Icyo Panobinostat ari cyo: Ibikoreshwa, Urutonde rw'imiti, Ingaruka zayo n'ibindi

Panobinostat ni umuti w'indwara ya kanseri ugamije guhagarika poroteyine zihariye zifasha selile za kanseri gukura no kubaho. Ihereranye mu cyiciro cy'imiti yitwa histone deacetylase inhibitors, ifasha umubiri wawe gukora neza uburyo bwo kurwanya ibibyimba. Uyu muti ukoreshwa cyane mu kuvura ubwoko bumwe na bumwe bwa kanseri y'amaraso, cyane cyane multiple myeloma iyo izindi miti zitagikora neza nk'uko byifuzwa.

Panobinostat ni iki?

Panobinostat ni umuti wa kanseri ufata selile za kanseri ku rwego rwa molekile. Ikora ihungabanya enzymes yitwa histone deacetylases, selile za kanseri zikeneye gukura no kwiyongera.

Tekereza nk'umuti ufasha gusubiza umubiri wawe ubushobozi bwo kugenzura imikurire idasanzwe ya selile. Bitandukanye na chimiothérapie igira ingaruka ku selile zose zikora vuba, panobinostat ihitamo uburyo ifata selile za kanseri. Ubu buryo bugamije burashobora gutuma bikora neza mugihe bishobora gutera ingaruka nke kurusha chimiothérapie gakondo.

Uyu muti uza mu buryo bwa capsule kandi ufashwe mu kanwa, bituma byoroha kurusha imiti isaba gusura ibitaro kugirango baterwe imiti. Muganga wawe azayandika nk'igice cy'umugambi wo kuvura kanseri wagenewe neza indwara yawe.

Panobinostat ikoreshwa mu kuvura iki?

Panobinostat yemerewe by'umwihariko kuvura multiple myeloma, ubwoko bwa kanseri y'amaraso igira ingaruka ku selile za plasma zo mu bwoko bwawe. Muri rusange yandikwa iyo umaze kugerageza nibura uburyo bubiri bwo kuvura, harimo immunomodulatory agent na proteasome inhibitor.

Multiple myeloma birashobora kugorana kuvura kuko selile za kanseri akenshi zigaragaza ubudahangarwa ku miti uko igihe kigenda. Panobinostat itanga uburyo butandukanye bwo gukora, bivuze ko bishobora gufasha iyo izindi miti zitagikora neza.

Umuvuzi wawe w’indwara z’umubiri (oncologist) ashobora kugusaba gukoresha panobinostat nk’igice cy’imiti ihurijwe hamwe, akenshi ikoreshwa hamwe n’indi miti nka bortezomib na dexamethasone. Ubu buryo bwo guhuriza hamwe bufasha kurwanya kanseri mu buryo bwinshi, bishobora guteza imbere imikorere y’imiti.

Panobinostat ikora ite?

Panobinostat ikora ibyara inzitizi ku enzymes zifite izina rya histone deacetylases (HDACs) kanseri ikeneye kugenzura imikorere y’urugero rw’uturemangingo. Iyo izo enzymes zibayeho inzitizi, uturemangingo twa kanseri ntibishobora kugenzura neza uko bikura n’uko bibaho.

Uyu muti ufatwa nk’umuti ukomeye wo kuvura kanseri ufite uburyo bwihariye bwo gukora. Ugenewe kuba ukomeye bihagije kugira ngo ugire ingaruka ku turemangingo twa kanseri mu gihe wihariye kurusha imiti gakondo ya chemotherapy.

Uyu muti mu by’ukuri ufasha gusubiza mu buryo busanzwe imikorere y’uturemangingo twahungabanyijwe na kanseri. Mu kwivanga muri izo nzira zihariye, panobinostat ishobora gutuma uturemangingo twa kanseri guhagarika gukura cyangwa no gupfa, mu gihe bigira ingaruka nkeya ku turemangingo twiza mu mubiri wawe wose.

Nkwiriye gufata panobinostat nte?

Fata panobinostat nk’uko muganga wawe abikwandikiye, akenshi inshuro eshatu mu cyumweru ku minsi yihariye. Gahunda isanzwe ni kuwa mbere, kuwa gatatu, na kuwa gatanu mu byumweru 1 na 2 bya buri cyiciro cy’imiti cy’iminsi 21.

