Pacritinib ni iki: Ibikoreshwa, Urutonde rw'imiti, Ingaruka ziterwa n'ibindi

Pacritinib ni umuti w'akanwa ugamije gufasha abantu bafite indwara zidasanzwe z'amaraso, cyane cyane indwara idasanzwe yitwa myelofibrosis. Uyu muti wandikirwa na muganga ukora ubugenzuzi bwo guhagarika proteyine zimwe na zimwe zigira uruhare mu iterambere rya kanseri y'amaraso, bitanga icyizere ku barwayi bashobora kuba bafite uburyo bwo kuvurwa butagoye.

Niba wowe cyangwa umuntu ukwitaho yarandikiwe pacritinib, birashoboka ko ushaka amakuru asobanutse kandi yizewe ku byo witegura. Reka tunyure mu bintu byose ukeneye kumenya kuri uyu muti mu buryo bworoshye kandi butanga imbaraga.

Pacritinib ni iki?

Pacritinib ni umuti wihariye w'akanwa wo mu cyiciro cy'imiti yitwa JAK inhibitors. Igamije by'umwihariko proteyine yitwa Janus kinases, igira uruhare mu buryo selile z'amaraso zikura kandi zigakora mu mubiri wawe.

Uyu muti watejwe imbere by'umwihariko ku bantu bafite myelofibrosis, indwara idasanzwe yo mu bwoko bw'amagufa aho imitsi y'amagufa yuzuye isimbuzwa imitsi ifite ibibazo. Iyi nzira ihungabanya ubushobozi bw'umubiri wawe bwo gukora selile z'amaraso zifite ubuzima busanzwe.

Igituma pacritinib idasanzwe mu miti isa n'iyo ni uko ishobora gukoreshwa neza kabone niyo umubare wa platelet yawe uri hasi cyane. Indi miti myinshi muri iki cyiciro isaba urwego rwo hejuru rwa platelet, bigatuma pacritinib iba uburyo bw'ingenzi ku barwayi bashobora kutujuje ibisabwa byo gukoresha ubundi buryo bwo kuvura.

Pacritinib ikoreshwa mu iki?

Pacritinib ikoreshwa cyane cyane ku bantu bakuru bafite myelofibrosis y'ibanze iri hagati cyangwa ifite ibyago byinshi, post-polycythemia vera myelofibrosis, cyangwa post-essential thrombocythemia myelofibrosis. Izi zose ni ubwoko bwa myelofibrosis, indwara aho imitsi y'amagufa yawe yangirika kandi ntishobore gukora selile z'amaraso neza.

Uyu muti wihariye wagenewe abarwayi umubare w'utunyangingo tw'amaraso (platelets) uri munsi ya 50,000 kuri mikrolitiri imwe y'amaraso. Uyu mubare muto w'utunyangingo tw'amaraso akenshi utuma izindi nshuti zitabasha gukoreshwa cyangwa zidakwiriye, ni yo mpamvu pacritinib yuzura icyuho gikomeye mu buryo bwo kuvura.

Muganga wawe ashobora kugusaba pacritinib niba urimo guhura n'ibimenyetso nk'umunaniro ukabije, kwiyongera kwa seleni, kuribwa mu magufa, cyangwa ibyuya by'ijoro bifitanye isano na myelofibrosis yawe. Intego ni ugufasha kugabanya ibi bimenyetso no kunoza imibereho yawe mu gihe urimo gucunga uburwayi bw'ibanze.

Pacritinib ikora ite?

Pacritinib ikora ibyara inzira zihariye zifite enzymes zifite izina rya JAK1 na JAK2, zikaba zikora cyane muri myelofibrosis. Tekereza kuri izi enzymes nk'ibishushanyo byashyizwe mu mwanya wa “on”, bigatuma umushongi wawe w'amagufa witwara mu buryo budasanzwe.

Iyo pacritinib yabuza izi switch, bifasha kugabanya ibimenyetso bidasanzwe by'ingirangingo bituma umushongi w'amagufa usharira n'ibimenyetso bidashimishije ushobora kuba urimo guhura nabyo. Ibi bishobora gufasha kugabanya ubunini bwa seleni, kugabanya umuvumo, no kunoza imibereho yawe muri rusange.

Nka terapiya yagenewe, pacritinib ifatwa nk'umuti ukomeye. Yagenewe by'umwihariko gukora ku rwego rwa molekile aho kugira ingaruka ku mubiri wawe wose muri rusange. Ubu buryo bwihariye akenshi busobanura ingaruka nke ugereranije na chimiothérapie gakondo, nubwo ari umuti ukomeye ugomba gukurikiranwa neza.

Nkwiriye gufata pacritinib nte?

