Icyo Palifermin ari cyo: Ibikoreshwa, Urutonde rw'imiti, Ingaruka zayo n'ibindi

Palifermin ni umuti wa poroteyine wihariye ufasha kurengera no gukiza imitsi yoroheje yo mu kanwa kawe no mu muhogo mu gihe cyo kuvurwa kanseri bikomeye. Niba wowe cyangwa umuntu witaho arwaje ubwoko runaka bwa kanseri, itsinda ryawe ry'abaganga rishobora kugusaba ubu buvuzi bufasha kugirango wirinde ibisebe bibabaza mu kanwa n'izindi ngorane.

Uyu muti ukora nk'umurinzi woroheje ku mitsi yoroshye ikora mu kanwa kawe, mu muhogo, no mu nzira yo mu gifu. Utangwa binyuze muri IV mbere na nyuma yo kuvurwa kanseri byihariye kugirango bifashe umubiri wawe gukomera mu gihe bari mu gihe cy'umunaniro.

Palifermin ni iki?

Palifermin ni verisiyo yakozwe n'abantu ya poroteyine karemano yitwa keratinocyte growth factor (KGF) umubiri wawe usanzwe ukora. Tekereza nk'abakozi b'umwuga b'ubwubatsi bagamije cyane selile zikora mu kanwa kawe, mu muhogo, no mu nzira yo mu gifu.

Uyu muti ubarirwa mu cyiciro cyitwa growth factors, ari zo poroteyine zifasha selile gukura, kwigabanya, no kwisana. Abahanga bahimbye palifermin bahindura KGF karemano kugirango ikore neza kandi igire akamaro iyo ikoreshejwe nk'umuti.

Uku si ukuvura kanseri ubwayo, ahubwo ni ubuvuzi bufasha burengera imitsi yuzuye mu gihe uri guhabwa izindi miti y'ingenzi. Ni nko kugira imbaraga zidasanzwe ku bice by'umubiri wawe byibasirwa cyane mu gihe cy'ubuvuzi bukomeye.

Palifermin ikoreshwa mu iki?

Palifermin ikoreshwa cyane cyane mu kurinda ibisebe bikomeye byo mu kanwa (byitwa oral mucositis) ku bantu bahabwa imiti ikomeye ya kanseri na radiyo mbere yo gukora imvura y'amagufa. Ubu buvuzi bushobora kurokora ubuzima ariko akenshi bwangiza selile nzima zikora mu kanwa kawe no mu muhogo.

Muganga wawe ashobora kugusaba palifermine niba witegura kwakira impinduka z'uturemangingo tw'amaraso, cyane cyane niba ufite kanseri z'amaraso nka leukemia, lymphoma, cyangwa multiple myeloma. Uyu muti wemerejwe by'umwihariko abarwayi bazahabwa imiti izwiho gutera ibibazo bikomeye mu kanwa no mu muhogo.

Intego ni ukugufasha kunyura mu kuvurwa kwa kanseri yawe ufite ububabare buke n'ibibazo bike. Iyo ibisebe byo mu kanwa birinzwe cyangwa bigabanutse, birashoboka cyane ko uzagumana imirire ikwiye, ugira indwara nkeya, kandi ukagira ibibazo bike muri rusange mu gihe cyo koroherwa kwawe.

Palifermine ikora ite?

Palifermine ikora iteza imbere imikurire no kurengera uturemangingo twa epithelial, ari two turemangingo tugize urukuta rurinda rwo mu kanwa kawe, umuhogo, n'inzira yo mu gifu. Iyo utu turemangingo turi muzima kandi twivugurura, turashobora kurwanya ingaruka z'imiti ikomeye ivura kanseri.

Uyu muti ufashwe nk'ubuvuzi bufasha bwihariye aho kuba ubuvuzi bukomeye cyangwa buke mu buryo busanzwe. Yagenewe by'umwihariko gukora ku bwoko runaka bw'uturemangingo hatabangamiye imikorere y'ubuvuzi bwa kanseri yawe.