Ukwiriye gufata ibinini hamwe n’amazi, kandi ushobora kubifata hamwe n’ibiryo cyangwa utabifata. Ariko, kubifata hamwe n’ibiryo bishobora gufasha kugabanya kuribwa mu nda niba wumva isesemi. Ntugasenye, utahe cyangwa ufungure ibinini - ubimire byose kugira ngo wemeze ko byinjira neza mu mubiri.

Ni ngombwa gufata imiti yawe ku gihe kimwe buri munsi kugira ngo ugumane urwego rwo hejuru rw’umuti mu mubiri wawe. Niba warutse mu isaha imwe nyuma yo gufata umuti, ntufate undi munsi uwo munsi - tegereza kugeza igihe cyo gufata umuti wawe uteganyijwe.

Mbere yo gutangira kuvurwa, muganga wawe ashobora kugusaba kurya ifunguro rito cyangwa agasupu mbere y'iminota 30 yo gufata umuti. Ibi bishobora gufasha kugabanya ingaruka zo mu gifu zimwe na zimwe abantu bahura nazo.

Nzamara Mfata Panobinostat Igihe Kingana Gite?

Igihe cyo kuvurwa na panobinostat gitandukana cyane ku muntu ku muntu kandi biterwa n'uko umuti ukora neza ku miterere yawe. Abantu benshi bakomeza kuvurwa igihe cyose bifasha kugenzura kanseri yabo kandi ingaruka zikaba zigikoreshwa.

Muganga wawe azagenzura uko witwara ku buvuzi binyuze mu bipimo by'amaraso bisanzwe, isesengura ry'amashusho, n'ibizamini by'umubiri. Ibi bisuzuma bifasha kumenya niba umuti ukora neza kandi niba ari byiza ko ukomeza.

Abantu bamwe bashobora gufata panobinostat amezi menshi, mu gihe abandi bashobora gukomeza umwaka cyangwa kurenza. Ikintu cy'ingenzi ni ukubona uburyo bwiza bwo kugenzura kanseri no kubaho neza. Itsinda ryawe ry'ubuvuzi rizakorana nawe kugira ngo ukore impinduka uko bikwiye mu rugendo rwawe rw'ubuvuzi.

Ni Iyihe Ngaruka Ziterwa na Panobinostat?

Kimwe n'imiti yose ya kanseri, panobinostat irashobora gutera ingaruka, nubwo atari buri wese uzihura nazo. Ingaruka zisanzwe zikoreshwa muri rusange zicungwa neza hamwe n'ubufasha n'ubugenzuzi bw'ubuvuzi bukwiye.

Dore ingaruka zisanzwe ushobora guhura nazo:

• Umunaniro no kunanuka
• Isesemi no kuruka
• Impiswi
• Kugabanya ubushake bwo kurya
• Umubare muto w'uturemangingo tw'amaraso
• Ukubura mu ntoki, ibirenge, cyangwa amaguru
• Urubavu cyangwa kubabara mu ngingo

Izi ngaruka mubisanzwe zoroheje kugeza hagati kandi akenshi zikora neza uko umubiri wawe wimenyereza umuti. Itsinda ryawe ry'ubuvuzi rishobora gutanga ingamba n'imiti yo gufasha gucunga ibi bimenyetso neza.

Ingaruka zikomeye ariko zitabaho cyane zirimo indwara zikomeye ziterwa n’umubare muto w’uturemangingo tw’amaraso twera, ibibazo by’umutima, cyangwa impiswi ikomeye itera umwuma. Nubwo ibi bitabaho kenshi, ni ngombwa kumenyesha muganga wawe ibimenyetso icyo aricyo cyose giteye inkeke ako kanya.

Abantu bamwe bashobora kugira ibibazo by’amaraso, umunaniro ukabije, cyangwa ibibazo by’umwijima. Muganga wawe azagukurikiranira hafi akoresheje ibizamini by’amaraso bya buri gihe kugira ngo amenye ibibazo byose bishoboka hakiri kare kandi ahindure imiti yawe niba bibaye ngombwa.

Ninde utagomba gufata Panobinostat?

Panobinostat ntikwiriye buri wese, kandi muganga wawe azasuzuma neza niba bikwiriye kuri wowe. Abantu bafite indwara zimwe na zimwe z’umutima, cyane cyane abafite amateka y’umutima utera cyangwa ibibazo by’umutima, ntibashobora kuba abakandida beza kuri uyu muti.