Pacritinib iza mu buryo bwa capsule ufata mu kanwa kabiri ku munsi, hafi amasaha 12. Urutonde rusanzwe rutangirira kuri 200 mg kabiri ku munsi, ariko muganga wawe azagena urugero nyarwo rukwiriye imiterere yawe yihariye.

Ushobora gufata pacritinib urya cyangwa utarya, ariko gerageza kugendana n'akamenyero kawe. Niba uhisemo kuyifata urya, komereza kuri uwo murongo, kandi niba ukunda kuyifata igifu cyuzuye, bikore buri gihe. Ibi bifasha kugumana urwego rwa medicament mu mubiri wawe.

Mimina ibinini byose hamwe n'ikirahure cyuzuye cy'amazi. Ntuyifungure, uyikubite, cyangwa uyimene, kuko ibi bishobora kugira ingaruka ku buryo umuti winjizwa kandi bishobora kongera ingaruka ziterwa n'umuti. Niba ugira ibibazo byo kumira ibinini, ganira n'ikipe yawe y'ubuzima ku bijyanye n'uburyo bushobora gufasha.

Birafasha gufata imiti yawe mu gihe kimwe buri munsi kugirango ushyireho akamenyero. Abantu benshi basanga byoroshye kwibuka igihe bahuza imiti yabo n'ibikorwa bya buri munsi nk'amafunguro cyangwa ibikorwa byo kuryama.

Nzamara Igihe Kingana Iki Ndafata Pacritinib?

Igihe cyo kuvura na pacritinib gitandukanye cyane ku muntu ku muntu kandi biterwa n'uburyo witwara neza ku muti n'uburyo uwihanganira. Abantu bamwe bashobora kuyifata mu mezi, mu gihe abandi bashobora gukomeza imyaka.

Muganga wawe azagenzura uko witwara binyuze mu bipimo by'amaraso bisanzwe no mu bizaminini by'umubiri. Bazagena niba ibimenyetso byawe birimo gukira, niba ubunini bwa splin yawe bugabanuka, n'uburyo imibare y'amaraso yawe isubiza ku kuvurwa.

Umutuzo wo gukomeza kuvurwa uzashingira ku gipimo kiri hagati y'inyungu urimo kubona n'ingaruka zose ushobora kugira. Ikipe yawe y'ubuzima izakorana nawe kugirango ubone uburyo bukwiye bw'imibereho yawe.

Ntuzigere uhagarika gufata pacritinib mu buryo butunguranye utabanje kubiganiraho na muganga wawe. Bashobora gukenera guhindura urugero rwawe buhoro buhoro cyangwa bakagukurikiranira hafi mugihe cyose cyo guhindura kuvurwa.

Ni Iyihe Ngaruka Ziterwa na Pacritinib?

Kimwe n'imiti yose, pacritinib ishobora gutera ingaruka ziterwa n'imiti, nubwo atari buri wese uzagira izo ngaruka. Kumenya icyo ugomba kwitaho bishobora kugufasha kumva witeguye kandi ukamenya igihe cyo kuvugana n'ikipe yawe y'ubuvuzi.

Ingaruka ziterwa n'imiti zisanzwe zikunda kuba zishobora gucungwa kandi akenshi zikagenda zikemuka umubiri wawe umaze kumenyera umuti. Hano hari ingaruka ziterwa n'imiti ushobora guhura nazo cyane:

• Impiswi, zishobora kuva ku zoroheje kugeza ku ziciriritse
• Urugimbu n'umuriro rimwe na rimwe
• Ukubura mu maguru yawe, mu birenge, cyangwa mu birenge
• Umunaniro cyangwa kumva urushye kurusha uko bisanzwe
• Gukomereka byoroshye kurusha uko bisanzwe
• Umuzunguruko cyangwa kumva urimo guta umutwe
• Urubavu cyangwa kubabara mu ngingo

Izi ngaruka ziterwa n'imiti zisanzwe akenshi ziba z'igihe gito kandi akenshi zishobora gucungwa no gufashwa cyangwa guhindura urugero rw'umuti. Ikipe yawe y'ubuvuzi ishobora gutanga ingamba zihariye zo kugufasha kumva umeze neza.

Bitari kenshi, abantu bamwe bahura n'ingaruka ziterwa n'imiti zikomeye zisaba ubufasha bwihutirwa bw'ubuvuzi. Nubwo ibi bidakunze kubaho, ni ngombwa kubimenya:

• Guhuhura cyane cyangwa gukomereka bidasanzwe
• Ibimenyetso byo kwandura nk'umuriro udashira cyangwa ibikonjo
• Impiswi ikomeye itera kumuka amazi mu mubiri
• Ukubura kugaragara cyangwa guhumeka bigoye
• Impinduka z'umutima cyangwa umutima wihuta cyane

Niba ubonye kimwe muri ibi bimenyetso bikomeye, vugana n'umuganga wawe ako kanya. Bashobora gufasha kumenya niba ibi bifitanye isano n'umuti wawe n'intambwe zikurikira.

