwitonderwa cyane ku bantu barwaye indwara y'impyiko, kuko imikorere micye y'impyiko ishobora kugira ingaruka ku buryo umubiri wawe ukoresha kandi ukavana imiti. Itsinda ryawe ry'ubuvuzi rishobora gukoresha doze ntoya cyangwa rikakugenzura neza niba ufite ibibazo by'impyiko.

Abantu barwaye indwara y'impyiko yoroheje barashobora guhabwa oliceridine mu buryo bwizewe hamwe no guhindura doze bikwiye. Ariko, abafite indwara y'impyiko ikomeye bashobora gukenera uburyo bundi bwo kuvura ububabare. Muganga wawe azasuzuma ibizamini by'imikorere y'impyiko yawe n'amateka yawe y'ubuvuzi kugirango amenye uburyo bwizewe cyane kubibazo byawe.

Nkwiriye gukora iki niba mbonye oliceridine nyinshi mu buryo butunganye?

Kubera ko oliceridine itangwa gusa n'abakora mu buvuzi mu bitaro, kwirenza doze mu buryo butunganye ni gake ariko bisaba ubufasha bwihuse bw'ubuvuzi. Niba ucyeka ko wabonye imiti myinshi, menyesha umuforomo wawe cyangwa muganga ako kanya.

Ibimenyetso byo kwakira oliceridine nyinshi birimo gusinzira cyane, guhumeka gake cyangwa bigoye, urujijo, cyangwa kutagira ubwenge. Itsinda ryawe ry'ubuvuzi rifite imiti nka naloxone (Narcan) iboneka byoroshye kugirango ihindure ingaruka za opioid niba bibaye ngombwa. Bazagenzura guhumeka kwawe, umuvuduko w'umutima, n'urwego rw'ubwenge kandi batange ubufasha nkuko bikwiye.

Nkwiriye gukora iki niba nciwe doze ya oliceridine?

Ntabwo ukeneye guhangayika kubera gucikanwa na doze ya oliceridine kuko itangwa n'itsinda ryawe ry'ubuvuzi ku buryo bwateganyijwe mu bitaro. Abaforomo bawe na ba muganga bagenzura igihe cyose n'imyanzuro yo gutanga imiti hashingiwe ku rwego rw'ububabare bwawe n'ibikenewe byawe by'ubuvuzi.

Niba wumva ububabare bwawe butagenzurwa neza cyangwa niba hashize igihe kirekire kuruta uko byari byitezwe kuva kuri doze yawe ya nyuma, menyesha gusa itsinda ryawe ry'ubuvuzi. Barashobora gusuzuma urwego rw'ububabare bwawe no kumenya niba imiti yinyongera ikwiye cyangwa niba hagomba guhindurwa gahunda yawe yo kuvura ububabare.

Nshobora kureka gufata oliceridine ryari?

Itsinda ry'ubuvuzi ryawe rizagena igihe cyo guhagarika oliceridine hashingiwe ku rwego rw'ububabare bwawe, uko urimo gukira, n'ubuzima bwawe muri rusange. Abantu benshi bahinduka bakava ku miti y'ububabare itangwa mu maraso nka oliceridine uko bakira kandi bitegura kuva mu bitaro.

Iyi mpinduka mubisanzwe ikubiyemo kugabanya buhoro buhoro imiti cyangwa guhindukira ku miti y'ububabare yo kunywa ushobora gufata uri mu rugo. Itsinda ryawe ry'ubuvuzi rizakorana nawe kugirango ububabare bwawe bukomeze kugenzurwa neza muri iyi mpinduka. Bazatanga kandi amabwiriza yo gucunga ububabare nyuma yo kuva mu bitaro ndetse n'igihe cyo kubahamagara niba ufite impungenge.

Ese nshobora gutwara imodoka nyuma yo guhabwa Oliceridine?

Ntugomba gutwara imodoka cyangwa gukoresha imashini mugihe urimo guhabwa oliceridine cyangwa igihe gito nyuma ya dose yawe ya nyuma. Uyu muti ushobora gutera gusinzira, isereri, no gutekereza nabi bituma gutwara imodoka bigira akaga.

Kubera ko oliceridine itangirwa mu bitaro, birashoboka ko uzaba ufite gahunda yo gutwara igihe uzaba ugiye. Itsinda ryawe ry'ubuvuzi rizagusaba igihe bizaba byemewe kongera gutwara imodoka hashingiwe ku gukira kwawe, indi miti urimo gufata, n'igihe gishize ufata dose yawe ya nyuma ya oliceridine.