Icyo Palonosetron ari cyo: Ibyo ikoreshwa, urugero rwa dose, ingaruka zayo n'ibindi

Palonosetron ni umuti wandikirwa ugahabwa unyuze mu muyoboro w'amaraso (intravenous) kugira ngo wirinde isesemi no kuruka. Yagenewe cyane cyane gufasha abantu bakira imiti ivura kanseri cyangwa babagwa bikunze gutera ibyo bimenyetso bitari byiza. Uyu muti ukora ubuhinga bwo kubuza ibimenyetso bimwe na bimwe mu bwonko bwawe byagutera kumva urwaye inda.

Palonosetron ni iki?

Palonosetron ni umuti wo mu cyiciro cy'imiti yitwa 5-HT3 receptor antagonists, ibyo byumvikana bigoye ariko bisobanura ko ibuza intumwa zidasanzwe z'imiti mu mubiri wawe. Izo ntumwa, zizwi nka serotonin, zishobora gutera isesemi no kuruka iyo zirekuwe mu bwinshi mugihe cy'imiti. Tekereza palonosetron nk'icyuma kirinda kibuza ibyo bimenyetso bitifuzwa kugera mu gice cy'ubwonko bwawe kigenzura isesemi.

Uyu muti uboneka gusa nk'urushinge kandi ugomba gutangwa n'umuganga mu rwego rw'ubuvuzi. Ntabwo ushobora gufata palonosetron uri murugo cyangwa unyuze mu kanwa - yateguwe by'umwihariko kugira ngo ikore binyuze mu maraso yawe iyo itanzwe mu buryo bwa intravenous.

Palonosetron ikoreshwa kubera iki?

Palonosetron ikoreshwa cyane cyane mu kurwanya isesemi no kuruka biterwa n'imiti ivura kanseri. Imiti myinshi ivura kanseri irashobora gutuma wumva urwaye cyane, kandi uyu muti ufasha guhagarika ibyo bimenyetso kugirango ushobore kwibanda ku kuvurwa no gukira. Bifasha cyane cyane mu kurwanya isesemi yihuse (mumasaha 24 ya mbere) n'isesemi itinda (ishobora kubaho nyuma yiminsi yo kuvurwa).

Uyu muti ukoreshwa kandi mu gukumira isesemi no kuruka nyuma yo kubagwa, cyane cyane iyo hakoreshejwe imiti rusange yo kubabaza. Abantu bamwe barushaho kugira isesemi nyuma yo kubagwa, kandi palonosetron ishobora gufasha gukira neza. Muganga wawe azemeza niba uri umuntu ukwiriye guhabwa uyu muti hashingiwe ku buryo uvurwa n'amateka yawe y'ubuzima.

Palonosetron ikora ite?

Palonosetron ikora ibungabunga imitsi yakira serotonin mu bice bibiri by'ingenzi by'umubiri wawe: urwungano rwawe rw'igogora n'agace k'ubwonko bwawe kitwa chemoreceptor trigger zone. Iyo imiti ivura kanseri cyangwa imiti yo kubabaza yinjira mu mubiri wawe, ishobora gutuma umubiri wawe usohora serotonin nyinshi, isanzwe itegeka ubwonko bwawe gutera isesemi no kuruka nk'uburyo bwo kwirinda.

Uyu muti ufatwa nk'ukomeye kandi ufite akamaro ugereranije n'imiti isanzwe ivura isesemi. Ifite ingaruka zirambye, bivuze ko ukeneye doze nkeya kugira ngo wirinde isesemi. Uyu muti utangira gukora mu minota nka 30 nyuma yo kuwutanga kandi ushobora gutanga uburinzi mu minsi myinshi, bitewe n'uburyo umubiri wawe ubyakira.

Nkwiriye gufata palonosetron nte?

Ntabwo uzifata palonosetron wenyine - itangwa n'umuforomo cyangwa umuganga binyuze mu muyoboro wa IV mu kuboko kwawe. Uyu muti utangwa nk'urushinge rutinda mu gihe cy'amasegonda nka 30, akenshi mu minota nka 30 mbere yo gutangira kuvurwa kanseri cyangwa mbere gato yo kujya mu cyumba cyo kubagiramo. Igihe ni ingenzi kuko bituma uyu muti ugera ku rwego rwo hejuru mu maraso yawe mbere yo gutangira kuvurwa gutera isesemi.

Nta kintu na kimwe ugomba gukora kugira ngo witegure urushinge, kandi ntugomba kwirinda kurya cyangwa kunywa mbere y'igihe. Mubyukuri, kurya ikintu cyoroheje mu gifu cyawe bishobora kugufasha kumva umeze neza muri rusange. Itsinda ryawe ry'ubuvuzi rizagukurikiranira hafi mugihe cyo guterwa urushinge no nyuma yarwo kugirango barebe niba urimo gusubiza neza imiti.