Ninde utagomba gufata Pacritinib?

Pacritinib ntabwo ikwiriye kuri buri wese, kandi muganga wawe azasuzuma neza niba ari wo mwanzuro ukwiriye kubera uko umeze. Uburwayi runaka cyangwa ibihe bishobora gutuma uyu muti utakwiriye cyangwa bisaba ingamba zidasanzwe.

Abantu bafite ibibazo bikomeye by'umwijima ntibagomba gufata pacritinib, kuko umuti ukoreshwa unyuze mu mwijima kandi ushobora gutuma imikorere y'umwijima irushaho kuba mibi. Muganga wawe azagenzura imikorere y'umwijima wawe mbere yo gutangira kuvurwa kandi azajya abikurikirana buri gihe igihe uri gufata uwo muti.

Niba waragize ibibazo bikomeye by'umutima, muganga wawe azagomba gupima neza inyungu n'ibibazo bishobora kuvuka. Pacritinib ishobora kugira ingaruka ku mutima ku bantu bamwe, bityo bikaba bisaba gukurikiranwa cyane no gutekereza ku bindi byavura.

Indwara zikomeye zikomeye ni ikindi kintu cy'ingenzi cyo gusuzuma. Kubera ko pacritinib ishobora kugira ingaruka ku buryo umubiri wawe urwanya indwara, gutangira kuvurwa igihe urwaye indwara ikomeye bishobora kuba bibi. Muganga wawe azashaka kuvura indwara zose mbere yo gutangira gufata pacritinib.

Gusama no konsa bisaba kwitonderwa by'umwihariko. Pacritinib ishobora gushobora kwangiza umwana ukiri mu nda, bityo abagore bafite imyaka yo kubyara bagomba gukoresha uburyo bwo kuboneza urubyaro neza igihe bari kuvurwa no mu gihe gito nyuma yo guhagarika gufata uwo muti.

Amazina y'ubwoko bwa Pacritinib

Pacritinib iboneka ku izina ry'ubwoko bwa Vonjo muri Leta Zunze Ubumwe z'Amerika. Iri ni izina ry'ubucuruzi uzabona ku icupa ryawe ryandikiwe n'umuganga n'ibipaki by'imiti.

Vonjo yemejwe na FDA by'umwihariko mu kuvura myelofibrosis ku barwayi bafite umubare muto wa platelet. Niba ubonye iri zina ku byanditswe byawe, ni umuti umwe twari tumaze kuvugaho muri iyi ngingo.

Kugeza ubu, pacritinib iboneka gusa nk'umuti w'izina ry'ubwoko. Ubwoko bwa generic ntiburaboneka, bivuze ko igiciro gishobora kuba kinini kuruta imiti ifite ubundi buryo bwa generic.

Uburyo bwo kuvura busimbura Pacritinib

Hariho indi miti myinshi iboneka mu kuvura myelofibrosis, nubwo buri imwe ifite ibyo isaba n'ibyo yitonderwa bitandukanye. Muganga wawe azagufasha kumenya uburyo bushobora kuba bwiza kuri wowe.

Ruxolitinib (Jakafi) ni ikindi kiyongera cya JAK gikoreshwa cyane mu kuvura myelofibrosis. Ariko, akenshi bisaba umubare munini wa plateleti kurusha pacritinib, bigatuma bitabereye abarwayi bafite plateleti nkeya cyane. Iri ni rimwe mu itandukaniro rikomeye hagati yiyi miti yombi.

Fedratinib (Inrebic) ni ubundi buryo bukora kimwe na pacritinib ariko bufite ingaruka zitandukanye kandi bufite ibyo bisaba. Abantu bamwe bashobora kwihanganira umuti umwe kurusha undi, bityo kugira uburyo bwinshi ni ingenzi.

Ku barwayi bamwe, izindi nzira nko gutanga amaraso, imiti yo gucunga ibimenyetso byihariye, cyangwa kwitabira igeragezwa ry'imiti bishobora gutekerezwa. Guhitamo neza biterwa n'ubuzima bwawe muri rusange, umubare w'amaraso, ubukana bw'ibimenyetso, n'ibyo ukunda.

Ese Pacritinib iruta Ruxolitinib?

Pacritinib na ruxolitinib zombi ni ibiyongera bya JAK bikora neza, ariko bikorera mu bice bitandukanye by'abarwayi kandi bifite inyungu zitandukanye. Guhitamo

Ibibazo Bikunze Kubazwa Kuri Pacritinib

Ese Pacritinib ifite umutekano ku bantu bafite ibibazo by'umutima?

Pacritinib bisaba kwitonderwa cyane niba ufite ibibazo by'umutima, cyane cyane indwara zo mu mutima. Uyu muti ushobora kugira ingaruka ku mutima, bityo muganga wawe azagomba gusuzuma ubuzima bw'umutima wawe mbere yo gutangira kuvurwa.

