Icyo Pamidronate ari cyo: Ibyo ikoreshwa, urugero rwayo, ingaruka zayo n'ibindi

Pamidronate ni umuti wandikirwa na muganga utangwa binyuze mu muyoboro w'amaraso (intravenous) kugira ngo ufashishe gukomeza amagufa no kuvura indwara zimwe na zimwe zifitanye isano n'amagufa. Uyu muti ubarirwa mu itsinda ry'imiti yitwa bisphosphonates, ikora igabanya umuvuduko w'uturemangingo dusenya amagufa.

Niba muganga wawe yaraguteye umuti wa pamidronate, ushobora kuba wibaza icyo witegura kuri ubu buvuzi. Uyu muti ukoreshwa cyane iyo izindi nshuti z'amagufa zitagize icyo zigeraho, cyangwa iyo ukeneye kurengerwa amagufa cyane kubera indwara zihariye.

Pamidronate ni iki?

Pamidronate ni umuti ukomeza amagufa ushobora gutangwa gusa binyuze mu muyoboro w'amaraso mu kuboko kwawe. Bitandukanye n'ibinini ufata mu rugo, uyu muti usaba ko usura ivuriro cyangwa ibitaro kugira ngo utangwe.

Tekereza amagufa yawe nk'aho ahora yongera kwiyubaka. Uturemangingo tumwe dusenya amagufa ya kera mu gihe ibindi byubaka amagufa mashya. Pamidronate ifasha gushyira iyi ngufu mu kubaka amagufa akomeye kandi mazima binyuze mu kugabanya umuvuduko wo gusenyuka.

Uyu muti uguma mu mubiri wawe mu byumweru cyangwa amezi nyuma ya buri nshinge, niyo mpamvu utawukeneye kenshi. Abantu benshi bahabwa imiti buri byumweru bike cyangwa amezi, bitewe n'indwara yabo yihariye.

Pamidronate ikoreshwa mu kuvura iki?

Pamidronate ikoreshwa cyane mu kuvura urugero rwo hejuru rwa kalisiyumu mu maraso n'ibibazo bimwe na bimwe by'amagufa bifitanye isano na kanseri. Muganga wawe ashobora kukwandikira uyu muti niba ufite hypercalcemia, indwara aho urugero rwa kalisiyumu rugera ku rwego rwo hejuru cyane.

Uyu muti kandi ukoreshwa cyane ku bantu bafite kanseri yageze mu magufa, cyane cyane kanseri y'ibere, kanseri y'ibihaha, cyangwa multiple myeloma. Muri ibi bihe, ifasha kwirinda amagufa avunika kandi igabanya ububabare bw'amagufa.

Ikindi kandi, pamidronate ishobora kuvura indwara ya Paget, indwara aho amagufa akura mu buryo budasanzwe akaba manini kandi adakomeye. Abaganga bamwe kandi barayikoresha mu kuvura osteoporosis ikaze iyo izindi nshuti zitagize icyo zikora.

Pamidronate ikora ite?

Pamidronate ifatwa nk'umuti ukomeye wo mu magufa ukora uhereye ku ngingo zihariye zo mu magufa yawe. Yifatira ku gice cy'amagufa ikabuza imikorere ya osteoclasts, zo ni za selile zishinzwe gusenya amagufa.

Iyo izi selile zisenya amagufa zigabanutse, amagufa yawe agira umwanya wo kongera kwiyubaka no kwikomeza. Ubu buryo bufasha kugabanya umubare wa kalisiyumu isohokera mu maraso yawe kandi bigatuma amagufa yawe arwanya imvune.

Uyu muti ntiukora ako kanya. Ushobora gutangira kubona impinduka mu rubabaza rw'amagufa cyangwa urwego rwa kalisiyumu mu minsi mike cyangwa mu byumweru nyuma yo guterwa urushinge rwa mbere. Ingaruka zose zo gukomeza amagufa zirashobora gufata amezi menshi kugira ngo zigaragare.

Nkwiriye gufata pamidronate nte?

Pamidronate ihabwa buri gihe nk'urushinge rucyenda mu buryo buhoro mu kigo cy'ubuvuzi, ntabwo ihabwa nk'ipilule cyangwa urushinge. Ubu buryo busanzwe bufata amasaha 2 kugeza kuri 4, kandi ugomba kuguma wumva umeze neza muri iki gihe.

Mbere yo guterwa urushinge, ni ngombwa kunywa amazi menshi keretse muganga wawe akubwiye ibitandukanye. Kunywa amazi menshi bifasha kurengera impyiko zawe kandi bigabanya ibyago by'ingaruka. Urashobora kurya uko bisanzwe mbere na nyuma yo kuvurwa.