Nzagenda Ndega Palonosetron Igihe Kingana Gite?

Igihe cyo kuvura na palonosetron giterwa n'uburwayi bwawe bwihariye. Kubarwayi ba chimiothérapie, mubisanzwe uzahabwa urugero rumwe mbere ya buri gihe cyo kuvurwa mugihe cyose cya chimiothérapie yawe. Ibi bishobora gusobanura ko uruhuka buri cyumweru, buri byumweru bike, cyangwa kuri gahunda iyo ariyo yose umuganga wawe yateguye kubera uburwayi bwawe bwa kanseri.

Kubarwayi babagwa, mubisanzwe uzahabwa urugero rumwe mbere yo kubagwa, kandi urwo rugero rumwe akenshi rurahagije kugirango wirinde isesemi nyuma yo kubagwa. Ariko, niba urimo kubagwa inshuro nyinshi cyangwa ibikorwa birebire, muganga wawe ashobora kugusaba izindi doze. Itsinda ryawe ry'ubuvuzi rizakora gahunda yihariye ishingiye ku gihe cyo kuvurwa kwawe n'uburyo wumva neza imiti.

Ni Iyihe Miterere Ibyara Palonosetron?

Abantu benshi bafata palonosetron neza, ariko nk'indi miti yose, irashobora gutera ibibazo bimwe na bimwe. Inkuru nziza ni uko ibibazo bikomeye bidakunze kubaho, kandi inyungu zo kwirinda isesemi ikabije akenshi ziruta ingaruka.

Hano hari ibibazo bisanzwe ushobora guhura nabyo, wibuke ko abantu benshi badafite ibibazo na gato:

• Umutwe (uyu niwo mutungo wamenyekanye cyane)
• Kugabanuka cyangwa impinduka mumikorere y'amara
• Urugero cyangwa kumva ureremba
• Kunanirwa cyangwa kumva warushye cyane kuruta uko bisanzwe
• Urubavu ruto cyangwa kwishimira ahaterwa urushinge

Ibi bimenyetso bigaragara ku ruhande muri rusange biroroshye kandi ntibiramba. Itsinda ryawe ry'ubuvuzi rizi uko ryabikemura nibiramuka bibayeho, bityo ntugatinye kuvuga ikintu icyo aricyo cyose utumva neza.

Hariho ibindi bimenyetso bigaragara ku ruhande ariko bikomeye bikeneye ubufasha bwihuse bw'abaganga. Nubwo ibi bitabaho kenshi, ni ngombwa kubimenya:

• Uburwayi bukomeye bwo kwibasirwa n'ibintu (kubura umwuka, kubyimba mu maso cyangwa mu muhogo, uruhu rurwaye cyane)
• Impinduka zikomeye mu mutima (umutima utagenda neza, kuribwa mu gituza)
• Kuguma mu nda bikomeye bitagira icyo bitanga nyuma yo kuvurwa
• Impinduka zidasanzwe z'imitekerereze cyangwa guhungabana
• Urugero rwo kuribwa cyane cyangwa guta ubwenge

Niba ubonye kimwe muri ibi bimenyetso bidasanzwe, itsinda ryawe ry'ubuvuzi rizabikemura ako kanya. Wibuke, uri mu rwego rw'ubuvuzi iyo wakiriye uyu muti, bityo ubufasha buri hafi buri gihe.

Ninde utagomba gufata Palonosetron?

Palonosetron muri rusange irinzwe kuri benshi, ariko hariho ibintu bimwe aho muganga wawe ashobora guhitamo undi muti. Ugomba kubwira itsinda ryawe ry'ubuvuzi ibijyanye n'uburwayi bwawe bwose n'imiti mbere yo kwakira palonosetron kugirango wemeze ko ari wo muti ukwiriye kuri wowe.

Muganga wawe azitonda cyane mu gutanga palonosetron niba ufite kimwe muri ibi biranga:

• Kumenya allergie kuri palonosetron cyangwa imiti isa nayo
• Ibibazo by'umutima cyangwa amateka y'umuryango y'uburwayi bw'umutima runaka
• Uburwayi bukomeye bw'impyiko cyangwa umwijima
• Kutaringanira kwa electrolyte (cyane cyane potasiyumu nkeya cyangwa magnesiyumu)
• Gukoresha imiti runaka ikora ku mutima

Gutwita no konsa bisaba kwitonderwa byihariye, nubwo palonosetron rimwe na rimwe ishobora gukoreshwa iyo inyungu ziruta ibyago. Muganga wawe azaganira nawe kuri ibi bintu niba bireba uko ubuzima bwawe bumeze.

