Pazopanib ni iki: Ibikoreshwa, Urutonde rw'imiti, Ingaruka ziterwa n'iyo miti n'ibindi

Pazopanib ni umuti w'indwara ya kanseri ugamije guhagarika proteyine zihariye zifasha selile za kanseri gukura no gukwirakwira. Ni kimwe mu itsinda ry'imiti yitwa tyrosine kinase inhibitors, ikora nk'inzitizi zikomeye zirwanya ibimenyetso byo gukura kwa kanseri.

Uyu muti ugaragaza iterambere rikomeye mu kuvura kanseri kuko ushobora gutuma igituntu kigenda gahoro kandi akenshi ukagufasha kugira ubuzima bwiza ugereranije na chimiothérapie ya kera. Muganga wawe yandika pazopanib iyo ashaka kuvura kanseri yawe akoresheje uburyo bwihariye.

Pazopanib ikoreshwa mu kuvura iki?

Pazopanib ikoreshwa cyane mu kuvura kanseri yo mu mpyiko igeze kure, yitwa kandi renal cell carcinoma. Ikoreshwa by'umwihariko iyo kanseri yafashe ahandi hantu hanze y'impyiko cyangwa iyo kubaga bidashoboka.

Muganga wawe ashobora kandi kugusaba pazopanib ku bwoko bumwe bwa sarcomas yo mu gice cyoroshye cy'umubiri, ari zo kanseri zigaragara mu misitsi, urugimbu, imitsi y'amaraso, cyangwa izindi ngingo zifasha mu mubiri wawe. Izi ni kanseri zitamenyerewe, ariko pazopanib yagaragaje ibisubizo byiza mu kugabanya imikorere yazo.

Uyu muti ukora neza cyane ku byiciro byateye imbere bya kanseri aho intego ari ukugenzura indwara no kugufasha kugumana ubuzima bwiza. Ntabwo akenshi ari uburyo bwa mbere bwo kuvura kanseri zo mu ntangiriro zishobora kubagwa.

Pazopanib ikora ite?

Pazopanib ikora ihagarika proteyine nyinshi zingenzi selile za kanseri zikeneye kugira ngo zikure kandi zikore imitsi mishya y'amaraso. Tekereza nk'aho uca imirongo y'ibikoresho bya kanseri aho gutera selile za kanseri ubwazo.

Uyu muti wibanda cyane kuri proteyine yitwa VEGFR, PDGFR, na c-Kit, zisa nk'ibishushanyo bibwira selile za kanseri kwiyongera no gukora imitsi mishya y'amaraso. Mu guhagarika izi switch, pazopanib yica igituntu intungamubiri na ogisijeni ikeneye kugira ngo ikure.

Ibi bituma pazopanib iba umuti ukomeye wo kurwanya kanseri, akenshi worohera umubiri kurusha imiti gakondo ya kanseri. Nubwo ifite imbaraga zihagije zo kugabanya ikwirakwiza rya kanseri, akenshi itera ingaruka nke zikomeye kurusha imiti ya kera ivura kanseri.

Nkwiriye Gufata Pazopanib Nte?

Fata pazopanib uko muganga wawe abikwandikiye, akenshi rimwe ku munsi ku gifu cyambaye ubusa. Ibi bivuze kuyifata mbere y'isaha imwe yo kurya cyangwa nyuma y'amasaha abiri umaze kurya.

Mimina ibinini byose hamwe n'amazi - ntukabikoremo agahombo, ntukayatobore cyangwa uyacagagure. Uyu muti ugomba kwinjizwa neza mu mubiri, kandi gucagagura ibinini bishobora kugira ingaruka ku kwinjira kwawo mu mubiri wawe.

Gerageza gufata urugero rwawe ku gihe kimwe buri munsi kugira ngo ugumane urugero ruzigama mu mubiri wawe. Abantu benshi babona ko bifasha kuyifata mu gitondo kare, hanyuma bagategereza nibura isaha mbere yo gufata ifunguro rya mugitondo.

Irinde imbuto za pome n'umutobe wazo mugihe ufata pazopanib, kuko ibi bishobora kongera urugero rw'uyu muti mu maraso yawe kandi bikaba byatera ingaruka nyinshi.