Niba ufite ibibazo bikomeye by’umwijima cyangwa indwara zikomeye zitagenzurwa, muganga wawe ashobora gusaba gutegereza kugeza igihe ibi bibazo bigenzurwa neza mbere yo gutangira panobinostat. Uyu muti ushobora kugira ingaruka ku mikorere y’ubwirinzi bw’umubiri wawe, bigatuma indwara zikara.

Abagore batwite cyangwa bonka ntibagomba gufata panobinostat, kuko ishobora kwangiza abana bakiri bato. Niba uri mu gihe cyo kubyara, uzakenera gukoresha uburyo bwo kuboneza urubyaro bukora neza mugihe uvurwa no mu mezi make nyuma yo guhagarika imiti.

Abantu bafite ibibazo bikomeye by’impyiko cyangwa abafata imiti imwe na rimwe igira ingaruka ku mutima bashobora no gukenera izindi miti. Muganga wawe azasuzuma imiti yawe yose ubu ufata n’ubuzima bwawe kugira ngo arebe neza ko panobinostat ikwiriye kuri wowe.

Amazina y’ubwoko bwa Panobinostat

Panobinostat iboneka ku izina ry’ubwoko rya Farydak mu bihugu byinshi, harimo n’Amerika. Iri ni ryo zina ry’ubwoko rya mbere uzabona ku icupa ryawe ry’imiti no ku gipfunyika cy’imiti.

Ubu, Farydak niyo izina rikoreshwa cyane, kuko panobinostat ni umuti mushya ukiri mu buryo bwo kurindwa na patenti. Ingero zidasanzwe ntizirahari cyane, nubwo ibi bishobora guhinduka mu gihe kizaza patenti zirangira.

Igihe uvugana n'abaganga cyangwa abagurisha imiti ku bijyanye n'ubuvuzi bwawe, ushobora kwerekeza ku muti ukoresha izina iryo ariryo ryose - panobinostat cyangwa Farydak - kandi bazahita bamenya neza icyo uvuga.

Izindi Miti Ishobora Gusimbura Panobinostat

Niba panobinostat itagukwiriye cyangwa itagikora neza, hari ubundi buvuzi bushobora kuboneka bwo kuvura kanseri ya myélome nyinshi. Muganga wawe ashobora gutekereza ku bindi bice bya histone deacetylase cyangwa imiti ikora mu buryo butandukanye.

Izindi miti harimo n'ubundi buvuzi bugamije ibintu runaka nka carfilzomib, pomalidomide, cyangwa daratumumab. Iyi miti ikora mu buryo butandukanye bwo kurwanya selile za kanseri, itanga amahitamo niba panobinostat itagukwiriye.

Uburyo bushya bwo kuvura hakoreshejwe imiti ikoresha ubudahangarwa, harimo n'ubuvuzi bwa selile za CAR-T, bushobora kuba amahitamo bitewe n'uko ubuzima bwawe bwifashe. Igeragezwa ry'imiti ikorerwa mu bigo by'ubushakashatsi rishobora gutanga andi mahitamo ku bantu bagerageje uburyo bwinshi bwo kuvura busanzwe.

Uburyo bwiza bwo gusimbuza buterwa n'ubuvuzi wahawe mbere, ubuzima bwawe muri rusange, n'imiterere yihariye ya kanseri yawe. Muganga wawe w'inzobere mu kuvura kanseri azakorana nawe kugira ngo amenye intambwe ikurikira ikwiriye niba panobinostat itagikora cyangwa itera ingaruka zitakwemerwa.

Ese Panobinostat iruta Bortezomib?

Panobinostat na bortezomib bikora mu buryo butandukanye, bityo kubigereranya ntibyoroshye. Bortezomib ni umuti uhagarika proteasome ukoreshwa kenshi mu ntangiriro yo kuvura kanseri ya myélome nyinshi, naho panobinostat ikoreshwa cyane mu gihe cyo kuvura nyuma y'ubundi buvuzi.

Mu bushakashatsi bwakozwe ku barwayi, panobinostat ikunze gukoreshwa ihuriye na bortezomib aho kuyisimbuza. Ubu buryo bwo guhuriza hamwe bwagaragaje umusaruro mwiza ugereranije n'imiti yombi ikoreshwa ukwayo ku bantu barwaye myeloma yagarutse.