Niba ufite amateka y'ibibazo by'umutima, muganga wawe ashobora gushaka gukora electrocardiogram (EKG) mbere yo gutangira pacritinib no kugukurikiranira hafi mugihe uvurwa. Barashobora kandi kugenzura urwego rwa electrolyte zawe buri gihe, kuko kutaringaniza bishobora kongera ibyago byo mu mutima.

Abantu benshi bafite ibibazo by'umutima byoroheje barashobora gufata pacritinib batekanye hamwe no gukurikiranwa neza. Ikintu cy'ingenzi ni ukuganira neza n'ikipe yawe y'ubuzima ku mateka yawe y'umutima n'ibimenyetso byose ubona mugihe uvurwa.

Nkwiriye gukora iki niba nanyweye pacritinib nyinshi bitunguranye?

Niba utunguranye ukanywa pacritinib nyinshi kuruta uko byategetswe, vugana na muganga wawe cyangwa ikigo gishinzwe kugenzura uburozi ako kanya. Ntukegere ngo urebe niba wumva umeze neza, kuko ingaruka zimwe zo kurenza urugero ntizishobora kugaragara ako kanya.

Kunywa pacritinib nyinshi bishobora kongera ibyago byo kugira ingaruka zikomeye, cyane cyane kuva amaraso, ibibazo by'umutima, cyangwa impiswi ikabije. Ubufasha bwihuse bw'ubuvuzi bushobora gufasha kwirinda cyangwa gucunga izi ngorane.

Igihe uhamagaye usaba ubufasha, gira icupa ry'imiti yawe ryiteguye kugirango ushobore gutanga amakuru yihariye kubijyanye n'urugero wanyoye n'igihe. Aya makuru afasha abaganga gutanga ubuyobozi bukwiye.

Nkwiriye gukora iki niba nciwe urugero rwa pacritinib?

Niba ucitswe urugero rwa pacritinib, nywa ako kanya wibuka, keretse hafi y'igihe cyo gufata urugero rwawe ruteganyijwe. Muricyo gihe, reka urugero wacitswe ukomeze gahunda yawe isanzwe.

Ntugafate imiti ibiri icyarimwe kugira ngo usimbure urugero rwatanzwe. Ibi bishobora kongera ibyago byo kugira ingaruka mbi utagize inyungu yinyongera. Biruta gukomeza gahunda yawe isanzwe imbere.

Niba ukunda kwibagirwa imiti, tekereza gushyiraho alarme kuri terefone, gukoresha umuteguro wimiti, cyangwa gusaba abagize umuryango kugufasha kukwibutsa. Gufata imiti buri gihe bifasha gukomeza urwego rwa medicament muri sisitemu yawe.

Ni ryari nshobora kureka gufata Pacritinib?

Umwanzuro wo kureka gufata pacritinib ugomba gufatwa buri gihe hamwe na muganga wawe. Bazatekereza ibintu nkuko umuti ukora neza, ingaruka mbi urimo guhura nazo, n'ubuzima bwawe muri rusange.

Abantu bamwe bashobora gukenera guhagarara niba bahuye ningaruka mbi zitihanganirwa cyangwa niba uburwayi bwabo bukomeje nubwo bavurwa. Abandi bashobora guhagarika niba bageze ku kugenzura indwara neza kandi muganga wabo akumva ko guhagarika kuvurwa bikwiye.

Muganga wawe ashobora gushaka kukugenzura neza nyuma yo guhagarika pacritinib kugirango arebe impinduka zose zigaragara mubuzima bwawe. Bashobora gushimangira guhindurira ku bundi buvuzi butandukanye cyangwa gushyira mubikorwa uburyo bwo gukurikirana.

Nshobora gufata indi miti nkanakoresha Pacritinib?

Imiti myinshi irashobora gufatwa neza hamwe na pacritinib, ariko hariho ubushobozi bwo guhura. Buri gihe menyesha muganga wawe imiti yose, ibyongerera imbaraga, nibindi byose utagomba kwandikirwa mbere yo gutangira pacritinib.

Imiti imwe irashobora kugira ingaruka kumikorere ya pacritinib cyangwa ikongera ibyago byo kugira ingaruka mbi. Muganga wawe ashobora gukenera guhindura doze, kukugenzura neza, cyangwa gushimangira indi miti niba imikoranire ikomeye yagaragaye.

Gira urutonde ruzwi rwa imiti yawe yose kandi ujyane na yo mugihe cyose cyo kwisuzumisha kwa muganga. Ibi bifasha ikipe yawe yubuzima gufata imyanzuro ifitiye akamaro kubijyanye na gahunda yawe yo kuvura no gufata ibibazo byose bishoboka hakiri kare.