Poroteyine ifatana n'uturemangingo twihariye kuri epithelial yawe, itanga ibimenyetso bibashishikariza gukura, kwiyongera, no kwisana vuba. Ubu buryo bufasha gukora urukuta rukomeye kandi ruramba mu kanwa kawe no mu muhogo mbere y'uko imiti igoye itangira.

Iyo bivuzwe, palifermine ifasha kandi utu turemangingo twisana vuba nyuma y'uko ibyangiritse byabayeho. Ni nko kugira ikipe y'abahanga mu gusana ikora kugira ngo ikomeze ubwirinzi bwawe mbere y'igihe kandi ikosore ibyangiritse byose byabayeho.

Nkwiriye gufata palifermine nte?

Palifermine itangwa gusa binyuze mu muyoboro wa intravenous (IV) n'abakozi b'ubuvuzi babihuguriwe mu bitaro cyangwa mu mavuriro. Ntabwo uzajya ufata uyu muti mu rugo cyangwa unywa.

Ubusanzwe gahunda ikubiyemo guhabwa doze eshatu mbere yuko uvurwa, hanyuma ugahabwa izindi doze eshatu nyuma yo kwimurirwa uturemangingo twawe. Itsinda ry’abaganga bazajya batanga izi doze mu gihe gihagije, akenshi bazitanga mu minsi ikurikirana.

Nta kintu na kimwe ugomba gukora kugira ngo witegure guhabwa palifermine. Ntabwo bisa n’imiti imwe n’imwe, ntibisaba ko ubanza kurya cyangwa kwirinda kurya mbere y’uko uyihabwa. Ubusanzwe gutera palifermine mu urugingo rw’umubiri bifata iminota 15-30.

Itsinda ry’abaganga bazajya bakugenzura igihe uri kuyihabwa no nyuma yo kuyihabwa kugira ngo barebe niba uyihanganira neza. Bazajya kandi bahuza igihe cyo kuyitanga n’ubundi buvuzi bwawe kugira ngo bagufashe kurinda umunwa n’umuhogo wawe.

Nzamara igihe kingana iki nkorera palifermine?

Ubusanzwe uburyo bwo kuvurwa na palifermine burangira mu byumweru bibiri, bukaba bugizwe na doze esheshatu zitangwa mu bihe byihariye. Uyu si umuti uzajya ufata amezi cyangwa imyaka.

Muganga wawe azaguha doze eshatu mbere yuko uvurwa, hanyuma aguhe izindi doze eshatu nyuma yo kwimurirwa uturemangingo twawe. Igihe nyacyo giterwa n’uburyo bwawe bwihariye bwo kuvurwa n’uko umubiri wawe witwara.

Igihe gito cyo kuvurwa ni nkana kandi cyateguwe neza. Palifermine igamije gutanga uburinzi mu gihe cy’ubuvuzi bwa kanseri buri mu kaga gakomeye, igihe umunwa n’umuhogo wawe bishobora kwangirika cyane.

Niba warangije uburyo bwose bwo kuvurwa kandi imyanya yo mu kanwa yawe yarazutse, ubusanzwe ntuzongera gukenera ubuvuzi bwa palifermine keretse waba ugiye gukorerwa ubundi buvuzi bukomeye mu gihe kizaza.

Ni izihe ngaruka ziterwa na palifermine?

Abantu benshi bafata palifermine neza, cyane cyane iyo tuzirikanye ubukana bw’ubuvuzi igamije gufasha. Ingaruka ziterwa na yo zikunda kuba zicungwa kandi zikaba zihita zishira, zikagenda igihe uburyo bwawe bwo kuvurwa burangiye.