Mugihe cyo guterwa urushinge, umuti uzamanuka buhoro mu muyoboro wawe w'amaraso unyuze mu tuyunguruzo duto. Umuforomo azakugenzura neza kandi ashobora kugenzura umuvuduko w'amaraso yawe n'ubushyuhe buri gihe. Ubusanzwe urashobora gusoma, gukoresha terefone yawe, cyangwa kuruhuka mugihe uvurwa.

Nyuma yo guterwa urushinge, ubusanzwe urashobora gusubira mu bikorwa byawe bisanzwe ako kanya. Ariko, abantu bamwe barumva bananiwe cyangwa bagira ibimenyetso byoroheje bisa n'ibicurane nyuma y'umunsi umwe cyangwa ibiri, cyane cyane nyuma yo kuvurwa bwa mbere.

Nkwiriye gufata pamidronate igihe kingana iki?

Ubukure bw'imiti ya pamidronate buratandukana cyane bitewe n'uburwayi bwawe n'uburyo umubiri wawe wakiriye imiti. Abantu bamwe bakeneye inshuro imwe cyangwa ebyiri gusa, mu gihe abandi bashobora gukomeza kuvurwa mu mezi cyangwa imyaka.

Kubera urugero rwo hejuru rwa kalisiyumu, ushobora gukenera inshuro imwe gusa igarura kalisiyumu yawe mu buryo busanzwe. Ariko, niba uburwayi buri hasi bukomeje, ushobora gukenera izindi nshuro buri byumweru bike cyangwa amezi.

Niba ufite ibibazo by'amagufa bifitanye isano na kanseri, muganga wawe ashobora gukugira inama yo gukomeza kuvurwa igihe cyose bifasha kandi ubasha kubyakira neza. Intego ni ukwirinda ibibazo by'amagufa no gukomeza ubuzima bwawe bwiza.

Muganga wawe azagenzura buri gihe uko umubiri wawe witwara binyuze mu igeragezwa ry'amaraso no gupima amagufa. Bazahindura gahunda yawe yo kuvurwa bitewe n'uko amagufa yawe yitwara niba hari ingaruka zikubaho.

Ni izihe ngaruka ziterwa na Pamidronate?

Kimwe n'imiti yose, pamidronate irashobora gutera ingaruka, nubwo atari buri wese uzibona. Ingaruka zisanzwe zikunda kuba zoroshye kandi zikamaraho igihe.

Abantu benshi bagira ibimenyetso bisa n'ibicurane nyuma yo guhabwa inshuro yambere, ibyo bikaba ari ikimenyetso cy'uko umuti ukora. Hano hari ingaruka zisanzwe ushobora kubona:

• Urubavu n'ubukonje, akenshi bitangira mu masaha 24 nyuma yo kuvurwa
• Uburibwe bw'imitsi n'ubuhumure bw'ingingo bumeze nk'uko umuntu arwaye ibicurane
• Umunaniro cyangwa kumva unaniwe kurusha uko byari bisanzwe umunsi umwe cyangwa ibiri
• Isesemi cyangwa guhungabana gato kw'inda
• Umutwe ushobora kumara umunsi umwe cyangwa ibiri
• Uburibwe cyangwa kwaka ahantu umuti watewe

Izi ngaruka zisanzwe zikunda gukira mu masaha 48 kandi zikunda kuba ntoya mu kuvurwa gukurikira. Gufata imiti igurishwa idakeneye uruhushya rwa muganga nka acetaminophen birashobora gufasha mu kugabanya kutumva neza.

Ingaruka zitagaragara cyane ariko zikomeye zirashobora kubaho, kandi ugomba kuvugana na muganga wawe niba ubona izi zikurikira:

• Uburibwe bukomeye mu ruhanga cyangwa kugorwa gufungura umunwa wawe
• Uburibwe bushya cyangwa budasanzwe mu itako, ikibuno, cyangwa mu gice cy'umubiri kiri hagati y'amaguru
• Impinduka mu mboni zawe cyangwa uburibwe mu jisho
• Isesemi rihoraho, kuruka, cyangwa kutagira ubushake bwo kurya
• Umunaniro ukabije utagabanuka nyuma y'iminsi mike
• Ibimenyetso byo kugabanuka kwa kalisiyumu nk'imitsi yikanyaga cyangwa kumva urugero

Ingaruka zidakunze kubaho ariko zikomeye zirimo osteonecrosis y'uruhanga (urupfu rw'amagufa mu ruhanga) no kuvunika kw'amagufa y'itako bidasanzwe. Izi ngorane ntizikunze kubaho ariko ni ngombwa kuzitaho, cyane cyane iyo bikoreshwa igihe kirekire.

Ninde utagomba gufata Pamidronate?

Pamidronate ntibereye buri wese, kandi muganga wawe azasuzuma neza amateka yawe mbere yo kuyandika. Ntugomba guhabwa uyu muti niba ufite indwara ikomeye y'impyiko cyangwa ufite allergie kuri bisphosphonates.