Amazina y'ubwoko bwa Palonosetron

Palonosetron iboneka ku izina rya Aloxi, rikaba ari ryo rikoreshwa cyane mu bitaro no mu bigo bivura. Ushobora kandi kuribona ryitwa izina ryaryo rusange, palonosetron hydrochloride, ku nyandiko z'ubuvuzi cyangwa ku makuru y'urwandiko rw'umuti.

Ibikorwa bimwe na bimwe bishobora gukoresha amazina y'ubundi bwoko cyangwa ubwoko rusange, ariko byose bikubiyemo ikintu kimwe gikora kandi bikora kimwe. Itsinda ryawe ry'ubuzima rizakumenyesha ubwoko bwihariye urimo guhabwa, nubwo izina ry'ubwoko ntirisanzwe rigira ingaruka ku buryo umuti ukora neza mu gukumira isesemi.

Uburyo bwo gusimbuza Palonosetron

Niba palonosetron itagukwiriye, hariho indi miti myinshi ikora neza yo kurwanya isesemi muganga wawe ashobora gutekereza. Buri imwe ifite ibyiza byayo kandi ishobora gukora neza ku bantu batandukanye cyangwa ibihe bitandukanye.

Uburyo bumwe bwo gusimbuza busanzwe burimo:

• Ondansetron (Zofran) - undi muti urwanya 5-HT3 ukora kimwe ariko ufite igihe gito
• Granisetron (Kytril) - na none mu cyiciro kimwe cy'imiti ifite igihe gito gitandukanye
• Dolasetron (Anzemet) - indi nzira mu muryango umwe w'imiti
• Metoclopramide (Reglan) - ikora hakoreshejwe uburyo butandukanye kandi ishobora guhuzwa n'indi miti
• Dexamethasone - steroid ishobora gukora neza cyane ku isesemi iterwa na chimiothérapie

Muganga wawe azahitamo uburyo bwo gusimbuza bwiza bushingiye ku bibazo byawe by'ubuzima, indi miti urimo gufata, n'uburyo wabyitwayemo ku miti yo kurwanya isesemi mu gihe gishize. Rimwe na rimwe, guhuza imiti itandukanye bikora neza kuruta umuti umwe gusa.

Ese Palonosetron iruta Ondansetron?

Bombi palonosetron na ondansetron ni imiti myiza cyane yo gukumira isesemi, ariko bafite itandukaniro rikomeye rishobora gutuma imwe ikwiriye kurusha iyindi mu bihe byawe. Palonosetron ikunda kumara igihe kirekire mu mubiri wawe, bivuze ko ubusanzwe ukeneye doze nkeya kandi ukabona uburinzi burambye ku isesemi.

Palonosetron akunda gukoreshwa cyane mu miti ikomeye itera isesemi (itera isesemi) ya chimiothérapie kuko itanga uburinzi bwiza ku isesemi itinda ishobora kubaho nyuma yiminsi 2-5 nyuma yubuvuzi. Ondansetron ikora neza cyane ku isesemi yihuse ariko irashobora kumara igihe gito. Ariko, ondansetron imaze imyaka myinshi ikoreshwa kandi ifite amateka maremare yo gukoreshwa neza, kandi iboneka mu buryo bwinshi burimo ibinini na twa dusate dushonga mu kanwa.

Muganga wawe azatekereza ibintu nk'ubwoko bwa chimiothérapie urimo guhabwa, amateka yawe bwite yubuvuzi, n'ubwishingizi bwawe mugihe uhitamo hagati yiyi miti. Byombi bifite akamaro kanini, kandi guhitamo "byiza" biterwa nibyo ukeneye kandi n'ibihe byawe.

Ibikunze Kubazwa Kuri Palonosetron

Ese Palonosetron iratekanye kubarwayi bafite indwara z'umutima?

Palonosetron irashobora gukoreshwa neza kubarwayi benshi bafite indwara z'umutima, ariko bisaba gukurikiranwa neza no gusuzuma indwara yawe yihariye y'umutima. Uyu muti ushobora kugira ingaruka ku mutima wawe mu bantu bamwe, cyane cyane abafite ubwoko runaka bw'indwara z'umutima cyangwa bafata imiti igira ingaruka ku mikorere y'amashanyarazi y'umutima.