Gu hitamo hagati y'iyo miti biterwa n'amateka y'ubuvuzi bwawe, uburyo kanseri yawe yitwaye mu buvuzi bwakoreshejwe mbere, n'ubuzima bwawe muri rusange. Muganga wawe azatekereza ku bintu nk'ingaruka zatewe n'imiti mbere, ibimenyetso byawe by'ubu, n'imiterere yihariye ya kanseri yawe mugihe atanga inama z'ubuvuzi.

Ibikunze Kubazwa Kuri Panobinostat

Ese Panobinostat irakwiriye ku bantu bafite ibibazo by'umutima?

Panobinostat isaba gukurikiranwa neza ku bantu bafite ibibazo by'umutima kuko ishobora kugira ingaruka ku mutima. Muganga wawe azakora electrocardiogram (ECG) mbere yo gutangira kuvurwa kandi buri gihe mugihe cy'ubuvuzi kugirango akurikirane imikorere y'amashanyarazi y'umutima wawe.

Niba ufite amateka y'ibibazo by'umutima, kunanirwa k'umutima, cyangwa izindi ndwara zikomeye z'umutima, muganga wawe ashobora kugusaba izindi miti cyangwa gufata ingamba zidasanzwe niba panobinostat ariyo nziza kuri wowe. Bazakorana bya hafi na cardiologist kugirango barebe ko ubuzima bw'umutima wawe burinzwe mugihe cyose cy'ubuvuzi.

Nigute nzakora niba nanyweye panobinostat nyinshi bitunguranye?

Niba utunguranye unyweye panobinostat nyinshi kuruta uko byategetswe, vugana na muganga wawe cyangwa ikigo gishinzwe kurwanya ubumara ako kanya. Ntukegere ngo urebe niba ibimenyetso bigaragara - ni byiza gushaka inama z'ubuvuzi ako kanya.

Kunywa panobinostat nyinshi bishobora kongera ibyago byo kugira ingaruka zikomeye, cyane cyane ibibazo by'umutima no kugabanuka gukabije kw'umubare w'uturemangingo tw'amaraso. Itsinda ryawe ry'ubuzima rishobora gushaka kukukurikirana cyane kandi rishobora guhindura imiti yawe iri imbere kugirango wirinde.

Nigute nzakora niba nciweho urugero rwa panobinostat?

Niba wibagiwe urugero rwa panobinostat, ntuyifate niba hashize amasaha arenga 12 uhereye igihe wari uteganyirijwe. Ahubwo, reka urugero wibagiwe, hanyuma ufate urugero rukurikira ku gihe cyagenwe.

Ntuzigere ufata urugero rurenze rumwe icyarimwe kugira ngo usimbure urugero wibagiwe, kuko ibi bishobora kongera ibyago byo kugira ingaruka zikomeye. Niba ukunda kwibagirwa urugero, ganira n'ikipe yawe y'ubuzima ku bijyanye n'uburyo bwo kugufasha kwibuka, nko gushyiraho alarme kuri terefone cyangwa gukoresha umuteguro w'imiti.

Ni ryari nshobora guhagarika gufata Panobinostat?

Ugomba guhagarika gufata panobinostat gusa ukurikije ubuyobozi bwa muganga wawe. Umwanzuro wo guhagarika imiti biterwa n'uko umuti ukora neza, ingaruka zikubaho, n'uko ubuzima bwawe muri rusange bumeze.

Abantu bamwe bashobora gukenera guhagarika by'agateganyo niba bagize ingaruka zikomeye, mu gihe abandi bashobora guhagarika burundu niba kanseri ikomeje cyangwa ingaruka zikaba zitagishoboka. Muganga wawe azagufasha gupima inyungu n'ibibazo kugira ngo ufate umwanzuro mwiza ku miterere yawe yihariye.

Nshobora gufata indi miti nkanjye kuri Panobinostat?

Imiti myinshi ishobora gukururana na panobinostat, bityo ni ngombwa kubwira muganga wawe imiti yose yanditswe na muganga, imiti igurishwa ku isoko, n'ibyongerera imiti ufata. Imiti imwe ishobora kongera urwego rwa panobinostat mu maraso yawe, bishobora gutera ingaruka nyinshi.

Muganga wawe azasuzuma imiti yawe yose kandi ashobora gukenera guhindura urugero cyangwa agasaba izindi mbiti zindi. Ntukoreshe indi miti mishya cyangwa ibyongerera imiti utabanje kubiganiraho n'ikipe yawe y'ubuzima, kuko ndetse n'ibicuruzwa bisa nkaho bidafite akamaro rimwe na rimwe bishobora gukururana n'imiti ivura kanseri.