Abagore batwite cyangwa bonka ntibagomba gukoresha pamidronate, kuko ishobora kwangiza umwana ukiri mu nda. Uyu muti ushobora kumara imyaka myinshi mu magufa yawe, bityo abagore bashobora kuzatwita bagomba kubiganiraho neza na muganga wabo.

Abantu bafite ibibazo by'amenyo runaka cyangwa abateganya gukorerwa ibikorwa by'amenyo bashobora gukenera gutinda kuvurwa. Muganga wawe ashobora kugusaba kubonana na muganga w'amenyo mbere yo gutangira gufata pamidronate, cyane cyane niba ukeneye gukuramo iryinyo cyangwa kubagwa mu kanwa.

Niba ufite urugero rwa kalisiyumu ruto, ibibazo by'umutima, cyangwa ufata imiti runaka, muganga wawe azakenera kugukurikiranira hafi cyangwa guhindura gahunda yawe yo kuvura.

Amazina ya Pamidronate

Pamidronate iboneka ku izina rya Aredia muri Leta Zunze Ubumwe z'Amerika. Ushobora kandi kuyibona yitwa izina ryayo rusange, pamidronate disodium.

Uyu muti ukorwa n'amasosiyete menshi y'imiti, ariko ibikoresho byayo by'ingenzi n'ingaruka biracyasa kimwe hatitawe ku izina ryayo. Farumasi y'ibitaro byawe cyangwa ivuriro rizemeza uburyo uzahabwamo.

Ubwoko bumwe na bumwe bw'ubwishingizi bushobora kugira ibyo bakunda ku nganda zimwe na zimwe, ariko ibyo ntibigomba kugira ingaruka ku mitwararire yawe. Ikintu cy'ingenzi ni uko urimo guhabwa urugero rukwiye rwa pamidronate ku ndwara yawe.

Uburyo bwo gusimbura Pamidronate

Imiti myinshi ishobora kuvura indwara zisa n'izo mu magufa, nubwo muganga wawe azahitamo uburyo bwiza bushingiye ku miterere yawe yihariye. Izindi bisphosphonates nka zoledronic acid (Zometa) zishobora gukoreshwa mu mwanya wa pamidronate.

Ku ndwara ya osteoporosis, bisphosphonates yo kunywa nka alendronate (Fosamax) cyangwa risedronate (Actonel) bishobora kuba amahitamo niba ushobora kwihanganira ibinini. Ibi bifatirwa mu kanwa aho gukoreshwa mu nzira ya IV.

Imiti mishya nka denosumab (Prolia) ikora mu buryo butandukanye na bisphosphonates kandi ishobora gukwira abantu bamwe batabasha gufata pamidronate. Imiti ivura imisemburo cyangwa indi miti yubaka amagufa nayo ishobora kuzirikanwa.

Muganga wawe azatekereza ibintu nk'imikorere y'impyiko zawe, indi miti, n'ibyo ukunda ku giti cyawe mugihe ahitamo uburyo bwiza bwo kuvura ubuzima bw'amagufa yawe.

Ese Pamidronate iruta Zoledronic Acid?

Pamidronate na zoledronic acid zombi ni bisphosphonates zikora neza, ariko zifite itandukaniro rishobora gutuma imwe ikwira kurusha iyindi. Zoledronic acid muri rusange ifatwa nk'ikomeye kandi itangwa kenshi.

Inshinge za Pamidronate zifata amasaha 2 kugeza kuri 4, mugihe zoledronic acid ishobora gutangwa mu minota 15 kugeza kuri 30. Ibi bishobora gutuma zoledronic acid yoroha kubantu bamwe, nubwo zombi ari imiti ikora neza.

Ukwihitiramo hagati yiyi miti akenshi biterwa n'indwara yawe yihariye, imikorere y'impyiko zawe, n'uburyo wihanganira buri miti. Abantu bamwe barushaho kumera neza hamwe n'umuti umwe kurusha undi mu bijyanye n'ingaruka ziterwa.

Muganga wawe azatekereza ibintu byawe byihariye, harimo izindi ndwara n'imiti, mugihe afata icyemezo cy'uko bisphosphonate ikwiriye kuri wowe.

Ibibazo Bikunze Kubazwa Kuri Pamidronate

Ese Pamidronate irakwiriye ku bantu barwaye indwara y'impyiko?

Pamidronate isaba kwitonderwa cyane ku bantu bafite ibibazo by'impyiko. Uyu muti unyuzwa mu mpyiko zawe, bityo kugabanuka kw'imikorere y'impyiko bishobora kongera ibyago byo kugira ingaruka ziterwa n'uyu muti.