Reka dutangire ku ngaruka zisanzwe ushobora guhura nazo, zikaba zifata abantu benshi bakira uyu muti:

• Uruhu rurashya cyangwa rugahinduka umutuku, akenshi bikagaragara nk'uburyaryate bworoheje bw'izuba
• Umuriro cyangwa ururimi bihindura ibara, akenshi bigaragara nk'uduce twera cyangwa ibishishwa
• Uburyohe buhinduka, aho ibiryo bishobora kumera ukundi cyangwa bikaryoha nk'icyuma
• Urubura ruto rw'umunwa cyangwa ururimi
• Kubabara mu ngingo cyangwa imitsi, bisa n'ibimenyetso byoroheje by'ibicurane

Izi ngaruka zisanzwe muri rusange ni uburyo umubiri wawe witwara ku kwiyongera kw'uturemangingo no gukora isuku. Abantu benshi basanga izi ngaruka zihanganirwa kandi z'agateganyo.

Abantu bamwe bahura n'ingaruka zitagaragara cyane ariko zikaba zigikemuka, izo ikipe yawe y'ubuvuzi izakurikirana:

• Umuriro cyangwa ibikonjo mu gihe cyangwa nyuma yo guterwa urushinge
• Isesemi cyangwa inda itameze neza
• Umutwe cyangwa isereri ryoroheje
• Ibyavuye ku guterwa urushinge nk'umutuku cyangwa urubura
• Impinduka mu gaciro k'amaraso y'ibizamini byo mu laboratori

Noneho, reka tuvuge ku ngaruka zitagaragara ariko zikomeye zisaba ubufasha bwihuse bw'abaganga. Nubwo ibi bitabaho kenshi, ni ngombwa kubimenya:

• Urugero rukomeye rw'uburwayi bwo mu mubiri hamwe no guhumeka bigoranye, umubiri ukanyarara, cyangwa uruhu rugaragara hose
• Urubura rugaragara rw'isura, iminwa, ururimi, cyangwa umuhogo
• Urugero rukomeye rw'uruhu hamwe no kubora cyangwa gushishuka
• Ibimenyetso by'ubwandu nk'umuriro udashira, ibikonjo, cyangwa intege nke idasanzwe
• Kubabara cyane mu nda cyangwa kuruka bidashira

Ikipe yawe y'ubuzima izagukurikiranira hafi ingaruka zose ziteye impungenge kandi izamenya neza uko izazikemura ziragaramye. Wibuke ko inyungu zo kwirinda ibisebe bikomeye byo mu kanwa akenshi zirenga izi ngaruka zishoboka ku barwayi benshi.

Ninde utagomba gufata Palifermin?

Palifermine ntibereye buri wese, kandi muganga wawe azasuzuma neza niba bikwiriye imiterere yawe yihariye. Icyemezo kirimo gupima inyungu n'ibishobora kuba byabangamira hashingiwe ku buzima bwawe bwite.

Ntabwo ukwiye guhabwa palifermine niba ufite allergie izwi ku muti ubwawo, ibice byawo byose, cyangwa kuri poroteyine zikomoka kuri E. coli. Kubera ko palifermine ikorwa hakoreshejwe bagiteri ya E. coli, abantu bafite allergie ikomeye ku bicuruzwa bikomoka kuri E. coli bakeneye uburyo bundi.

Itsinda ryawe ry’ubuvuzi rizongera kwitonda niba ufite ubwoko runaka bwa kanseri. Palifermine ishobora gutera imikurire ya zimwe mu ngirangingo za kanseri zifite ibyitwa byihariye, bityo ntibisabwa kuri kanseri zimwe zitari iz'amaraso.

Abantu bafite indwara zandura zidakontrolwa bashobora gukenera gutegereza kugeza igihe indwara yabo ivuriwe mbere yo gutangira palifermine. Sisitemu yawe y'ubudahangarwa ikeneye kuba mu mimerere myiza ishoboka kugira ngo unungukirwe n'iyi terapiya ishyigikira.

Niba utwite cyangwa wonka, muganga wawe azakenera gusuzuma neza ibyago n'inyungu. Mugihe hari amakuru make ku mikoreshereze ya palifermine mugihe cyo gutwita, umuti akenshi ubikirwa ibihe byica ubuzima aho inyungu zigaragara neza kurusha ibishobora kuba byabangamira.