Nkwiriye Kumara Igihe Kingana Gite Ndafata Pazopanib?

Uzakomeza gufata pazopanib igihe cyose ifasha kugenzura kanseri yawe kandi uyihanganira neza. Ibi bishobora kumara amezi cyangwa imyaka, bitewe n'uko umubiri wawe witwara.

Muganga wawe azakurikiza iterambere ryawe binyuze mu bipimo bisanzwe n'ibizamini by'amaraso kugira ngo arebe uko umuti ukora neza. Bazareba kandi ingaruka zose zishobora gusaba guhindura urugero rwawe cyangwa guhagarika ubuvuzi.

Umwanzuro wo gukomeza cyangwa guhagarika pazopanib biterwa n'ibintu byinshi: niba kanseri yawe ihagaze cyangwa ikwirakwira, uko wumva umeze muri rusange, niba inyungu ziruta ingaruka zose urimo guhura nazo.

Ni Izihe Ngaruka Ziterwa na Pazopanib?

Abantu benshi bafata pazopanib bagira ingaruka zinyuranye, ariko akenshi zirashobora guhangana nazo bitewe no kwitabwaho neza no gukurikiranwa. Kumenya ibyo witegura bishobora kugufasha kwitegura no kumenya igihe cyo kuvugana n’ikipe yawe y’ubuzima.

Dore ingaruka zikunze kugaragara ushobora guhura nazo:

• Impiswi no kurwara mu nda
• Umunaniro no kumva unaniwe
• Isesemi no kugabanya ubushake bwo kurya
• Umubyimbirwe w'amaraso
• Imbunda zihinduka ibara (akenshi zihinduka umweru cyangwa umvi)
• Uruhu rurashya cyangwa uruhu ruma
• Urubavu n'ububabare bw'ingingo

Izi ngaruka akenshi ziragenda zikemuka uko umubiri wawe wimenyereza umuti, kandi muganga wawe ashobora kugufasha kuzihangana n'imiti ifasha.

Ingaruka zitagaragara cyane ariko zikomeye zisaba ubufasha bwihuse bw'abaganga. Nubwo ibi bitaba kuri buri wese, ni ngombwa kuzimenya:

• Ibibazo bikomeye by'umwijima (uruhu cyangwa amaso y'umuhondo, inkari z'umukara)
• Guhinduka kw'umuvuduko w'umutima cyangwa kubabara mu gituza
• Gusohoka amaraso menshi cyangwa gukomereka bidasanzwe
• Ibimenyetso by'amaraso yiziba (gufata umwuka mu buryo butunguranye, kubyimba kw'ukuguru)
• Uruhu rukomeye cyangwa ibisebe mu kanwa
• Ibibazo bya tiroyide (umunaniro ukabije, guhinduka kw'ibiro)

Ikipe yawe y'ubuvuzi izagukurikiranira hafi izi ngaruka binyuze mu bipimo by'amaraso bisanzwe no kugenzura. Ingaruka nyinshi zirashobora guhangana nazo iyo zamenyekanye hakiri kare.

Ninde utagomba gufata Pazopanib?

Pazopanib ntabwo ikwiriye kuri buri wese, kandi muganga wawe azasuzuma neza amateka yawe y'ubuzima mbere yo kuyandika. Ibyiciro bimwe na bimwe bishobora gutuma uyu muti utaba umutekano cyangwa utagira akamaro.

Ntabwo ugomba gufata pazopanib niba ufite indwara ikomeye y'umwijima, kuko uyu muti ushobora gutuma imikorere y'umwijima irushaho kuba mibi. Abantu bafite indwara zimwe na zimwe z'umutima, umubyimbirwe w'amaraso udakontrolwa, cyangwa ibibazo by'amaraso bya vuba aha bashobora kandi gukenera kwirinda ubu buvuzi.

Niba utwite cyangwa wonka, pazopanib ishobora gukomeretsa umwana wawe kandi ntibisabwa. Abagore bafite imyaka yo kubyara bakwiye gukoresha uburyo bwo kuboneza urubyaro bukora neza mugihe bavurwa no muminsi mike nyuma yo guhagarika imiti.