Muganga wawe azasuzuma ubuzima bw'umutima wawe, imiti urimo gufata, n'ibisubizo bya vuba by'ibizamini mbere yo gufata icyemezo niba palonosetron ikwiriye kuri wewe. Niba ufite amateka y'ibibazo by'umutima, ikipe yawe y'ubuvuzi irashobora guhitamo undi muti cyangwa itange gukurikiranwa kwiyongereye mugihe cy'ubuvuzi. Buri gihe menyesha abaganga bawe ibijyanye n'indwara z'umutima, n'iyo zisa nkizoroheje cyangwa zigenzurwa neza.

Ninkora iki niba mbonye Palonosetron nyinshi mu buryo butunguranye?

Kubera ko palonosetron itangwa n'abashinzwe ubuzima mu rwego rw'ubuvuzi, kwiyongera kw'umuti mu buryo butunguranye ni gake cyane. Uyu muti upimwa neza kandi ugatangwa hakurikijwe amabwiriza akomeye. Ariko, niba ufite impungenge ko ushobora kuba warabonye umuti mwinshi, bimenyeshe umuforomo wawe cyangwa muganga ako kanya.

Ibimenyetso bishobora kugaragaza ko wabonye umuti mwinshi harimo isereri rikomeye, umuvuduko w'umutima utamenyerewe, umunaniro ukabije, cyangwa ibindi bimenyetso bisa nkaho byiyongereye cyane kurusha uko byari byitezwe. Itsinda ryawe ry'abaganga ryatojwe kumenya no gukemura ibi bibazo vuba. Wibuke, uri ahantu h'ubuvuzi hatekanye aho ubufasha buhari ako kanya niba bibaye ngombwa.

Ninkora iki niba nciwe urugero rwa Palonosetron?

Gucikanwa n'urugero rwa palonosetron mubisanzwe ntabwo ari ikintu ugomba guhangayikishwa kuko bitangwa nk'igice cy'ubuvuzi bwawe bwateganyijwe. Niba ucikanwa n'igikorwa cyo kuvura kanseri aho wagombaga guhabwa palonosetron, vugana n'ikipe yawe y'ubuvuzi bw'indwara z'umubiri kugirango utegure kabiri vuba bishoboka.

Ku barwayi bazabagwa, niba igikorwa cyawe cyigijwe inyuma cyangwa giteganyijwe, ikipe yawe y'abaganga izahindura igihe cyo gutanga urugero rwa palonosetron uko bikwiye. Ntugerageze kwishyura urugero waciwe wenyine - buri gihe korana n'abaganga bawe kugirango umenye uburyo bwiza bwo gukora. Bashobora kugusaba imiti ivura isesemi niba bibaye ngombwa mugihe utegereje ubuvuzi bwawe bwongeye gutegurwa.

Nshobora kureka gufata Palonosetron ryari?

Uzahagarika guhabwa palonosetron igihe utakigomba ubuvuzi bwawe bukeneye kurinda isesemi. Ku barwayi barwaye kanseri, mubisanzwe bivuze igihe urangije ubuvuzi bwawe bwose bwa kanseri. Ku barwayi bazabagwa, mubisanzwe ukeneye urugero rumwe gusa, bityo "guhagarika" bibaho mu buryo busanzwe nyuma y'igikorwa cyawe.

Muganga wawe azakumenyesha igihe palonosetron itagikenewe mu buryo bwo kuvura. Bitandukanye n'imiti imwe na imwe ikeneye kugabanywa buhoro buhoro, palonosetron irashobora guhagarikwa ako kanya nta buryo bwo kuyigabanya. Niba ukigaragaza isesemi nyuma yo kurangiza uburyo bwawe bw'ibanze bwo kuvurwa, muganga wawe ashobora kugusaba imiti itandukanye ikwiriye gukoreshwa igihe kirekire.

Ese nshobora gutwara imodoka nyuma yo guhabwa Palonosetron?

Palonosetron irashobora gutera isereri cyangwa gusinzira ku bantu bamwe, bityo ntibisanzwe ko byemezwa gutwara imodoka ako kanya nyuma yo guhabwa umuti. Kubera ko ushobora kuba urimo guhabwa palonosetron nk'igice cyo kuvurwa na chemotherapy cyangwa kubagwa, birashoboka ko umaze gutegura uburyo bwo gutwara.

Ibitaro byinshi by'ubuvuzi byemeza ko ugomba kugira undi muntu ugutwara nyuma yo guhabwa chemotherapy cyangwa kubagwa, hatitawe ku muti urwanya isesemi ukoreshwa. Tegereza kugeza wumva umeze neza kandi utuje mbere yo gutwara, bishobora gufata amasaha menshi cyangwa ndetse n'umunsi ukurikira bitewe n'ubundi buryo bwo kuvurwa. Mu gihe ushidikanya, saba ikipe yawe y'ubuzima ubuyobozi bwihariye bushingiye ku miterere yawe bwite n'uburyo wakiriye umuti.