Amazina ya Palifermine

Palifermine iboneka munsi y'izina ry'ubwoko rya Kepivance, ryo izina rizwi cyane kuri uyu muti. Kepivance ikorwa na Sobi (Swedish Orphan Biovitrum) kandi ni ubwoko bwibanze buboneka mubihugu byinshi.

Ushobora kubona uyu muti witaweho n'izina ryayo rusange, palifermine, cyangwa izina ryayo ry'ubwoko, Kepivance, bitewe n'imiterere yawe y'ubuzima. Amazina yombi yerekeza ku muti umwe ufite ibikoresho bikora bimwe.

Mu turere tumwe na tumwe, imiti ishobora kuboneka mu mazina y'ubucuruzi atandukanye cyangwa ikorwa n'abakora imiti batandukanye, ariko ibikoresho by'ingenzi n'ingaruka zivura ziracyari zimwe. Itsinda ryawe ry'ubuvuzi rizagufasha kubona umuti ukwiye hatitawe ku izina ry'ubucuruzi rikoreshwa.

Uburyo bwo gusimbura Palifermin

Ubu, nta buryo bwo gusimbura palifermin bukora mu buryo bumwe. Ni wo muti wemewe na FDA wenyine wagenewe gukumira mucositis yo mu kanwa ku barwayi bakoresha imiti ikaze ya chemotherapy na radiation mbere yo gukora transplant ya stem cell.

Ariko, itsinda ryawe ry'abaganga rishobora gukoresha izindi nzira zifasha hamwe na palifermin cyangwa mu mwanya wayo, bitewe n'uko ubuzima bwawe bumeze. Ubu buryo bwo gusimbura bushingiye ku gucunga ibimenyetso no guteza imbere gukira hakoreshejwe uburyo butandukanye.

Abaganga bamwe bakoresha uburyo bwo kwita ku kanwa burimo imiti yo mu kanwa yihariye, ibintu bifunga, cyangwa uburyo bwo gucunga ububabare. Ubu buryo bushobora kugira akamaro ariko ntibitanga uburinzi bw'uturemangingo nk'uko palifermin ibitanga.

Uburyo bwo gukoresha laser yo ku rwego rwo hasi n'ibindi byongerera imirire byagaragaye ko bifite akamaro mu bushakashatsi bumwe, ariko ntibigaragazwa ko bifite akamaro nka palifermin mu gukumira ibisebe bikomeye byo mu kanwa ku barwayi bafite ibyago byinshi.

Muganga wawe azagusaba uburyo bwiza bushingiye ku gahunda yawe y'ubuvuzi, ibintu byongera ibyago, n'ubuzima bwawe muri rusange. Rimwe na rimwe guhuza uburyo butandukanye bikora neza kuruta kwishingikiriza ku buryo bumwe.

Ese Palifermin iruta izindi mvura zikumira?

Palifermin ubu ifatwa nk'urwego rwa zahabu mu gukumira mucositis ikomeye yo mu kanwa ku barwayi bakoresha imiti ikaze mbere yo gukora transplant ya stem cell. Ubushakashatsi bwakozwe bugaragaza neza akamaro kayo mu kugabanya ubukana n'igihe ibisebe byo mu kanwa bimara.

Ugereranije no kwita ku kanwa gusa, palifermine igabanya cyane ubukana bw'ibisebe bikomeye byo mu kanwa kuva kuri 98% kugera kuri 63% ku barwayi bari mu kaga gakomeye. Ibi bigaragaza iterambere rikomeye mu mibereho myiza mu gihe cyo kuvurwa bigoye.

Uyu muti kandi wagaragaye ko ugabanya umubare w'imiti ikoreshwa mu kubabaza kandi ugabanya igihe cy'ububabare bukomeye bwo mu kanwa. Abarwayi benshi bakira palifermine bavuga ko bashobora kurya no kunywa neza mu gihe cyo koroherwa n'uburwayi bwabo.

Ariko,

Kubera ko palifermine itangwa n'abaganga mu buryo bugenzurwa, kwirengagiza imiti ntibigenda. Itsinda ryawe ry'ubuvuzi ribara neza kandi rigasuzuma kabiri urugero rwawe mbere yo gutanga buri dose.