Muganga wawe azanatekereza ku zindi miti urimo gufata, kuko pazopanib ishobora gukurura ibibazo n'imiti myinshi, harimo imiti imwe ifasha amaraso gutembera neza, imiti y'umutima, ndetse n'ibindi byongerera imbaraga umubiri.

Amazina y'Ubwoko bwa Pazopanib

Pazopanib igurishwa ku izina ry'ubwoko rya Votrient mu bihugu byinshi, harimo n'Amerika. Iyi ni yo miterere isanzwe uzahura nayo muri farumasi.

Ibihugu bimwe bishobora kugira amazina y'ubwoko atandukanye cyangwa ubwoko bwa generic. Buri gihe menya neza ko urimo gufata umuti ukwiye ukoresheje muganga wawe w'abafarumasiyo niba ufite ikibazo icyo aricyo cyose cyerekeye izina cyangwa imiterere y'ibinini byawe.

Uburyo bwo gusimbuza Pazopanib

Imiti myinshi ivura indwara yibanda ku ntego imwe ikora kimwe na pazopanib mugufasha kuvura kanseri y'impyiko na sarcomas y'imitsi yoroshye. Muganga wawe ashobora gutekereza kuri izi nzira niba pazopanib itagukwiriye cyangwa ihagaritse gukora neza.

Kubera kanseri y'impyiko, ibisubizo birimo sunitinib (Sutent), sorafenib (Nexavar), n'imiti mishya nka cabozantinib (Cabometyx) cyangwa nivolumab (Opdivo). Buri kimwe gifite inyungu zacyo n'ingaruka.

Kubera sarcomas y'imitsi yoroshye, amahitamo ashobora kuba chemotherapy ishingiye kuri doxorubicin, ifosfamide, cyangwa izindi terapiya zibanda ku ntego nka trabectedin. Ihitamo ryiza riterwa n'ubwoko bwawe bwa sarcoma n'ubuzima bwawe muri rusange.

Umuvuzi wawe w'indwara z'umubiri azagufasha gusobanukirwa impamvu bagusaba pazopanib kurusha izi nzira, bakita ku bwoko bwa kanseri yawe, amateka yawe y'ubuvuzi, n'ibyo ukunda.

Ese Pazopanib iruta Sunitinib?

Pazopanib na sunitinib zombi ni imiti ikora neza mu kuvura kanseri y’impyiko igeze kure, ariko zikora mu buryo butandukanye kandi zikagira ingaruka zitandukanye. Nta na rimwe rifatwa nk’iriruta irindi - biterwa n’uko ubuzima bwawe bumeze.

Ubushakashatsi bwagaragaje ko pazopanib na sunitinib bifite ubushobozi bungana mu kugabanya ikwirakwira rya kanseri no kongera igihe cyo kubaho. Ariko, abantu benshi basanga pazopanib yoroshye kwihanganira umunsi ku wundi, ifite umunaniro muke n’ibisebe bike mu kanwa.

Sunitinib ifatwa mu byiciro bifite akaruhuko, naho pazopanib ifatwa buri gihe. Abantu bamwe bakunda uburyo bwo gufata imiti buri gihe, mu gihe abandi bakunda akaruhuko mu kuvurwa. Muganga wawe azatekereza ku mibereho yawe, izindi ndwara ufite, n'ibyo ukunda ku giti cyawe mu gihe ahitamo hagati yazo.

Icyemezo akenshi kigenda ku muti ufitanye isano ryiza n'ubuzima bwawe kandi ufite ingaruka zoroshye kwihanganira.

Ibibazo Bikunze Kubazwa Kuri Pazopanib

Ese Pazopanib irakwiriye ku bantu barwaye indwara z'umutima?

Pazopanib ishobora kugira ingaruka ku mutima wawe n'umuvuduko w'amaraso, bityo abantu bafite indwara z'umutima basanzwe bakeneye gukurikiranwa neza. Muganga wawe azasuzuma ubuzima bw'umutima wawe mbere yo gutangira kuvurwa kandi ashobora gutegeka ibizamini by'umutima nk'icyo bita echocardiogram cyangwa EKG.

Niba ufite ibibazo byoroheje by'umutima, urashobora gukomeza gufata pazopanib ukurikiranwa neza kandi wenda ugahabwa imiti y'umutima yo kugenzura umuvuduko w'amaraso. Ariko, guhagarara k'umutima cyangwa gutera umutima mu buryo bukomeye vuba aha, akenshi bituma pazopanib iba ifite ibyago byinshi.