Muganga wawe azagenzura imikorere y'impyiko zawe akoresheje ibizamini by'amaraso mbere ya buri kuvurwa kandi ashobora guhindura urugero rw'umuti cyangwa umuvuduko wo kuwutera niba bibaye ngombwa. Abantu bafite indwara zikomeye z'impyiko mubisanzwe ntibashobora guhabwa pamidronate mu buryo bwizewe.

Niba ufite ibibazo byoroheje cyangwa by'ikigereranyo by'impyiko, muganga wawe ashobora kuguha urugero ruto rw'umuti cyangwa akongera igihe cyo kuwutera kugira ngo agabanye umunaniro ku mpyiko zawe. Kuguma ufite amazi ahagije mbere na nyuma yo kuvurwa ni ingenzi cyane.

Nkwiriye gukora iki niba nahawe pamidronate nyinshi mu buryo butunganye?

Kubera ko pamidronate itangwa mu buryo bugenzurwa na muganga, kwirenza urugero rw'umuti ni gake cyane. Ariko, niba ufite impungenge zo guhabwa umuti mwinshi, bwira ikipe yawe y'ubuvuzi ako kanya.

Ibimenyetso byo guhabwa pamidronate nyinshi bishobora kuba birimo ibimenyetso bikomeye bisa n'ibicurane, kugabanuka cyane kw'urugero rwa kalisiyumu, cyangwa ibibazo by'impyiko. Abakozi b'ubuvuzi bazagukurikiranira hafi kandi bashobora gutanga ubufasha niba bibaye ngombwa.

Inkuru nziza ni uko kwirenza urugero rwa pamidronate bidakunze kubaho cyane kuko uyu muti ubarwa neza kandi ukatangwa n'abantu babihuguriwe. Ikipe yawe y'ubuvuzi izahora igenzura kabiri urugero rw'umuti mbere yo gutangira kuwutera.

Nkwiriye gukora iki niba nciweho urugero rwa pamidronate?

Niba ucikanwe no guterwa pamidronate, vugana n'ibiro bya muganga wawe vuba bishoboka kugira ngo wongere uteganyirizwe. Ntugerageze gusubiza urugero rwakucitseho ukoresha umuti wiyongereyeho nyuma.

Gucikanwa no kuvurwa rimwe mubisanzwe ntibizatera ibibazo ako kanya, ariko ni ingenzi gukurikiza gahunda yawe yo kuvurwa kugira ngo ugire ibisubizo byiza. Muganga wawe ashobora guhindura igihe cyo gufata urugero rwawe rutaha hashingiwe ku gihe cyashize utaraterwa umuti.

Niba warasibye imiti myinshi, muganga wawe ashobora kwifuza gupima urugero rwa kalisiyumu mu maraso yawe cyangwa ibimenyetso by'amagufa mbere yo gusubukura imiti. Bazagufasha gusubira mu murongo w'umugambi wawe w'imiti.

Ni ryari nshobora guhagarika gufata Pamidronate?

Umwanzuro wo guhagarika pamidronate biterwa n'uburwayi bwawe bw'ibanze n'uburyo urimo gusubiza neza ku miti. Ntukigere uhagarika imiti utabanje kubiganiraho na muganga wawe.

Ku rwego rwo hejuru rwa kalisiyumu, ushobora guhagarika igihe kalisiyumu yawe isubiye mu buryo busanzwe kandi igahoraho. Ariko, niba icyateye ikibazo gikomeje, ushobora gukenera imiti ikomeza kugirango wirinde ko urwego rwa kalisiyumu ruzamuka.

Abantu bafite ibibazo by'amagufa bifitanye isano na kanseri akenshi bakomeza imiti igihe cyose ifasha kandi bayihanganira neza. Muganga wawe azagenzura buri gihe niba inyungu zigikomeza kurusha ibyago cyangwa ingaruka ziterwa nayo.

Nshobora gufata izindi miti nkanjye mfata Pamidronate?

Imiti myinshi irashobora gufatwa neza hamwe na pamidronate, ariko ni ngombwa kubwira muganga wawe imiti yose, ibyongerera imbaraga, na vitamine urimo gufata. Imwe mu miti ishobora kugirana imikoranire na pamidronate cyangwa ikagira ingaruka ku miti yawe.

Ibyongerera kalisiyumu n'imiti irwanya aside bigomba gufatwa mu bihe bitandukanye n'urushinge rwawe rwa pamidronate kugirango wirinde imbogamizi. Muganga wawe ashobora gushishikariza igihe cyihariye cy'ibi byongerera imbaraga.

Imiti ituma amaraso ataguma, imiti yica mikorobe, na zimwe mu miti ya kanseri bishobora gusaba gukurikiranwa byihariye iyo bikoreshejwe hamwe na pamidronate. Itsinda ryawe ryita ku buzima rizakorana imiti yawe kugirango ryemeze ko ikora neza hamwe.