Niba ufite impungenge zo guhabwa imiti myinshi, ntugatinye kubaza itsinda ryawe ry'ubuvuzi ku bijyanye n'inzira yo gutanga imiti. Barashobora gusobanura uburyo babara urugero rwawe rwihariye n'ingamba z'umutekano zishyirwaho.

Mu gihe kitazwi cyane cyo kwibeshya mu gutanga imiti, itsinda ryawe ry'ubuvuzi ryatojwe kumenya no gucunga ibibazo byose ako kanya. Bafite uburyo bwo gukurikirana no gukemura ibibazo byose.

Nkwiriye gukora iki niba nciwe dose ya palifermine?

Niba ucikanwe na dose ya palifermine yateganyijwe, vugana n'itsinda ryawe ry'ubuvuzi ako kanya kugira ngo muganire ku kongera guteganya. Igihe cyo gutanga dose ya palifermine gihuzwa neza n'izindi mvura zawe, bityo impinduka zigomba gucungwa n'abaganga bawe.

Muganga wawe ashobora guhindura gahunda yawe kugira ngo akire dose yacikanwe, cyangwa ashobora kugusaba gukomeza gahunda yawe yo kuvura no kugukurikiranira hafi ibisebe byo mu kanwa. Umwanzuro uterwa n'igihe dose yacikanwe n'aho uri muri gahunda yawe yo kuvura.

Ntugerageze kwishyura dose yacikanwe wenyine. Gahunda y'imiti yateguwe by'umwihariko kugira ngo itange uburinzi bwiza, kandi impinduka zose zigomba gukorwa hakurikijwe ubuyobozi bw'abaganga.

Nshobora kureka gufata palifermine ryari?

Ntabwo ukeneye gufata umwanzuro wo kureka palifermine kuko itangwa nk'inzira yo kuvura yagenwe mbere. Uburyo busanzwe burimo dose esheshatu zose, kandi umaze kurangiza iyi nzira, imiti irarangiye.

Itsinda ryawe ry'ubuvuzi rizakurikirana imiterere y'umunwa wawe n'umuhogo wawe mu gihe cyose uvurwa kanseri kugira ngo barebe niba palifermine itanga uburinzi bwagenewe. Bazareba kandi ibimenyetso byose byerekana ko hakenerwa ubufasha bwiyongereye.

Niba ugize ingaruka ziteye impungenge, muganga wawe ashobora guhindura gahunda yawe y'ubuvuzi, ariko iki cyemezo kizahora gifatwa mu biganiro n'itsinda ryawe ryose ry'abaganga kugira ngo umutekano wawe n'ubuvuzi bugende neza.

Nshobora Kwakira Palifermine Muri Igihe Cy'Inda?

Gukoresha palifermine mu gihe cy'inda bisaba ko itsinda ryawe ry'abaganga ribitekerezaho cyane. Hariho amakuru make yerekeye uburyo umuti ugira ingaruka ku bagore batwite n'abana bakiri bato, bityo akenshi bikoreshwa gusa mu bihe inyungu ziruta cyane ibishobora kuba bibi.

Niba utwite kandi ukeneye ubuvuzi bukomeye bwa kanseri, abaganga bawe bazakorana n'inzobere mu gutwita bikomeye kugira ngo bateze imbere gahunda y'ubuvuzi ifite umutekano mwinshi. Ibi bishobora gushobora gukoresha uburyo bundi bwo gukumira ibisebe byo mu kanwa cyangwa guhindura uburyo bwo kuvura.

Icyemezo kizaterwa n'ibintu nk'ubwoko n'icyiciro cya kanseri yawe, uko umaze kugera mu gihe cy'inda yawe, n'ubundi buryo bwo kuvura buhari. Itsinda ryawe ry'abaganga rizagufasha kubona amakuru yose ukeneye kugira ngo ufate icyemezo cyiza kuri wowe n'umwana wawe.