Itsinda ryawe rishinzwe kuvura kanseri n'umutima rizakorana kugira ngo rimenye niba inyungu zo kuvura kanseri zirenze ibyago by'umutima mu miterere yawe yihariye.

Nkwiriye gukora iki niba mfashe pazopanib nyinshi ku buryo butunguranye?

Niba ufata pazopanib nyinshi ku buryo butunguranye kuruta uko byateganijwe, vugana na muganga wawe cyangwa ikigo gishinzwe kugenzura uburozi ako kanya. Ntukegere ngo urebe niba wumva ibimenyetso - gufata inama z'abaganga vuba ni bwo buryo bwiza buri gihe.

Kunywa pazopanib nyinshi cyane bishobora gutera ingaruka zikomeye zirimo umuvuduko w'amaraso uri hasi cyane, ibibazo by'umutima, cyangwa kwangirika kw'umwijima. Izi ngaruka ntizishobora kugaragara ako kanya, bityo gukurikiranwa kwa muganga ni ngombwa kabone n'iyo wumva umeze neza.

Zana urupapuro rw'imiti yawe ku bitaro cyangwa urugireho igihe uhamagaye, kugira ngo abaganga bamenye neza icyo wanyoye n'ingano yacyo.

Nkwiriye gukora iki niba nciwe urugero rwa pazopanib?

Niba waciwe urugero kandi hashize amasaha atarenze 12 uhereye igihe usanzwe ufata imiti, yifate uko wibukije. Niba hashize amasaha arenga 12, reka urugero waciwe hanyuma ufate urugero rwawe rukurikira ku gihe gisanzwe.

Ntuzigere ufata imiti irenze urugero rumwe kugira ngo wuzuze urugero waciwe, kuko ibi bishobora kongera ibyago byo kugira ingaruka zikomeye. Biruta gucikanwa n'urugero rumwe kuruta gukuba kabiri.

Niba ukunda kwibagirwa urugero, ganira n'ikipe yawe y'ubuvuzi ku bijyanye n'uburyo bwo kugufasha kwibuka, nk'amasaha ya terefone, abategura imiti, cyangwa porogaramu za terefone zigendanwa zagenewe kwibutsa imiti.

Nshobora guhagarika ryari gufata pazopanib?

Ugomba guhagarika gufata pazopanib gusa ukurikije ubuyobozi bwa muganga wawe. N'iyo wumva umeze neza cyangwa ufite ingaruka, guhagarika ako kanya utabifashijwemo na muganga bishobora korohereza kanseri yawe gukura vuba.

Muganga wawe azagusaba guhagarika pazopanib niba kanseri yawe ikomeje nubwo uvurwa, niba ugize ingaruka zikomeye zitashobora gucungwa, cyangwa niba izindi miti zikwiriye kurushaho kubera uko umeze.

Rimwe na rimwe muganga wawe ashobora guhagarika kuvura by'agateganyo kugira ngo umubiri wawe ukire ingaruka, hanyuma ugasubira gutangira ku rugero ruto. Ubu buryo bushobora kugufasha gukomeza kungukirwa n'umuti mugihe ukomeza kumva umeze neza.

Nshobora kunywa inzoga niba mfata pazopanib?

Ni byiza kwirinda inzoga cyangwa kunywa gusa mu bwinshi buto cyane mugihe ukoresha pazopanib. Zombi, inzoga na pazopanib, zishobora kugira ingaruka ku mwijima wawe, kandi kuzivanga byongera ibyago byo kwangirika kw'umwijima.

Inzoga kandi irashobora gutuma bimwe mubyiciro bya pazopanib birushaho kuba bibi, nka isesemi, isereri, no kunanirwa. Niba uhisemo kunywa rimwe na rimwe, wikwiriza ku kinyobwa kimwe kandi witondere uko wumva.

Buri gihe ganira ku ikoreshwa ry'inzoga n'ikipe yawe y'ubuzima, kuko bashobora gutanga inama zihariye zishingiye ku bizami by'imikorere y'umwijima wawe n'ubuzima muri rusange.